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The map label for this gene is dld [H]

Identifier: 119899721

GI number: 119899721

Start: 3761183

End: 3762592

Strand: Direct

Name: dld [H]

Synonym: azo3432

Alternate gene names: 119899721

Gene position: 3761183-3762592 (Clockwise)

Preceding gene: 119899677

Following gene: 119899722

Centisome position: 85.95

GC content: 67.38

Gene sequence:

>1410_bases
ATGACACAGCAGGCCCCCGCGAACGCCGCGCTCCCCGAGGCGCTGGACACCGTACTCCAGACGAAATTCGGCAGCCGCTA
CACCACCTCGGGCGGTGTTCGCGCCCACCATGGGCACGACGAGTCGCATTTCCCCGACGCGCCGCCCCAGGCGGTGCTGT
TTCCCCACACCACCGAGGAGGTTGCGGAGGTGGTAATGCGGTGCGCGCAGTACGGCGTTCCGCTGATCCCCTACGGCGCC
GGGACGTCGCTGGAGGGACACGTCCTCGCGATCCGCGGCGGGATCTGCCTCGACTTCAGCGAAATGAACAAGGTGCTGGC
GATTCGCGCCGAGGACATGGACGTGGTCGTACAGCCGGGTGTCACCCGCAAGCAGCTCAATGCCGCGCTTCACGGCAGCG
GCCTGTTCTTCCCGATCGACCCCGGCGCCGATGCCAGCCTTGGCGGCATGGCCGCGACGCGGGCGTCGGGAACCAACGCG
GTCCGCTACGGCACGATGCGCGATAACGTGCTGGGCCTCACGGCGGTGATGGCGGACGGCAGCATCGTTCGCACCGGAAG
TCGGGCCCGCAAGTCTTCCGCCGGTTACGACCTCACACGTCTTCTGATCGGCTCGGAAGGCACGCTCGGCATCATCACCG
AACTGACGGTACGCCTTCACCCGCTACCGGAAGCGGTTTCCAGCGCGGTGTGCGCCTTCCCCGACGTGGATAGCGCCGTT
CGTACCGTCATCGCCACCATCCAGCTCGGTGTTCCGGTCGCGCGGATCGAACTGCTCGACGCGCTGACGGTGAGCGCGGT
CAATCGCTACAGCAAGACCACCCTGCGCGAAGCGCCGATGCTGTTCTTCGAGTTTCACGGCTCGCCTGCCGGGGTGGAGG
AGCAAGCCGGGATCGTGCAGACGCTGGCGCACGACCACGGCGGACTCGACTTCGAGTGGGCAAGCCGCCCCGAGGAGCGC
AGCCGACTGTGGGCGGCCCGCCACGACGTCTATTTCGCCAGCCTCAATCTTCGCCCCGGCAGCCGCGGCATCACTTCGGA
CGTGTGCGTGCCGATCTCGCGGCTGGCTGAGTGCGTCGCCGGCACGCGCGACGACATCGCGGCCTCCGGCTTCATCGCGC
CCATCGTCGGACATGTGGGTGACGGCAACTTCCACACCATCATCCTCGTCGATCCGGACGACCCGGCCGAGATCGAACGT
GCGGAAGCGCTCAACCACCGCATCGTCGAGCGTGCGCTGGCGCTGGGCGGCACCTGCACCGGAGAGCACGGCGTGGGGAT
GGGCAAGCAGCACTTCCTTGCCGCGGAGCACGGCGAAAACGCGGTTCGCGCGATGAGACTGATCAAGCAGGCGCTCGACC
CGCACAATTTGCTGAATCCAGGCAAGGTGGTGCCGTGGCCTGCGGATTGA

Upstream 100 bases:

>100_bases
TTTCCCGCGAACAGCGCCCGCTTGGGCGCTGGCCCGCGCGCGGGCGGTCGCCCACAATGCACCACCATCCCAGATAACAA
CGATATCCAGGAGACGACAG

Downstream 100 bases:

>100_bases
ACGAACCCGCGCCGGCTTAGGGTATCCAAGGATTGAGCCGTCGCCCGCAGGCGACCACGATGTTGCCGGCTTCGCCGTAT
TCGCCGCGGAGCCGTCGCGC

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTQQAPANAALPEALDTVLQTKFGSRYTTSGGVRAHHGHDESHFPDAPPQAVLFPHTTEEVAEVVMRCAQYGVPLIPYGA
GTSLEGHVLAIRGGICLDFSEMNKVLAIRAEDMDVVVQPGVTRKQLNAALHGSGLFFPIDPGADASLGGMAATRASGTNA
VRYGTMRDNVLGLTAVMADGSIVRTGSRARKSSAGYDLTRLLIGSEGTLGIITELTVRLHPLPEAVSSAVCAFPDVDSAV
RTVIATIQLGVPVARIELLDALTVSAVNRYSKTTLREAPMLFFEFHGSPAGVEEQAGIVQTLAHDHGGLDFEWASRPEER
SRLWAARHDVYFASLNLRPGSRGITSDVCVPISRLAECVAGTRDDIAASGFIAPIVGHVGDGNFHTIILVDPDDPAEIER
AEALNHRIVERALALGGTCTGEHGVGMGKQHFLAAEHGENAVRAMRLIKQALDPHNLLNPGKVVPWPAD

Sequences:

>Translated_469_residues
MTQQAPANAALPEALDTVLQTKFGSRYTTSGGVRAHHGHDESHFPDAPPQAVLFPHTTEEVAEVVMRCAQYGVPLIPYGA
GTSLEGHVLAIRGGICLDFSEMNKVLAIRAEDMDVVVQPGVTRKQLNAALHGSGLFFPIDPGADASLGGMAATRASGTNA
VRYGTMRDNVLGLTAVMADGSIVRTGSRARKSSAGYDLTRLLIGSEGTLGIITELTVRLHPLPEAVSSAVCAFPDVDSAV
RTVIATIQLGVPVARIELLDALTVSAVNRYSKTTLREAPMLFFEFHGSPAGVEEQAGIVQTLAHDHGGLDFEWASRPEER
SRLWAARHDVYFASLNLRPGSRGITSDVCVPISRLAECVAGTRDDIAASGFIAPIVGHVGDGNFHTIILVDPDDPAEIER
AEALNHRIVERALALGGTCTGEHGVGMGKQHFLAAEHGENAVRAMRLIKQALDPHNLLNPGKVVPWPAD
>Mature_468_residues
TQQAPANAALPEALDTVLQTKFGSRYTTSGGVRAHHGHDESHFPDAPPQAVLFPHTTEEVAEVVMRCAQYGVPLIPYGAG
TSLEGHVLAIRGGICLDFSEMNKVLAIRAEDMDVVVQPGVTRKQLNAALHGSGLFFPIDPGADASLGGMAATRASGTNAV
RYGTMRDNVLGLTAVMADGSIVRTGSRARKSSAGYDLTRLLIGSEGTLGIITELTVRLHPLPEAVSSAVCAFPDVDSAVR
TVIATIQLGVPVARIELLDALTVSAVNRYSKTTLREAPMLFFEFHGSPAGVEEQAGIVQTLAHDHGGLDFEWASRPEERS
RLWAARHDVYFASLNLRPGSRGITSDVCVPISRLAECVAGTRDDIAASGFIAPIVGHVGDGNFHTIILVDPDDPAEIERA
EALNHRIVERALALGGTCTGEHGVGMGKQHFLAAEHGENAVRAMRLIKQALDPHNLLNPGKVVPWPAD

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=455, Percent_Identity=54.5054945054945, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI37595754, Length=478, Percent_Identity=51.8828451882845, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI119964728, Length=425, Percent_Identity=30.8235294117647, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4501993, Length=455, Percent_Identity=24.3956043956044, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789351, Length=421, Percent_Identity=30.8788598574822, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787977, Length=527, Percent_Identity=28.2732447817837, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI48994907, Length=446, Percent_Identity=25.5605381165919, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI48994914, Length=138, Percent_Identity=32.6086956521739, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=460, Percent_Identity=48.2608695652174, Blast_Score=461, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71992381, Length=460, Percent_Identity=47.1739130434783, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71992392, Length=381, Percent_Identity=50.9186351706037, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17534361, Length=432, Percent_Identity=26.1574074074074, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17556096, Length=462, Percent_Identity=22.7272727272727, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320027, Length=444, Percent_Identity=41.2162162162162, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6320023, Length=441, Percent_Identity=27.891156462585, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6320764, Length=441, Percent_Identity=26.530612244898, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18921117, Length=426, Percent_Identity=28.4037558685446, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24639277, Length=426, Percent_Identity=28.4037558685446, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24639275, Length=426, Percent_Identity=28.4037558685446, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24653753, Length=464, Percent_Identity=25.4310344827586, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 49814; Mature: 49683

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQAPANAALPEALDTVLQTKFGSRYTTSGGVRAHHGHDESHFPDAPPQAVLFPHTTEE
CCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCCCCCCEEECCCCHHH
VAEVVMRCAQYGVPLIPYGAGTSLEGHVLAIRGGICLDFSEMNKVLAIRAEDMDVVVQPG
HHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCEEEEHHHCCCEEEEEECCCEEEECCC
VTRKQLNAALHGSGLFFPIDPGADASLGGMAATRASGTNAVRYGTMRDNVLGLTAVMADG
CCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCEEEECCCCCCHHEEEEEECCC
SIVRTGSRARKSSAGYDLTRLLIGSEGTLGIITELTVRLHPLPEAVSSAVCAFPDVDSAV
CEEECCCHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEECCCHHHHHHHEECCCCCHHHH
RTVIATIQLGVPVARIELLDALTVSAVNRYSKTTLREAPMLFFEFHGSPAGVEEQAGIVQ
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
TLAHDHGGLDFEWASRPEERSRLWAARHDVYFASLNLRPGSRGITSDVCVPISRLAECVA
HHHHCCCCCCCHHCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHC
GTRDDIAASGFIAPIVGHVGDGNFHTIILVDPDDPAEIERAEALNHRIVERALALGGTCT
CCCCHHHHCCCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GEHGVGMGKQHFLAAEHGENAVRAMRLIKQALDPHNLLNPGKVVPWPAD
CCCCCCCCHHHEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQQAPANAALPEALDTVLQTKFGSRYTTSGGVRAHHGHDESHFPDAPPQAVLFPHTTEE
CCCCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCCCCCCCEEECCCCHHH
VAEVVMRCAQYGVPLIPYGAGTSLEGHVLAIRGGICLDFSEMNKVLAIRAEDMDVVVQPG
HHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCEEEEHHHCCCEEEEEECCCEEEECCC
VTRKQLNAALHGSGLFFPIDPGADASLGGMAATRASGTNAVRYGTMRDNVLGLTAVMADG
CCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCEEEECCCCCCHHEEEEEECCC
SIVRTGSRARKSSAGYDLTRLLIGSEGTLGIITELTVRLHPLPEAVSSAVCAFPDVDSAV
CEEECCCHHHHCCCCCCEEEEEECCCCCEEEEEEEEEEECCCHHHHHHHEECCCCCHHHH
RTVIATIQLGVPVARIELLDALTVSAVNRYSKTTLREAPMLFFEFHGSPAGVEEQAGIVQ
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
TLAHDHGGLDFEWASRPEERSRLWAARHDVYFASLNLRPGSRGITSDVCVPISRLAECVA
HHHHCCCCCCCHHCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHC
GTRDDIAASGFIAPIVGHVGDGNFHTIILVDPDDPAEIERAEALNHRIVERALALGGTCT
CCCCHHHHCCCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GEHGVGMGKQHFLAAEHGENAVRAMRLIKQALDPHNLLNPGKVVPWPAD
CCCCCCCCHHHEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]