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The map label for this gene is mdtA [H]

Identifier: 119898624

GI number: 119898624

Start: 2564464

End: 2565738

Strand: Direct

Name: mdtA [H]

Synonym: azo2333

Alternate gene names: 119898624

Gene position: 2564464-2565738 (Clockwise)

Preceding gene: 119898623

Following gene: 119898625

Centisome position: 58.6

GC content: 74.12

Gene sequence:

>1275_bases
ATGGGCTTCAACCTCCGCACCCTGCTCAACAAACGCACGCTTGCACTCGCCATCGGCCTGCTGGCCGGCGGCGCCTCCGT
CTATGCCTACCTGCAACCCGCCGGCCGCGCGCCCAACCCCCAGGCCGCACCCGGTGCGCCCGGCGGCGAAGGCGCCCGCG
CGCTGCGCCGCGGCCCCGGCGCCCCGCCGCCGGTGCTGGCGGTGCGCGCTACCGCCGCGCGGGTGGGCGATCTCGACATC
GCGCTGTCCGCGCTCGGCACGGTTACCGCGTCCAACACCGCGGTGGTCAAGCCGCGCGTGGGCGGCCAGCTCACCGCGCT
GCACTTCCGCGAAGGCCAGGTGGTGAAGGCGGGCGAACTGCTCGCCGAGATCGACCCGCGGCCGTTCCGCATCGCGCTCG
ATCAGGCGCGCGCGCAGCGCCTGCGCGACGAGGCCACGCTGGGCGCGGCACGGGTGGACCTCGAACGCTACCGCGCGCTG
CTGGCGCAGGACTCGATCGCCCGCCAGCAGGTGGATGCGCAGGAAGCGCTGGTGCGCCAGCTCGAAGGCACGGTCGCCGC
CGATGCCGCGCTGGAAGCGCAGGCCGCGCTGCAGCTGGAATTCACCCGCGTCACCGCGCCGGCCGCCGGCCGCCTCGGGC
TGCGCGTGGTGGACATCGGCAACCAGGTGGACGCGCAGGACGCCGCCGGCCTGGTCGTCATCACCCAGACGCAGCCCATC
CACGCGGTGTTCGCGCTCGCGGCGGACGCGCTGACGCCGCAGCTCGGCCAGTTGCAGCAGGGCGCGCGCGGCGCGGTGGT
GGAAGCCTGGAGCCGCGACGGCCGCACCCGGCTGGCCGAGGGGCGGCTGATCAGCATCGACAACCAGATCGATGTCGCCA
CCGGCACGCTGAAGCTGAAGGCCGAGTTCGCCAACGGCGACAACAGCCTGTTCCCCAACCAGTTCATCAACGTGCGGCTG
CGCGCCGAGACCCGCCGCGACAGCGTGCTGGTGCACAGCGCCGCGGTGCAGCGCAACGCGCAGGGCAGCTATGTGTTCGT
GGTGGGCGACGACCAGCGCGTGCAGGCGCGGCAGATCCGCACCGGGCCGAGCGCCAACGAGCTGACCGTGGTGGAAGACG
GCCTTGCCGGCGGCGAACGCATCGTGCTCGACGGCACCGACCAGTTGCGCGACGGCGCGCGCGTGGATGTGCTGAGCGTG
GACGGGGTCACCGTGGCGCTGGCGGAGCCGGCCACGGCCCGAAACGAGCGCCGTCCGCCCGGGGCGGCGCAATGA

Upstream 100 bases:

>100_bases
GTCAACCGCCCCCGCGCTGTCGCGGGGGCGTTGGCATGCCCGTTACACCGCCCCCCGGGGCGGCATTGCCTCCCAACTCT
TGCGCCCCGCCAGGCTTCCC

Downstream 100 bases:

>100_bases
ACCCCTCGCGGCTCTACATCCTGCGGCCGGTGGCGACCTCGCTGCTGATGCTCGCGATCCTGCTCGCCGGACTGATCGGC
TACCGGCTGCTGCCGGTGGC

Product: membrane fusion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MGFNLRTLLNKRTLALAIGLLAGGASVYAYLQPAGRAPNPQAAPGAPGGEGARALRRGPGAPPPVLAVRATAARVGDLDI
ALSALGTVTASNTAVVKPRVGGQLTALHFREGQVVKAGELLAEIDPRPFRIALDQARAQRLRDEATLGAARVDLERYRAL
LAQDSIARQQVDAQEALVRQLEGTVAADAALEAQAALQLEFTRVTAPAAGRLGLRVVDIGNQVDAQDAAGLVVITQTQPI
HAVFALAADALTPQLGQLQQGARGAVVEAWSRDGRTRLAEGRLISIDNQIDVATGTLKLKAEFANGDNSLFPNQFINVRL
RAETRRDSVLVHSAAVQRNAQGSYVFVVGDDQRVQARQIRTGPSANELTVVEDGLAGGERIVLDGTDQLRDGARVDVLSV
DGVTVALAEPATARNERRPPGAAQ

Sequences:

>Translated_424_residues
MGFNLRTLLNKRTLALAIGLLAGGASVYAYLQPAGRAPNPQAAPGAPGGEGARALRRGPGAPPPVLAVRATAARVGDLDI
ALSALGTVTASNTAVVKPRVGGQLTALHFREGQVVKAGELLAEIDPRPFRIALDQARAQRLRDEATLGAARVDLERYRAL
LAQDSIARQQVDAQEALVRQLEGTVAADAALEAQAALQLEFTRVTAPAAGRLGLRVVDIGNQVDAQDAAGLVVITQTQPI
HAVFALAADALTPQLGQLQQGARGAVVEAWSRDGRTRLAEGRLISIDNQIDVATGTLKLKAEFANGDNSLFPNQFINVRL
RAETRRDSVLVHSAAVQRNAQGSYVFVVGDDQRVQARQIRTGPSANELTVVEDGLAGGERIVLDGTDQLRDGARVDVLSV
DGVTVALAEPATARNERRPPGAAQ
>Mature_423_residues
GFNLRTLLNKRTLALAIGLLAGGASVYAYLQPAGRAPNPQAAPGAPGGEGARALRRGPGAPPPVLAVRATAARVGDLDIA
LSALGTVTASNTAVVKPRVGGQLTALHFREGQVVKAGELLAEIDPRPFRIALDQARAQRLRDEATLGAARVDLERYRALL
AQDSIARQQVDAQEALVRQLEGTVAADAALEAQAALQLEFTRVTAPAAGRLGLRVVDIGNQVDAQDAAGLVVITQTQPIH
AVFALAADALTPQLGQLQQGARGAVVEAWSRDGRTRLAEGRLISIDNQIDVATGTLKLKAEFANGDNSLFPNQFINVRLR
AETRRDSVLVHSAAVQRNAQGSYVFVVGDDQRVQARQIRTGPSANELTVVEDGLAGGERIVLDGTDQLRDGARVDVLSVD
GVTVALAEPATARNERRPPGAAQ

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=394, Percent_Identity=44.9238578680203, Blast_Score=320, Evalue=8e-89,
Organism=Escherichia coli, GI1786668, Length=335, Percent_Identity=30.1492537313433, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789665, Length=328, Percent_Identity=27.4390243902439, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789929, Length=312, Percent_Identity=28.525641025641, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081951, Length=129, Percent_Identity=32.5581395348837, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44534; Mature: 44403

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFNLRTLLNKRTLALAIGLLAGGASVYAYLQPAGRAPNPQAAPGAPGGEGARALRRGPG
CCCCHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCC
APPPVLAVRATAARVGDLDIALSALGTVTASNTAVVKPRVGGQLTALHFREGQVVKAGEL
CCCCEEEEEEHHHHCCCHHHHHHHHHEEECCCEEEECCCCCCEEEEEEECCCCEEEHHHH
LAEIDPRPFRIALDQARAQRLRDEATLGAARVDLERYRALLAQDSIARQQVDAQEALVRQ
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEGTVAADAALEAQAALQLEFTRVTAPAAGRLGLRVVDIGNQVDAQDAAGLVVITQTQPI
HCCCHHHHHHHHCEEEEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCH
HAVFALAADALTPQLGQLQQGARGAVVEAWSRDGRTRLAEGRLISIDNQIDVATGTLKLK
HHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCEEECCCCEEEECCCEEEEEEEEEEE
AEFANGDNSLFPNQFINVRLRAETRRDSVLVHSAAVQRNAQGSYVFVVGDDQRVQARQIR
EEECCCCCCCCCCCEEEEEEEECCCCCEEEEEHHHHHCCCCCCEEEEECCCCCEEHHHHC
TGPSANELTVVEDGLAGGERIVLDGTDQLRDGARVDVLSVDGVTVALAEPATARNERRPP
CCCCCCEEEEEECCCCCCCEEEECCCHHHCCCCEEEEEEECCEEEEEECCCCCCCCCCCC
GAAQ
CCCC
>Mature Secondary Structure 
GFNLRTLLNKRTLALAIGLLAGGASVYAYLQPAGRAPNPQAAPGAPGGEGARALRRGPG
CCCHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCC
APPPVLAVRATAARVGDLDIALSALGTVTASNTAVVKPRVGGQLTALHFREGQVVKAGEL
CCCCEEEEEEHHHHCCCHHHHHHHHHEEECCCEEEECCCCCCEEEEEEECCCCEEEHHHH
LAEIDPRPFRIALDQARAQRLRDEATLGAARVDLERYRALLAQDSIARQQVDAQEALVRQ
HHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEGTVAADAALEAQAALQLEFTRVTAPAAGRLGLRVVDIGNQVDAQDAAGLVVITQTQPI
HCCCHHHHHHHHCEEEEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCH
HAVFALAADALTPQLGQLQQGARGAVVEAWSRDGRTRLAEGRLISIDNQIDVATGTLKLK
HHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCEEECCCCEEEECCCEEEEEEEEEEE
AEFANGDNSLFPNQFINVRLRAETRRDSVLVHSAAVQRNAQGSYVFVVGDDQRVQARQIR
EEECCCCCCCCCCCEEEEEEEECCCCCEEEEEHHHHHCCCCCCEEEEECCCCCEEHHHHC
TGPSANELTVVEDGLAGGERIVLDGTDQLRDGARVDVLSVDGVTVALAEPATARNERRPP
CCCCCCEEEEEECCCCCCCEEEECCCHHHCCCCEEEEEEECCEEEEEECCCCCCCCCCCC
GAAQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA