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The map label for this gene is folK [H]

Identifier: 119899431

GI number: 119899431

Start: 3450110

End: 3450607

Strand: Direct

Name: folK [H]

Synonym: azo3141

Alternate gene names: 119899431

Gene position: 3450110-3450607 (Clockwise)

Preceding gene: 119899430

Following gene: 119899432

Centisome position: 78.84

GC content: 71.69

Gene sequence:

>498_bases
ATGACCGCCCCGACGCGCGCCTACGTGGCGTTCGGGGCCAACCTCGGCGATCCGGCTGCAGCCTTTGCCCTGGCACTAGA
ACGCATCGCCGCCCTGCCCGGCACCCGCATCGCCGCCCGCTCGGCGCTCTATCGCACCGCGCCGGTCGGTGTGGGTGTTG
ATCTGAGCAGCCAGCCCGACTACATCAATGCGGTGATCGCGCTCGACACCACGCTCGCACCGCATGCGCTGCTCGATGCG
CTGCTGGCGATCGAGCACGAGGGCGGCCGCACCCGCGACTACCACCAGGCGCCGCGCACCATGGACCTCGACCTGCTGCT
GCACGGCGACACGGTGCTGGACGACGCCGGCCTGGTGCTGCCCCACCCGCGCATGCACCAGCGCGCCTTCGTGCTGCAGC
CGCTCGCCGAGATCGCACCGACCGCGGTCGTGCCGCGCCACGGCGCCGTTGCCGACCTCCTCGCCGGAGTTTCCGGCCAA
GCCATCCAACGCCTCTGA

Upstream 100 bases:

>100_bases
GCGACGCGCCGCAGGCCGAGGCACCCGCCAAGAAGCGCCGCCGGCGGCGGCGCAAACCCGGCGGCGCCGACAGCGCCGCA
CTGCCCGCCGAAGCCTCGTG

Downstream 100 bases:

>100_bases
CCCCCGATGCCTCCCCTGCTCCAAGCCGCGGCAACGCCGCTCCAGGCCCTGCCGGTATGGCTGCAGACCGCCGGCCTGCT
CACCGTCGCCAACGTGTTCA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTAPTRAYVAFGANLGDPAAAFALALERIAALPGTRIAARSALYRTAPVGVGVDLSSQPDYINAVIALDTTLAPHALLDA
LLAIEHEGGRTRDYHQAPRTMDLDLLLHGDTVLDDAGLVLPHPRMHQRAFVLQPLAEIAPTAVVPRHGAVADLLAGVSGQ
AIQRL

Sequences:

>Translated_165_residues
MTAPTRAYVAFGANLGDPAAAFALALERIAALPGTRIAARSALYRTAPVGVGVDLSSQPDYINAVIALDTTLAPHALLDA
LLAIEHEGGRTRDYHQAPRTMDLDLLLHGDTVLDDAGLVLPHPRMHQRAFVLQPLAEIAPTAVVPRHGAVADLLAGVSGQ
AIQRL
>Mature_164_residues
TAPTRAYVAFGANLGDPAAAFALALERIAALPGTRIAARSALYRTAPVGVGVDLSSQPDYINAVIALDTTLAPHALLDAL
LAIEHEGGRTRDYHQAPRTMDLDLLLHGDTVLDDAGLVLPHPRMHQRAFVLQPLAEIAPTAVVPRHGAVADLLAGVSGQA
IQRL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=142, Percent_Identity=42.9577464788732, Blast_Score=113, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=147, Percent_Identity=31.2925170068027, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17345; Mature: 17214

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTRAYVAFGANLGDPAAAFALALERIAALPGTRIAARSALYRTAPVGVGVDLSSQPD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
YINAVIALDTTLAPHALLDALLAIEHEGGRTRDYHQAPRTMDLDLLLHGDTVLDDAGLVL
CEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCEEEEEECCEEECCCCEEC
PHPRMHQRAFVLQPLAEIAPTAVVPRHGAVADLLAGVSGQAIQRL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
TAPTRAYVAFGANLGDPAAAFALALERIAALPGTRIAARSALYRTAPVGVGVDLSSQPD
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
YINAVIALDTTLAPHALLDALLAIEHEGGRTRDYHQAPRTMDLDLLLHGDTVLDDAGLVL
CEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCEEEEEECCEEECCCCEEC
PHPRMHQRAFVLQPLAEIAPTAVVPRHGAVADLLAGVSGQAIQRL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]