Click here to switch to the map view.

The map label for this gene is mvaB [H]

Identifier: 119899355

GI number: 119899355

Start: 3374096

End: 3375016

Strand: Reverse

Name: mvaB [H]

Synonym: azo3065

Alternate gene names: 119899355

Gene position: 3375016-3374096 (Counterclockwise)

Preceding gene: 119899356

Following gene: 119899353

Centisome position: 77.12

GC content: 70.36

Gene sequence:

>921_bases
ATGACCCTGCCCAATGCCGTCCGCATCGTCGAGGTCGGCCCGCGCGACGGGCTGCAGAACGAGAAGCAGCTGGTGAGCGC
CGACACCAAGGTGGAACTCATCCGCCGGCTGGAAGCCGCCGGCCTGAAGGCGATCGAGACCACCTCCTTTGTGTCGCCCA
AGTGGGTGCCGCAGATGGGCGACAACACCGAGGTGCTGACCCGCGTGCTGGCCGCGGCGAAGCGGGGCGTCGCCTACCCG
GTGCTCACCCCCAACCTCAAGGGTTTCGAGGCGGCGCTCGCTGCCGGCGCCACCGAGGTGGCGGTGTTCGGCGCGGCGAG
CGAGTCCTTCAGCCAGAAGAACATCAACTGCTCGATCGCCGAATCGCTGGAACGCTTCCGCCCGGTCACCGAGGCGGCGC
GCGCGGCCGGGGTGAAGGTGCGCGGCTACGTCTCCTGCGTCGCCGGCTGCCCCTACGAGGGCCTGATCGCACCGCAGGCG
GTGGCGGACGTGGCCGCCACGCTGCTGGAGATGGGCTGCTACGAAATCTCGCTCGGCGACACCATCGGCGGCGGCAACCC
GGCGAGCATCGCCCGCATGTTGGAAGCGGTGATGAAACAGGTGCCGGTGGCGCAACTCGCCGGCCACTACCACGACACCT
ACGGCATGGCGATCGCCAACATCCACGCCTCGCTGCAGATGGGGGTGGCGGTGTTCGACGCGTCGGTCGGCGGGCTGGGC
GGCTGCCCGTATGCCGCCGGGGCGTCAGGCAATGTCGCAACCGAGGATGTGGTGTGGCTGCTGGATGGGCTGGGGGTGCA
GACAGGCGTCGGGCTGGGGGCGTTGGTAGATACCGCCGCCTGGATCAGCGCGCAGCTGGGGCGCGAGCCGGCGTCGAGGG
TGGCGCGGGCGGTGCTGGCGAAGCGCGGGGCAGTGTCCTGA

Upstream 100 bases:

>100_bases
CCGATGACCGTGACCGGCAAGATCCAGAAATTCCAGATCCGCGAGCAGATGAAGCGCGAGCTGGCGCTGGACGAAGCGAA
GACCGCGTGAGGAGCGAGCG

Downstream 100 bases:

>100_bases
GCTTTTCCCCCTCCCCTTCAAGGGGGCGTAGGCGGGGTTTCGCAGAGCGCCGCTCTGCGCCGCCGGAGCGGCGGAGCGAA
GCGGAGACTCCCGGGCTGGG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTLPNAVRIVEVGPRDGLQNEKQLVSADTKVELIRRLEAAGLKAIETTSFVSPKWVPQMGDNTEVLTRVLAAAKRGVAYP
VLTPNLKGFEAALAAGATEVAVFGAASESFSQKNINCSIAESLERFRPVTEAARAAGVKVRGYVSCVAGCPYEGLIAPQA
VADVAATLLEMGCYEISLGDTIGGGNPASIARMLEAVMKQVPVAQLAGHYHDTYGMAIANIHASLQMGVAVFDASVGGLG
GCPYAAGASGNVATEDVVWLLDGLGVQTGVGLGALVDTAAWISAQLGREPASRVARAVLAKRGAVS

Sequences:

>Translated_306_residues
MTLPNAVRIVEVGPRDGLQNEKQLVSADTKVELIRRLEAAGLKAIETTSFVSPKWVPQMGDNTEVLTRVLAAAKRGVAYP
VLTPNLKGFEAALAAGATEVAVFGAASESFSQKNINCSIAESLERFRPVTEAARAAGVKVRGYVSCVAGCPYEGLIAPQA
VADVAATLLEMGCYEISLGDTIGGGNPASIARMLEAVMKQVPVAQLAGHYHDTYGMAIANIHASLQMGVAVFDASVGGLG
GCPYAAGASGNVATEDVVWLLDGLGVQTGVGLGALVDTAAWISAQLGREPASRVARAVLAKRGAVS
>Mature_305_residues
TLPNAVRIVEVGPRDGLQNEKQLVSADTKVELIRRLEAAGLKAIETTSFVSPKWVPQMGDNTEVLTRVLAAAKRGVAYPV
LTPNLKGFEAALAAGATEVAVFGAASESFSQKNINCSIAESLERFRPVTEAARAAGVKVRGYVSCVAGCPYEGLIAPQAV
ADVAATLLEMGCYEISLGDTIGGGNPASIARMLEAVMKQVPVAQLAGHYHDTYGMAIANIHASLQMGVAVFDASVGGLGG
CPYAAGASGNVATEDVVWLLDGLGVQTGVGLGALVDTAAWISAQLGREPASRVARAVLAKRGAVS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=62.5, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI109150427, Length=295, Percent_Identity=59.6610169491525, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI109150422, Length=295, Percent_Identity=59.6610169491525, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=58.0882352941177, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17510563, Length=299, Percent_Identity=51.8394648829431, Blast_Score=324, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24582381, Length=293, Percent_Identity=62.7986348122867, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31505; Mature: 31374

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPNAVRIVEVGPRDGLQNEKQLVSADTKVELIRRLEAAGLKAIETTSFVSPKWVPQMG
CCCCCCEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCC
DNTEVLTRVLAAAKRGVAYPVLTPNLKGFEAALAAGATEVAVFGAASESFSQKNINCSIA
CCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCHHEEEEECCHHHHHHCCCCCHHH
ESLERFRPVTEAARAAGVKVRGYVSCVAGCPYEGLIAPQAVADVAATLLEMGCYEISLGD
HHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCC
TIGGGNPASIARMLEAVMKQVPVAQLAGHYHDTYGMAIANIHASLQMGVAVFDASVGGLG
CCCCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
GCPYAAGASGNVATEDVVWLLDGLGVQTGVGLGALVDTAAWISAQLGREPASRVARAVLA
CCCCCCCCCCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KRGAVS
HCCCCC
>Mature Secondary Structure 
TLPNAVRIVEVGPRDGLQNEKQLVSADTKVELIRRLEAAGLKAIETTSFVSPKWVPQMG
CCCCCEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCC
DNTEVLTRVLAAAKRGVAYPVLTPNLKGFEAALAAGATEVAVFGAASESFSQKNINCSIA
CCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCHHEEEEECCHHHHHHCCCCCHHH
ESLERFRPVTEAARAAGVKVRGYVSCVAGCPYEGLIAPQAVADVAATLLEMGCYEISLGD
HHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCC
TIGGGNPASIARMLEAVMKQVPVAQLAGHYHDTYGMAIANIHASLQMGVAVFDASVGGLG
CCCCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
GCPYAAGASGNVATEDVVWLLDGLGVQTGVGLGALVDTAAWISAQLGREPASRVARAVLA
CCCCCCCCCCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KRGAVS
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]