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The map label for this gene is gloA2 [H]

Identifier: 119899517

GI number: 119899517

Start: 3559582

End: 3559950

Strand: Reverse

Name: gloA2 [H]

Synonym: azo3228

Alternate gene names: 119899517

Gene position: 3559950-3559582 (Counterclockwise)

Preceding gene: 119899518

Following gene: 119899513

Centisome position: 81.35

GC content: 62.6

Gene sequence:

>369_bases
ATGTTGCGTGTCGGCGATCTTGATCGGTCGCTGGCGTTTTATACCGAGGTGCTCGGGATGCGTCTGCTGCGTCGTAACGA
CTATCCGGACGGCAAGTTCACGCTGGCCTTTGTCGGCTATCAGGACGAGGCGGACGGCGCGGTGCTGGAACTGACCCACA
ACTGGGGCGTGGAGCGCTATGAACTCGGCACCGCGTACGGTCATATTGCGCTCGAGGTGCCGGATGCGGCCAAGGCATGC
GACGAGATCCGGGCCCGTGGAGGCAAGGTGGTGCGCGAGGCCGGGCCGATGAAACACGGTTCGACCGTGATCGCCTTTGT
CGAGGACCCGGATGGCTACAAGGTGGAACTGATCGAAAGGCGCGCTTAG

Upstream 100 bases:

>100_bases
CGGGCTGTTGAAGAAGGCGGCCGCTACGCTGCCGCATATCGAACCGGGTGAGCTGCTTCCCCAACCTGTCGAGGACTGAA
GAATGAGGCTATTGCACACG

Downstream 100 bases:

>100_bases
TCGCGGCCGTCGGCCGTGGCCGTAAAGGCCGGCGCAAAAGACAAGAGCCAACCCCTGCGGGTTGGCTCTTGTCTTTGGAT
TGGTGGGCCCCCTGGGAGTC

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MLRVGDLDRSLAFYTEVLGMRLLRRNDYPDGKFTLAFVGYQDEADGAVLELTHNWGVERYELGTAYGHIALEVPDAAKAC
DEIRARGGKVVREAGPMKHGSTVIAFVEDPDGYKVELIERRA

Sequences:

>Translated_122_residues
MLRVGDLDRSLAFYTEVLGMRLLRRNDYPDGKFTLAFVGYQDEADGAVLELTHNWGVERYELGTAYGHIALEVPDAAKAC
DEIRARGGKVVREAGPMKHGSTVIAFVEDPDGYKVELIERRA
>Mature_122_residues
MLRVGDLDRSLAFYTEVLGMRLLRRNDYPDGKFTLAFVGYQDEADGAVLELTHNWGVERYELGTAYGHIALEVPDAAKAC
DEIRARGGKVVREAGPMKHGSTVIAFVEDPDGYKVELIERRA

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI118402586, Length=144, Percent_Identity=40.2777777777778, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1787940, Length=121, Percent_Identity=68.5950413223141, Blast_Score=177, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323639, Length=134, Percent_Identity=40.2985074626866, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129743, Length=145, Percent_Identity=38.6206896551724, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 13602; Mature: 13602

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00935 GLYOXALASE_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVGDLDRSLAFYTEVLGMRLLRRNDYPDGKFTLAFVGYQDEADGAVLELTHNWGVERY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEE
ELGTAYGHIALEVPDAAKACDEIRARGGKVVREAGPMKHGSTVIAFVEDPDGYKVELIER
EECCEEEEEEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEEE
RA
CC
>Mature Secondary Structure
MLRVGDLDRSLAFYTEVLGMRLLRRNDYPDGKFTLAFVGYQDEADGAVLELTHNWGVERY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEE
ELGTAYGHIALEVPDAAKACDEIRARGGKVVREAGPMKHGSTVIAFVEDPDGYKVELIER
EECCEEEEEEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEEE
RA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]