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The map label for this gene is acoR [H]

Identifier: 119899222

GI number: 119899222

Start: 3216979

End: 3219003

Strand: Reverse

Name: acoR [H]

Synonym: azo2932

Alternate gene names: 119899222

Gene position: 3219003-3216979 (Counterclockwise)

Preceding gene: 119899227

Following gene: 119899221

Centisome position: 73.56

GC content: 70.52

Gene sequence:

>2025_bases
ATGAAAGGTCTGGCTACGGCCGAGGACACCCACGTCCTGCGGGTGCAGGAAGCGCGTCGGCGCTTCTTCGACCTCGGCGA
CGATCCCGACGGTGATCTGCCTGCCGAGGTACTGCGCTCCTGGCAGCGCTGCCGCGACGGCGGGGTGTCGGCGCAATCCA
CGGTTGCCGGTGATCCGGCCGGCCGCTCGCGGCTGGCGGAGGTGCGCGAGCGCAGCGAGCACCTGCTGACCCAGGCGGCG
GGCATCATGGAGCACGTCTTCGAGCAGATCCGGGCCAGCGGCAGCATGGTGCTGCTGGCCGACGTCGACGGCGTCATCCT
GCACAGCCTCGGCGACCCCGACTTCATCGCCCGCGCCCAGCGCGTCGCGCTGCAGCCCGGCGCCTCGTGGGACGAGGCCG
CGCGCGGCACCAACGCGGTGGGCATCGCGCTGATCGAACAGCGCCCGGCCGAAGTGCTCGGCGCGGAGCACTTCCTCGAG
CGCAACGGCATCCTCACCTGCAGCGCGGCGCCGGTGTTCAAGCCCTGCGGCATGCTCGCCGGGGTGCTCGACATTTCCGG
CGACTATCGCAGCAACCAGCGCCACACCATGGGGCTGGTGAGGCTGGCCGCGCAGTTGCTGGAAAAGCGGCTGTTCGAGG
TCGATTTCGCGCGTCAGGTGCTGATCGCGGTGCACGCGCGGCCGGAATGCGTGGGCAGCCTGCAGGAGGGCTTGCTCGCG
GTGTCGGCCGATGGCTGCATCGTCGGCGCCAACCCGGCTGCGCGCGAGGCGCTCGGCATTACCGACATCGGCCCGGGCGG
GCTCGCCTTCAGCAGCGTGTTCCGCGTCTCGCTCGACGTCTTCTTCGACCGCTCCCGGCGTGATCCGGCTTCGCTGCAGA
TGCTGGAGGCACGGCGCGGCGAGCGTATCTACACCCGGCTCAAGAGCAGCCTGCCGCCGCGCACCGAGCCGGTCGGCGGC
AGCGCTCCGGCGCGTCCGGCGGTGACGGCAAAAGCTGAAACCTCCGAAGCGGTGCCGCGCGACGGCCGCGTGACGCTGGC
GTGCCTCGCCACCGGCGACAGCCGTCTGCAACTGGCGCTCGACCGCGCCGGCAAGGTCATCGGCAAGGACATTCCGCTGC
TGATCCAGGGCGAGTCAGGCGTAGGCAAGGAACTCTTCGCGCGCGCCTTCCACTTCAGCGGCCCGCGTCGTGACGGCCCC
TTCGTTGCGCTCAACTGTGCGGCCATTCCAGAAAACCTGATCGAGTCCGAACTGTTCGGCTATGTCGGCGGCGCCTTCAC
CGGGGCGCGGCGCGAGGGCGCGGTCGGCAAGATCCAGCAGGCGCACGGCGGCACCCTGTTCCTCGACGAGATCGGCGACA
TGCCGCTGGGCATGCAGGCACGGCTGCTGCGCGTGCTGCAGGAGCGCAGCGTCACGCCGATCGGCTCGGTGCGGCAGGTG
CCGGTGGATATCTCGCTGGTGTGCGCCACCCACCGCCTGCTGCGCGAGTCGGTGCAGAAGGGCAGCTTCCGCGAGGATCT
CTACTACCGCGTCAACGGGCTGACGGTCACCTTGCCGCCGTTGCGCGAGCGGGGCGACATCGGGAGGATCGTCAGCAACA
TCCTTGCGGCGGAGGCCGGCGACGGGCGGCAGATACGCATCGGCGCCGAGGTGATGGACTTCTTCGAGCGTTATCCGTGG
CCGGGCAACGTGCGCCAGCTGCAGAACGTCATCCGCGTGGCGGTGGCGCTGCTCGACGACGACGAGGACGAGATCCGTCC
GCTGCACCTGCCGGAGGAGCTGTTCGGCGCCGACACCATGACCGAAGGCGACCGCCACCGTCCGGACGAGCGTCCCTCGT
CGGTGGTGACGCCGCTCGGCCAGCCGGCGGCCGGTATCGCCACCGGGGGCCGCAGTCTGGACGAGATCGAGCTGGAAGCG
ATCGCCGTGGTGATGCGCGAGGTGGGCGGCAACGTCTCCGCCGCGGCGCGCCGCCTCGGCATCAGCCGCAACACCCTGTA
CCGCAAGATCGGCCGCATCGGCTGA

Upstream 100 bases:

>100_bases
TTTGCGGCCTCGTTGCTGCGAAACGTGGCAAGTGCTAAGTTTTGTGACACCCGCCAAAAACAAAAAACGAGGCGGGGGAC
GAGAAGAAGGAGGAGGAGGG

Downstream 100 bases:

>100_bases
TCGGCGCCACCCCTTTCACTCCCCGGGATTTTTCCGCAGGCCGGCCCTTGGAGATGAAGTTCGCAGACCGGTATGAAGTG
TGCTTCATAGGTGCTGCTAC

Product: sigma-54 dependent transcriptional regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MKGLATAEDTHVLRVQEARRRFFDLGDDPDGDLPAEVLRSWQRCRDGGVSAQSTVAGDPAGRSRLAEVRERSEHLLTQAA
GIMEHVFEQIRASGSMVLLADVDGVILHSLGDPDFIARAQRVALQPGASWDEAARGTNAVGIALIEQRPAEVLGAEHFLE
RNGILTCSAAPVFKPCGMLAGVLDISGDYRSNQRHTMGLVRLAAQLLEKRLFEVDFARQVLIAVHARPECVGSLQEGLLA
VSADGCIVGANPAAREALGITDIGPGGLAFSSVFRVSLDVFFDRSRRDPASLQMLEARRGERIYTRLKSSLPPRTEPVGG
SAPARPAVTAKAETSEAVPRDGRVTLACLATGDSRLQLALDRAGKVIGKDIPLLIQGESGVGKELFARAFHFSGPRRDGP
FVALNCAAIPENLIESELFGYVGGAFTGARREGAVGKIQQAHGGTLFLDEIGDMPLGMQARLLRVLQERSVTPIGSVRQV
PVDISLVCATHRLLRESVQKGSFREDLYYRVNGLTVTLPPLRERGDIGRIVSNILAAEAGDGRQIRIGAEVMDFFERYPW
PGNVRQLQNVIRVAVALLDDDEDEIRPLHLPEELFGADTMTEGDRHRPDERPSSVVTPLGQPAAGIATGGRSLDEIELEA
IAVVMREVGGNVSAAARRLGISRNTLYRKIGRIG

Sequences:

>Translated_674_residues
MKGLATAEDTHVLRVQEARRRFFDLGDDPDGDLPAEVLRSWQRCRDGGVSAQSTVAGDPAGRSRLAEVRERSEHLLTQAA
GIMEHVFEQIRASGSMVLLADVDGVILHSLGDPDFIARAQRVALQPGASWDEAARGTNAVGIALIEQRPAEVLGAEHFLE
RNGILTCSAAPVFKPCGMLAGVLDISGDYRSNQRHTMGLVRLAAQLLEKRLFEVDFARQVLIAVHARPECVGSLQEGLLA
VSADGCIVGANPAAREALGITDIGPGGLAFSSVFRVSLDVFFDRSRRDPASLQMLEARRGERIYTRLKSSLPPRTEPVGG
SAPARPAVTAKAETSEAVPRDGRVTLACLATGDSRLQLALDRAGKVIGKDIPLLIQGESGVGKELFARAFHFSGPRRDGP
FVALNCAAIPENLIESELFGYVGGAFTGARREGAVGKIQQAHGGTLFLDEIGDMPLGMQARLLRVLQERSVTPIGSVRQV
PVDISLVCATHRLLRESVQKGSFREDLYYRVNGLTVTLPPLRERGDIGRIVSNILAAEAGDGRQIRIGAEVMDFFERYPW
PGNVRQLQNVIRVAVALLDDDEDEIRPLHLPEELFGADTMTEGDRHRPDERPSSVVTPLGQPAAGIATGGRSLDEIELEA
IAVVMREVGGNVSAAARRLGISRNTLYRKIGRIG
>Mature_674_residues
MKGLATAEDTHVLRVQEARRRFFDLGDDPDGDLPAEVLRSWQRCRDGGVSAQSTVAGDPAGRSRLAEVRERSEHLLTQAA
GIMEHVFEQIRASGSMVLLADVDGVILHSLGDPDFIARAQRVALQPGASWDEAARGTNAVGIALIEQRPAEVLGAEHFLE
RNGILTCSAAPVFKPCGMLAGVLDISGDYRSNQRHTMGLVRLAAQLLEKRLFEVDFARQVLIAVHARPECVGSLQEGLLA
VSADGCIVGANPAAREALGITDIGPGGLAFSSVFRVSLDVFFDRSRRDPASLQMLEARRGERIYTRLKSSLPPRTEPVGG
SAPARPAVTAKAETSEAVPRDGRVTLACLATGDSRLQLALDRAGKVIGKDIPLLIQGESGVGKELFARAFHFSGPRRDGP
FVALNCAAIPENLIESELFGYVGGAFTGARREGAVGKIQQAHGGTLFLDEIGDMPLGMQARLLRVLQERSVTPIGSVRQV
PVDISLVCATHRLLRESVQKGSFREDLYYRVNGLTVTLPPLRERGDIGRIVSNILAAEAGDGRQIRIGAEVMDFFERYPW
PGNVRQLQNVIRVAVALLDDDEDEIRPLHLPEELFGADTMTEGDRHRPDERPSSVVTPLGQPAAGIATGGRSLDEIELEA
IAVVMREVGGNVSAAARRLGISRNTLYRKIGRIG

Specific function: Required for sigma-54-dependent transcription of acoXABC [H]

COG id: COG3284

COG function: function code QK; Transcriptional activator of acetoin/glycerol metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=325, Percent_Identity=43.3846153846154, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1789233, Length=304, Percent_Identity=41.7763157894737, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1790437, Length=322, Percent_Identity=42.2360248447205, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788905, Length=318, Percent_Identity=39.937106918239, Blast_Score=215, Evalue=1e-56,
Organism=Escherichia coli, GI1788550, Length=324, Percent_Identity=39.5061728395062, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082117, Length=328, Percent_Identity=40.5487804878049, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786524, Length=314, Percent_Identity=40.4458598726115, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1787583, Length=330, Percent_Identity=36.6666666666667, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=38.3177570093458, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI87082152, Length=216, Percent_Identity=45.3703703703704, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87081858, Length=642, Percent_Identity=23.98753894081, Blast_Score=163, Evalue=4e-41,
Organism=Escherichia coli, GI87081872, Length=234, Percent_Identity=40.5982905982906, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1789828, Length=330, Percent_Identity=34.8484848484849, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 72729; Mature: 72729

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLATAEDTHVLRVQEARRRFFDLGDDPDGDLPAEVLRSWQRCRDGGVSAQSTVAGDPA
CCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GRSRLAEVRERSEHLLTQAAGIMEHVFEQIRASGSMVLLADVDGVILHSLGDPDFIARAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHH
RVALQPGASWDEAARGTNAVGIALIEQRPAEVLGAEHFLERNGILTCSAAPVFKPCGMLA
HHHCCCCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
GVLDISGDYRSNQRHTMGLVRLAAQLLEKRLFEVDFARQVLIAVHARPECVGSLQEGLLA
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCEEE
VSADGCIVGANPAAREALGITDIGPGGLAFSSVFRVSLDVFFDRSRRDPASLQMLEARRG
EECCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
ERIYTRLKSSLPPRTEPVGGSAPARPAVTAKAETSEAVPRDGRVTLACLATGDSRLQLAL
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCEEEHH
DRAGKVIGKDIPLLIQGESGVGKELFARAFHFSGPRRDGPFVALNCAAIPENLIESELFG
HHHCHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHHHH
YVGGAFTGARREGAVGKIQQAHGGTLFLDEIGDMPLGMQARLLRVLQERSVTPIGSVRQV
HHHHHHCCCCCCCCCCHHHHCCCCEEEEHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEC
PVDISLVCATHRLLRESVQKGSFREDLYYRVNGLTVTLPPLRERGDIGRIVSNILAAEAG
CCCHHHHHHHHHHHHHHHHCCCCHHCCEEEECCEEEECCCCCCCCCHHHHHHHHHHHCCC
DGRQIRIGAEVMDFFERYPWPGNVRQLQNVIRVAVALLDDDEDEIRPLHLPEELFGADTM
CCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHCCCCC
TEGDRHRPDERPSSVVTPLGQPAAGIATGGRSLDEIELEAIAVVMREVGGNVSAAARRLG
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHC
ISRNTLYRKIGRIG
CCHHHHHHHHCCCC
>Mature Secondary Structure
MKGLATAEDTHVLRVQEARRRFFDLGDDPDGDLPAEVLRSWQRCRDGGVSAQSTVAGDPA
CCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GRSRLAEVRERSEHLLTQAAGIMEHVFEQIRASGSMVLLADVDGVILHSLGDPDFIARAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHH
RVALQPGASWDEAARGTNAVGIALIEQRPAEVLGAEHFLERNGILTCSAAPVFKPCGMLA
HHHCCCCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
GVLDISGDYRSNQRHTMGLVRLAAQLLEKRLFEVDFARQVLIAVHARPECVGSLQEGLLA
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCEEE
VSADGCIVGANPAAREALGITDIGPGGLAFSSVFRVSLDVFFDRSRRDPASLQMLEARRG
EECCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
ERIYTRLKSSLPPRTEPVGGSAPARPAVTAKAETSEAVPRDGRVTLACLATGDSRLQLAL
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCEEEHH
DRAGKVIGKDIPLLIQGESGVGKELFARAFHFSGPRRDGPFVALNCAAIPENLIESELFG
HHHCHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHHHH
YVGGAFTGARREGAVGKIQQAHGGTLFLDEIGDMPLGMQARLLRVLQERSVTPIGSVRQV
HHHHHHCCCCCCCCCCHHHHCCCCEEEEHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEC
PVDISLVCATHRLLRESVQKGSFREDLYYRVNGLTVTLPPLRERGDIGRIVSNILAAEAG
CCCHHHHHHHHHHHHHHHHCCCCHHCCEEEECCEEEECCCCCCCCCHHHHHHHHHHHCCC
DGRQIRIGAEVMDFFERYPWPGNVRQLQNVIRVAVALLDDDEDEIRPLHLPEELFGADTM
CCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHCCCCC
TEGDRHRPDERPSSVVTPLGQPAAGIATGGRSLDEIELEAIAVVMREVGGNVSAAARRLG
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHC
ISRNTLYRKIGRIG
CCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1378052 [H]