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The map label for this gene is vsrB [H]

Identifier: 119899727

GI number: 119899727

Start: 3769862

End: 3771781

Strand: Direct

Name: vsrB [H]

Synonym: azo3438

Alternate gene names: 119899727

Gene position: 3769862-3771781 (Clockwise)

Preceding gene: 119899726

Following gene: 119899728

Centisome position: 86.15

GC content: 69.69

Gene sequence:

>1920_bases
ATGATGCTGCGTTCCGGAGTGCGTGCGCGGGTGATGCTGGCCGCGGTGCTGCCGATGCTGGTGCTTGCGCTGGTGCTGAC
CGTCTCCTTCACCCACTCCCGGCTGGCCGATCTCGATGCCGCCCTCACTGCGCGCGGCCAGGCCTATGCACGCCAGCTCG
CTGCCGCGAGCGAGTACGCGGTGTTCTCCGGCAACCGCGAAGCGCTGCAGCAACTCGCGAGCGCCGTCCTGTCGGAAGAG
GACGTCGTCGGCGTCAGCATCGTGGACCACAACGGCGACGCGCTGGCGCGCAGCGGCATCCTCGACGCCCAGTTGCCGCC
GCTGCCGGTCAGCGCGGTGGCCGCACCCGCCCGCCTGGTCCAGGGACCGACGCTGCGCTTGATCGAACCGATCCGCCCCA
GCCGACTCGAGCTGGACGATGGTTTCACCTCGATCAGCCCGGATTCGGCCGCCCAGCTCGGCGGTGCGCAGCTCGGCAGC
GTGGTACTGGAGCTATCGCTCAAGCGCCTCAACAGCCGTCGTGACGAATTGCTGTGGACCAGCGCCGGCTCGGTGCTGCT
GGTACTCGTGGGCAGCCTGCTGCTCGCCAGCCACCTCAGCCGTGGGGTCAGCGGCCCGATCCGCATCGTCGCCGAAACGG
TCACCCGCATCGGCCAGGGGCGGCTCGGTGAACGTGTGCCGGTCATCGGCGGCGGCAGCCTGCGCACGCTGGCGGAGGGC
GTCAACGAGATGGCCTGGCGGCTCGCGACCTCCCACGAGGAAATGGCGCGCAAGATCGAGGAAGCCACGGCAGAACTGCG
TGCCCGCAAGGAAGAGGCGGAGCGCGCCAACCTCGCCAAGTCGCGCTTTCTCGCCGCCGCCAGCCACGATCTGCGCCAAC
CGATGCATGCGTTGGGGCTGTTCATCTCGGAACTCGCGCAGCAATCCAGCTCGCACCACGAGCGCCGCCTCGTGCAACGC
ATTGCTGCGTCGGCGGAGGCGATGGAGAACCTGCTCGACAGCCTGCTCGACATTTCCAAGCTCGACGCCGGCGTCCTGCA
ACCCAATATCCGCACGTTCGCGCTCGAGCCGCTGCTCGACCGGCTCGCCACCCAGATGAGTTCCGCAGCGGCCGAGCACG
ACCTCGCCTTCAAGGTCCGTCCCTGCGCGGCCTGGATCGAAAGCGATCCGGTGCTGTTCGAGCGCATCCTCACCAACCTC
GTCAGCAACGCGCTGCGCTATACCCCCCAAGGCCGCGTGCTGGTGGCCTGCCGCCGGCGCCGCAACCGGCTGCGGGTGGA
AGTCCGCGACAGCGGCATCGGCATTGCGCCCGAAGCGCAGGAGATCATCTTCCAGGAGTTCGTCCAGCTCGATAACGACG
AACGCGCGCGCGACAAGGGCCTCGGCCTCGGGCTGGCGATCGTCCGCCGGCTGGCCAGCCTGATGGGACACCGTCTCGAT
CTGCGCTCCGCGCCCGGACGCGGCTCGGTATTCGCGATCGAGGTGCCGCTGGCACCTCCACAGCCGACGCTGGCCGCCGA
AGACGGCACGCGCGCGCCGGGCGACCTCGGTGGCGTGGTGATCGCGGTGGTGGACGACGACGCGCTGGCCCGCAGCGGCA
TGGAAGGGCTGCTTACCGCCTGGGGCTGCGAAGTGATCGCGGCGGAGACGCCAGCCGATCTCCTGGCTGCTCTTTCTGCC
CATCGGCCGCCGCAACTGGTGATCAGCGACTTCAGCCTGCACGGCTCGCACAACGGAGTCGACATCATCGCGGCGCTGCG
TCAGCAGGTCGGCCCCGGCCTCGCGGCGGTGCTGATCAGCGGGGACACCGGCCCGGAGGCGCAACGGCTCGCGCAGGACG
CCGGGGTGCCGCTGCTGCACAAACCGGTACGGCCGGCCCGGCTGCGGGCGCTGCTGCATCGCCTGCTGCATAACGATTGA

Upstream 100 bases:

>100_bases
AGGTCGCGGTAAACACCAACGTTGCACGCTCGCTCGGCATTCCGCTAGAAAGCGGCGAGCGGCTCACGGCCGAACTCCAG
CGTCTGGAAGGAGGCACGCC

Downstream 100 bases:

>100_bases
CCCGCACGGGCCGGGTGCGGTCGCCCGGTTCGTCGGTTAAGATGCCAACACCACCAGCCAGCCGGAGCACCTCGATGTCT
CATGAGCATTCCGCCCAGGA

Product: putative virulence regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MMLRSGVRARVMLAAVLPMLVLALVLTVSFTHSRLADLDAALTARGQAYARQLAAASEYAVFSGNREALQQLASAVLSEE
DVVGVSIVDHNGDALARSGILDAQLPPLPVSAVAAPARLVQGPTLRLIEPIRPSRLELDDGFTSISPDSAAQLGGAQLGS
VVLELSLKRLNSRRDELLWTSAGSVLLVLVGSLLLASHLSRGVSGPIRIVAETVTRIGQGRLGERVPVIGGGSLRTLAEG
VNEMAWRLATSHEEMARKIEEATAELRARKEEAERANLAKSRFLAAASHDLRQPMHALGLFISELAQQSSSHHERRLVQR
IAASAEAMENLLDSLLDISKLDAGVLQPNIRTFALEPLLDRLATQMSSAAAEHDLAFKVRPCAAWIESDPVLFERILTNL
VSNALRYTPQGRVLVACRRRRNRLRVEVRDSGIGIAPEAQEIIFQEFVQLDNDERARDKGLGLGLAIVRRLASLMGHRLD
LRSAPGRGSVFAIEVPLAPPQPTLAAEDGTRAPGDLGGVVIAVVDDDALARSGMEGLLTAWGCEVIAAETPADLLAALSA
HRPPQLVISDFSLHGSHNGVDIIAALRQQVGPGLAAVLISGDTGPEAQRLAQDAGVPLLHKPVRPARLRALLHRLLHND

Sequences:

>Translated_639_residues
MMLRSGVRARVMLAAVLPMLVLALVLTVSFTHSRLADLDAALTARGQAYARQLAAASEYAVFSGNREALQQLASAVLSEE
DVVGVSIVDHNGDALARSGILDAQLPPLPVSAVAAPARLVQGPTLRLIEPIRPSRLELDDGFTSISPDSAAQLGGAQLGS
VVLELSLKRLNSRRDELLWTSAGSVLLVLVGSLLLASHLSRGVSGPIRIVAETVTRIGQGRLGERVPVIGGGSLRTLAEG
VNEMAWRLATSHEEMARKIEEATAELRARKEEAERANLAKSRFLAAASHDLRQPMHALGLFISELAQQSSSHHERRLVQR
IAASAEAMENLLDSLLDISKLDAGVLQPNIRTFALEPLLDRLATQMSSAAAEHDLAFKVRPCAAWIESDPVLFERILTNL
VSNALRYTPQGRVLVACRRRRNRLRVEVRDSGIGIAPEAQEIIFQEFVQLDNDERARDKGLGLGLAIVRRLASLMGHRLD
LRSAPGRGSVFAIEVPLAPPQPTLAAEDGTRAPGDLGGVVIAVVDDDALARSGMEGLLTAWGCEVIAAETPADLLAALSA
HRPPQLVISDFSLHGSHNGVDIIAALRQQVGPGLAAVLISGDTGPEAQRLAQDAGVPLLHKPVRPARLRALLHRLLHND
>Mature_639_residues
MMLRSGVRARVMLAAVLPMLVLALVLTVSFTHSRLADLDAALTARGQAYARQLAAASEYAVFSGNREALQQLASAVLSEE
DVVGVSIVDHNGDALARSGILDAQLPPLPVSAVAAPARLVQGPTLRLIEPIRPSRLELDDGFTSISPDSAAQLGGAQLGS
VVLELSLKRLNSRRDELLWTSAGSVLLVLVGSLLLASHLSRGVSGPIRIVAETVTRIGQGRLGERVPVIGGGSLRTLAEG
VNEMAWRLATSHEEMARKIEEATAELRARKEEAERANLAKSRFLAAASHDLRQPMHALGLFISELAQQSSSHHERRLVQR
IAASAEAMENLLDSLLDISKLDAGVLQPNIRTFALEPLLDRLATQMSSAAAEHDLAFKVRPCAAWIESDPVLFERILTNL
VSNALRYTPQGRVLVACRRRRNRLRVEVRDSGIGIAPEAQEIIFQEFVQLDNDERARDKGLGLGLAIVRRLASLMGHRLD
LRSAPGRGSVFAIEVPLAPPQPTLAAEDGTRAPGDLGGVVIAVVDDDALARSGMEGLLTAWGCEVIAAETPADLLAALSA
HRPPQLVISDFSLHGSHNGVDIIAALRQQVGPGLAAVLISGDTGPEAQRLAQDAGVPLLHKPVRPARLRALLHRLLHND

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=677, Percent_Identity=29.2466765140325, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI87081816, Length=438, Percent_Identity=28.9954337899543, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI145693157, Length=343, Percent_Identity=25.3644314868805, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788713, Length=335, Percent_Identity=27.1641791044776, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI48994928, Length=332, Percent_Identity=30.7228915662651, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082128, Length=324, Percent_Identity=25.3086419753086, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786783, Length=340, Percent_Identity=25.2941176470588, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=295, Percent_Identity=28.4745762711864, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=278, Percent_Identity=29.136690647482, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=26.457399103139, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=27.7056277056277, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789808, Length=203, Percent_Identity=29.064039408867, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=25.8333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=29.8578199052133, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788393, Length=299, Percent_Identity=23.4113712374582, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=25.3275109170306, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68373; Mature: 68373

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50885 HAMP ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLRSGVRARVMLAAVLPMLVLALVLTVSFTHSRLADLDAALTARGQAYARQLAAASEYA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSGNREALQQLASAVLSEEDVVGVSIVDHNGDALARSGILDAQLPPLPVSAVAAPARLV
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHCCCCCCCCCCCCHHHHHHHHHHH
QGPTLRLIEPIRPSRLELDDGFTSISPDSAAQLGGAQLGSVVLELSLKRLNSRRDELLWT
CCCCHHHCCCCCCCCEECCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHCCHHHHEEEE
SAGSVLLVLVGSLLLASHLSRGVSGPIRIVAETVTRIGQGRLGERVPVIGGGSLRTLAEG
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHH
VNEMAWRLATSHEEMARKIEEATAELRARKEEAERANLAKSRFLAAASHDLRQPMHALGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FISELAQQSSSHHERRLVQRIAASAEAMENLLDSLLDISKLDAGVLQPNIRTFALEPLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHH
RLATQMSSAAAEHDLAFKVRPCAAWIESDPVLFERILTNLVSNALRYTPQGRVLVACRRR
HHHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
RNRLRVEVRDSGIGIAPEAQEIIFQEFVQLDNDERARDKGLGLGLAIVRRLASLMGHRLD
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCC
LRSAPGRGSVFAIEVPLAPPQPTLAAEDGTRAPGDLGGVVIAVVDDDALARSGMEGLLTA
CCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCEEEEEECCHHHHHCCHHHHHHH
WGCEVIAAETPADLLAALSAHRPPQLVISDFSLHGSHNGVDIIAALRQQVGPGLAAVLIS
HCCEEEECCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEE
GDTGPEAQRLAQDAGVPLLHKPVRPARLRALLHRLLHND
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMLRSGVRARVMLAAVLPMLVLALVLTVSFTHSRLADLDAALTARGQAYARQLAAASEYA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSGNREALQQLASAVLSEEDVVGVSIVDHNGDALARSGILDAQLPPLPVSAVAAPARLV
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHCCCCCCCCCCCCHHHHHHHHHHH
QGPTLRLIEPIRPSRLELDDGFTSISPDSAAQLGGAQLGSVVLELSLKRLNSRRDELLWT
CCCCHHHCCCCCCCCEECCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHCCHHHHEEEE
SAGSVLLVLVGSLLLASHLSRGVSGPIRIVAETVTRIGQGRLGERVPVIGGGSLRTLAEG
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHH
VNEMAWRLATSHEEMARKIEEATAELRARKEEAERANLAKSRFLAAASHDLRQPMHALGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FISELAQQSSSHHERRLVQRIAASAEAMENLLDSLLDISKLDAGVLQPNIRTFALEPLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHH
RLATQMSSAAAEHDLAFKVRPCAAWIESDPVLFERILTNLVSNALRYTPQGRVLVACRRR
HHHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
RNRLRVEVRDSGIGIAPEAQEIIFQEFVQLDNDERARDKGLGLGLAIVRRLASLMGHRLD
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCC
LRSAPGRGSVFAIEVPLAPPQPTLAAEDGTRAPGDLGGVVIAVVDDDALARSGMEGLLTA
CCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCEEEEEECCHHHHHCCHHHHHHH
WGCEVIAAETPADLLAALSAHRPPQLVISDFSLHGSHNGVDIIAALRQQVGPGLAAVLIS
HCCEEEECCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEE
GDTGPEAQRLAQDAGVPLLHKPVRPARLRALLHRLLHND
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]