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The map label for this gene is ilvC

Identifier: 119899446

GI number: 119899446

Start: 3464912

End: 3465928

Strand: Direct

Name: ilvC

Synonym: azo3156

Alternate gene names: 119899446

Gene position: 3464912-3465928 (Clockwise)

Preceding gene: 119899445

Following gene: 119899447

Centisome position: 79.18

GC content: 62.54

Gene sequence:

>1017_bases
ATGAAAGTCTATTACGACAAGGACGCCGATCTCTCCCTGATCAAGGGCAAGAAGGTCACCATCGTCGGCTACGGCTCGCA
GGGCCACGCCCACGCGCAGAACCTGAACGACTCCGGCGTCAAGGTCACCGTCGCCGTGCGCAAGGGTGGCGCGTCGTGGG
ACAAGGCCAAGGCCGCCGGCCTCAAGGTCGAGGAAATCGCCAAGGCCGTGAAGACCGCCGACCTGGTCATGATCCTGCTG
CCGGACGAGAACATCCCGCAGGTCTACAAGGAAGAAGTCGAGCCCAACATCAAGAAGGGCGCCACCCTGGCCTTCGCCCA
CGGCTTCAACGTGCATTACAACCAGGTCGTGCCGCGTGAAGATCTGGACGTGATCATGGTCGCCCCGAAGGGCCCCGGCC
ACACCGTGCGCTCGGAGTACCTGCGCGGAGGCGGCGTGCCGTCGCTGATCGCGGTCTACCAGGACAAGTCCGGCAAGGCC
AAGGACATCGCGCTGTCGTACGCGGCGGCCAACGGCGGCACCAAGGGCGGCGTGATCGAGACCAACTTCAAGGAAGAGAC
CGAGACCGACCTCTTCGGCGAACAGGCCGTGCTGTGCGGTGGCGCGGTGGAACTGGTCAAGATGGGCTTCGAAACCCTGA
CCGAAGCCGGCTACGCGCCGGAAATGGCCTACTTCGAGTGCCTGCACGAACTCAAGCTGATCGTCGACCTGATGTACGAA
GGCGGCATTGCCAACATGAACTACTCCATCTCCAACAACGCGGAGTATGGCGAGTACGTGACCGGCCCCGAAGTCATCAA
CGCCCAGTCGCGCGAAGCGATGCGCAACGCGCTCAAGCGCATCCAGACTGGCGAATACGCCAAGATGTTCATCCAGGAAG
GCAAGACCAACTACCCGAGCATGACCGCGCGTCGTCGCCTCAATGCCGAGCACCCGATCGAGCAGGTCGGCGGCCAGCTG
CGTGACATGATGCCGTGGATCAAGGCCAAGGCCCTGGTCGACAAGTCCAAGAACTAA

Upstream 100 bases:

>100_bases
TCAAGCTCTGATTCACCGCCTCCCGTTTTGCGGCTGGCGGCCGCGCTCCCATCCTGGCCGCCGCCGGCACTCCCCGCCCT
AGAAAGCTGAAAGGAAAAAC

Downstream 100 bases:

>100_bases
GCTTCACGCCTGGTTCCGCGCGGGCCGGCGCCGCTGTCAGCGGCGACCGGCCCGCGCTGCGTTTACACCCCCGGCGGCCG
GTCCGCGCACGATGCGCTAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVYYDKDADLSLIKGKKVTIVGYGSQGHAHAQNLNDSGVKVTVAVRKGGASWDKAKAAGLKVEEIAKAVKTADLVMILL
PDENIPQVYKEEVEPNIKKGATLAFAHGFNVHYNQVVPREDLDVIMVAPKGPGHTVRSEYLRGGGVPSLIAVYQDKSGKA
KDIALSYAAANGGTKGGVIETNFKEETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINAQSREAMRNALKRIQTGEYAKMFIQEGKTNYPSMTARRRLNAEHPIEQVGGQL
RDMMPWIKAKALVDKSKN

Sequences:

>Translated_338_residues
MKVYYDKDADLSLIKGKKVTIVGYGSQGHAHAQNLNDSGVKVTVAVRKGGASWDKAKAAGLKVEEIAKAVKTADLVMILL
PDENIPQVYKEEVEPNIKKGATLAFAHGFNVHYNQVVPREDLDVIMVAPKGPGHTVRSEYLRGGGVPSLIAVYQDKSGKA
KDIALSYAAANGGTKGGVIETNFKEETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINAQSREAMRNALKRIQTGEYAKMFIQEGKTNYPSMTARRRLNAEHPIEQVGGQL
RDMMPWIKAKALVDKSKN
>Mature_338_residues
MKVYYDKDADLSLIKGKKVTIVGYGSQGHAHAQNLNDSGVKVTVAVRKGGASWDKAKAAGLKVEEIAKAVKTADLVMILL
PDENIPQVYKEEVEPNIKKGATLAFAHGFNVHYNQVVPREDLDVIMVAPKGPGHTVRSEYLRGGGVPSLIAVYQDKSGKA
KDIALSYAAANGGTKGGVIETNFKEETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINAQSREAMRNALKRIQTGEYAKMFIQEGKTNYPSMTARRRLNAEHPIEQVGGQL
RDMMPWIKAKALVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=289, Percent_Identity=39.1003460207612, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=272, Percent_Identity=35.2941176470588, Blast_Score=129, Evalue=9e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_AZOSB (A1KAB7)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934659.1
- ProteinModelPortal:   A1KAB7
- SMR:   A1KAB7
- STRING:   A1KAB7
- GeneID:   4609074
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3156
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   A1KAB7
- ProtClustDB:   PRK05479
- BioCyc:   ASP62928:AZO3156-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36910; Mature: 36910

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDKDADLSLIKGKKVTIVGYGSQGHAHAQNLNDSGVKVTVAVRKGGASWDKAKAAG
CEEEECCCCCEEEECCCEEEEEEECCCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHCC
LKVEEIAKAVKTADLVMILLPDENIPQVYKEEVEPNIKKGATLAFAHGFNVHYNQVVPRE
CCHHHHHHHHHHCCEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCCC
DLDVIMVAPKGPGHTVRSEYLRGGGVPSLIAVYQDKSGKAKDIALSYAAANGGTKGGVIE
CCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCEEE
TNFKEETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPEVINAQSREAMRNALKRIQTGEYAKMFIQEGKTNYPS
CCCCCEEEEECCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
MTARRRLNAEHPIEQVGGQLRDMMPWIKAKALVDKSKN
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVYYDKDADLSLIKGKKVTIVGYGSQGHAHAQNLNDSGVKVTVAVRKGGASWDKAKAAG
CEEEECCCCCEEEECCCEEEEEEECCCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHCC
LKVEEIAKAVKTADLVMILLPDENIPQVYKEEVEPNIKKGATLAFAHGFNVHYNQVVPRE
CCHHHHHHHHHHCCEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCCC
DLDVIMVAPKGPGHTVRSEYLRGGGVPSLIAVYQDKSGKAKDIALSYAAANGGTKGGVIE
CCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCEEE
TNFKEETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPEVINAQSREAMRNALKRIQTGEYAKMFIQEGKTNYPS
CCCCCEEEEECCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
MTARRRLNAEHPIEQVGGQLRDMMPWIKAKALVDKSKN
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA