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The map label for this gene is trpC

Identifier: 119899611

GI number: 119899611

Start: 3661872

End: 3662666

Strand: Reverse

Name: trpC

Synonym: azo3322

Alternate gene names: 119899611

Gene position: 3662666-3661872 (Counterclockwise)

Preceding gene: 119899612

Following gene: 119899610

Centisome position: 83.7

GC content: 69.18

Gene sequence:

>795_bases
ATGAGCGACATCCTGCAGAAGATCTGCGCGGTCAAGCGCGAGGAAGTCACCGCCGCGCTTGCGGCCAAACCGCTCGCCAT
CGTGCGGGCAGAGGCCGAGGCGCAGCCCGCGGCGCGCGATTTCGTCGGCGCGATCCGCGGCAGGATCACCGCGGGCCGAC
CGGCGGTGATCGCCGAGATCAAGAAGGCCAGTCCCTCCAAAGGGGTGATCCGCGAGGACTTCCGGCCCGCCGACATCGCG
CCCTCGTACGAGGCCGCGGGCGCGGCCTGCCTGTCGGTGCTGACCGACAAACCCTTCTTCCAGGGCGCGCCGGAATACCT
GCAGGCTGCCCGCGCCGCCTGCGCGCTGCCGGCGCTGCGCAAGGATTTCCTCGTCGACGCCTATCAGGTGTACGAAGCGC
GCGCGATGGGTGCGGACGCCATCCTGCTGATCGCCGCCTGCCTTTCGCTGGCCGAGATGCAGGACATGGAGGCGATCGCC
CACGGCCTCGGCATGGGCGTGCTGGTCGAGGTCCATGACGGCGCCGAACTCGAACAGGCCTTGAAGCTGCGCACGCCGCT
CGTCGGCATCAACAACCGTAACCTGCGCACGTTCGAAGTCTCGCTGCAGACCACGCTCGGTCTGCTGCCGCGGCTGGCGG
CGGAGGCGGACCGCATCGTCGTCACCGAGTCCGGCATTCTCGCGCCGGCCGATGTCGCCTTGATGCGCGAGAACGGCGTG
AATGCCTTCCTGGTCGGGGAGGCCTTCATGCGCGTACCCGACCCCGGCGCCGGTTTGCGCGCCTTGTTCGGCTAA

Upstream 100 bases:

>100_bases
AGGCCGGCATCGTCCGCGCGCGCGAACTCGTCGCGAGCGGCGCGGCACGGGCCAAGCTGGACGAGTACGTGCAATTCACG
CGCAAGTTCGGAGGCGCCTG

Downstream 100 bases:

>100_bases
GGCATGGACGGGCCGGACGACAGCGCCGACGCGCCCCCGGCCCCGCCCGCGCCCGCACCCCGGCGGGCGCGCCGTCGCCG
CTGGCCGCTGCTGCTGACGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSDILQKICAVKREEVTAALAAKPLAIVRAEAEAQPAARDFVGAIRGRITAGRPAVIAEIKKASPSKGVIREDFRPADIA
PSYEAAGAACLSVLTDKPFFQGAPEYLQAARAACALPALRKDFLVDAYQVYEARAMGADAILLIAACLSLAEMQDMEAIA
HGLGMGVLVEVHDGAELEQALKLRTPLVGINNRNLRTFEVSLQTTLGLLPRLAAEADRIVVTESGILAPADVALMRENGV
NAFLVGEAFMRVPDPGAGLRALFG

Sequences:

>Translated_264_residues
MSDILQKICAVKREEVTAALAAKPLAIVRAEAEAQPAARDFVGAIRGRITAGRPAVIAEIKKASPSKGVIREDFRPADIA
PSYEAAGAACLSVLTDKPFFQGAPEYLQAARAACALPALRKDFLVDAYQVYEARAMGADAILLIAACLSLAEMQDMEAIA
HGLGMGVLVEVHDGAELEQALKLRTPLVGINNRNLRTFEVSLQTTLGLLPRLAAEADRIVVTESGILAPADVALMRENGV
NAFLVGEAFMRVPDPGAGLRALFG
>Mature_263_residues
SDILQKICAVKREEVTAALAAKPLAIVRAEAEAQPAARDFVGAIRGRITAGRPAVIAEIKKASPSKGVIREDFRPADIAP
SYEAAGAACLSVLTDKPFFQGAPEYLQAARAACALPALRKDFLVDAYQVYEARAMGADAILLIAACLSLAEMQDMEAIAH
GLGMGVLVEVHDGAELEQALKLRTPLVGINNRNLRTFEVSLQTTLGLLPRLAAEADRIVVTESGILAPADVALMRENGVN
AFLVGEAFMRVPDPGAGLRALFG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=260, Percent_Identity=42.3076923076923, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322638, Length=227, Percent_Identity=37.0044052863436, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_AZOSB (A1KAT2)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934824.1
- ProteinModelPortal:   A1KAT2
- SMR:   A1KAT2
- STRING:   A1KAT2
- GeneID:   4607918
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3322
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   A1KAT2
- ProtClustDB:   PRK00278
- BioCyc:   ASP62928:AZO3322-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27916; Mature: 27785

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILQKICAVKREEVTAALAAKPLAIVRAEAEAQPAARDFVGAIRGRITAGRPAVIAEI
CHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHH
KKASPSKGVIREDFRPADIAPSYEAAGAACLSVLTDKPFFQGAPEYLQAARAACALPALR
HHCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFLVDAYQVYEARAMGADAILLIAACLSLAEMQDMEAIAHGLGMGVLVEVHDGAELEQA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
LKLRTPLVGINNRNLRTFEVSLQTTLGLLPRLAAEADRIVVTESGILAPADVALMRENGV
HHHHCCEEECCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCC
NAFLVGEAFMRVPDPGAGLRALFG
CEEEECHHHHCCCCCCCCHHHHCC
>Mature Secondary Structure 
SDILQKICAVKREEVTAALAAKPLAIVRAEAEAQPAARDFVGAIRGRITAGRPAVIAEI
HHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHH
KKASPSKGVIREDFRPADIAPSYEAAGAACLSVLTDKPFFQGAPEYLQAARAACALPALR
HHCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFLVDAYQVYEARAMGADAILLIAACLSLAEMQDMEAIAHGLGMGVLVEVHDGAELEQA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
LKLRTPLVGINNRNLRTFEVSLQTTLGLLPRLAAEADRIVVTESGILAPADVALMRENGV
HHHHCCEEECCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCC
NAFLVGEAFMRVPDPGAGLRALFG
CEEEECHHHHCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA