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The map label for this gene is hemH

Identifier: 119898873

GI number: 119898873

Start: 2862075

End: 2863166

Strand: Direct

Name: hemH

Synonym: azo2582

Alternate gene names: 119898873

Gene position: 2862075-2863166 (Clockwise)

Preceding gene: 119898872

Following gene: 119898874

Centisome position: 65.4

GC content: 69.96

Gene sequence:

>1092_bases
ATGGCCCGATTCTGGACCGAAGCCCCGCATCGCCACGGCAGCACCGCGCGCACCGGCATCCTGCTGGTCAACCTCGGCAC
CCCGGTTGCGCCAACGGCGGCTGCGCTGCGCCCCTACCTGCAGCAGTTCCTGTCCGACCCGCGGGTGGTGGAAATCCCAC
GCGCGGTGTGGCTGCCGCTTTTGAATGGGGTGATTCTCAACACCCGCCCGAGAAAATCCGCCGCCAAGTACGCCAGCATC
TGGACCGACGAAGGGTCGCCGCTGGCGGTTCATACCCGCCGCCAGGCCGAACTGATCGCGGCGCGCTTCGCCAGCCGCGA
CGATGTACGGGTGGACTGGGCGATGCGCTACGGCGCGCCTGCGGTGGCCGACAAGCTGGGCGCGCTGCGGGCGGCGGGCT
GCACCCGGATCCTCGTCGTTCCGATGTATCCCCAATACGCCGCGAGCACCACCGCCAGCGTCATGGATGAAGTGGCGCGC
TGCCTGCAGCACTGGCGCAACCTGCCCGAGTTGCGCTTCGTGCGCAGCTTTCATGACGACCCCGGCTACATCGGCGCGCT
CGCGGCCAGCGTCCGCGAGCACTGGACGCGGCACGGCCAGCCCGACCGTCTGTTGATGAGCTTTCACGGGCTGCCGCGCT
ATACCCTGGAACGGGGTGATCCCTACCACTGCGAGTGCCACCGCACCGCCCGCCTGCTGGCCGAGTCCCTTGGGCTGGCG
CCGGAACGCGTCATCGTGAGCTTCCAGTCCCGCTTCGGCCGCACCCGCTGGCTGGAACCCTACACCCAGCCCACGCTCGA
AGCCCTCGCGCGCGACGGCGTCGGCCGCGTCGATGTGATGTGCCCGGGTTTCGTCGCAGACTGCCTGGAAACCCTGGAGG
AGATCGCCATGGAATGCCGCGCCGCATTTCTCGGTGCCGGAGGGCGCGAGTTCCACTACATCCCGTGCCTGAATGAACGG
CCGGACTGGATCGACGCGCTGGAACGGCGCGTGCGGAGCGAGGCCGGCAACTGGCTGACCGCCACGCCGCCCACCGACGC
CGAGCGCGAAGCCGCGCGCGGCCGCGCGTTGGCCCTGGGAGCGGCCGAGTGA

Upstream 100 bases:

>100_bases
ATCGTCGACATCACCGCGCGCCTGCTGTCGAACGCGCTGTCGTCCAATCACTGAATCGCTGCCCGCGCCGCGGGCCGACA
ACCCAATCCCGGAAGATCCC

Downstream 100 bases:

>100_bases
TGCGGCTGATCCTGCGCTGGATACTCAACGCCGTCGCCCTGCTGCTGTTGCCGGAGCTGATCTCCGGCCTGCGGGTGGAT
AGCTATGCGGCCGCGCTCGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MARFWTEAPHRHGSTARTGILLVNLGTPVAPTAAALRPYLQQFLSDPRVVEIPRAVWLPLLNGVILNTRPRKSAAKYASI
WTDEGSPLAVHTRRQAELIAARFASRDDVRVDWAMRYGAPAVADKLGALRAAGCTRILVVPMYPQYAASTTASVMDEVAR
CLQHWRNLPELRFVRSFHDDPGYIGALAASVREHWTRHGQPDRLLMSFHGLPRYTLERGDPYHCECHRTARLLAESLGLA
PERVIVSFQSRFGRTRWLEPYTQPTLEALARDGVGRVDVMCPGFVADCLETLEEIAMECRAAFLGAGGREFHYIPCLNER
PDWIDALERRVRSEAGNWLTATPPTDAEREAARGRALALGAAE

Sequences:

>Translated_363_residues
MARFWTEAPHRHGSTARTGILLVNLGTPVAPTAAALRPYLQQFLSDPRVVEIPRAVWLPLLNGVILNTRPRKSAAKYASI
WTDEGSPLAVHTRRQAELIAARFASRDDVRVDWAMRYGAPAVADKLGALRAAGCTRILVVPMYPQYAASTTASVMDEVAR
CLQHWRNLPELRFVRSFHDDPGYIGALAASVREHWTRHGQPDRLLMSFHGLPRYTLERGDPYHCECHRTARLLAESLGLA
PERVIVSFQSRFGRTRWLEPYTQPTLEALARDGVGRVDVMCPGFVADCLETLEEIAMECRAAFLGAGGREFHYIPCLNER
PDWIDALERRVRSEAGNWLTATPPTDAEREAARGRALALGAAE
>Mature_362_residues
ARFWTEAPHRHGSTARTGILLVNLGTPVAPTAAALRPYLQQFLSDPRVVEIPRAVWLPLLNGVILNTRPRKSAAKYASIW
TDEGSPLAVHTRRQAELIAARFASRDDVRVDWAMRYGAPAVADKLGALRAAGCTRILVVPMYPQYAASTTASVMDEVARC
LQHWRNLPELRFVRSFHDDPGYIGALAASVREHWTRHGQPDRLLMSFHGLPRYTLERGDPYHCECHRTARLLAESLGLAP
ERVIVSFQSRFGRTRWLEPYTQPTLEALARDGVGRVDVMCPGFVADCLETLEEIAMECRAAFLGAGGREFHYIPCLNERP
DWIDALERRVRSEAGNWLTATPPTDAEREAARGRALALGAAE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=340, Percent_Identity=25, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI60499021, Length=340, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=49.2063492063492, Blast_Score=304, Evalue=5e-84,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=24.4047619047619, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651774, Length=272, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_AZOSB (A1K8P4)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934086.1
- ProteinModelPortal:   A1K8P4
- SMR:   A1K8P4
- STRING:   A1K8P4
- GeneID:   4609028
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2582
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   IRPAKSA
- PhylomeDB:   A1K8P4
- ProtClustDB:   PRK00035
- BioCyc:   ASP62928:AZO2582-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 40512; Mature: 40381

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFWTEAPHRHGSTARTGILLVNLGTPVAPTAAALRPYLQQFLSDPRVVEIPRAVWLPL
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHH
LNGVILNTRPRKSAAKYASIWTDEGSPLAVHTRRQAELIAARFASRDDVRVDWAMRYGAP
HCCEEECCCCCHHHHHHHHEECCCCCEEEEECHHHHHHHHHHHCCCCCCEEEEHHHCCCH
AVADKLGALRAAGCTRILVVPMYPQYAASTTASVMDEVARCLQHWRNLPELRFVRSFHDD
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
PGYIGALAASVREHWTRHGQPDRLLMSFHGLPRYTLERGDPYHCECHRTARLLAESLGLA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
PERVIVSFQSRFGRTRWLEPYTQPTLEALARDGVGRVDVMCPGFVADCLETLEEIAMECR
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHH
AAFLGAGGREFHYIPCLNERPDWIDALERRVRSEAGNWLTATPPTDAEREAARGRALALG
HHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCEEEEC
AAE
CCC
>Mature Secondary Structure 
ARFWTEAPHRHGSTARTGILLVNLGTPVAPTAAALRPYLQQFLSDPRVVEIPRAVWLPL
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHH
LNGVILNTRPRKSAAKYASIWTDEGSPLAVHTRRQAELIAARFASRDDVRVDWAMRYGAP
HCCEEECCCCCHHHHHHHHEECCCCCEEEEECHHHHHHHHHHHCCCCCCEEEEHHHCCCH
AVADKLGALRAAGCTRILVVPMYPQYAASTTASVMDEVARCLQHWRNLPELRFVRSFHDD
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
PGYIGALAASVREHWTRHGQPDRLLMSFHGLPRYTLERGDPYHCECHRTARLLAESLGLA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
PERVIVSFQSRFGRTRWLEPYTQPTLEALARDGVGRVDVMCPGFVADCLETLEEIAMECR
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHH
AAFLGAGGREFHYIPCLNERPDWIDALERRVRSEAGNWLTATPPTDAEREAARGRALALG
HHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCEEEEC
AAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA