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The map label for this gene is hda [H]

Identifier: 119899428

GI number: 119899428

Start: 3447272

End: 3447961

Strand: Direct

Name: hda [H]

Synonym: azo3138

Alternate gene names: 119899428

Gene position: 3447272-3447961 (Clockwise)

Preceding gene: 119899427

Following gene: 119899429

Centisome position: 78.78

GC content: 73.04

Gene sequence:

>690_bases
GTGAAGCAACTCGTACTCGACATCCGCCCCGACGCGCCGCCGTCGCTCGACAACTTCGTCGCCGGCGCCAACGCCGAACT
GCTCGCCGCGCTGTCGCTGCTCGGCTCGGCGGAACAGGCCGCCGCCCTGCCCGCCCGCCACCTCTACCTGTGGGGTGCCC
GCGGCAGCGGCCGCAGCCACCTGCTGCGCGCCGCCACCGCCGCGGCCGGCGGGCAGCGCCCGGTGCACCTGCTCGACGCC
GCGACGATAGGCGACACCCTGCCGGACACCGCCGACGCGCTGGTCGCCATCGACGACATCGACCAACTCGGCGACGCCGC
GCAGATCGCGCTTTTCAACGCTTTCAACCGTGCGCGCACCAATGGCCAGGCGCTGCTGCTGGCAGGCCCGTGCGCGCCGC
TGGAACTCACGCTGCGCGAGGACCTGCGCACCCGCATCGGCCAGAGCCTGATCTACGAGGTGCAGTCGCTCGACGACGAT
TCGCGCGCCGCCATCCTGGTCGCGCTCGCCGAGCGCCGCGGGCTGCGGCTGGCGGACGAGGTGATCGACTTCCTGCTGCG
CCACGGCCGCCGCGACCTGCCCAGCCTGCTGGCGGTACTCGAAGCGCTCGACGCCGCCTCGCTCGAACGCAAGCGCGCGG
TCACCCTGCCGCTGCTGCGCGAGATGATGCAGCAGGGCCTGGCGATCTGA

Upstream 100 bases:

>100_bases
TGCGCGAAGTGCGCAGCGCATGGTTCAGCAGCCGGCTCTACCTCGGCACCGGGCCGCACATCGCCACCGGCGCCGAAATC
CAGGACATGGACGCGCCGCG

Downstream 100 bases:

>100_bases
GCCCGCAGCCCCCTTTACCCTCAACGGAAACCGCTTCGTGGATCTCGTACTCTTCGACCTCGACAACACCCTGCTCGCCG
GCGACTCCGACTTCGCCTGG

Product: DnaA regulatory inactivator Hda

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKQLVLDIRPDAPPSLDNFVAGANAELLAALSLLGSAEQAAALPARHLYLWGARGSGRSHLLRAATAAAGGQRPVHLLDA
ATIGDTLPDTADALVAIDDIDQLGDAAQIALFNAFNRARTNGQALLLAGPCAPLELTLREDLRTRIGQSLIYEVQSLDDD
SRAAILVALAERRGLRLADEVIDFLLRHGRRDLPSLLAVLEALDAASLERKRAVTLPLLREMMQQGLAI

Sequences:

>Translated_229_residues
MKQLVLDIRPDAPPSLDNFVAGANAELLAALSLLGSAEQAAALPARHLYLWGARGSGRSHLLRAATAAAGGQRPVHLLDA
ATIGDTLPDTADALVAIDDIDQLGDAAQIALFNAFNRARTNGQALLLAGPCAPLELTLREDLRTRIGQSLIYEVQSLDDD
SRAAILVALAERRGLRLADEVIDFLLRHGRRDLPSLLAVLEALDAASLERKRAVTLPLLREMMQQGLAI
>Mature_229_residues
MKQLVLDIRPDAPPSLDNFVAGANAELLAALSLLGSAEQAAALPARHLYLWGARGSGRSHLLRAATAAAGGQRPVHLLDA
ATIGDTLPDTADALVAIDDIDQLGDAAQIALFNAFNRARTNGQALLLAGPCAPLELTLREDLRTRIGQSLIYEVQSLDDD
SRAAILVALAERRGLRLADEVIDFLLRHGRRDLPSLLAVLEALDAASLERKRAVTLPLLREMMQQGLAI

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=222, Percent_Identity=34.2342342342342, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367267, Length=239, Percent_Identity=27.1966527196653, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 24454; Mature: 24454

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLVLDIRPDAPPSLDNFVAGANAELLAALSLLGSAEQAAALPARHLYLWGARGSGRSH
CCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCCCHHH
LLRAATAAAGGQRPVHLLDAATIGDTLPDTADALVAIDDIDQLGDAAQIALFNAFNRART
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHEEEHHHHHHHCCHHHHHHHHHHHHHCC
NGQALLLAGPCAPLELTLREDLRTRIGQSLIYEVQSLDDDSRAAILVALAERRGLRLADE
CCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEHHHCCCHHHHH
VIDFLLRHGRRDLPSLLAVLEALDAASLERKRAVTLPLLREMMQQGLAI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQLVLDIRPDAPPSLDNFVAGANAELLAALSLLGSAEQAAALPARHLYLWGARGSGRSH
CCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCCCHHH
LLRAATAAAGGQRPVHLLDAATIGDTLPDTADALVAIDDIDQLGDAAQIALFNAFNRART
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHEEEHHHHHHHCCHHHHHHHHHHHHHCC
NGQALLLAGPCAPLELTLREDLRTRIGQSLIYEVQSLDDDSRAAILVALAERRGLRLADE
CCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEHHHCCCHHHHH
VIDFLLRHGRRDLPSLLAVLEALDAASLERKRAVTLPLLREMMQQGLAI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA