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The map label for this gene is ksgA [H]

Identifier: 119899174

GI number: 119899174

Start: 3164700

End: 3165497

Strand: Reverse

Name: ksgA [H]

Synonym: azo2884

Alternate gene names: 119899174

Gene position: 3165497-3164700 (Counterclockwise)

Preceding gene: 119899175

Following gene: 119899169

Centisome position: 72.34

GC content: 67.67

Gene sequence:

>798_bases
ATGCAAGACCGCGAAACCGACGGCCACCGCGCCAGAAAGCGCTTCGGCCAGAACTTCCTGTCCGACCCCAACATCATCCG
CCGCATCATCGACGCGATCCGCCCAAAGGAGGGCGACATCATGGTCGAGATCGGCCCGGGTCTCGGCGCGATGACCACGC
CGCTGATCGAGCGCCTCGGGCATCTCAACGTGGTCGAGATCGACCGCGACCTGATCGCCCGCCTGCGCGAAACCTGGACG
CCGGAGCAGCTCACGATCCACGAGGGCGACGCGCTGAAGTTTGATTTCGGCAGCCTCGGCAGCCCGCTGCGCGTGGTCGG
CAACCTGCCCTACAACATCTCCACGCCCATCCTGTTCCACCTGTCCACGTTCGCCGACCGGGTGAAGGACATGACCTTCA
TGCTGCAGAAGGAGGTGGTGATGCGCATGGTGGCGGAGCCCGGCACCGAGGAATACGGCCGCCTGTCGGTGATGCTGCAA
TACCGCTTCCGGATGGCGCGGGTGTTCGACGTGCCGCCCGGTGCGTTCCGGCCGGCGCCCAAGGTGATGTCGAGTATCGT
GCGGATGGCGCCCTTGCCGCCCGAAGAGCTGGGCGCGCGCGACGAGGCGCTGCTGGGTCAGATCGTCACCGCCGCGTTCG
GCCAGCGCCGCAAGACGCTGCGCAATACGCTGAAGGATTTCCTCGGCGAAGCCGACTTTGCCGCGCTCGGGCTGGACCCC
GGTCTGCGCGGCGAGCGGCTGTCGGTGGCGGAGTTTGTCGCCATCGCCAACCACGTCGCCGCCGCGCGCGCCGGCTGA

Upstream 100 bases:

>100_bases
CGCGCCGACCCCGGCAGCCTGTACGCCGCGGTCGAGCTGGCCGTGTCGATGGCCGAGGCCCGTGCCCGCCAGCCGCGCTG
AGCGGCGTTCGAGGAATTTC

Downstream 100 bases:

>100_bases
TGAACGCGCGGCCGGCAGCCGCTTGCGCGGGTGCCGGCCGTGTTGCTGCGGGTAAGGCTCAGGACTTCTTCAGCGGGCAG
GTGCTGATGCCCAGCAGCGG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MQDRETDGHRARKRFGQNFLSDPNIIRRIIDAIRPKEGDIMVEIGPGLGAMTTPLIERLGHLNVVEIDRDLIARLRETWT
PEQLTIHEGDALKFDFGSLGSPLRVVGNLPYNISTPILFHLSTFADRVKDMTFMLQKEVVMRMVAEPGTEEYGRLSVMLQ
YRFRMARVFDVPPGAFRPAPKVMSSIVRMAPLPPEELGARDEALLGQIVTAAFGQRRKTLRNTLKDFLGEADFAALGLDP
GLRGERLSVAEFVAIANHVAAARAG

Sequences:

>Translated_265_residues
MQDRETDGHRARKRFGQNFLSDPNIIRRIIDAIRPKEGDIMVEIGPGLGAMTTPLIERLGHLNVVEIDRDLIARLRETWT
PEQLTIHEGDALKFDFGSLGSPLRVVGNLPYNISTPILFHLSTFADRVKDMTFMLQKEVVMRMVAEPGTEEYGRLSVMLQ
YRFRMARVFDVPPGAFRPAPKVMSSIVRMAPLPPEELGARDEALLGQIVTAAFGQRRKTLRNTLKDFLGEADFAALGLDP
GLRGERLSVAEFVAIANHVAAARAG
>Mature_265_residues
MQDRETDGHRARKRFGQNFLSDPNIIRRIIDAIRPKEGDIMVEIGPGLGAMTTPLIERLGHLNVVEIDRDLIARLRETWT
PEQLTIHEGDALKFDFGSLGSPLRVVGNLPYNISTPILFHLSTFADRVKDMTFMLQKEVVMRMVAEPGTEEYGRLSVMLQ
YRFRMARVFDVPPGAFRPAPKVMSSIVRMAPLPPEELGARDEALLGQIVTAAFGQRRKTLRNTLKDFLGEADFAALGLDP
GLRGERLSVAEFVAIANHVAAARAG

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=216, Percent_Identity=34.7222222222222, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI156415992, Length=283, Percent_Identity=30.3886925795053, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786236, Length=265, Percent_Identity=50.9433962264151, Blast_Score=271, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI25146882, Length=183, Percent_Identity=34.4262295081967, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25141369, Length=283, Percent_Identity=27.9151943462898, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324989, Length=179, Percent_Identity=31.2849162011173, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358017, Length=229, Percent_Identity=34.9344978165939, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21357273, Length=246, Percent_Identity=31.7073170731707, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 29532; Mature: 29532

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDRETDGHRARKRFGQNFLSDPNIIRRIIDAIRPKEGDIMVEIGPGLGAMTTPLIERLG
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
HLNVVEIDRDLIARLRETWTPEQLTIHEGDALKFDFGSLGSPLRVVGNLPYNISTPILFH
CCCEEEECHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCHHHHCCCCCCCCCHHHHH
LSTFADRVKDMTFMLQKEVVMRMVAEPGTEEYGRLSVMLQYRFRMARVFDVPPGAFRPAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
KVMSSIVRMAPLPPEELGARDEALLGQIVTAAFGQRRKTLRNTLKDFLGEADFAALGLDP
HHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
GLRGERLSVAEFVAIANHVAAARAG
CCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQDRETDGHRARKRFGQNFLSDPNIIRRIIDAIRPKEGDIMVEIGPGLGAMTTPLIERLG
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
HLNVVEIDRDLIARLRETWTPEQLTIHEGDALKFDFGSLGSPLRVVGNLPYNISTPILFH
CCCEEEECHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCHHHHCCCCCCCCCHHHHH
LSTFADRVKDMTFMLQKEVVMRMVAEPGTEEYGRLSVMLQYRFRMARVFDVPPGAFRPAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
KVMSSIVRMAPLPPEELGARDEALLGQIVTAAFGQRRKTLRNTLKDFLGEADFAALGLDP
HHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
GLRGERLSVAEFVAIANHVAAARAG
CCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA