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The map label for this gene is fsr [H]

Identifier: 119898864

GI number: 119898864

Start: 2851794

End: 2853032

Strand: Reverse

Name: fsr [H]

Synonym: azo2573

Alternate gene names: 119898864

Gene position: 2853032-2851794 (Counterclockwise)

Preceding gene: 119898866

Following gene: 119898863

Centisome position: 65.2

GC content: 72.64

Gene sequence:

>1239_bases
ATGACCCACGTTCGAACCCCGGTCCGCCACGATGCCGGCGTGATTGCCGTAGTGGCCTTCGCCCACGGCACCTCGCACTT
CTTCCAGCTCGTGCTGCCGTCCTTGTTCCCGTGGCTGATGCGCGACTTCGGGCTCGACTTCACCGGCGTCGGCCTCGCGA
TGACCGCTTTCTTCGTCGTTTCCGGCCTCGGCCAGGCGGCCGCCGGATTCGCGGTGGACCGCTTCGGCGCCTTCCGCGTG
CTGTGCGCCGGGCTTGCCTGCCTGGGCGTGGCGGCGCTGCTGGTGGCGGTGGCACAGGGGCTGGCGGGTCTGGTGCTGGC
GGCGCTGGTAGCCGGTGCCGGCAACGCGGTGTTCCATCCGGCGGATTTCAGCCTGCTCAACCGCAAGGTGTCCGAAGGCC
GGCTCGGCCACGCGTTCTCCGCGCATGGTTTGTCCGGCAGCCTGGGGTGGGCGCTGGCGCCGGTGTTCGTCGTCGGTCTC
GCCACGGCGTTCGGCTGGCGGTGGGCCGCGGTGGGCGCGGCGGTTGTCGCGCTGCTCGCCATTGTCGGGCTGGTGGCGGC
GCGTGGCTGGCTTGCCGACGGCGCCGAGCGCGCGGCCACGCGCCGCGGCGGGGGCGCCCAGGCCTCGTCGTTCGACTTTC
TCGGCGTGCCAGCGGTATGGCTGTGCTTCCTGTTCTTCTTTTTCACCACGATGGCCTTCGGCGCCTTCCAGAACTACGGC
ACGCCGCTGCTGCAGGCGCTGTTCGACCTGACCCTGGCCGCAGCCGCGAGCGGCATCACTGCCTTCCTGCTCGCGGCGGC
CGGGGGCATGTTCCTGGGCGGTTTCATTGCCGCCCGCTACGCGGCGCACGACCGCCTGGTCGCGGTGTTCCTCGGCGGTG
CCGCGCTGATCGCGGTCATCCTCGCCGCAGGCGTGCTCCCCACCGCGGCAGCGCTGCCGGCGCTCGCCGGCATCGGCTTC
TGCACCGGGGTCGCCGGCCCCTCGCGTGACATCCTGGTGCGCCGCGCAGCGGTGGCGCGCTTCGGTGCCGGGGCCTATGG
CCGCATCTACGGACTGGTCTATTCCGGCATCGACGCCGGCATGGCGCTGGCCCCGCTTGCCTTCGGGCCTTTGATGGACA
GCCGCCGCTTCTGGATGGTGATGGCCGGGGTGGCGGTGCTGCAGATCGGCGCCGTGGTGGTGGCGCTGGCGGCGGCGCGG
CGCGCAGGCGGTGCCGCCCCCGCAGCCGCAGCGGCCTGA

Upstream 100 bases:

>100_bases
CGTGGCATGTTCTCGATAGTAGTTGTCCGGCTCGCGCATATTTGCCAAACGATCGCCGGATTATCATCGGTTTGCCTTCT
TTTGTCGCAAGGAGCCGCTG

Downstream 100 bases:

>100_bases
GCGCGGCGGCGATTGCCGCGCGCGCCTCGGCTCCGTATGCTCGTGGCCTACCGTCCGCAGCCGCGCCGCGCGCAGGAGCC
GCCATGCTGGAAATGCTCGA

Product: putative fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTHVRTPVRHDAGVIAVVAFAHGTSHFFQLVLPSLFPWLMRDFGLDFTGVGLAMTAFFVVSGLGQAAAGFAVDRFGAFRV
LCAGLACLGVAALLVAVAQGLAGLVLAALVAGAGNAVFHPADFSLLNRKVSEGRLGHAFSAHGLSGSLGWALAPVFVVGL
ATAFGWRWAAVGAAVVALLAIVGLVAARGWLADGAERAATRRGGGAQASSFDFLGVPAVWLCFLFFFFTTMAFGAFQNYG
TPLLQALFDLTLAAAASGITAFLLAAAGGMFLGGFIAARYAAHDRLVAVFLGGAALIAVILAAGVLPTAAALPALAGIGF
CTGVAGPSRDILVRRAAVARFGAGAYGRIYGLVYSGIDAGMALAPLAFGPLMDSRRFWMVMAGVAVLQIGAVVVALAAAR
RAGGAAPAAAAA

Sequences:

>Translated_412_residues
MTHVRTPVRHDAGVIAVVAFAHGTSHFFQLVLPSLFPWLMRDFGLDFTGVGLAMTAFFVVSGLGQAAAGFAVDRFGAFRV
LCAGLACLGVAALLVAVAQGLAGLVLAALVAGAGNAVFHPADFSLLNRKVSEGRLGHAFSAHGLSGSLGWALAPVFVVGL
ATAFGWRWAAVGAAVVALLAIVGLVAARGWLADGAERAATRRGGGAQASSFDFLGVPAVWLCFLFFFFTTMAFGAFQNYG
TPLLQALFDLTLAAAASGITAFLLAAAGGMFLGGFIAARYAAHDRLVAVFLGGAALIAVILAAGVLPTAAALPALAGIGF
CTGVAGPSRDILVRRAAVARFGAGAYGRIYGLVYSGIDAGMALAPLAFGPLMDSRRFWMVMAGVAVLQIGAVVVALAAAR
RAGGAAPAAAAA
>Mature_411_residues
THVRTPVRHDAGVIAVVAFAHGTSHFFQLVLPSLFPWLMRDFGLDFTGVGLAMTAFFVVSGLGQAAAGFAVDRFGAFRVL
CAGLACLGVAALLVAVAQGLAGLVLAALVAGAGNAVFHPADFSLLNRKVSEGRLGHAFSAHGLSGSLGWALAPVFVVGLA
TAFGWRWAAVGAAVVALLAIVGLVAARGWLADGAERAATRRGGGAQASSFDFLGVPAVWLCFLFFFFTTMAFGAFQNYGT
PLLQALFDLTLAAAASGITAFLLAAAGGMFLGGFIAARYAAHDRLVAVFLGGAALIAVILAAGVLPTAAALPALAGIGFC
TGVAGPSRDILVRRAAVARFGAGAYGRIYGLVYSGIDAGMALAPLAFGPLMDSRRFWMVMAGVAVLQIGAVVVALAAARR
AGGAAPAAAAA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=274, Percent_Identity=27.7372262773723, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41582; Mature: 41451

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
THVRTPVRHDAGVIAVVAFAHGTSHFFQLVLPSLFPWLMRDFGLDFTGVGLAMTAFFVV
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH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HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]