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The map label for this gene is lon2 [H]

Identifier: 119898423

GI number: 119898423

Start: 2337022

End: 2337999

Strand: Reverse

Name: lon2 [H]

Synonym: azo2132

Alternate gene names: 119898423

Gene position: 2337999-2337022 (Counterclockwise)

Preceding gene: 119898425

Following gene: 119898420

Centisome position: 53.43

GC content: 65.95

Gene sequence:

>978_bases
ATGTTGACGACAGCGACGGCAAACGAAATTTCCATCCCTCTCGCCGACGCACGGCAGATCTATCGCGTCGAAGACGTGGA
CAAGGCGCTCGAGGCCAGCGCACCGGCCCGCAATGAGGCGCTTGCGGCGTTCTACGAGCGCATGCGCGAAACCGGCGGGA
CGCGCTTCGTCGTCAAGCCCAGCCGCGCCGATACGGTGGACCGGCTGTATGAAAGCTGCCCCAACTTCGGCGAGGTGATC
GAGGACATCCGGAAGTCGCTGGCGCTGGCGGTGTCCGGTAACGAGCCGGTGTCGTTCGCGCCCATCCTGCTGCTGGGCGA
GCCCGGCATCGGCAAGACTCATTTCGCGCGCAGCCTGGCCGACAGGCTGGGCACGGGCTATCACTTCGTGTCCATGAGTT
CGCTGACCGCCGGCTGGGTTCTTTCAGGCGCCTCGGCGCAGTGGAATCACGCCAAGCCGGGCAAGGTGGCCCAGGCCCTG
GTCGGCGGCGAACTCGCGAATCCGGTCATCGTGCTCGACGAGGTGGACAAGGCGGGGGGCGATTCCCGCTACGATCCGCT
CGGGCCGCTGTACGAACTGCTGGAGCACGACACGGCGCGCCGCTTCCGTGACGAATACGTCGATGTCGAGATGGACGCGT
CGCACATCCTGTGGATCACGACCGCCAACGACGAGCGCAATATCCCCGAGCCGATCCTGAACCGGATGAACGTCTATTGC
GTGCCGCGGCCCGACGCGGACGAGTCGCTGATGATCGCGTGCCGCCTGTACCGCGACATCGTCGGCGCACACGATTGGGG
TTTTCCGGACGAGCCGCCGGCGGACGTCATGGAATGCCTCGCCACGCTGCCGCCGCGCTCGCAGCGCAGGGCGCTGATGT
CTGCCTTTGGTACCGCCAAGCTTGCCGGGCGCGATTACCTGACGGCTGACGATCTCGACAGCTTCCGGCCGGGCAGCAAG
CGCAAGATCGGTTTCTGA

Upstream 100 bases:

>100_bases
CACGCGTCCTGCTTGTCGAAGCCCGTAGATCGACGCGCGCATCCACGAGAGCGGCGTGTCGGCCCGGACCGCAATTCCAG
CGCACGCCCAGGAGGCCATG

Downstream 100 bases:

>100_bases
AGATGCGTCTCCGGCCCGTCACTTCAGGCAATGAAGACCGGGTCGGAGAACACCAGCGTGCCGTCCTTGCGCATCATCAG
GTTGTTGGCGTTGAGGATAT

Product: ATPase

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MLTTATANEISIPLADARQIYRVEDVDKALEASAPARNEALAAFYERMRETGGTRFVVKPSRADTVDRLYESCPNFGEVI
EDIRKSLALAVSGNEPVSFAPILLLGEPGIGKTHFARSLADRLGTGYHFVSMSSLTAGWVLSGASAQWNHAKPGKVAQAL
VGGELANPVIVLDEVDKAGGDSRYDPLGPLYELLEHDTARRFRDEYVDVEMDASHILWITTANDERNIPEPILNRMNVYC
VPRPDADESLMIACRLYRDIVGAHDWGFPDEPPADVMECLATLPPRSQRRALMSAFGTAKLAGRDYLTADDLDSFRPGSK
RKIGF

Sequences:

>Translated_325_residues
MLTTATANEISIPLADARQIYRVEDVDKALEASAPARNEALAAFYERMRETGGTRFVVKPSRADTVDRLYESCPNFGEVI
EDIRKSLALAVSGNEPVSFAPILLLGEPGIGKTHFARSLADRLGTGYHFVSMSSLTAGWVLSGASAQWNHAKPGKVAQAL
VGGELANPVIVLDEVDKAGGDSRYDPLGPLYELLEHDTARRFRDEYVDVEMDASHILWITTANDERNIPEPILNRMNVYC
VPRPDADESLMIACRLYRDIVGAHDWGFPDEPPADVMECLATLPPRSQRRALMSAFGTAKLAGRDYLTADDLDSFRPGSK
RKIGF
>Mature_325_residues
MLTTATANEISIPLADARQIYRVEDVDKALEASAPARNEALAAFYERMRETGGTRFVVKPSRADTVDRLYESCPNFGEVI
EDIRKSLALAVSGNEPVSFAPILLLGEPGIGKTHFARSLADRLGTGYHFVSMSSLTAGWVLSGASAQWNHAKPGKVAQAL
VGGELANPVIVLDEVDKAGGDSRYDPLGPLYELLEHDTARRFRDEYVDVEMDASHILWITTANDERNIPEPILNRMNVYC
VPRPDADESLMIACRLYRDIVGAHDWGFPDEPPADVMECLATLPPRSQRRALMSAFGTAKLAGRDYLTADDLDSFRPGSK
RKIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=179, Percent_Identity=38.5474860335196, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI31377667, Length=157, Percent_Identity=35.6687898089172, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1786643, Length=168, Percent_Identity=34.5238095238095, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17505831, Length=149, Percent_Identity=36.9127516778523, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17556486, Length=156, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319449, Length=153, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221513036, Length=195, Percent_Identity=35.8974358974359, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24666867, Length=195, Percent_Identity=35.8974358974359, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35726; Mature: 35726

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTATANEISIPLADARQIYRVEDVDKALEASAPARNEALAAFYERMRETGGTRFVVKP
CCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECC
SRADTVDRLYESCPNFGEVIEDIRKSLALAVSGNEPVSFAPILLLGEPGIGKTHFARSLA
CCCHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHH
DRLGTGYHFVSMSSLTAGWVLSGASAQWNHAKPGKVAQALVGGELANPVIVLDEVDKAGG
HHHCCCEEEEEHHHCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCC
DSRYDPLGPLYELLEHDTARRFRDEYVDVEMDASHILWITTANDERNIPEPILNRMNVYC
CCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEEECCCCCCCCHHHHHCCCEEE
VPRPDADESLMIACRLYRDIVGAHDWGFPDEPPADVMECLATLPPRSQRRALMSAFGTAK
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHH
LAGRDYLTADDLDSFRPGSKRKIGF
HCCCCCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MLTTATANEISIPLADARQIYRVEDVDKALEASAPARNEALAAFYERMRETGGTRFVVKP
CCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECC
SRADTVDRLYESCPNFGEVIEDIRKSLALAVSGNEPVSFAPILLLGEPGIGKTHFARSLA
CCCHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHH
DRLGTGYHFVSMSSLTAGWVLSGASAQWNHAKPGKVAQALVGGELANPVIVLDEVDKAGG
HHHCCCEEEEEHHHCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCC
DSRYDPLGPLYELLEHDTARRFRDEYVDVEMDASHILWITTANDERNIPEPILNRMNVYC
CCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEEECCCCCCCCHHHHHCCCEEE
VPRPDADESLMIACRLYRDIVGAHDWGFPDEPPADVMECLATLPPRSQRRALMSAFGTAK
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHH
LAGRDYLTADDLDSFRPGSKRKIGF
HCCCCCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA