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The map label for this gene is nadC [H]

Identifier: 119898370

GI number: 119898370

Start: 2284399

End: 2285247

Strand: Direct

Name: nadC [H]

Synonym: azo2079

Alternate gene names: 119898370

Gene position: 2284399-2285247 (Clockwise)

Preceding gene: 119898369

Following gene: 119898374

Centisome position: 52.2

GC content: 66.08

Gene sequence:

>849_bases
ATGACAATCTCAGAGCAACTCCGCGTCGAGATCCAGCGCAACGTATCCGCCTCGCTGGCGGAAGACATCGGCACCGGTGA
CCTCACCGCCCGCCTCATCGCGGCCGAAACCGAAGCGCGAGGCCGCGTCATCACCCGTGAAGACGCCGTGGTCTGCGGCA
CCGCATGGTTCGACGCGACCTTTGCCGCCCTGAGCCCGACCACCTCGGTGCTGTGGCACGTGCGTGACGGTGAACGGGTC
GAAGCGGGGCAGCTGCTGTGCGAGGTGGACGCCAGCGCGCGCGTGCTGCTGACGGCTGAGCGTACCGCGCTCAACTTCCT
GCAGCTCTTGTCCGGCACCGCCACCGTCACCCGCCGCTTCGTCGATGCCGTGGCCGGTACCCGCGCCAAGATCGTCGATA
CCCGCAAGACACTGCCCGGTCTGCGTCTGGCGCAGAAGTACGCGGTATCCGTCGGCGGCGGCACCAATCACCGGGTTGGC
CTCTACGACGGCATCCTCGTGAAGGAAAACCACATCATCGCTGCCGGTGGTATCCGCCAGGTGGTGGAGCAGGCGCGAGC
GATCGCGCCGTCCAACGTCTTCATCGAGGTCGAAGTGGAGAACCTCGACGAGTTGCGCGAAGCGCTCGATGCCGGCGTCA
CCATGGTGTTGCTGGACAACATGAGCCTGGAAGAAATGCGCGAAGCGGTGAGGATCACCGCCGGGCGTGCCGAGCTTGAG
GCTTCGGGCGGCGTCAATCTCGAGCGCGTGCGCGCGATCGCCGAAACCGGTGTGGACCGGATATCCATCGGCAGCCTGAC
CAAGGACGTCCGCGCGCTCGACCTCTCGCTGCGGCACGTCGAGGAATAA

Upstream 100 bases:

>100_bases
GACGCCACAAGGCCTGAGCCACAACATCGAGATGCCCCGCGGAGGCCGGGCGCCCTTGCGGTGCTAGAATCGCCGTCCCG
CAACTCGACCGTCTCCCGTC

Downstream 100 bases:

>100_bases
GGGGCGCAAGCGGCCGCAGCACTTCGCGTGTTGCGGCCTTGCCCTTGCCCGCTACGCGGCGCGGAACCAAGACTGGAGCC
CCGCCGAGGCCCCCCCGGCG

Product: nicotinate-nucleotide diphosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTISEQLRVEIQRNVSASLAEDIGTGDLTARLIAAETEARGRVITREDAVVCGTAWFDATFAALSPTTSVLWHVRDGERV
EAGQLLCEVDASARVLLTAERTALNFLQLLSGTATVTRRFVDAVAGTRAKIVDTRKTLPGLRLAQKYAVSVGGGTNHRVG
LYDGILVKENHIIAAGGIRQVVEQARAIAPSNVFIEVEVENLDELREALDAGVTMVLLDNMSLEEMREAVRITAGRAELE
ASGGVNLERVRAIAETGVDRISIGSLTKDVRALDLSLRHVEE

Sequences:

>Translated_282_residues
MTISEQLRVEIQRNVSASLAEDIGTGDLTARLIAAETEARGRVITREDAVVCGTAWFDATFAALSPTTSVLWHVRDGERV
EAGQLLCEVDASARVLLTAERTALNFLQLLSGTATVTRRFVDAVAGTRAKIVDTRKTLPGLRLAQKYAVSVGGGTNHRVG
LYDGILVKENHIIAAGGIRQVVEQARAIAPSNVFIEVEVENLDELREALDAGVTMVLLDNMSLEEMREAVRITAGRAELE
ASGGVNLERVRAIAETGVDRISIGSLTKDVRALDLSLRHVEE
>Mature_281_residues
TISEQLRVEIQRNVSASLAEDIGTGDLTARLIAAETEARGRVITREDAVVCGTAWFDATFAALSPTTSVLWHVRDGERVE
AGQLLCEVDASARVLLTAERTALNFLQLLSGTATVTRRFVDAVAGTRAKIVDTRKTLPGLRLAQKYAVSVGGGTNHRVGL
YDGILVKENHIIAAGGIRQVVEQARAIAPSNVFIEVEVENLDELREALDAGVTMVLLDNMSLEEMREAVRITAGRAELEA
SGGVNLERVRAIAETGVDRISIGSLTKDVRALDLSLRHVEE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=269, Percent_Identity=34.5724907063197, Blast_Score=141, Evalue=7e-34,
Organism=Escherichia coli, GI1786299, Length=280, Percent_Identity=50.7142857142857, Blast_Score=251, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=29.5373665480427, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30424; Mature: 30293

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISEQLRVEIQRNVSASLAEDIGTGDLTARLIAAETEARGRVITREDAVVCGTAWFDAT
CCCCHHHHHHHHHCCHHHHHHHCCCCCHHEEEEEECCCCCCCEEEECCCEEEEEHHHHHH
FAALSPTTSVLWHVRDGERVEAGQLLCEVDASARVLLTAERTALNFLQLLSGTATVTRRF
HHHCCCCCCEEEEECCCCEECCCCEEEEECCCCEEEEEEHHHHHHHHHHHCCHHHHHHHH
VDAVAGTRAKIVDTRKTLPGLRLAQKYAVSVGGGTNHRVGLYDGILVKENHIIAAGGIRQ
HHHHHCCCEEEEECHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEEEECHHHH
VVEQARAIAPSNVFIEVEVENLDELREALDAGVTMVLLDNMSLEEMREAVRITAGRAELE
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
ASGGVNLERVRAIAETGVDRISIGSLTKDVRALDLSLRHVEE
CCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TISEQLRVEIQRNVSASLAEDIGTGDLTARLIAAETEARGRVITREDAVVCGTAWFDAT
CCCHHHHHHHHHCCHHHHHHHCCCCCHHEEEEEECCCCCCCEEEECCCEEEEEHHHHHH
FAALSPTTSVLWHVRDGERVEAGQLLCEVDASARVLLTAERTALNFLQLLSGTATVTRRF
HHHCCCCCCEEEEECCCCEECCCCEEEEECCCCEEEEEEHHHHHHHHHHHCCHHHHHHHH
VDAVAGTRAKIVDTRKTLPGLRLAQKYAVSVGGGTNHRVGLYDGILVKENHIIAAGGIRQ
HHHHHCCCEEEEECHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEEEECHHHH
VVEQARAIAPSNVFIEVEVENLDELREALDAGVTMVLLDNMSLEEMREAVRITAGRAELE
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
ASGGVNLERVRAIAETGVDRISIGSLTKDVRALDLSLRHVEE
CCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]