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The map label for this gene is mtnP [H]

Identifier: 119898289

GI number: 119898289

Start: 2199402

End: 2200142

Strand: Reverse

Name: mtnP [H]

Synonym: azo1998

Alternate gene names: 119898289

Gene position: 2200142-2199402 (Counterclockwise)

Preceding gene: 119898291

Following gene: 119898268

Centisome position: 50.28

GC content: 67.21

Gene sequence:

>741_bases
ATGCTCGCAATCATCGGTGGTAGCGGACTGACCCAGCTTTCTACGCTGGAAGTCGTACGTCGCGAGGTCTGTCGCACCCC
CTATGGCGAGCCCTCCGGCGCACTCACTTTCGGCACGCTTGCCGGCAAGCCGGTGGTCTTTCTCGCCCGCCATGGCTACG
GCCATACGATTCCGCCGCACCTGGTGAACTACCGCGCCAACATCTGGGCGCTGCATCAGGCACGGGCCACCGCGGTGGTG
TCCGTCGCGTCGGTGGGCGGAATCCGCGCCGATTTCGCGCCGGGCACGCTCGCGGTGCCGGACCAGATCATCGACTACAC
CTGGGGCCGCAAGAACACCTTCTTCGATGGCGGCGAGGCCCCTGTCCGTCACATCGACTTCACCCACCCCTACGACGAAA
AACTGCGCCGCAGCCTGCTCGCGGCGGCAACCGACGCGGGCGAACCGATCTTCGACGGCGGCGTGTACGCCAGCATGCAG
GGGCCGCGGCTGGAAACCGCCGCCGAAATCAACCGCCTGGAACGCGACGGCGCCGACCTGGTGGGCATGACCGGCATGCC
GGAAGCCGCCCTCGCGCGTGAGCTGGATCTGCCCTACGCGGCGCTGAACGTGGTGGTGAACTACGCGGCGGGACGTTCGT
CCAGCGAGCACGGCATCCACTTCGACAGCATCGAACTGGTGTTGCAGGAAGCGATGCTGCGGGTGCGGCGCGTGCTGGAA
GCCCTGTGCCGGGCAGGTTGA

Upstream 100 bases:

>100_bases
CGCGGATTCTAACACGTGCTGCGGCGTCGCAGCATGAATTCCGCGGGGGCGGGAGGGGGCCGCGTGCTAGAATCCGCGCC
CTTCGTCGAGGAGTGCCCAC

Downstream 100 bases:

>100_bases
GCCGCGCAGTACTTCAGCTGGCGCCGCTGTCCAGTGCGGTGAGGTGGCGCTTCAGGCGGTTCAGCAGATCGAGCAACTGA
ATCTTCTCGTCGTGGTCGAG

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLAIIGGSGLTQLSTLEVVRREVCRTPYGEPSGALTFGTLAGKPVVFLARHGYGHTIPPHLVNYRANIWALHQARATAVV
SVASVGGIRADFAPGTLAVPDQIIDYTWGRKNTFFDGGEAPVRHIDFTHPYDEKLRRSLLAAATDAGEPIFDGGVYASMQ
GPRLETAAEINRLERDGADLVGMTGMPEAALARELDLPYAALNVVVNYAAGRSSSEHGIHFDSIELVLQEAMLRVRRVLE
ALCRAG

Sequences:

>Translated_246_residues
MLAIIGGSGLTQLSTLEVVRREVCRTPYGEPSGALTFGTLAGKPVVFLARHGYGHTIPPHLVNYRANIWALHQARATAVV
SVASVGGIRADFAPGTLAVPDQIIDYTWGRKNTFFDGGEAPVRHIDFTHPYDEKLRRSLLAAATDAGEPIFDGGVYASMQ
GPRLETAAEINRLERDGADLVGMTGMPEAALARELDLPYAALNVVVNYAAGRSSSEHGIHFDSIELVLQEAMLRVRRVLE
ALCRAG
>Mature_246_residues
MLAIIGGSGLTQLSTLEVVRREVCRTPYGEPSGALTFGTLAGKPVVFLARHGYGHTIPPHLVNYRANIWALHQARATAVV
SVASVGGIRADFAPGTLAVPDQIIDYTWGRKNTFFDGGEAPVRHIDFTHPYDEKLRRSLLAAATDAGEPIFDGGVYASMQ
GPRLETAAEINRLERDGADLVGMTGMPEAALARELDLPYAALNVVVNYAAGRSSSEHGIHFDSIELVLQEAMLRVRRVLE
ALCRAG

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=241, Percent_Identity=34.4398340248963, Blast_Score=152, Evalue=2e-37,
Organism=Escherichia coli, GI1788746, Length=183, Percent_Identity=28.9617486338798, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71980569, Length=214, Percent_Identity=40.1869158878505, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323045, Length=229, Percent_Identity=31.8777292576419, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI20130079, Length=241, Percent_Identity=37.344398340249, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221459247, Length=210, Percent_Identity=39.0476190476191, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 26491; Mature: 26491

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAIIGGSGLTQLSTLEVVRREVCRTPYGEPSGALTFGTLAGKPVVFLARHGYGHTIPPH
CEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHH
LVNYRANIWALHQARATAVVSVASVGGIRADFAPGTLAVPDQIIDYTWGRKNTFFDGGEA
HHHCCCCEEEEHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCC
PVRHIDFTHPYDEKLRRSLLAAATDAGEPIFDGGVYASMQGPRLETAAEINRLERDGADL
CEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAALARELDLPYAALNVVVNYAAGRSSSEHGIHFDSIELVLQEAMLRVRRVLE
ECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
ALCRAG
HHHCCC
>Mature Secondary Structure
MLAIIGGSGLTQLSTLEVVRREVCRTPYGEPSGALTFGTLAGKPVVFLARHGYGHTIPPH
CEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHH
LVNYRANIWALHQARATAVVSVASVGGIRADFAPGTLAVPDQIIDYTWGRKNTFFDGGEA
HHHCCCCEEEEHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCC
PVRHIDFTHPYDEKLRRSLLAAATDAGEPIFDGGVYASMQGPRLETAAEINRLERDGADL
CEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAALARELDLPYAALNVVVNYAAGRSSSEHGIHFDSIELVLQEAMLRVRRVLE
ECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
ALCRAG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]