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The map label for this gene is acoR [H]

Identifier: 119899230

GI number: 119899230

Start: 3225116

End: 3226705

Strand: Direct

Name: acoR [H]

Synonym: azo2940

Alternate gene names: 119899230

Gene position: 3225116-3226705 (Clockwise)

Preceding gene: 119899226

Following gene: 119899232

Centisome position: 73.7

GC content: 69.94

Gene sequence:

>1590_bases
ATGGACTCCGCAACACCTCCGATCCCGCTTTCTGCCGCGTTGCGCGAATCCTGGGCGCGTTGCCATCGCCATGGCCTCGA
TCCGGATGAGCCGCTGCCCACCCACGCGTTGGCGCGAGCGGACCTCGCCGACCGCCTGGAAGCCAACGCGCGGCTGCTGA
CATTCTCGCGCCCGGTGATCGAGAACCTGTACCGCCAGATCGACTGCCCCGCCTCCACCGTGCTGCTGACCGACAGCCAG
GGGCTGATCCTTTCTGCGCTCGGTGACACGGCCTTTCTCGATCGCGCCGCGCGCGTCGCGCTCAGCCCCGGGGTGGAATG
GACCGAAGCGGCCATGGGCACCAACGCGATCGGCACCGCGCTGCAACTGGGCGAGGTGGTGACGGTGCAGGGCGACGAGC
ACTTCTTCACGCGCAACCGGGTGCTCACCTGCGTTGCCACGCCCATCCTCGCCCCCACCGGCGGCATCGCCGGCATCCTC
GACATCTCCACCGACGCGCGCGCCGACCTGTCGCACGCCGACGCCCTGCTGCGCACCACCGCGGAACTGATCGAGCACAG
GCTGGTGGAGTCACTGGACGACGGCTTCCTGACGCTGCGCTTCCATTCCCGCCAGGACCTGATCGGCACGCCCTTCGAGG
GCCTCGCGGTGTTCGACGAAAGCGGCCGGCTGCTGGCCTGCAACCGTGCGGCCCGATCGCAGCTGAGGCTGTACCGCGAG
TTTCCCGACACCAGCTTCGCGGAGTGCTTCGCCACCGACTGGCGCCGCCTGATCGACTGGGCGGCACTCGGCCACGCCAC
GCCCTTCCCGCTTCGCACCGCGGTTGCGGGCACCTGCGTGGCGCGCGCAACCCTGCGGGGACAACGCAGGCATTCGCCCG
CCGCCGAAACGCCCGCGCCGCCCCGATCCACCGTGGTGGACGCCATCAACCTCGGTGACGAACGCGTGGCAACGGCGCTC
GCCACCCTCGCCACGTGGGCGCAGGAAAGCGGTCCCTTGTTGATCGCCGGCGAAACCGGCACCGGCAAACGCCATCTGGT
CCATGCCTTCCACCACGACCACGCCGAGCAACGGCCGCTGGTGACGCTGGACTGCGCGGCGGTCGCCGCCGGCCCCCAAC
TGCGGGCGGAAACCGAGCATGCGCTGCGTCAGGCCGAAAGCGGCATCCTGTACCTGATCGACAGCGAAGCGCTGCCTTAT
GCGGAGCAGGTTTTCCTGTTCCGCGCGGCCTCTTCAAGCACGCGGATCATCGCCGCCACGCGTGTCCCGCTGGTGCAGCT
CCACGAGCAGCAACGCATCCCCTTCGGCACCTTCGACGCATGCGGCGGCCGCCGGATCGAACTCCCGCCCCTGCGCGAAC
GCAGCGACTTCGATGCGCTGGTCCGCCGCTTCGTGCGCGACGCCTGCCCGGACCGGCCGGTGTACGTCTGCCCGGATGCG
CTCGCCCTGCTGCGCCGTCATCGCTGGCCCGGCAACCTGAGCGAACTGAACAACCGCCTGCGCCTCATCCTCGCGCTGAT
GGGGGACGACGCGGGGCAGCTGTGCCCCGAGGACATTCCCGAAGAACTGCTGGAGCCGGTGGCGGGCTGA

Upstream 100 bases:

>100_bases
CCGTCCTGCGCGGGGGTGCCTCACACGCTGGCGCCATCGCCCACGCAGCTGGAACACGCCAAATGAAAGCCAAGCGGCAT
GAGTTTTGCTCGTGCAGCAC

Downstream 100 bases:

>100_bases
GCAGCCGCCGTACAACGGACGCCCCGCTGCGCGGCGCGCCGTCAGCCCGGCTTGAGGCGGCCCGCGCTTAGCCGGCGCGG
TCCGAACGGGACGGCGTGCC

Product: sigma-54 dependent transcriptional regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MDSATPPIPLSAALRESWARCHRHGLDPDEPLPTHALARADLADRLEANARLLTFSRPVIENLYRQIDCPASTVLLTDSQ
GLILSALGDTAFLDRAARVALSPGVEWTEAAMGTNAIGTALQLGEVVTVQGDEHFFTRNRVLTCVATPILAPTGGIAGIL
DISTDARADLSHADALLRTTAELIEHRLVESLDDGFLTLRFHSRQDLIGTPFEGLAVFDESGRLLACNRAARSQLRLYRE
FPDTSFAECFATDWRRLIDWAALGHATPFPLRTAVAGTCVARATLRGQRRHSPAAETPAPPRSTVVDAINLGDERVATAL
ATLATWAQESGPLLIAGETGTGKRHLVHAFHHDHAEQRPLVTLDCAAVAAGPQLRAETEHALRQAESGILYLIDSEALPY
AEQVFLFRAASSSTRIIAATRVPLVQLHEQQRIPFGTFDACGGRRIELPPLRERSDFDALVRRFVRDACPDRPVYVCPDA
LALLRRHRWPGNLSELNNRLRLILALMGDDAGQLCPEDIPEELLEPVAG

Sequences:

>Translated_529_residues
MDSATPPIPLSAALRESWARCHRHGLDPDEPLPTHALARADLADRLEANARLLTFSRPVIENLYRQIDCPASTVLLTDSQ
GLILSALGDTAFLDRAARVALSPGVEWTEAAMGTNAIGTALQLGEVVTVQGDEHFFTRNRVLTCVATPILAPTGGIAGIL
DISTDARADLSHADALLRTTAELIEHRLVESLDDGFLTLRFHSRQDLIGTPFEGLAVFDESGRLLACNRAARSQLRLYRE
FPDTSFAECFATDWRRLIDWAALGHATPFPLRTAVAGTCVARATLRGQRRHSPAAETPAPPRSTVVDAINLGDERVATAL
ATLATWAQESGPLLIAGETGTGKRHLVHAFHHDHAEQRPLVTLDCAAVAAGPQLRAETEHALRQAESGILYLIDSEALPY
AEQVFLFRAASSSTRIIAATRVPLVQLHEQQRIPFGTFDACGGRRIELPPLRERSDFDALVRRFVRDACPDRPVYVCPDA
LALLRRHRWPGNLSELNNRLRLILALMGDDAGQLCPEDIPEELLEPVAG
>Mature_529_residues
MDSATPPIPLSAALRESWARCHRHGLDPDEPLPTHALARADLADRLEANARLLTFSRPVIENLYRQIDCPASTVLLTDSQ
GLILSALGDTAFLDRAARVALSPGVEWTEAAMGTNAIGTALQLGEVVTVQGDEHFFTRNRVLTCVATPILAPTGGIAGIL
DISTDARADLSHADALLRTTAELIEHRLVESLDDGFLTLRFHSRQDLIGTPFEGLAVFDESGRLLACNRAARSQLRLYRE
FPDTSFAECFATDWRRLIDWAALGHATPFPLRTAVAGTCVARATLRGQRRHSPAAETPAPPRSTVVDAINLGDERVATAL
ATLATWAQESGPLLIAGETGTGKRHLVHAFHHDHAEQRPLVTLDCAAVAAGPQLRAETEHALRQAESGILYLIDSEALPY
AEQVFLFRAASSSTRIIAATRVPLVQLHEQQRIPFGTFDACGGRRIELPPLRERSDFDALVRRFVRDACPDRPVYVCPDA
LALLRRHRWPGNLSELNNRLRLILALMGDDAGQLCPEDIPEELLEPVAG

Specific function: Required for sigma-54-dependent transcription of acoXABC [H]

COG id: COG3284

COG function: function code QK; Transcriptional activator of acetoin/glycerol metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=296, Percent_Identity=28.7162162162162, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789233, Length=235, Percent_Identity=29.3617021276596, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=245, Percent_Identity=27.7551020408163, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082117, Length=205, Percent_Identity=30.7317073170732, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57729; Mature: 57729

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4 ; PS01067 SECE_SEC61G

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSATPPIPLSAALRESWARCHRHGLDPDEPLPTHALARADLADRLEANARLLTFSRPVI
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHH
ENLYRQIDCPASTVLLTDSQGLILSALGDTAFLDRAARVALSPGVEWTEAAMGTNAIGTA
HHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHH
LQLGEVVTVQGDEHFFTRNRVLTCVATPILAPTGGIAGILDISTDARADLSHADALLRTT
HHHCCEEEEECCCEEEHHCCEEEEEHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AELIEHRLVESLDDGFLTLRFHSRQDLIGTPFEGLAVFDESGRLLACNRAARSQLRLYRE
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCEEEECHHHHHHHHHHHH
FPDTSFAECFATDWRRLIDWAALGHATPFPLRTAVAGTCVARATLRGQRRHSPAAETPAP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PRSTVVDAINLGDERVATALATLATWAQESGPLLIAGETGTGKRHLVHAFHHDHAEQRPL
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCE
VTLDCAAVAAGPQLRAETEHALRQAESGILYLIDSEALPYAEQVFLFRAASSSTRIIAAT
EEEEHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHEEEEEECCCCCEEEEEC
RVPLVQLHEQQRIPFGTFDACGGRRIELPPLRERSDFDALVRRFVRDACPDRPVYVCPDA
CCCHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCHH
LALLRRHRWPGNLSELNNRLRLILALMGDDAGQLCPEDIPEELLEPVAG
HHHHHHCCCCCCHHHHHHHHHEEHHHHCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MDSATPPIPLSAALRESWARCHRHGLDPDEPLPTHALARADLADRLEANARLLTFSRPVI
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHH
ENLYRQIDCPASTVLLTDSQGLILSALGDTAFLDRAARVALSPGVEWTEAAMGTNAIGTA
HHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHH
LQLGEVVTVQGDEHFFTRNRVLTCVATPILAPTGGIAGILDISTDARADLSHADALLRTT
HHHCCEEEEECCCEEEHHCCEEEEEHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AELIEHRLVESLDDGFLTLRFHSRQDLIGTPFEGLAVFDESGRLLACNRAARSQLRLYRE
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCEEEECHHHHHHHHHHHH
FPDTSFAECFATDWRRLIDWAALGHATPFPLRTAVAGTCVARATLRGQRRHSPAAETPAP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PRSTVVDAINLGDERVATALATLATWAQESGPLLIAGETGTGKRHLVHAFHHDHAEQRPL
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCE
VTLDCAAVAAGPQLRAETEHALRQAESGILYLIDSEALPYAEQVFLFRAASSSTRIIAAT
EEEEHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHEEEEEECCCCCEEEEEC
RVPLVQLHEQQRIPFGTFDACGGRRIELPPLRERSDFDALVRRFVRDACPDRPVYVCPDA
CCCHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCHH
LALLRRHRWPGNLSELNNRLRLILALMGDDAGQLCPEDIPEELLEPVAG
HHHHHHCCCCCCHHHHHHHHHEEHHHHCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1378052 [H]