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The map label for this gene is zraR [H]

Identifier: 119899321

GI number: 119899321

Start: 3332594

End: 3333922

Strand: Reverse

Name: zraR [H]

Synonym: azo3031

Alternate gene names: 119899321

Gene position: 3333922-3332594 (Counterclockwise)

Preceding gene: 119899326

Following gene: 119899320

Centisome position: 76.19

GC content: 68.4

Gene sequence:

>1329_bases
ATGGTGGTCCGCAGGGGTGTATTGCTTGATCATGGGGGAGAGGTCGCGCAGGCGCTCGCCCGTCTCCAGCTGACGGGTTG
GGAGTTCCAGCCGGTGTCTTCGCTGGAGGCGGCCCGCAAGCTGCTGGCCGCCGAGGCGCCGCCCGTCGGCGTGGTCGTGT
TCGACGGCGAGGACGCCTGGCCCGCGCGTGATCTCGAGGCGCTGCTCGCGCGCTTCAATGTGGAATGGATCGCGGTGCTG
CACCGCGAGCTGTTCGACAGCGAACGCCTGGTGCCGCTGCTGCGGCGCAATTTCTACGATTTCCATTCCTTGCCGCTCGA
CCGCGAGCGGCTGCTGGTTACGCTCGGCCATGCCTACGGCAAGGCGATGCTGGGGCCGAAGCCGGTGCCGCACCTGGGCG
CCGAAGGCGCGTTCGGCATGACCGGGCGCAGCCCGCGGATGCTGCAGCTGTTCCGCCAGATCGAGAAGGTGATCACGGTG
GATGCGCCGGTGCTGATCGGCGGCGCCTCGGGCACCGGCAAGGAGCTGGTGGCGCACGCGATCCACCAGCATTCGGCGCG
GGCCAAGGGCCCCTTCATCGCGATGAACTGCGGCGCCATTCCGGCCAACCTGATCCATTCCGAGCTGTTCGGCTACGAGC
GCGGCGCCTTCACCGGGGCGGTGCAGCGCAAGTTCGGCAATATCGAGGCCGCCAACAACGGCGTGCTCTTCCTCGACGAG
ATCGGCGACCTGCCGCTCGACCTGCAGGCCAGCCTGCTGCGCTTCCTGCAGGAGAAGACCATCGTCCGCGTCGGCGGCAC
CGAGCGGCTGCGGATGAACGTGCGGGTGATCGCCGCGACCCATGTGGACCTCAAGCGCGCGGTCGCCGAGGGCCGCTTCC
GCGAGGACCTCTACTACCGGCTCAATGTGCTGCACCTTCCGGTGCCGGCGCTGCGCGAACGGCGCGAGGACATCAGCCTG
CTGGCGCAGGCGGTGTACGCCGCGCATGAAGACCAGCGCAGCCCGCAGGTGCGCGGCTTCAGCGCCGAGGCCACGCTGGC
GATGGAGGCTTACGACTGGCCGGGCAACGTGCGCGAGCTGATCAACCGCGTGCAGCAGGCCATGATCATGAGCGAGAACC
GCTTCATCTCCGCGGCGGACCTCGGCCTGCCGATGCCGGAGGGCGCCGCGCCGACGACGCTGGACGAGGCGCGCGCGTCG
GTGGAGCGCGAGATGATCGAAACCCGGTTGCGCAAATGCCAGAACAATGTTTCCGAAACGGCGCGCCAGCTCGGCATCTC
GCGGGTGACGCTGTACCGGATGATCGACCGGTTGAAGATCGTGTTGTAG

Upstream 100 bases:

>100_bases
AGCGCGCTGTGCCGCTTGTCCGGCCACGCGTCGCGGGCGTTCGCCGGCACTCCTCCTGGTTCGATACAGGTGGCATGTTT
TCGGCCAGGGGCAGGTATTG

Downstream 100 bases:

>100_bases
CGGCAGGGGACGCGGCGCGAGGGGGCGCCGCTTTTCATTTGGGGGAGGAGACTCATGAAGCACAGGCAGAGGCTTGCCGC
GCGCGCCCTTGGGAGGGGGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MVVRRGVLLDHGGEVAQALARLQLTGWEFQPVSSLEAARKLLAAEAPPVGVVVFDGEDAWPARDLEALLARFNVEWIAVL
HRELFDSERLVPLLRRNFYDFHSLPLDRERLLVTLGHAYGKAMLGPKPVPHLGAEGAFGMTGRSPRMLQLFRQIEKVITV
DAPVLIGGASGTGKELVAHAIHQHSARAKGPFIAMNCGAIPANLIHSELFGYERGAFTGAVQRKFGNIEAANNGVLFLDE
IGDLPLDLQASLLRFLQEKTIVRVGGTERLRMNVRVIAATHVDLKRAVAEGRFREDLYYRLNVLHLPVPALRERREDISL
LAQAVYAAHEDQRSPQVRGFSAEATLAMEAYDWPGNVRELINRVQQAMIMSENRFISAADLGLPMPEGAAPTTLDEARAS
VEREMIETRLRKCQNNVSETARQLGISRVTLYRMIDRLKIVL

Sequences:

>Translated_442_residues
MVVRRGVLLDHGGEVAQALARLQLTGWEFQPVSSLEAARKLLAAEAPPVGVVVFDGEDAWPARDLEALLARFNVEWIAVL
HRELFDSERLVPLLRRNFYDFHSLPLDRERLLVTLGHAYGKAMLGPKPVPHLGAEGAFGMTGRSPRMLQLFRQIEKVITV
DAPVLIGGASGTGKELVAHAIHQHSARAKGPFIAMNCGAIPANLIHSELFGYERGAFTGAVQRKFGNIEAANNGVLFLDE
IGDLPLDLQASLLRFLQEKTIVRVGGTERLRMNVRVIAATHVDLKRAVAEGRFREDLYYRLNVLHLPVPALRERREDISL
LAQAVYAAHEDQRSPQVRGFSAEATLAMEAYDWPGNVRELINRVQQAMIMSENRFISAADLGLPMPEGAAPTTLDEARAS
VEREMIETRLRKCQNNVSETARQLGISRVTLYRMIDRLKIVL
>Mature_442_residues
MVVRRGVLLDHGGEVAQALARLQLTGWEFQPVSSLEAARKLLAAEAPPVGVVVFDGEDAWPARDLEALLARFNVEWIAVL
HRELFDSERLVPLLRRNFYDFHSLPLDRERLLVTLGHAYGKAMLGPKPVPHLGAEGAFGMTGRSPRMLQLFRQIEKVITV
DAPVLIGGASGTGKELVAHAIHQHSARAKGPFIAMNCGAIPANLIHSELFGYERGAFTGAVQRKFGNIEAANNGVLFLDE
IGDLPLDLQASLLRFLQEKTIVRVGGTERLRMNVRVIAATHVDLKRAVAEGRFREDLYYRLNVLHLPVPALRERREDISL
LAQAVYAAHEDQRSPQVRGFSAEATLAMEAYDWPGNVRELINRVQQAMIMSENRFISAADLGLPMPEGAAPTTLDEARAS
VEREMIETRLRKCQNNVSETARQLGISRVTLYRMIDRLKIVL

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=355, Percent_Identity=43.6619718309859, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1788905, Length=344, Percent_Identity=42.1511627906977, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1788550, Length=364, Percent_Identity=41.2087912087912, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1790299, Length=327, Percent_Identity=42.5076452599388, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789087, Length=315, Percent_Identity=42.5396825396825, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082117, Length=318, Percent_Identity=42.1383647798742, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=43.0379746835443, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=39.4984326018809, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786524, Length=318, Percent_Identity=42.7672955974843, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1787583, Length=296, Percent_Identity=38.1756756756757, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081872, Length=312, Percent_Identity=37.8205128205128, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=39.6551724137931, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081858, Length=282, Percent_Identity=31.2056737588652, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49132; Mature: 49132

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVRRGVLLDHGGEVAQALARLQLTGWEFQPVSSLEAARKLLAAEAPPVGVVVFDGEDAW
CEEECCEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
PARDLEALLARFNVEWIAVLHRELFDSERLVPLLRRNFYDFHSLPLDRERLLVTLGHAYG
CHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCHHHHEEEHHHHHC
KAMLGPKPVPHLGAEGAFGMTGRSPRMLQLFRQIEKVITVDAPVLIGGASGTGKELVAHA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
IHQHSARAKGPFIAMNCGAIPANLIHSELFGYERGAFTGAVQRKFGNIEAANNGVLFLDE
HHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCCCEEEEEC
IGDLPLDLQASLLRFLQEKTIVRVGGTERLRMNVRVIAATHVDLKRAVAEGRFREDLYYR
CCCCCCCHHHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEHHHHHHHHHCCHHHHHHHHE
LNVLHLPVPALRERREDISLLAQAVYAAHEDQRSPQVRGFSAEATLAMEAYDWPGNVREL
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHH
INRVQQAMIMSENRFISAADLGLPMPEGAAPTTLDEARASVEREMIETRLRKCQNNVSET
HHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARQLGISRVTLYRMIDRLKIVL
HHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVRRGVLLDHGGEVAQALARLQLTGWEFQPVSSLEAARKLLAAEAPPVGVVVFDGEDAW
CEEECCEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
PARDLEALLARFNVEWIAVLHRELFDSERLVPLLRRNFYDFHSLPLDRERLLVTLGHAYG
CHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCCHHHHEEEHHHHHC
KAMLGPKPVPHLGAEGAFGMTGRSPRMLQLFRQIEKVITVDAPVLIGGASGTGKELVAHA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
IHQHSARAKGPFIAMNCGAIPANLIHSELFGYERGAFTGAVQRKFGNIEAANNGVLFLDE
HHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCCCEEEEEC
IGDLPLDLQASLLRFLQEKTIVRVGGTERLRMNVRVIAATHVDLKRAVAEGRFREDLYYR
CCCCCCCHHHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEHHHHHHHHHCCHHHHHHHHE
LNVLHLPVPALRERREDISLLAQAVYAAHEDQRSPQVRGFSAEATLAMEAYDWPGNVREL
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHH
INRVQQAMIMSENRFISAADLGLPMPEGAAPTTLDEARASVEREMIETRLRKCQNNVSET
HHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARQLGISRVTLYRMIDRLKIVL
HHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]