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The map label for this gene is holC [H]

Identifier: 119899195

GI number: 119899195

Start: 3187931

End: 3188368

Strand: Direct

Name: holC [H]

Synonym: azo2905

Alternate gene names: 119899195

Gene position: 3187931-3188368 (Clockwise)

Preceding gene: 119899194

Following gene: 119899196

Centisome position: 72.85

GC content: 69.18

Gene sequence:

>438_bases
GTGACCAAGGTCCAGTTCTATCACAACGCCCCCGACCAGCTCGCGCTCGCCTGCGAGCTGGTCGCCAAGGCGCAGGCAGG
CGGACGCCAGGTCGCGGTTCGCGCTGCGGACCCGGCGATGGCGCGCAAGCTGGACCTGATGCTGTGGACGGTCGAACCGC
TCGCCTTCGTACCGCACGTGATGAACGGCGGCCCGCTCGCCGATGAAACCCCGGTGCAGATCGGCGCCCCTGGCAGCGAC
GCGCGCTGGCCGCATGCCGACATCCTGTTCAACCTTGCGGCCGACCTCGCACCCGGCTTCGAAGGTTTTCGCACCGTGGT
CGAGATCGTCGGCCGCAGCGAAGCAGAGAAAGCGCCCGCGCGTGCGCGCTGGACCCAATACAAGACGCGCGGCCTCCCGC
TCAAGGCCTTCGATGCGGAACGGCGGGTGGCGCTGTGA

Upstream 100 bases:

>100_bases
CCTGGGTGTCGGGCGACGCGAAGGGCGCCACCGGACGTCCGGTGCCCTTGCTGGCGGAGTTCCTCGTCGGCCGCGCCGCG
GCCAAGGCAGACTGACGGTC

Downstream 100 bases:

>100_bases
AGGACTGGTCTTCGATGCGGCGTGAAACCGAGGCCGAGCTGGAGCGCGCCGACGACCTGCTGGGCAAGGCCGACGCGCTG
CTGCGCCGCCACCGTGGGAC

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MTKVQFYHNAPDQLALACELVAKAQAGGRQVAVRAADPAMARKLDLMLWTVEPLAFVPHVMNGGPLADETPVQIGAPGSD
ARWPHADILFNLAADLAPGFEGFRTVVEIVGRSEAEKAPARARWTQYKTRGLPLKAFDAERRVAL

Sequences:

>Translated_145_residues
MTKVQFYHNAPDQLALACELVAKAQAGGRQVAVRAADPAMARKLDLMLWTVEPLAFVPHVMNGGPLADETPVQIGAPGSD
ARWPHADILFNLAADLAPGFEGFRTVVEIVGRSEAEKAPARARWTQYKTRGLPLKAFDAERRVAL
>Mature_144_residues
TKVQFYHNAPDQLALACELVAKAQAGGRQVAVRAADPAMARKLDLMLWTVEPLAFVPHVMNGGPLADETPVQIGAPGSDA
RWPHADILFNLAADLAPGFEGFRTVVEIVGRSEAEKAPARARWTQYKTRGLPLKAFDAERRVAL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 15758; Mature: 15627

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVQFYHNAPDQLALACELVAKAQAGGRQVAVRAADPAMARKLDLMLWTVEPLAFVPHV
CCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHEEEECCHHHHHHHH
MNGGPLADETPVQIGAPGSDARWPHADILFNLAADLAPGFEGFRTVVEIVGRSEAEKAPA
CCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
RARWTQYKTRGLPLKAFDAERRVAL
HHHHHHHHCCCCCEEECCCCCCCCC
>Mature Secondary Structure 
TKVQFYHNAPDQLALACELVAKAQAGGRQVAVRAADPAMARKLDLMLWTVEPLAFVPHV
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHEEEECCHHHHHHHH
MNGGPLADETPVQIGAPGSDARWPHADILFNLAADLAPGFEGFRTVVEIVGRSEAEKAPA
CCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
RARWTQYKTRGLPLKAFDAERRVAL
HHHHHHHHCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9864319; 10984043 [H]