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The map label for this gene is pepA

Identifier: 119899194

GI number: 119899194

Start: 3186423

End: 3187925

Strand: Direct

Name: pepA

Synonym: azo2904

Alternate gene names: 119899194

Gene position: 3186423-3187925 (Clockwise)

Preceding gene: 119899191

Following gene: 119899195

Centisome position: 72.82

GC content: 68.53

Gene sequence:

>1503_bases
GTGGAATTTACCATAAAGACCGCCACCCCGGAGAAGGTCCGGACCGGCGTTCTGGTCGTCGGTCTCTTTGCCGACGGCAT
CCTGCCCCCCGCCGCGCACGCGGTCGACAAGGCCTCCAAGGGCAAGCTCGCGCAGCTCGTGAAGCGCGGCGATCTCGACG
AGAAAGCCGGCGCCGCCGTGATGCTGCACGACCTAGCCGGCATTGCCGCGGAGCGCGTGCTGGTGGTCAGCCTGGGTAAA
TCCGCCGAGTTCTCCGACAAGGCCTATCGCGACGCGCTCAACAGCGTTGCCAAAGCGCTCGCGAGCGGCGTCGCCAAGGT
CGCCGCCGTCGCGATTGCGGACGCCGAGCTGGACGGCCGCACGCTCGCCTGGCGCCTGCAGCAGGCCACGCGCCAGATCG
CCGACGGCGCCTACCGCTTCGACGCGCCCAAGGCCGGCGCGAAGGACGCGAAGAAGGAACGCGGCGCACGCAAGATCACG
CTGCTGATCGGTGACAAGGTCAGCGACGAGCTGGAAGCGGCGGTGCGGCGCGGCCAGGCCGTCGCCGAAGGGATGGCGCT
CGCCAAGGATCTCGGCAACCTGCCCGGCAACGTGTGCACGCCCGCCTACCTCGCCGATACCGCGGAAGCGCTCGGCAAGC
AGTTCAAGTTCGACGTCGAGGTGCTCGAACGCGCCGACATGGAAAAGCTCGGCATGGGCTCGCTGCTGTCGGTGGCCAAG
GGCTCGCACATCCCGCCCAAGTTCATCGTCATGCACTACAAGGGCGGCAAGTCCAAGGCCAAGCCGGTGGTGCTGGTCGG
CAAGGGCATCACCTTCGACACCGGCGGCATCTCGCTGAAGCCCGGCGCCGAAATGGACGAGATGAAGTACGACATGTGCG
GCGCCGCCAGCGTGCTCGGCACCTTCAAGGCAATTGCGCGCATGGCGCTGCCGCTCAATGTCGTCGGCATCGTCCCGGCG
ACCGAGAACATGCCGGGCGGCAACGCCACGCGGCCGGGCGACGTGGTCACCTCGATGTCCGGCCAGACCATCGAGATCCT
CAACACCGACGCCGAGGGCCGCCTGATCCTGTGCGACGCGCTCACCTACGCCGAGCGCTTCAAGCCCGCGTGCGTGATCG
ACATCGCCACCCTCACCGGGGCCTGCGTGGTTGCGCTGGGCAAGATTCCCAGCGGCCTGCTCGCCAACGACGACGACCTC
GCCGCCGAGCTGCTCAAGCGCGGCACCGAATCCGGCGACCGCGCCTGGCAGCTGCCGCTGTGGGACGAGTACCAGGATCT
GCTGAAGAGCAATTTCGCCGACATGGCCAACATCGGCGGCCGCTATGGCGGCACCATCACCGCGGCGTGCTTCCTGGCGC
GCTTCACCAAGGCCTACAAGTGGGCCCACCTCGACATCGCCGGCACCGCCTGGGTGTCGGGCGACGCGAAGGGCGCCACC
GGACGTCCGGTGCCCTTGCTGGCGGAGTTCCTCGTCGGCCGCGCCGCGGCCAAGGCAGACTGA

Upstream 100 bases:

>100_bases
TGGCCCGGCCGCTGCCGGGGGCGTTTTTGACGGCGTTGACGGCTACGGTCCATAATCGGCCAAAAGCCCAAAACACCCGT
CTTTCCCCAGGAGCAAGCCC

Downstream 100 bases:

>100_bases
CGGTCGTGACCAAGGTCCAGTTCTATCACAACGCCCCCGACCAGCTCGCGCTCGCCTGCGAGCTGGTCGCCAAGGCGCAG
GCAGGCGGACGCCAGGTCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MEFTIKTATPEKVRTGVLVVGLFADGILPPAAHAVDKASKGKLAQLVKRGDLDEKAGAAVMLHDLAGIAAERVLVVSLGK
SAEFSDKAYRDALNSVAKALASGVAKVAAVAIADAELDGRTLAWRLQQATRQIADGAYRFDAPKAGAKDAKKERGARKIT
LLIGDKVSDELEAAVRRGQAVAEGMALAKDLGNLPGNVCTPAYLADTAEALGKQFKFDVEVLERADMEKLGMGSLLSVAK
GSHIPPKFIVMHYKGGKSKAKPVVLVGKGITFDTGGISLKPGAEMDEMKYDMCGAASVLGTFKAIARMALPLNVVGIVPA
TENMPGGNATRPGDVVTSMSGQTIEILNTDAEGRLILCDALTYAERFKPACVIDIATLTGACVVALGKIPSGLLANDDDL
AAELLKRGTESGDRAWQLPLWDEYQDLLKSNFADMANIGGRYGGTITAACFLARFTKAYKWAHLDIAGTAWVSGDAKGAT
GRPVPLLAEFLVGRAAAKAD

Sequences:

>Translated_500_residues
MEFTIKTATPEKVRTGVLVVGLFADGILPPAAHAVDKASKGKLAQLVKRGDLDEKAGAAVMLHDLAGIAAERVLVVSLGK
SAEFSDKAYRDALNSVAKALASGVAKVAAVAIADAELDGRTLAWRLQQATRQIADGAYRFDAPKAGAKDAKKERGARKIT
LLIGDKVSDELEAAVRRGQAVAEGMALAKDLGNLPGNVCTPAYLADTAEALGKQFKFDVEVLERADMEKLGMGSLLSVAK
GSHIPPKFIVMHYKGGKSKAKPVVLVGKGITFDTGGISLKPGAEMDEMKYDMCGAASVLGTFKAIARMALPLNVVGIVPA
TENMPGGNATRPGDVVTSMSGQTIEILNTDAEGRLILCDALTYAERFKPACVIDIATLTGACVVALGKIPSGLLANDDDL
AAELLKRGTESGDRAWQLPLWDEYQDLLKSNFADMANIGGRYGGTITAACFLARFTKAYKWAHLDIAGTAWVSGDAKGAT
GRPVPLLAEFLVGRAAAKAD
>Mature_500_residues
MEFTIKTATPEKVRTGVLVVGLFADGILPPAAHAVDKASKGKLAQLVKRGDLDEKAGAAVMLHDLAGIAAERVLVVSLGK
SAEFSDKAYRDALNSVAKALASGVAKVAAVAIADAELDGRTLAWRLQQATRQIADGAYRFDAPKAGAKDAKKERGARKIT
LLIGDKVSDELEAAVRRGQAVAEGMALAKDLGNLPGNVCTPAYLADTAEALGKQFKFDVEVLERADMEKLGMGSLLSVAK
GSHIPPKFIVMHYKGGKSKAKPVVLVGKGITFDTGGISLKPGAEMDEMKYDMCGAASVLGTFKAIARMALPLNVVGIVPA
TENMPGGNATRPGDVVTSMSGQTIEILNTDAEGRLILCDALTYAERFKPACVIDIATLTGACVVALGKIPSGLLANDDDL
AAELLKRGTESGDRAWQLPLWDEYQDLLKSNFADMANIGGRYGGTITAACFLARFTKAYKWAHLDIAGTAWVSGDAKGAT
GRPVPLLAEFLVGRAAAKAD

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=473, Percent_Identity=38.2663847780127, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI47155554, Length=322, Percent_Identity=34.472049689441, Blast_Score=139, Evalue=8e-33,
Organism=Escherichia coli, GI1790710, Length=501, Percent_Identity=50.0998003992016, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=37.9746835443038, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=357, Percent_Identity=34.733893557423, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=271, Percent_Identity=33.210332103321, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24661038, Length=497, Percent_Identity=32.9979879275654, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21355725, Length=497, Percent_Identity=33.6016096579477, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129969, Length=496, Percent_Identity=30.8467741935484, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21355645, Length=475, Percent_Identity=30.1052631578947, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24662223, Length=475, Percent_Identity=30.1052631578947, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI161077148, Length=508, Percent_Identity=31.1023622047244, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20130057, Length=508, Percent_Identity=31.1023622047244, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24662227, Length=496, Percent_Identity=29.6370967741936, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19922386, Length=496, Percent_Identity=31.25, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI20129963, Length=332, Percent_Identity=32.8313253012048, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI221379063, Length=313, Percent_Identity=34.5047923322684, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI221379062, Length=313, Percent_Identity=34.5047923322684, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI21357381, Length=313, Percent_Identity=34.5047923322684, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24646701, Length=257, Percent_Identity=29.1828793774319, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=257, Percent_Identity=29.1828793774319, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=257, Percent_Identity=29.1828793774319, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_AZOSB (A1K9L5)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934407.1
- ProteinModelPortal:   A1K9L5
- SMR:   A1K9L5
- STRING:   A1K9L5
- MEROPS:   M17.003
- GeneID:   4607676
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2904
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- PhylomeDB:   A1K9L5
- ProtClustDB:   PRK00913
- BioCyc:   ASP62928:AZO2904-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52409; Mature: 52409

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 280-280 ACT_SITE 354-354

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTIKTATPEKVRTGVLVVGLFADGILPPAAHAVDKASKGKLAQLVKRGDLDEKAGAAV
CCEEEECCCHHHHHCCEEEEEEHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCEE
MLHDLAGIAAERVLVVSLGKSAEFSDKAYRDALNSVAKALASGVAKVAAVAIADAELDGR
EHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TLAWRLQQATRQIADGAYRFDAPKAGAKDAKKERGARKITLLIGDKVSDELEAAVRRGQA
HHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
VAEGMALAKDLGNLPGNVCTPAYLADTAEALGKQFKFDVEVLERADMEKLGMGSLLSVAK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCHHHCCCHHHHHHHC
GSHIPPKFIVMHYKGGKSKAKPVVLVGKGITFDTGGISLKPGAEMDEMKYDMCGAASVLG
CCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHH
TFKAIARMALPLNVVGIVPATENMPGGNATRPGDVVTSMSGQTIEILNTDAEGRLILCDA
HHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHH
LTYAERFKPACVIDIATLTGACVVALGKIPSGLLANDDDLAAELLKRGTESGDRAWQLPL
HHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCC
WDEYQDLLKSNFADMANIGGRYGGTITAACFLARFTKAYKWAHLDIAGTAWVSGDAKGAT
HHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCCCC
GRPVPLLAEFLVGRAAAKAD
CCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEFTIKTATPEKVRTGVLVVGLFADGILPPAAHAVDKASKGKLAQLVKRGDLDEKAGAAV
CCEEEECCCHHHHHCCEEEEEEHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCEE
MLHDLAGIAAERVLVVSLGKSAEFSDKAYRDALNSVAKALASGVAKVAAVAIADAELDGR
EHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TLAWRLQQATRQIADGAYRFDAPKAGAKDAKKERGARKITLLIGDKVSDELEAAVRRGQA
HHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
VAEGMALAKDLGNLPGNVCTPAYLADTAEALGKQFKFDVEVLERADMEKLGMGSLLSVAK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCHHHCCCHHHHHHHC
GSHIPPKFIVMHYKGGKSKAKPVVLVGKGITFDTGGISLKPGAEMDEMKYDMCGAASVLG
CCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHH
TFKAIARMALPLNVVGIVPATENMPGGNATRPGDVVTSMSGQTIEILNTDAEGRLILCDA
HHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHH
LTYAERFKPACVIDIATLTGACVVALGKIPSGLLANDDDLAAELLKRGTESGDRAWQLPL
HHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCC
WDEYQDLLKSNFADMANIGGRYGGTITAACFLARFTKAYKWAHLDIAGTAWVSGDAKGAT
HHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCCCC
GRPVPLLAEFLVGRAAAKAD
CCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA