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The map label for this gene is atoC [H]

Identifier: 119899481

GI number: 119899481

Start: 3505919

End: 3507280

Strand: Reverse

Name: atoC [H]

Synonym: azo3191

Alternate gene names: 119899481

Gene position: 3507280-3505919 (Counterclockwise)

Preceding gene: 119899482

Following gene: 119899480

Centisome position: 80.15

GC content: 62.7

Gene sequence:

>1362_bases
ATGATGTCTGAGAAGCAACGGCTCCTGCTGATCGTCGAGGACGATCCCGCGCTGCAGAAACAGATGCGGTGGGCATTCGA
CGGTTTTGAAACCGTGGTGGCCGACGATCGGGAGTCAGCAATCGCCCAGTTGAGGCGATACGAACCCGCGGTTGTGACGA
TGGACCTCGGCTTGCCGCCTGAGCCCGACGCTACGACCGAGGGCTTCAACCTGTTGGGGGAAATGCTCGCGCTCGCGCCT
GACACCAAGGTGATTGTCCTTACGGGGCAGCACGACCGAGAAAACGCTGTCCGGGCCGTGGGCATGGGCGCCTACGACTT
CTTCGCGAAACCGTTCGAGCCGGAACTGCTCGCGTTGACGATAGATCGCGCGTTCCGACTTCACGACCTGCAACTCGAGA
ACGCCCGTTTGAGGGCCTCCCAGGGTACGGCCCTCGCCGGCCTGGTGACGCGCGACGTGGTGATGCTGAAGGTGTGCCGT
ACGGTAGAGAAGGTTGCCAACGCGGCGGTGACGGTTGCGTTGCTCGGCGAAAGCGGTACCGGCAAGGAGGTTCTCGCCCG
TGGGCTGCACGCCTTGTCCCCTCGCGCCAAGGAGCGTTTCGTTGCCATCAACTGCGCCGCGATTCCCGACAACCTGCTGG
AGAGCGAACTCTTCGGCTACGAAAAGGGGGCTTTCACCGGTGCGGTGAAGCAGACCCTGGGCAAAATCGAAACCGCCCAT
AAGGGAACACTGTTCCTCGACGAAATCGGCGACCTGCCGATGCCGCTTCAGGCGAAGCTGCTCCGCTTCCTGCAGGAACG
GGTGATCGAACGGATTGGCGGGCGCGAGGAAATTCCGGTGGACGTCCGCATCGTATGTGCCACTCACCGGGACCTGAAGG
CGCAGATCCGGGAAGGGCTCTTTCGCGAAGACCTGTACTACCGCTTGGCAGAGATCGTCATCGACATTCCACCGCTGCGC
GACCGCGAAGGCGACGCAGTCCTGCTTGCGCATGCGTTCGTCCAACGTTTCGCACGCGAAAACGGCCGGGGGTCGATGGC
TCTTACCGAAGATGCCATCGCCGCGATCGAGGCCCACCCCTGGCCCGGCAACGTGCGGGAACTCGAGAACTGCCTGAAGC
GCGCCGTGATCATGGCCGATGGCAACCGGATTACAGCGGAGGACCTGGGGCTCAGTTCCGCCGAAGACGACGCGGAGCAT
CTGAACCTGCGGCAGATCCGGGACGAGGCGGAACGCAAGGCAGTCGTCCGCGTGCTTGCCAGGACGAATGGAAATATCGC
GCGCGCTGCCGAAGTCCTCGGCATCAGCCGACCCTCCCTGTACGACCTCATGAATCGCTTTGGCCTCAAGAAGGAGAACT
GA

Upstream 100 bases:

>100_bases
TTGAGTTATGACAGCGAGGTCGGACGGGGAACCCGTGCAGAGATAGAGCTGCCGGAAACCGTCAGGGGCTCGGTTTCGGG
GGGTGCCGAAGTGGAGTTTG

Downstream 100 bases:

>100_bases
TGTTGCCAAAACCGCGTTTCCGTCCCGAAGGCCTCGGCGCCGGCGGCAAGCGAGCCCTCGCGGCAATCGGCGCTGCGCTG
CTGGTTTCAGCCTGCAGCCC

Product: acetoacetate metabolism regulatory protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MMSEKQRLLLIVEDDPALQKQMRWAFDGFETVVADDRESAIAQLRRYEPAVVTMDLGLPPEPDATTEGFNLLGEMLALAP
DTKVIVLTGQHDRENAVRAVGMGAYDFFAKPFEPELLALTIDRAFRLHDLQLENARLRASQGTALAGLVTRDVVMLKVCR
TVEKVANAAVTVALLGESGTGKEVLARGLHALSPRAKERFVAINCAAIPDNLLESELFGYEKGAFTGAVKQTLGKIETAH
KGTLFLDEIGDLPMPLQAKLLRFLQERVIERIGGREEIPVDVRIVCATHRDLKAQIREGLFREDLYYRLAEIVIDIPPLR
DREGDAVLLAHAFVQRFARENGRGSMALTEDAIAAIEAHPWPGNVRELENCLKRAVIMADGNRITAEDLGLSSAEDDAEH
LNLRQIRDEAERKAVVRVLARTNGNIARAAEVLGISRPSLYDLMNRFGLKKEN

Sequences:

>Translated_453_residues
MMSEKQRLLLIVEDDPALQKQMRWAFDGFETVVADDRESAIAQLRRYEPAVVTMDLGLPPEPDATTEGFNLLGEMLALAP
DTKVIVLTGQHDRENAVRAVGMGAYDFFAKPFEPELLALTIDRAFRLHDLQLENARLRASQGTALAGLVTRDVVMLKVCR
TVEKVANAAVTVALLGESGTGKEVLARGLHALSPRAKERFVAINCAAIPDNLLESELFGYEKGAFTGAVKQTLGKIETAH
KGTLFLDEIGDLPMPLQAKLLRFLQERVIERIGGREEIPVDVRIVCATHRDLKAQIREGLFREDLYYRLAEIVIDIPPLR
DREGDAVLLAHAFVQRFARENGRGSMALTEDAIAAIEAHPWPGNVRELENCLKRAVIMADGNRITAEDLGLSSAEDDAEH
LNLRQIRDEAERKAVVRVLARTNGNIARAAEVLGISRPSLYDLMNRFGLKKEN
>Mature_453_residues
MMSEKQRLLLIVEDDPALQKQMRWAFDGFETVVADDRESAIAQLRRYEPAVVTMDLGLPPEPDATTEGFNLLGEMLALAP
DTKVIVLTGQHDRENAVRAVGMGAYDFFAKPFEPELLALTIDRAFRLHDLQLENARLRASQGTALAGLVTRDVVMLKVCR
TVEKVANAAVTVALLGESGTGKEVLARGLHALSPRAKERFVAINCAAIPDNLLESELFGYEKGAFTGAVKQTLGKIETAH
KGTLFLDEIGDLPMPLQAKLLRFLQERVIERIGGREEIPVDVRIVCATHRDLKAQIREGLFREDLYYRLAEIVIDIPPLR
DREGDAVLLAHAFVQRFARENGRGSMALTEDAIAAIEAHPWPGNVRELENCLKRAVIMADGNRITAEDLGLSSAEDDAEH
LNLRQIRDEAERKAVVRVLARTNGNIARAAEVLGISRPSLYDLMNRFGLKKEN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=41.5384615384615, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=39.1982182628062, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87082117, Length=339, Percent_Identity=45.1327433628319, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=36.4444444444444, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=34.453781512605, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1789087, Length=309, Percent_Identity=45.6310679611651, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789233, Length=313, Percent_Identity=43.1309904153355, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082152, Length=310, Percent_Identity=40.3225806451613, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=35.5623100303951, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI87081872, Length=308, Percent_Identity=39.2857142857143, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1786524, Length=309, Percent_Identity=37.8640776699029, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI87081858, Length=296, Percent_Identity=32.0945945945946, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=35.2, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50198; Mature: 50198

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSEKQRLLLIVEDDPALQKQMRWAFDGFETVVADDRESAIAQLRRYEPAVVTMDLGLPP
CCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCC
EPDATTEGFNLLGEMLALAPDTKVIVLTGQHDRENAVRAVGMGAYDFFAKPFEPELLALT
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCHHHHCCCCCCCCEEEEE
IDRAFRLHDLQLENARLRASQGTALAGLVTRDVVMLKVCRTVEKVANAAVTVALLGESGT
EHHHHHHEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GKEVLARGLHALSPRAKERFVAINCAAIPDNLLESELFGYEKGAFTGAVKQTLGKIETAH
CHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
KGTLFLDEIGDLPMPLQAKLLRFLQERVIERIGGREEIPVDVRIVCATHRDLKAQIREGL
CCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHCH
FREDLYYRLAEIVIDIPPLRDREGDAVLLAHAFVQRFARENGRGSMALTEDAIAAIEAHP
HHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCEEECHHHHHHHCCCC
WPGNVRELENCLKRAVIMADGNRITAEDLGLSSAEDDAEHLNLRQIRDEAERKAVVRVLA
CCCCHHHHHHHHHHEEEEECCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RTNGNIARAAEVLGISRPSLYDLMNRFGLKKEN
HCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMSEKQRLLLIVEDDPALQKQMRWAFDGFETVVADDRESAIAQLRRYEPAVVTMDLGLPP
CCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCC
EPDATTEGFNLLGEMLALAPDTKVIVLTGQHDRENAVRAVGMGAYDFFAKPFEPELLALT
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCHHHHCCCCCCCCEEEEE
IDRAFRLHDLQLENARLRASQGTALAGLVTRDVVMLKVCRTVEKVANAAVTVALLGESGT
EHHHHHHEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GKEVLARGLHALSPRAKERFVAINCAAIPDNLLESELFGYEKGAFTGAVKQTLGKIETAH
CHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
KGTLFLDEIGDLPMPLQAKLLRFLQERVIERIGGREEIPVDVRIVCATHRDLKAQIREGL
CCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHCH
FREDLYYRLAEIVIDIPPLRDREGDAVLLAHAFVQRFARENGRGSMALTEDAIAAIEAHP
HHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCEEECHHHHHHHCCCC
WPGNVRELENCLKRAVIMADGNRITAEDLGLSSAEDDAEHLNLRQIRDEAERKAVVRVLA
CCCCHHHHHHHHHHEEEEECCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RTNGNIARAAEVLGISRPSLYDLMNRFGLKKEN
HCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]