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The map label for this gene is lolE [H]

Identifier: 119899466

GI number: 119899466

Start: 3485581

End: 3486774

Strand: Direct

Name: lolE [H]

Synonym: azo3176

Alternate gene names: 119899466

Gene position: 3485581-3486774 (Clockwise)

Preceding gene: 119899463

Following gene: 119899467

Centisome position: 79.65

GC content: 65.75

Gene sequence:

>1194_bases
ATGGCCGCGCGGAACATCGTGCGGCAGAGACGACGCTCGGCCATGGCGCTGCTGACGGTGTGCGGGGGCGTGGTCGCGAT
CCTGCTCGCAGGGGGGTTCGTGGAATGGGTGTTCTCGGCGCTTCGCGACTCCACCATCCATTCGCAACTCGGGCACATCC
AGGTCACCCGGCCAGGGTACTTCCGCCAGGGCATCGCCGACCCCTACAACTACCTGCTTCCGGCAGAGATCGCGCCCGAG
GTTCAGGAAGAACGTGGCCACATCGTCTCGGTGGCGCCCCGCCTTGCCTTCAGCGGGCTGCTCGGGACGGGAGAGTCGTC
CGTCTCCTTCATCGGCGAGGGCATCGATCCGGTACGGGAACGGCAGATCACACGCGCCCTCAAGATCGTCAGTGGCCGCG
ACCTCCGTGATAACGGCGACCAAGCCGCCGTACTCGGCCGCGGCCTGGCCAGCGCGCTCGGGGTGAAGGCAGGCGATCGC
GTGGTGCTGCTGGTCAACGCGGCGGCGGGCGGCGTCAATGCGGTAGAGCTGGAAGTCGCCGGCGTCTTTTCGTCGATGAT
CAAGGCCTATGACGACAGCGCGCTGCGGGTGCCGGTGGATATTGCACGCAAGTTGTTGCGGGTGGACGGTGCAACAAGCT
GGGTTCTGCTCCTGGACGACCATGCGCACACCACGGTGGAGGCAAACCGTCTCAAACGGGAGGCTCGCGACGTGGAGGTC
ACGCCTTGGTACGACATGGCCGACTTCTACAACAAGACGGTCGGCCTGTTCTCGCGGCAGTTGGGCGTTGTCCAGACCCT
GATCGGATTGATCGTGGTATTGACGATCACGAATACGCTGGCGATGGCGGTACGCGAACGCACCGGGGAGATCGGCACCA
TTCTGGCAACCGGTTCGCGGCGCCGCGAGGTACTGAGCCTGTTCGTGTGCGAAGGCGCCCTGCTGGGGCTGTTCGGCGGC
ATCCTGGGCCTCATCTTAGGGGCCATCCTGGCCGCCGTCATTTCGGCGATTGGCATTCCGATGCCCGCGGCGCCGGGCAT
GACCGAAGGGTATACGGGCGAAATCCTCATCACCCCCGCCCTCGGCCTGCAGGCCCTGCTCCTGGCCGCGGCCACCACGA
CGATTGCCAGCATCGTGCCGGCCATGCACGCTGCGCGCATGAACATTGTCGATGCTCTGAGGCATGCCCGCTGA

Upstream 100 bases:

>100_bases
GCAAGGGTATGATCGGAGCAGGACGAAATTACCCCGCGAAGAGATGGCTCACCGCCTTGCGCTGCAGTTCCCCACACTCA
CCCTGGCCCGGCACTTCCGC

Downstream 100 bases:

>100_bases
TGCTTGCCACGATCGCCCTTCGCAACGTGTTCCGGCACGCCTGGCGCACCGCCATGACCCTGCTCGCGATCGTCATGGGC
GTTGCCAGCCTGATCGTTGG

Product: permease of an ABC-transporter system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MAARNIVRQRRRSAMALLTVCGGVVAILLAGGFVEWVFSALRDSTIHSQLGHIQVTRPGYFRQGIADPYNYLLPAEIAPE
VQEERGHIVSVAPRLAFSGLLGTGESSVSFIGEGIDPVRERQITRALKIVSGRDLRDNGDQAAVLGRGLASALGVKAGDR
VVLLVNAAAGGVNAVELEVAGVFSSMIKAYDDSALRVPVDIARKLLRVDGATSWVLLLDDHAHTTVEANRLKREARDVEV
TPWYDMADFYNKTVGLFSRQLGVVQTLIGLIVVLTITNTLAMAVRERTGEIGTILATGSRRREVLSLFVCEGALLGLFGG
ILGLILGAILAAVISAIGIPMPAAPGMTEGYTGEILITPALGLQALLLAAATTTIASIVPAMHAARMNIVDALRHAR

Sequences:

>Translated_397_residues
MAARNIVRQRRRSAMALLTVCGGVVAILLAGGFVEWVFSALRDSTIHSQLGHIQVTRPGYFRQGIADPYNYLLPAEIAPE
VQEERGHIVSVAPRLAFSGLLGTGESSVSFIGEGIDPVRERQITRALKIVSGRDLRDNGDQAAVLGRGLASALGVKAGDR
VVLLVNAAAGGVNAVELEVAGVFSSMIKAYDDSALRVPVDIARKLLRVDGATSWVLLLDDHAHTTVEANRLKREARDVEV
TPWYDMADFYNKTVGLFSRQLGVVQTLIGLIVVLTITNTLAMAVRERTGEIGTILATGSRRREVLSLFVCEGALLGLFGG
ILGLILGAILAAVISAIGIPMPAAPGMTEGYTGEILITPALGLQALLLAAATTTIASIVPAMHAARMNIVDALRHAR
>Mature_396_residues
AARNIVRQRRRSAMALLTVCGGVVAILLAGGFVEWVFSALRDSTIHSQLGHIQVTRPGYFRQGIADPYNYLLPAEIAPEV
QEERGHIVSVAPRLAFSGLLGTGESSVSFIGEGIDPVRERQITRALKIVSGRDLRDNGDQAAVLGRGLASALGVKAGDRV
VLLVNAAAGGVNAVELEVAGVFSSMIKAYDDSALRVPVDIARKLLRVDGATSWVLLLDDHAHTTVEANRLKREARDVEVT
PWYDMADFYNKTVGLFSRQLGVVQTLIGLIVVLTITNTLAMAVRERTGEIGTILATGSRRREVLSLFVCEGALLGLFGGI
LGLILGAILAAVISAIGIPMPAAPGMTEGYTGEILITPALGLQALLLAAATTTIASIVPAMHAARMNIVDALRHAR

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=276, Percent_Identity=27.8985507246377, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787360, Length=325, Percent_Identity=26.4615384615385, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787105, Length=146, Percent_Identity=33.5616438356164, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 42123; Mature: 41992

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARNIVRQRRRSAMALLTVCGGVVAILLAGGFVEWVFSALRDSTIHSQLGHIQVTRPGY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEECCCH
FRQGIADPYNYLLPAEIAPEVQEERGHIVSVAPRLAFSGLLGTGESSVSFIGEGIDPVRE
HHHCCCCHHHCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHCCCCHHHH
RQITRALKIVSGRDLRDNGDQAAVLGRGLASALGVKAGDRVVLLVNAAAGGVNAVELEVA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEHHH
GVFSSMIKAYDDSALRVPVDIARKLLRVDGATSWVLLLDDHAHTTVEANRLKREARDVEV
HHHHHHHHHHCCCCEEECHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCC
TPWYDMADFYNKTVGLFSRQLGVVQTLIGLIVVLTITNTLAMAVRERTGEIGTILATGSR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCH
RREVLSLFVCEGALLGLFGGILGLILGAILAAVISAIGIPMPAAPGMTEGYTGEILITPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECH
LGLQALLLAAATTTIASIVPAMHAARMNIVDALRHAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AARNIVRQRRRSAMALLTVCGGVVAILLAGGFVEWVFSALRDSTIHSQLGHIQVTRPGY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEECCCH
FRQGIADPYNYLLPAEIAPEVQEERGHIVSVAPRLAFSGLLGTGESSVSFIGEGIDPVRE
HHHCCCCHHHCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHCCCCHHHH
RQITRALKIVSGRDLRDNGDQAAVLGRGLASALGVKAGDRVVLLVNAAAGGVNAVELEVA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEHHH
GVFSSMIKAYDDSALRVPVDIARKLLRVDGATSWVLLLDDHAHTTVEANRLKREARDVEV
HHHHHHHHHHCCCCEEECHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCC
TPWYDMADFYNKTVGLFSRQLGVVQTLIGLIVVLTITNTLAMAVRERTGEIGTILATGSR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCH
RREVLSLFVCEGALLGLFGGILGLILGAILAAVISAIGIPMPAAPGMTEGYTGEILITPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECH
LGLQALLLAAATTTIASIVPAMHAARMNIVDALRHAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]