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The map label for this gene is ffh [H]

Identifier: 119899521

GI number: 119899521

Start: 3562254

End: 3563612

Strand: Reverse

Name: ffh [H]

Synonym: azo3232

Alternate gene names: 119899521

Gene position: 3563612-3562254 (Counterclockwise)

Preceding gene: 119899538

Following gene: 119899520

Centisome position: 81.43

GC content: 64.9

Gene sequence:

>1359_bases
ATGCTCGACAATCTCACTCAGCGCCTTTCCAAGGTCGTTAAGACACTGCGCGGTCAGGCCCGCCTGACCGAGGACAACAT
CCAGGACGCCATGCGCGAGGTGCGCATGGCGCTTCTCGAGGCCGATGTGGCTTTGCCCGTGGTGAAGGATTTCATTGCCA
AGGTCAAGCTCAAGGCCGTCGGGCAGGAGGTGGTGGGGTCGCTGACGCCGGGGCAGGCGCTGGTCGGTGTGGTCCACGAC
GAACTGAAAGCGCTCATGGGCGGGGCCCATGAAGGCCTGAACCTCGCCACCCAGCCGCCGGCCGTCATCCTGATGGCCGG
CTTGCAGGGCGCGGGCAAGACCACGACGACCGGCAAGCTCGCCAAGCATCTGAAGGAGTCGCAGAAGAAGAAGGTGCTGG
TCGTCTCCACCGACGTCTATCGCCCTGCCGCCATCGAGCAGCTGAAGGCAGTGGCGGCGCAGGCCGGGGTGGAGTTTTTC
CCCTCGCAGGTCGATCAGCGCCCGGTCGACATCGCGCTCGGGGCGGTGGATTTCGCGCGCAAGCACCATGTCGACGTGCT
GCTGGTGGATACGGCCGGCCGCCTCGCGATCGACGAAGCCATGATGGCGGAAATCCAGGCCCTGCACGCCGCTGTCAAGC
CGATCGAGACGCTGTTTGTCGTGGATGCGATGTTGGGCCAGGACGCGGTGAACACCGCCCGCGCCTTCAACGATGCACTC
CCGCTGACCGGTGTTGTCCTCACGAAGCTGGATGGCGACGCACGCGGCGGCGCGGCGCTGTCGGTGCGTCACGTGACCGG
CAAGCCGCTCAAGTTCGCCGGTGTCGGGGAGAAGCTCTCCGGCCTCGAACCTTTCCACCCGGACCGGATGGCCAGCCGCA
TCCTCGGCATGGGCGACATCCTGGGCCTGGTGGAAGAGGCACGACGCGGGGTCGATGAAGAAAAGGCGAAGGCGTTTGCG
CACAAGCTGAAGAGTGGCAAGGGTTTCGACCTCAACGACTTCAAGGATCAGATCGCCCAGATGCGCAAGATGGGCGGCAT
TTCCTCGCTGCTCGACAAACTGCCGGCGCAGTTCGCGCAGGCCGCCGGCCAGCTGCAGGGTGGCGTGGAGGAAAAGGCGA
TCGGGCGGATCGAAGGCATCATCAATTCGATGACGCCGCTCGAGCGTGCAAAGCCCGAACTGCTCAAGGCCAGTCGAAAG
CGCCGGATTGCGGCCGGCGCGGGGGTGACCGTGCAGGAGGTCAACCGACTGCTCAATCAGTTCGAGCAGACGCAGAAGGT
CATGAAGCAGTTCTCCAAGGGCGGGCTGCAGAAGATGATGCGCGGCATGAAGGGCATGCTCCCCGGCATGCCCCGCTAG

Upstream 100 bases:

>100_bases
GCCGGCGTAAAGCGAGGCGGGAAGGAGATGAAGTAGAATCGGGGGCATACGTTGCTGCAGTTTACTCCAAGTCATCCCGG
CCCGAAGGCTCCCCGCGAAC

Downstream 100 bases:

>100_bases
GACGTCCGTGCGCAGCATCCTGCTTGCTTTTGGGCGCACGCTGCGCAGTCTCGCGCGGCGGGAAGTGCTGTGGCATCTGC
TGTGGCCGGGCCTCGTCGCC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MLDNLTQRLSKVVKTLRGQARLTEDNIQDAMREVRMALLEADVALPVVKDFIAKVKLKAVGQEVVGSLTPGQALVGVVHD
ELKALMGGAHEGLNLATQPPAVILMAGLQGAGKTTTTGKLAKHLKESQKKKVLVVSTDVYRPAAIEQLKAVAAQAGVEFF
PSQVDQRPVDIALGAVDFARKHHVDVLLVDTAGRLAIDEAMMAEIQALHAAVKPIETLFVVDAMLGQDAVNTARAFNDAL
PLTGVVLTKLDGDARGGAALSVRHVTGKPLKFAGVGEKLSGLEPFHPDRMASRILGMGDILGLVEEARRGVDEEKAKAFA
HKLKSGKGFDLNDFKDQIAQMRKMGGISSLLDKLPAQFAQAAGQLQGGVEEKAIGRIEGIINSMTPLERAKPELLKASRK
RRIAAGAGVTVQEVNRLLNQFEQTQKVMKQFSKGGLQKMMRGMKGMLPGMPR

Sequences:

>Translated_452_residues
MLDNLTQRLSKVVKTLRGQARLTEDNIQDAMREVRMALLEADVALPVVKDFIAKVKLKAVGQEVVGSLTPGQALVGVVHD
ELKALMGGAHEGLNLATQPPAVILMAGLQGAGKTTTTGKLAKHLKESQKKKVLVVSTDVYRPAAIEQLKAVAAQAGVEFF
PSQVDQRPVDIALGAVDFARKHHVDVLLVDTAGRLAIDEAMMAEIQALHAAVKPIETLFVVDAMLGQDAVNTARAFNDAL
PLTGVVLTKLDGDARGGAALSVRHVTGKPLKFAGVGEKLSGLEPFHPDRMASRILGMGDILGLVEEARRGVDEEKAKAFA
HKLKSGKGFDLNDFKDQIAQMRKMGGISSLLDKLPAQFAQAAGQLQGGVEEKAIGRIEGIINSMTPLERAKPELLKASRK
RRIAAGAGVTVQEVNRLLNQFEQTQKVMKQFSKGGLQKMMRGMKGMLPGMPR
>Mature_452_residues
MLDNLTQRLSKVVKTLRGQARLTEDNIQDAMREVRMALLEADVALPVVKDFIAKVKLKAVGQEVVGSLTPGQALVGVVHD
ELKALMGGAHEGLNLATQPPAVILMAGLQGAGKTTTTGKLAKHLKESQKKKVLVVSTDVYRPAAIEQLKAVAAQAGVEFF
PSQVDQRPVDIALGAVDFARKHHVDVLLVDTAGRLAIDEAMMAEIQALHAAVKPIETLFVVDAMLGQDAVNTARAFNDAL
PLTGVVLTKLDGDARGGAALSVRHVTGKPLKFAGVGEKLSGLEPFHPDRMASRILGMGDILGLVEEARRGVDEEKAKAFA
HKLKSGKGFDLNDFKDQIAQMRKMGGISSLLDKLPAQFAQAAGQLQGGVEEKAIGRIEGIINSMTPLERAKPELLKASRK
RRIAAGAGVTVQEVNRLLNQFEQTQKVMKQFSKGGLQKMMRGMKGMLPGMPR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=450, Percent_Identity=30.8888888888889, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI226371618, Length=349, Percent_Identity=33.2378223495702, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.1515151515151, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI23308697, Length=312, Percent_Identity=28.2051282051282, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI295424842, Length=312, Percent_Identity=28.2051282051282, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=64.3805309734513, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1789874, Length=238, Percent_Identity=35.7142857142857, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=453, Percent_Identity=30.4635761589404, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=307, Percent_Identity=29.9674267100977, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=437, Percent_Identity=31.5789473684211, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17647949, Length=459, Percent_Identity=31.3725490196078, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24641198, Length=270, Percent_Identity=28.8888888888889, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48461; Mature: 48461

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTQRLSKVVKTLRGQARLTEDNIQDAMREVRMALLEADVALPVVKDFIAKVKLKAV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVVGSLTPGQALVGVVHDELKALMGGAHEGLNLATQPPAVILMAGLQGAGKTTTTGKL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKHLKESQKKKVLVVSTDVYRPAAIEQLKAVAAQAGVEFFPSQVDQRPVDIALGAVDFAR
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KHHVDVLLVDTAGRLAIDEAMMAEIQALHAAVKPIETLFVVDAMLGQDAVNTARAFNDAL
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
PLTGVVLTKLDGDARGGAALSVRHVTGKPLKFAGVGEKLSGLEPFHPDRMASRILGMGDI
CHHHHHEEECCCCCCCCCEEEEEECCCCCEEECCCCCHHCCCCCCCHHHHHHHHHHHHHH
LGLVEEARRGVDEEKAKAFAHKLKSGKGFDLNDFKDQIAQMRKMGGISSLLDKLPAQFAQ
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAGQLQGGVEEKAIGRIEGIINSMTPLERAKPELLKASRKRRIAAGAGVTVQEVNRLLNQ
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FEQTQKVMKQFSKGGLQKMMRGMKGMLPGMPR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDNLTQRLSKVVKTLRGQARLTEDNIQDAMREVRMALLEADVALPVVKDFIAKVKLKAV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVVGSLTPGQALVGVVHDELKALMGGAHEGLNLATQPPAVILMAGLQGAGKTTTTGKL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKHLKESQKKKVLVVSTDVYRPAAIEQLKAVAAQAGVEFFPSQVDQRPVDIALGAVDFAR
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KHHVDVLLVDTAGRLAIDEAMMAEIQALHAAVKPIETLFVVDAMLGQDAVNTARAFNDAL
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
PLTGVVLTKLDGDARGGAALSVRHVTGKPLKFAGVGEKLSGLEPFHPDRMASRILGMGDI
CHHHHHEEECCCCCCCCCEEEEEECCCCCEEECCCCCHHCCCCCCCHHHHHHHHHHHHHH
LGLVEEARRGVDEEKAKAFAHKLKSGKGFDLNDFKDQIAQMRKMGGISSLLDKLPAQFAQ
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAGQLQGGVEEKAIGRIEGIINSMTPLERAKPELLKASRKRRIAAGAGVTVQEVNRLLNQ
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FEQTQKVMKQFSKGGLQKMMRGMKGMLPGMPR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]