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The map label for this gene is mdtE [H]

Identifier: 119898859

GI number: 119898859

Start: 2844563

End: 2845765

Strand: Direct

Name: mdtE [H]

Synonym: azo2568

Alternate gene names: 119898859

Gene position: 2844563-2845765 (Clockwise)

Preceding gene: 119898856

Following gene: 119898860

Centisome position: 65.0

GC content: 72.9

Gene sequence:

>1203_bases
ATGCCCCGCCTGCGCAAGCCCTACGCCCTTGCCACCACCCTCGCGATCGCGCTCGCCCTTGGCGGCGGTGCGGTGGCGCT
CAGCGTGCAGTCCGACGCCCGCGCCAACACCGCCGCCAGCGCCGCGATGCCGCCCAGCCCGGTGGACGTCGCCACCGTTG
CAGCCCAGCAGATCACCGACTGGCGCAGCTATTCCGGCCGGCTGGAAGCGGTGGACCGCGTCGAGATCCGCCCGCTGGTC
TCCGGCACCGTCACCGAGGTGCACTTCCAGGACGGCGCGCTGGTGAAGAAGGGCGACCCGCTGTTCACCATAGACCCCCG
CCCCTACGCTGCCGCGCTGGAACACGCCCGCGCCCAGCTTGCCGCGGCCGAGGCGCGCGCCGCCTACACCGCCAACGACC
TCGCCCGCGGCGAGCGGCTGATCGCCGACAACGCGATCGCCCGCCGCGACTACGAGGAAAAGCAGAACGCCGCGCGCGAG
GCCGAGGCCAACCGGCTGGCCGCGCGCGCCGCGGTCGAATCCGCCCGCCTCAACCTGGAATACACCCGCATCACCGCGCC
GGTGGCGGGCAAGCTGTCGCGCGCCGAGGTGACGGTGGGCAACGTGGTGGCCGCCGGCGCCGGCACGCCGCCGCTCACCA
CGCTGGTGTCGATGGCGCGCATGTACGCCGCGTTCGATGTCGATGAGCAGAGCTTCCTCGCCTCGATCAACGGCAAGCAG
GGCGCCGCGGTGCCGGTGCATCTGGGGCTGGCCAACGAGGACGACTACCCGCGCAGCGGCACGGTCAGCTCGGTCGATAA
CCGCATGGATACCTCCAGCGGCACGATCCGCGTGCGCGCGGTCTTCGACAACCCGGACGCGAGCCTGCTGCCGGGCCTTT
ACGCCCGCATCCGGCTGGGTAGCGCCACCCCGCGCCAGGCCCTGCTGATCGACGAGAAGGCGATCGGCACCGATCAGGAC
AAGCGCTTCGTGCTGGTGGTGGACGACGCCAACCGCACCGCCTACCGCGAGGTGAAGCTGGGCGCCGCGCAAGGCCCGCT
GCGCGTGGTGGAAAGCGGCCTCGCCGCCGGCGAGCGCATCGTGGTGAACGGGCTGCAGCGCGCCCGCCCCGGCCAGATCG
TCAATCCCAACGAGGTGCTGATGTCCGGCACCGCCAGCCCGGCCGCGCCCACCGCCCGCGCGGCCAGCGGCGCCAACAGC
TGA

Upstream 100 bases:

>100_bases
GCATAAAAATGCCGCCGCCATGGTGTCCGCCTGCCCGGCGGCAAAAACGAAAAAAGCCGGATCGTCCGCCCGCGCGCGAT
CCCCGACAAGGAGTTCCACG

Downstream 100 bases:

>100_bases
GCACGCTCCCATGAACATCTCGAAATTCTTCATCGACCGGCCGATCTTCGCCGGCGTGCTGTCGGTGCTGATCCTGCTCG
GCGGCCTCCTGGCGATGTTC

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MPRLRKPYALATTLAIALALGGGAVALSVQSDARANTAASAAMPPSPVDVATVAAQQITDWRSYSGRLEAVDRVEIRPLV
SGTVTEVHFQDGALVKKGDPLFTIDPRPYAAALEHARAQLAAAEARAAYTANDLARGERLIADNAIARRDYEEKQNAARE
AEANRLAARAAVESARLNLEYTRITAPVAGKLSRAEVTVGNVVAAGAGTPPLTTLVSMARMYAAFDVDEQSFLASINGKQ
GAAVPVHLGLANEDDYPRSGTVSSVDNRMDTSSGTIRVRAVFDNPDASLLPGLYARIRLGSATPRQALLIDEKAIGTDQD
KRFVLVVDDANRTAYREVKLGAAQGPLRVVESGLAAGERIVVNGLQRARPGQIVNPNEVLMSGTASPAAPTARAASGANS

Sequences:

>Translated_400_residues
MPRLRKPYALATTLAIALALGGGAVALSVQSDARANTAASAAMPPSPVDVATVAAQQITDWRSYSGRLEAVDRVEIRPLV
SGTVTEVHFQDGALVKKGDPLFTIDPRPYAAALEHARAQLAAAEARAAYTANDLARGERLIADNAIARRDYEEKQNAARE
AEANRLAARAAVESARLNLEYTRITAPVAGKLSRAEVTVGNVVAAGAGTPPLTTLVSMARMYAAFDVDEQSFLASINGKQ
GAAVPVHLGLANEDDYPRSGTVSSVDNRMDTSSGTIRVRAVFDNPDASLLPGLYARIRLGSATPRQALLIDEKAIGTDQD
KRFVLVVDDANRTAYREVKLGAAQGPLRVVESGLAAGERIVVNGLQRARPGQIVNPNEVLMSGTASPAAPTARAASGANS
>Mature_399_residues
PRLRKPYALATTLAIALALGGGAVALSVQSDARANTAASAAMPPSPVDVATVAAQQITDWRSYSGRLEAVDRVEIRPLVS
GTVTEVHFQDGALVKKGDPLFTIDPRPYAAALEHARAQLAAAEARAAYTANDLARGERLIADNAIARRDYEEKQNAAREA
EANRLAARAAVESARLNLEYTRITAPVAGKLSRAEVTVGNVVAAGAGTPPLTTLVSMARMYAAFDVDEQSFLASINGKQG
AAVPVHLGLANEDDYPRSGTVSSVDNRMDTSSGTIRVRAVFDNPDASLLPGLYARIRLGSATPRQALLIDEKAIGTDQDK
RFVLVVDDANRTAYREVKLGAAQGPLRVVESGLAAGERIVVNGLQRARPGQIVNPNEVLMSGTASPAAPTARAASGANS

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=367, Percent_Identity=34.0599455040872, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1789665, Length=317, Percent_Identity=35.3312302839117, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082036, Length=330, Percent_Identity=31.8181818181818, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1786668, Length=397, Percent_Identity=32.4937027707809, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87081796, Length=325, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081951, Length=229, Percent_Identity=31.0043668122271, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1789637, Length=136, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790519, Length=203, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41981; Mature: 41850

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLRKPYALATTLAIALALGGGAVALSVQSDARANTAASAAMPPSPVDVATVAAQQITD
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
WRSYSGRLEAVDRVEIRPLVSGTVTEVHFQDGALVKKGDPLFTIDPRPYAAALEHARAQL
HHHCCCCEEEECCEEEEEECCCCEEEEEECCCCEEECCCCEEEECCCCHHHHHHHHHHHH
AAAEARAAYTANDLARGERLIADNAIARRDYEEKQNAAREAEANRLAARAAVESARLNLE
HHHHHHHHHHHHHHHCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
YTRITAPVAGKLSRAEVTVGNVVAAGAGTPPLTTLVSMARMYAAFDVDEQSFLASINGKQ
EEEEECCCCCCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHEECCCCC
GAAVPVHLGLANEDDYPRSGTVSSVDNRMDTSSGTIRVRAVFDNPDASLLPGLYARIRLG
CCEEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCHHHCCCEEEEEEC
SATPRQALLIDEKAIGTDQDKRFVLVVDDANRTAYREVKLGAAQGPLRVVESGLAAGERI
CCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEE
VVNGLQRARPGQIVNPNEVLMSGTASPAAPTARAASGANS
EEECHHHCCCCCCCCCCHHEEECCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
PRLRKPYALATTLAIALALGGGAVALSVQSDARANTAASAAMPPSPVDVATVAAQQITD
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
WRSYSGRLEAVDRVEIRPLVSGTVTEVHFQDGALVKKGDPLFTIDPRPYAAALEHARAQL
HHHCCCCEEEECCEEEEEECCCCEEEEEECCCCEEECCCCEEEECCCCHHHHHHHHHHHH
AAAEARAAYTANDLARGERLIADNAIARRDYEEKQNAAREAEANRLAARAAVESARLNLE
HHHHHHHHHHHHHHHCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
YTRITAPVAGKLSRAEVTVGNVVAAGAGTPPLTTLVSMARMYAAFDVDEQSFLASINGKQ
EEEEECCCCCCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHEECCCCC
GAAVPVHLGLANEDDYPRSGTVSSVDNRMDTSSGTIRVRAVFDNPDASLLPGLYARIRLG
CCEEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCHHHCCCEEEEEEC
SATPRQALLIDEKAIGTDQDKRFVLVVDDANRTAYREVKLGAAQGPLRVVESGLAAGERI
CCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEE
VVNGLQRARPGQIVNPNEVLMSGTASPAAPTARAASGANS
EEECHHHCCCCCCCCCCHHEEECCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]