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The map label for this gene is coxA [H]

Identifier: 119899592

GI number: 119899592

Start: 3638035

End: 3639612

Strand: Reverse

Name: coxA [H]

Synonym: azo3303

Alternate gene names: 119899592

Gene position: 3639612-3638035 (Counterclockwise)

Preceding gene: 119899593

Following gene: 119899591

Centisome position: 83.17

GC content: 64.32

Gene sequence:

>1578_bases
ATGGCTGCCGTCACCCCGGAACAGTTGCATGGTCATCCCCATCCGCCCGCCGGGCTGATGCGGTGGGTGACGACCACCAA
TCACAAAGACATCGGCACGATGTACCTGCTGTTCAGCTTCGTGATGTTCCTGTCCGGCGGCGTGATGGCGCTGACGATAC
GCTCCGAGCTGTTCCAGCCGGGCCTGCAGATCGTGCAGCCGGAGTTCTTCAACCAGCTCACCACCATGCATGGGCTGGTG
ATGGTGTTCGGCGCGATCATGCCGGCCTTCGTCGGCTTTGCGAACTGGATGATTCCGCTGATGATCGGCGCCAGCGACAT
GGCCTTTGCGCGCATGAACAACTGGAGCTTCTGGCTGCTGCCGCCGGCGGCCATCCTGCTGCTCGGCTCCTTCTTCGTGC
CCGGCGGCGCCACCGCGGCGGGGTGGACGCTGTACGCCCCGCTGTCGGTGCAGATGGGCATGGGCATGGACATGGCGATC
TTCGCCATCCACATCATGGGCCTCAGCTCGATCATGGGCGCGATCAACATCATCGTCACCGTGCTCAACATGCGCGCGCC
AGGCATGACGCTGATGAAGATGCCGCTGTTCTGCTGGACCTGGCTGATCACCGCCTACCTGCTGATCGCGGTGATGCCGG
TGCTGGCGGGCGCGGTCACCATGATCCTGACCGACCGCCACTTCGGCACCAGCTTCTTCAACGCCGCCGGCGGCGGCGAC
CCGGTGATGTACCAGCACATCTTCTGGTTCTTCGGCCACCCGGAGGTCTACATCATGATCCTCCCGGCCTTCGGCATCGT
CAGCCAGATCATCCCCACCTTCGCGAGGAAGCCGCTGTTCGGCTACGCCTCGATGGTCTATGCCACCGCGTCGATCGCGA
TCCTGTCCTTCATGGTGTGGGCGCACCACATGTTCTCCACCGGCATGCCGGTGGTGGGGCAGCTCTACTTCATGTACGCG
ACGATGCTGATCGCCGTGCCGACCGGGGTGAAGGTGTTCAACTGGGTGGCGACGATGTGGCGCGGCGCGCTCAGCTTCGA
GACGCCGATGCTGTGGGCGACCGGCTTCATCTTCGTGTTCACCATCGGCGGTTTCACCGGGCTGATCTGCGCGATCGCGC
CGATCGACATCCAGATCCACGACACCTACTACGTGGTGGCCCACTTCCACTACGTGCTGGTGGCCGGCAGCCTGTTCGCG
CTGTTCGCGGGGGCCTATTTCTGGTTGCCGAAATGGACCGGGCGCATGCCGGACGAGCGGCTGGGCAAGCTGCACTTCTG
GAGTTCGATGGTGTTCTTCAACATCACCTTCTTCCCGATGCACTTTCTCGGCCTCGCGGGCATGCCGCGGCGGATTCCCG
ACTACGCGCTGCAGTTCGCCGATTTCAACGCACTCGCCACGGTGGGCGCCTTCGGCTTCGGTTTGTCGCAGCTCATCTTC
ATCGCGGTCGTGGTGAAGTCGATGCGCGCCGGAGAACGGGCCGCGGCCAAGCCCTGGGAGGGCGCCGAGGGGCTGGAATG
GACGGTGCCGTCGCCCGCGCCGCACCACACCTTCGAGCATCCGCCGGTGGTGGCCTGA

Upstream 100 bases:

>100_bases
ATGCCACCGGCGAGGCCGTGCAGCCCGCCGACATCAAGGCCGGTCGCAAGGGCTGAGGCGCCGCGCAGGCGCCGCGCCGC
TTCGAGGAGGATTTCCGCAA

Downstream 100 bases:

>100_bases
ACCGGGCCGAAAGGAGGAGAACACGTGGACAAGCCGCTGGACCGCCGCCGCGCCAATCGCCGCCTTGCGCTGGCGCATGC
GCTGCTGGCCGTGGTCTTCT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAAVTPEQLHGHPHPPAGLMRWVTTTNHKDIGTMYLLFSFVMFLSGGVMALTIRSELFQPGLQIVQPEFFNQLTTMHGLV
MVFGAIMPAFVGFANWMIPLMIGASDMAFARMNNWSFWLLPPAAILLLGSFFVPGGATAAGWTLYAPLSVQMGMGMDMAI
FAIHIMGLSSIMGAINIIVTVLNMRAPGMTLMKMPLFCWTWLITAYLLIAVMPVLAGAVTMILTDRHFGTSFFNAAGGGD
PVMYQHIFWFFGHPEVYIMILPAFGIVSQIIPTFARKPLFGYASMVYATASIAILSFMVWAHHMFSTGMPVVGQLYFMYA
TMLIAVPTGVKVFNWVATMWRGALSFETPMLWATGFIFVFTIGGFTGLICAIAPIDIQIHDTYYVVAHFHYVLVAGSLFA
LFAGAYFWLPKWTGRMPDERLGKLHFWSSMVFFNITFFPMHFLGLAGMPRRIPDYALQFADFNALATVGAFGFGLSQLIF
IAVVVKSMRAGERAAAKPWEGAEGLEWTVPSPAPHHTFEHPPVVA

Sequences:

>Translated_525_residues
MAAVTPEQLHGHPHPPAGLMRWVTTTNHKDIGTMYLLFSFVMFLSGGVMALTIRSELFQPGLQIVQPEFFNQLTTMHGLV
MVFGAIMPAFVGFANWMIPLMIGASDMAFARMNNWSFWLLPPAAILLLGSFFVPGGATAAGWTLYAPLSVQMGMGMDMAI
FAIHIMGLSSIMGAINIIVTVLNMRAPGMTLMKMPLFCWTWLITAYLLIAVMPVLAGAVTMILTDRHFGTSFFNAAGGGD
PVMYQHIFWFFGHPEVYIMILPAFGIVSQIIPTFARKPLFGYASMVYATASIAILSFMVWAHHMFSTGMPVVGQLYFMYA
TMLIAVPTGVKVFNWVATMWRGALSFETPMLWATGFIFVFTIGGFTGLICAIAPIDIQIHDTYYVVAHFHYVLVAGSLFA
LFAGAYFWLPKWTGRMPDERLGKLHFWSSMVFFNITFFPMHFLGLAGMPRRIPDYALQFADFNALATVGAFGFGLSQLIF
IAVVVKSMRAGERAAAKPWEGAEGLEWTVPSPAPHHTFEHPPVVA
>Mature_524_residues
AAVTPEQLHGHPHPPAGLMRWVTTTNHKDIGTMYLLFSFVMFLSGGVMALTIRSELFQPGLQIVQPEFFNQLTTMHGLVM
VFGAIMPAFVGFANWMIPLMIGASDMAFARMNNWSFWLLPPAAILLLGSFFVPGGATAAGWTLYAPLSVQMGMGMDMAIF
AIHIMGLSSIMGAINIIVTVLNMRAPGMTLMKMPLFCWTWLITAYLLIAVMPVLAGAVTMILTDRHFGTSFFNAAGGGDP
VMYQHIFWFFGHPEVYIMILPAFGIVSQIIPTFARKPLFGYASMVYATASIAILSFMVWAHHMFSTGMPVVGQLYFMYAT
MLIAVPTGVKVFNWVATMWRGALSFETPMLWATGFIFVFTIGGFTGLICAIAPIDIQIHDTYYVVAHFHYVLVAGSLFAL
FAGAYFWLPKWTGRMPDERLGKLHFWSSMVFFNITFFPMHFLGLAGMPRRIPDYALQFADFNALATVGAFGFGLSQLIFI
AVVVKSMRAGERAAAKPWEGAEGLEWTVPSPAPHHTFEHPPVVA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=506, Percent_Identity=50.197628458498, Blast_Score=462, Evalue=1e-130,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=40.272373540856, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=45.8646616541353, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=50.3105590062112, Blast_Score=325, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=46.3709677419355, Blast_Score=210, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 58040; Mature: 57909

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.4 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
7.3 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVTPEQLHGHPHPPAGLMRWVTTTNHKDIGTMYLLFSFVMFLSGGVMALTIRSELFQP
CCCCCHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHC
GLQIVQPEFFNQLTTMHGLVMVFGAIMPAFVGFANWMIPLMIGASDMAFARMNNWSFWLL
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCEEEEE
PPAAILLLGSFFVPGGATAAGWTLYAPLSVQMGMGMDMAIFAIHIMGLSSIMGAINIIVT
CHHHHHHHHHHCCCCCCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLNMRAPGMTLMKMPLFCWTWLITAYLLIAVMPVLAGAVTMILTDRHFGTSFFNAAGGGD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCC
PVMYQHIFWFFGHPEVYIMILPAFGIVSQIIPTFARKPLFGYASMVYATASIAILSFMVW
CHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AHHMFSTGMPVVGQLYFMYATMLIAVPTGVKVFNWVATMWRGALSFETPMLWATGFIFVF
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TIGGFTGLICAIAPIDIQIHDTYYVVAHFHYVLVAGSLFALFAGAYFWLPKWTGRMPDER
HHHHHHHHHHHHCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LGKLHFWSSMVFFNITFFPMHFLGLAGMPRRIPDYALQFADFNALATVGAFGFGLSQLIF
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IAVVVKSMRAGERAAAKPWEGAEGLEWTVPSPAPHHTFEHPPVVA
HHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAVTPEQLHGHPHPPAGLMRWVTTTNHKDIGTMYLLFSFVMFLSGGVMALTIRSELFQP
CCCCHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHC
GLQIVQPEFFNQLTTMHGLVMVFGAIMPAFVGFANWMIPLMIGASDMAFARMNNWSFWLL
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCEEEEE
PPAAILLLGSFFVPGGATAAGWTLYAPLSVQMGMGMDMAIFAIHIMGLSSIMGAINIIVT
CHHHHHHHHHHCCCCCCCCCCEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLNMRAPGMTLMKMPLFCWTWLITAYLLIAVMPVLAGAVTMILTDRHFGTSFFNAAGGGD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCC
PVMYQHIFWFFGHPEVYIMILPAFGIVSQIIPTFARKPLFGYASMVYATASIAILSFMVW
CHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AHHMFSTGMPVVGQLYFMYATMLIAVPTGVKVFNWVATMWRGALSFETPMLWATGFIFVF
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TIGGFTGLICAIAPIDIQIHDTYYVVAHFHYVLVAGSLFALFAGAYFWLPKWTGRMPDER
HHHHHHHHHHHHCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LGKLHFWSSMVFFNITFFPMHFLGLAGMPRRIPDYALQFADFNALATVGAFGFGLSQLIF
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IAVVVKSMRAGERAAAKPWEGAEGLEWTVPSPAPHHTFEHPPVVA
HHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]