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The map label for this gene is elmS [H]

Identifier: 119899269

GI number: 119899269

Start: 3271523

End: 3272992

Strand: Direct

Name: elmS [H]

Synonym: azo2979

Alternate gene names: 119899269

Gene position: 3271523-3272992 (Clockwise)

Preceding gene: 119899268

Following gene: 119899270

Centisome position: 74.76

GC content: 72.31

Gene sequence:

>1470_bases
ATGAAAGCCGCCGCCTCGTCTCCGTCCCCCCGCCGCGCCGCACTCAGCCTGCACGCGCGCGTCAGCCTGGTGCTGTGCGC
GCTGGTGGCCGCGCTGCTGCTGGCCGCGGGCTTTGCCTGGGTGAGCGAGACGCGCAACGCCATCCGCGAGGAAACCGAGG
CCGCCGGCCGCGTTGCCGGGCAGTGGCTGACGGTGCTGGCGCGCGAAACCGACCGCGACCCGGCGCACGGCGCCGAGCGG
CTGATGACCAACCTGCGCGAAGTCGGCCGCCTGCGCTCCAACGTGCTCGAAGTGATCAGCGCGGACGGCAGCACCGTCTA
CCAGTCGCCGGCATCGGCCTACAAGGCCGGCCGCGACGCGCCCGCCTGGTTCGCCAACTGGCTGGCGCCGCTGCCGCTGG
AGCGCCGCTTCGACGCGGGCGAGCAGCAACTGGTGCTGCGGCCCGACAGCTCGCGCTCGGTGCTCGACGCCTGGGATGAG
CTGGTGGCGATGTCCGGCTGGGCGCTCGCCGCGCTGGCGTTGATCGCCTTCGCCTGCCACCACGCGCTGCGCCGCGCGCT
GGCGCCGCTGCACTCGATCGACGCCGCGCTCGCCCGTGGCGCCGACGGCCTCTTCGACCGCCGCCTGCCCGCGCTCGCCG
CGCCCGAACTCGACCGCCTGGCGCAGAGCTACAACCGCCTTGCCGAACGCCTGGACGACACCCTGGCCGACAACCAGCGC
CTGGAAGAAGACCAGCGCTTCGCCCGCGCGCTGCAGGCCCGGCTGGAGGAAGAACGCCGCATCATCGCCCGCGAACTGCA
CGACGAACTCGCGCAAGGCATCACCGCCGTGCGCGCCATCGCCGGCGCCATCGGCCAGCGCAGCGCAGACCAGCCCGGCA
TCCACGGCAGCGCCCAGACCATCGTCGCCATGACCGGCCAGATGCAGGACGGCGTGCGCGCCATCCTGCAACGCCTGCGC
CCGCCCACGGTGGCCACCGGCGGCCGCATCGACGAAGCAGTGGCCGCCTGGTGCGCGCAGTGGGGCGCGCTCTATCCGCA
GATCCAGGTGGATTGCCGCACCGAGGCGCCGCAAGGCGAAGTCACCGATGAAGTGGCCCTGACCGTGCAGCGCCTGCTGC
AGGAAGGCCTCACGAATGTCGCCCGCCACGCCGGCGCCAGCACGGTGTTGGTAAGCCTGGCCTGCAGCGCGGATGCGATC
GAGCTTTCGATCGCCGACAACGGCTGCGGTTTGGCCGGCGCGGAAGGCGACAAGCCCCGCTTCGGCCTGACCGGCATGCA
GGAGCGCGTGCTGGACCTGGGCGGGGAACTGCACTTCGAGACCGCCGCAGGGGGTGGGCTGTGCGTGCGGGCGCGGCTGC
CGCTTGGCGGGGAAGAGAAGGTTTGCCCCTCCCCCTTCAAGGGGGAGGTTGGGAGGGGGATGGGGTCGGCCGCAGCACTG
AACCAGATGCAAAACTCTCCGAGAGTATGA

Upstream 100 bases:

>100_bases
AGACCAATTCGGGCGACTGGGCGCGCGAAACCTTCTACGCCCCCGGCGCCCCGCGCGCCGGCTGGATCGGCCTGCGTTAC
CGCTGGGGAGCCTGACCGCC

Downstream 100 bases:

>100_bases
GTATGACGACTTCCGAGTGCAGTCCAACGCTTCCCTTTGTGATGGAAGCGGCTTGCAGGCTGTTTTGAGCGGTTGGCCTT
TTCATCGCACGCGTAGAAAT

Product: putative two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MKAAASSPSPRRAALSLHARVSLVLCALVAALLLAAGFAWVSETRNAIREETEAAGRVAGQWLTVLARETDRDPAHGAER
LMTNLREVGRLRSNVLEVISADGSTVYQSPASAYKAGRDAPAWFANWLAPLPLERRFDAGEQQLVLRPDSSRSVLDAWDE
LVAMSGWALAALALIAFACHHALRRALAPLHSIDAALARGADGLFDRRLPALAAPELDRLAQSYNRLAERLDDTLADNQR
LEEDQRFARALQARLEEERRIIARELHDELAQGITAVRAIAGAIGQRSADQPGIHGSAQTIVAMTGQMQDGVRAILQRLR
PPTVATGGRIDEAVAAWCAQWGALYPQIQVDCRTEAPQGEVTDEVALTVQRLLQEGLTNVARHAGASTVLVSLACSADAI
ELSIADNGCGLAGAEGDKPRFGLTGMQERVLDLGGELHFETAAGGGLCVRARLPLGGEEKVCPSPFKGEVGRGMGSAAAL
NQMQNSPRV

Sequences:

>Translated_489_residues
MKAAASSPSPRRAALSLHARVSLVLCALVAALLLAAGFAWVSETRNAIREETEAAGRVAGQWLTVLARETDRDPAHGAER
LMTNLREVGRLRSNVLEVISADGSTVYQSPASAYKAGRDAPAWFANWLAPLPLERRFDAGEQQLVLRPDSSRSVLDAWDE
LVAMSGWALAALALIAFACHHALRRALAPLHSIDAALARGADGLFDRRLPALAAPELDRLAQSYNRLAERLDDTLADNQR
LEEDQRFARALQARLEEERRIIARELHDELAQGITAVRAIAGAIGQRSADQPGIHGSAQTIVAMTGQMQDGVRAILQRLR
PPTVATGGRIDEAVAAWCAQWGALYPQIQVDCRTEAPQGEVTDEVALTVQRLLQEGLTNVARHAGASTVLVSLACSADAI
ELSIADNGCGLAGAEGDKPRFGLTGMQERVLDLGGELHFETAAGGGLCVRARLPLGGEEKVCPSPFKGEVGRGMGSAAAL
NQMQNSPRV
>Mature_489_residues
MKAAASSPSPRRAALSLHARVSLVLCALVAALLLAAGFAWVSETRNAIREETEAAGRVAGQWLTVLARETDRDPAHGAER
LMTNLREVGRLRSNVLEVISADGSTVYQSPASAYKAGRDAPAWFANWLAPLPLERRFDAGEQQLVLRPDSSRSVLDAWDE
LVAMSGWALAALALIAFACHHALRRALAPLHSIDAALARGADGLFDRRLPALAAPELDRLAQSYNRLAERLDDTLADNQR
LEEDQRFARALQARLEEERRIIARELHDELAQGITAVRAIAGAIGQRSADQPGIHGSAQTIVAMTGQMQDGVRAILQRLR
PPTVATGGRIDEAVAAWCAQWGALYPQIQVDCRTEAPQGEVTDEVALTVQRLLQEGLTNVARHAGASTVLVSLACSADAI
ELSIADNGCGLAGAEGDKPRFGLTGMQERVLDLGGELHFETAAGGGLCVRARLPLGGEEKVCPSPFKGEVGRGMGSAAAL
NQMQNSPRV

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=230, Percent_Identity=33.9130434782609, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788812, Length=205, Percent_Identity=31.219512195122, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787474, Length=228, Percent_Identity=25.4385964912281, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52225; Mature: 52225

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAASSPSPRRAALSLHARVSLVLCALVAALLLAAGFAWVSETRNAIREETEAAGRVAG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWLTVLARETDRDPAHGAERLMTNLREVGRLRSNVLEVISADGSTVYQSPASAYKAGRDA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHCCCCC
PAWFANWLAPLPLERRFDAGEQQLVLRPDSSRSVLDAWDELVAMSGWALAALALIAFACH
HHHHHHHHCCCCCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
HALRRALAPLHSIDAALARGADGLFDRRLPALAAPELDRLAQSYNRLAERLDDTLADNQR
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEDQRFARALQARLEEERRIIARELHDELAQGITAVRAIAGAIGQRSADQPGIHGSAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
IVAMTGQMQDGVRAILQRLRPPTVATGGRIDEAVAAWCAQWGALYPQIQVDCRTEAPQGE
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
VTDEVALTVQRLLQEGLTNVARHAGASTVLVSLACSADAIELSIADNGCGLAGAEGDKPR
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
FGLTGMQERVLDLGGELHFETAAGGGLCVRARLPLGGEEKVCPSPFKGEVGRGMGSAAAL
CCCCHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
NQMQNSPRV
HHHHCCCCC
>Mature Secondary Structure
MKAAASSPSPRRAALSLHARVSLVLCALVAALLLAAGFAWVSETRNAIREETEAAGRVAG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWLTVLARETDRDPAHGAERLMTNLREVGRLRSNVLEVISADGSTVYQSPASAYKAGRDA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHCCCCC
PAWFANWLAPLPLERRFDAGEQQLVLRPDSSRSVLDAWDELVAMSGWALAALALIAFACH
HHHHHHHHCCCCCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
HALRRALAPLHSIDAALARGADGLFDRRLPALAAPELDRLAQSYNRLAERLDDTLADNQR
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEDQRFARALQARLEEERRIIARELHDELAQGITAVRAIAGAIGQRSADQPGIHGSAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
IVAMTGQMQDGVRAILQRLRPPTVATGGRIDEAVAAWCAQWGALYPQIQVDCRTEAPQGE
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
VTDEVALTVQRLLQEGLTNVARHAGASTVLVSLACSADAIELSIADNGCGLAGAEGDKPR
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
FGLTGMQERVLDLGGELHFETAAGGGLCVRARLPLGGEEKVCPSPFKGEVGRGMGSAAAL
CCCCHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
NQMQNSPRV
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]