Click here to switch to the map view.

The map label for this gene is pcoA [H]

Identifier: 119899240

GI number: 119899240

Start: 3236323

End: 3237729

Strand: Direct

Name: pcoA [H]

Synonym: azo2950

Alternate gene names: 119899240

Gene position: 3236323-3237729 (Clockwise)

Preceding gene: 119899239

Following gene: 119899241

Centisome position: 73.96

GC content: 68.73

Gene sequence:

>1407_bases
ATGAGCCAAGATCCCAAACCCGACCGCCGCCGTTTTCTCGCCGGTGCCGGCCTCGCCGGCCTGGGCGTGGCCGCCGCCGG
CGTCAGCCGGGTGGCACTGGCCGCCCTGCCCGAACCCATCATCCAGACCAGCGCCGCCACCGCGCCGCCGCTGCAGCCGA
AGAGCGGCCGCCCCTACAACCCGGTGGTCACCCTCAACGGCTGGACGGCGCCCTGGCGGATGAACAACGGCGTGAAGGAA
TTCCACCTCGTCGCCGAGCCGGTGGAGCGCGAGATCGCCCCCGGCATGGTCGCCCGCCTGTGGGGCTACAACGGCCAGTC
GCCCGGCCCCACCATCGAGGTGGTGGAAGGCGACCGGGTGCGCGTCTTCGTCACCAACCGGCTGCCCGAGCACACCACCA
TCCATTGGCACGGCCAGCGCCTGCCCAACGGCATGGACGGCGTCGGCGGCCTCACCCAGCCGCAGATCCCGCCCGGCAAG
ACCTTCGTCTACGAATTCGTCGCGCGGCGTCCCGGCACCTTCATGTACCACCCGCATGCCGACGAGATGACGCAGATGGC
GATGGGCATGATGGGCTTCTGGGTCACCCACCCGCGCTCGCCGCATCCGCACATCGCCGCGGTGGATCGCGACTTCTGTT
TCCTGCTCAACGCCTTCGACATCGAGCCGGGCAGCTACGTCCCCAAGGTGAACACCATGCTGGACTTCAACCTGTGGACC
TGGAACAGCCGGGCCTTTCCCGGCATCGATACGCTCAACGTGCGCAAGGGCGACCGCGTGCGGGTACGCATCGGCAACCT
GACGATGACCAACCACCCCATCCACATCCACGGTCACGAGTTCGAGGTCACCGGCACCGACGGCGGCCCGACGCGGCCGG
AATCGCGCTGGCCGGAGGTCACCACCGACATCGCCGTCGGCCAGATGCGCCAGATCGAATTCGTCGCCGATGAAGAAGGC
GACTGGGCGATGCACTGCCACAAGTCGCACCACACCATGAACGCGATGGGCCACGACGTGCCGACGATGATAGGCGTGGA
CCACCGCGGCCTGGTCGAGCAGATCCAGCAGGTGGTGCCGGACTACATGCTGATGGGCGAACGCGGCATGGCCGACATGG
GCGAGATGGAGATGCCGCTGCCCGACAACACCTTGCCGATGATGACCGGTCAGGGCCCCTTCGGCGCGATCGAGATGGGC
GGCATGTTCACCACGCTGAAGGTAAGACGCGGGCAGAAGCCGGGCGACTATTCCGATCCGGGCTGGTTCAAGCATCCGCC
GGGGACGGTGGCGCGCGAATGGACCGGCGAAGTGCCTGCGCCCGCGCGCGACAAGGCGGCGGGCGGGCAAGCCGCGCCGG
CGGCGGACGTGACGGTGCGCAAGCCCGCCGGCCACCACGGCCATTGA

Upstream 100 bases:

>100_bases
CGCCATGCTCGGCACGCCGATCGCCCCGCTCGCGCTGCAGGCGAGCGCCGCCCCCGCCGCCGCTGACGGCGGCCACTGAG
ATTCCCGGAGTCTGTCCCCG

Downstream 100 bases:

>100_bases
GTAACCGGGACCGCTGCGGCGCTTTCCAGGCTCGCGGCGGTCGAACCCCTGGCACGACGAACAGGAGACACACCATGACC
GACCGTCGCCGCTTTCTCGC

Product: multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSQDPKPDRRRFLAGAGLAGLGVAAAGVSRVALAALPEPIIQTSAATAPPLQPKSGRPYNPVVTLNGWTAPWRMNNGVKE
FHLVAEPVEREIAPGMVARLWGYNGQSPGPTIEVVEGDRVRVFVTNRLPEHTTIHWHGQRLPNGMDGVGGLTQPQIPPGK
TFVYEFVARRPGTFMYHPHADEMTQMAMGMMGFWVTHPRSPHPHIAAVDRDFCFLLNAFDIEPGSYVPKVNTMLDFNLWT
WNSRAFPGIDTLNVRKGDRVRVRIGNLTMTNHPIHIHGHEFEVTGTDGGPTRPESRWPEVTTDIAVGQMRQIEFVADEEG
DWAMHCHKSHHTMNAMGHDVPTMIGVDHRGLVEQIQQVVPDYMLMGERGMADMGEMEMPLPDNTLPMMTGQGPFGAIEMG
GMFTTLKVRRGQKPGDYSDPGWFKHPPGTVAREWTGEVPAPARDKAAGGQAAPAADVTVRKPAGHHGH

Sequences:

>Translated_468_residues
MSQDPKPDRRRFLAGAGLAGLGVAAAGVSRVALAALPEPIIQTSAATAPPLQPKSGRPYNPVVTLNGWTAPWRMNNGVKE
FHLVAEPVEREIAPGMVARLWGYNGQSPGPTIEVVEGDRVRVFVTNRLPEHTTIHWHGQRLPNGMDGVGGLTQPQIPPGK
TFVYEFVARRPGTFMYHPHADEMTQMAMGMMGFWVTHPRSPHPHIAAVDRDFCFLLNAFDIEPGSYVPKVNTMLDFNLWT
WNSRAFPGIDTLNVRKGDRVRVRIGNLTMTNHPIHIHGHEFEVTGTDGGPTRPESRWPEVTTDIAVGQMRQIEFVADEEG
DWAMHCHKSHHTMNAMGHDVPTMIGVDHRGLVEQIQQVVPDYMLMGERGMADMGEMEMPLPDNTLPMMTGQGPFGAIEMG
GMFTTLKVRRGQKPGDYSDPGWFKHPPGTVAREWTGEVPAPARDKAAGGQAAPAADVTVRKPAGHHGH
>Mature_467_residues
SQDPKPDRRRFLAGAGLAGLGVAAAGVSRVALAALPEPIIQTSAATAPPLQPKSGRPYNPVVTLNGWTAPWRMNNGVKEF
HLVAEPVEREIAPGMVARLWGYNGQSPGPTIEVVEGDRVRVFVTNRLPEHTTIHWHGQRLPNGMDGVGGLTQPQIPPGKT
FVYEFVARRPGTFMYHPHADEMTQMAMGMMGFWVTHPRSPHPHIAAVDRDFCFLLNAFDIEPGSYVPKVNTMLDFNLWTW
NSRAFPGIDTLNVRKGDRVRVRIGNLTMTNHPIHIHGHEFEVTGTDGGPTRPESRWPEVTTDIAVGQMRQIEFVADEEGD
WAMHCHKSHHTMNAMGHDVPTMIGVDHRGLVEQIQQVVPDYMLMGERGMADMGEMEMPLPDNTLPMMTGQGPFGAIEMGG
MFTTLKVRRGQKPGDYSDPGWFKHPPGTVAREWTGEVPAPARDKAAGGQAAPAADVTVRKPAGHHGH

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=104, Percent_Identity=41.3461538461538, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323703, Length=101, Percent_Identity=42.5742574257426, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=221, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859919, Length=249, Percent_Identity=31.3253012048193, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28574104, Length=149, Percent_Identity=34.8993288590604, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24650186, Length=203, Percent_Identity=32.0197044334975, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51455; Mature: 51324

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPKPDRRRFLAGAGLAGLGVAAAGVSRVALAALPEPIIQTSAATAPPLQPKSGRPYN
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCC
PVVTLNGWTAPWRMNNGVKEFHLVAEPVEREIAPGMVARLWGYNGQSPGPTIEVVEGDRV
CEEEECCCCCCCCCCCCCHHHHEEHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEECCEE
RVFVTNRLPEHTTIHWHGQRLPNGMDGVGGLTQPQIPPGKTFVYEFVARRPGTFMYHPHA
EEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCH
DEMTQMAMGMMGFWVTHPRSPHPHIAAVDRDFCFLLNAFDIEPGSYVPKVNTMLDFNLWT
HHHHHHHHHHHHHEEECCCCCCCCEEEECCCEEEEEEEEECCCCCCCCCCCEEEEEEEEE
WNSRAFPGIDTLNVRKGDRVRVRIGNLTMTNHPIHIHGHEFEVTGTDGGPTRPESRWPEV
ECCCCCCCCCEEECCCCCEEEEEECCEEEECCCEEEECCEEEEEECCCCCCCCCCCCCCC
TTDIAVGQMRQIEFVADEEGDWAMHCHKSHHTMNAMGHDVPTMIGVDHRGLVEQIQQVVP
HHHHHHCCEEEEEEEECCCCCEEEEEECCCCCHHHCCCCCCCEECCCCHHHHHHHHHHCC
DYMLMGERGMADMGEMEMPLPDNTLPMMTGQGPFGAIEMGGMFTTLKVRRGQKPGDYSDP
HHEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCEEEEEEEECCCCCCCCCCC
GWFKHPPGTVAREWTGEVPAPARDKAAGGQAAPAADVTVRKPAGHHGH
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
SQDPKPDRRRFLAGAGLAGLGVAAAGVSRVALAALPEPIIQTSAATAPPLQPKSGRPYN
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCC
PVVTLNGWTAPWRMNNGVKEFHLVAEPVEREIAPGMVARLWGYNGQSPGPTIEVVEGDRV
CEEEECCCCCCCCCCCCCHHHHEEHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEECCEE
RVFVTNRLPEHTTIHWHGQRLPNGMDGVGGLTQPQIPPGKTFVYEFVARRPGTFMYHPHA
EEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCH
DEMTQMAMGMMGFWVTHPRSPHPHIAAVDRDFCFLLNAFDIEPGSYVPKVNTMLDFNLWT
HHHHHHHHHHHHHEEECCCCCCCCEEEECCCEEEEEEEEECCCCCCCCCCCEEEEEEEEE
WNSRAFPGIDTLNVRKGDRVRVRIGNLTMTNHPIHIHGHEFEVTGTDGGPTRPESRWPEV
ECCCCCCCCCEEECCCCCEEEEEECCEEEECCCEEEECCEEEEEECCCCCCCCCCCCCCC
TTDIAVGQMRQIEFVADEEGDWAMHCHKSHHTMNAMGHDVPTMIGVDHRGLVEQIQQVVP
HHHHHHCCEEEEEEEECCCCCEEEEEECCCCCHHHCCCCCCCEECCCCHHHHHHHHHHCC
DYMLMGERGMADMGEMEMPLPDNTLPMMTGQGPFGAIEMGGMFTTLKVRRGQKPGDYSDP
HHEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCEEEEEEEECCCCCCCCCCC
GWFKHPPGTVAREWTGEVPAPARDKAAGGQAAPAADVTVRKPAGHHGH
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]