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The map label for this gene is coxB [H]

Identifier: 119899593

GI number: 119899593

Start: 3639657

End: 3640799

Strand: Reverse

Name: coxB [H]

Synonym: azo3304

Alternate gene names: 119899593

Gene position: 3640799-3639657 (Counterclockwise)

Preceding gene: 119899594

Following gene: 119899592

Centisome position: 83.2

GC content: 67.28

Gene sequence:

>1143_bases
ATGAGTCATGCCGTTCGAATCGCAGCCGCAGCCCCGGCTTTGACGCTGGCCTTGCCGCAGCGCGTCATGGCCGATGTCGG
CCCGAGCCGTTTCAACCTGCAGCCGCCGGTCACCGAGATCGCGGCGCACATCTACGACATGCACACGCTGATGCTGCTGC
TGTGCCTGTTGATCTTCATCGGCGTATTCGGCGTGATGTTCTGGGCGGTGATCCACCACCGCAAATCGCGCGGCGCCACC
GCCGCCCATTTCCACGAGAACACCGCGGTCGAGATCGCCTGGACGGTCGCGCCGGTGCTGATCCTGCTCGGCATGGCGTG
GCCCGCGACCCGCACGGTGATCGCAATGAAGGACACCTCGGAAGCCGACATCACGGTCAAGGTCACCGGCTACCAGTGGA
AATGGGGCTACGACTACCTGCAGGGCGAAGGCGAGGGCATCCGCTTCCTGTCCGCGCTGTCCACACCGCGCGATCAGATC
GAGGGCAAGGCCCCGAAGGGCGAGAACTATCTGGTCGAGGTCGATAACCCGATGGTGGTGCCCGCGGGCAAGAAGATCCG
CGTCATCACTACCGCCAACGATGTGATCCACGCGTGGTGGGTGCCTGCCTTCGGCGCCAAGCAGGACGCCATCCCCGGCT
TCATCCGCGACACCTGGTTCCGCACCGACAAGGAAGGCGTCTATCGCGGCAGCTGCGCCGAGCTGTGCGGGCGCGAGCAC
GCCTTCATGCCGATCGAGGTGCACGTCGTTTCCGCCGAGGCCTACACCGCCTGGGTGGCGAAGCAGCGCGCCGGCGCCGC
GGCCCTGAGTGCGGACGACAGCCGCGAATGGGCGCTGGCCGAACTCGTCGCCCGCGGGCAGAAGGTGTTCGCCGCCAACT
GCCAGGCCTGCCATCAGGAAAACGGCAAGGGCCTGCCACCGGCTTTCCCGCCGCTGGATGGCTCCGCCCTGGTGCTGGGC
GACAAGAACGGGCAGATCGACGTGGTGCTGCACGGTCGCCCGGGCACGGCGATGGCTGCGTTCGGGCCGCAGCTGTCGGA
TGCGGATCTGGCCGCGGTGATCACCTACACCCGCAACAGCTGGAGCAATGCCACCGGCGAGGCCGTGCAGCCCGCCGACA
TCAAGGCCGGTCGCAAGGGCTGA

Upstream 100 bases:

>100_bases
GAGGAGACATCGATCCGTTGTGGCGCCGGGATGGCAAGGTCATCCATGGCGGTCATGGCCGCAGGCTCATTGGTCGAAGC
TGCATTACTCGGGGGTGCCC

Downstream 100 bases:

>100_bases
GGCGCCGCGCAGGCGCCGCGCCGCTTCGAGGAGGATTTCCGCAAATGGCTGCCGTCACCCCGGAACAGTTGCATGGTCAT
CCCCATCCGCCCGCCGGGCT

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSHAVRIAAAAPALTLALPQRVMADVGPSRFNLQPPVTEIAAHIYDMHTLMLLLCLLIFIGVFGVMFWAVIHHRKSRGAT
AAHFHENTAVEIAWTVAPVLILLGMAWPATRTVIAMKDTSEADITVKVTGYQWKWGYDYLQGEGEGIRFLSALSTPRDQI
EGKAPKGENYLVEVDNPMVVPAGKKIRVITTANDVIHAWWVPAFGAKQDAIPGFIRDTWFRTDKEGVYRGSCAELCGREH
AFMPIEVHVVSAEAYTAWVAKQRAGAAALSADDSREWALAELVARGQKVFAANCQACHQENGKGLPPAFPPLDGSALVLG
DKNGQIDVVLHGRPGTAMAAFGPQLSDADLAAVITYTRNSWSNATGEAVQPADIKAGRKG

Sequences:

>Translated_380_residues
MSHAVRIAAAAPALTLALPQRVMADVGPSRFNLQPPVTEIAAHIYDMHTLMLLLCLLIFIGVFGVMFWAVIHHRKSRGAT
AAHFHENTAVEIAWTVAPVLILLGMAWPATRTVIAMKDTSEADITVKVTGYQWKWGYDYLQGEGEGIRFLSALSTPRDQI
EGKAPKGENYLVEVDNPMVVPAGKKIRVITTANDVIHAWWVPAFGAKQDAIPGFIRDTWFRTDKEGVYRGSCAELCGREH
AFMPIEVHVVSAEAYTAWVAKQRAGAAALSADDSREWALAELVARGQKVFAANCQACHQENGKGLPPAFPPLDGSALVLG
DKNGQIDVVLHGRPGTAMAAFGPQLSDADLAAVITYTRNSWSNATGEAVQPADIKAGRKG
>Mature_379_residues
SHAVRIAAAAPALTLALPQRVMADVGPSRFNLQPPVTEIAAHIYDMHTLMLLLCLLIFIGVFGVMFWAVIHHRKSRGATA
AHFHENTAVEIAWTVAPVLILLGMAWPATRTVIAMKDTSEADITVKVTGYQWKWGYDYLQGEGEGIRFLSALSTPRDQIE
GKAPKGENYLVEVDNPMVVPAGKKIRVITTANDVIHAWWVPAFGAKQDAIPGFIRDTWFRTDKEGVYRGSCAELCGREHA
FMPIEVHVVSAEAYTAWVAKQRAGAAALSADDSREWALAELVARGQKVFAANCQACHQENGKGLPPAFPPLDGSALVLGD
KNGQIDVVLHGRPGTAMAAFGPQLSDADLAAVITYTRNSWSNATGEAVQPADIKAGRKG

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=166, Percent_Identity=35.5421686746988, Blast_Score=125, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6226540, Length=253, Percent_Identity=31.2252964426877, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 41085; Mature: 40953

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHAVRIAAAAPALTLALPQRVMADVGPSRFNLQPPVTEIAAHIYDMHTLMLLLCLLIFI
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GVFGVMFWAVIHHRKSRGATAAHFHENTAVEIAWTVAPVLILLGMAWPATRTVIAMKDTS
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCC
EADITVKVTGYQWKWGYDYLQGEGEGIRFLSALSTPRDQIEGKAPKGENYLVEVDNPMVV
CCEEEEEEEEEEEECCCHHHCCCCCCEEEEHHHCCCHHHHCCCCCCCCCEEEEECCCEEE
PAGKKIRVITTANDVIHAWWVPAFGAKQDAIPGFIRDTWFRTDKEGVYRGSCAELCGREH
CCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHCCCCC
AFMPIEVHVVSAEAYTAWVAKQRAGAAALSADDSREWALAELVARGQKVFAANCQACHQE
CEEEEEEEEEECHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHC
NGKGLPPAFPPLDGSALVLGDKNGQIDVVLHGRPGTAMAAFGPQLSDADLAAVITYTRNS
CCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEECCC
WSNATGEAVQPADIKAGRKG
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHAVRIAAAAPALTLALPQRVMADVGPSRFNLQPPVTEIAAHIYDMHTLMLLLCLLIFI
CCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GVFGVMFWAVIHHRKSRGATAAHFHENTAVEIAWTVAPVLILLGMAWPATRTVIAMKDTS
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEEECCC
EADITVKVTGYQWKWGYDYLQGEGEGIRFLSALSTPRDQIEGKAPKGENYLVEVDNPMVV
CCEEEEEEEEEEEECCCHHHCCCCCCEEEEHHHCCCHHHHCCCCCCCCCEEEEECCCEEE
PAGKKIRVITTANDVIHAWWVPAFGAKQDAIPGFIRDTWFRTDKEGVYRGSCAELCGREH
CCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHCCCCC
AFMPIEVHVVSAEAYTAWVAKQRAGAAALSADDSREWALAELVARGQKVFAANCQACHQE
CEEEEEEEEEECHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHC
NGKGLPPAFPPLDGSALVLGDKNGQIDVVLHGRPGTAMAAFGPQLSDADLAAVITYTRNS
CCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEECCC
WSNATGEAVQPADIKAGRKG
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1648008 [H]