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The map label for this gene is acS1 [H]

Identifier: 119898287

GI number: 119898287

Start: 2197112

End: 2198719

Strand: Direct

Name: acS1 [H]

Synonym: azo1996

Alternate gene names: 119898287

Gene position: 2197112-2198719 (Clockwise)

Preceding gene: 119898286

Following gene: 119898288

Centisome position: 50.21

GC content: 67.91

Gene sequence:

>1608_bases
ATGAACAGCAGCGCCCATCTCGACCGCTTCGTCATCGACAACCTGCCGCCGGCCGAACAGTGGCCGGAACTGATCTTCGA
GCGGCCGGAGCTGCAGTTCCCCGAGCAGCTCAACGCCACCGCCGAACTGCTCGACCGCGCGCTCGCGGAAGGCCACGCCG
AGCGTCCCGCGATCATCGGCAAGAACATCCACTGGACTTACCGCCAGCTGCACCAGCAGGTCAATCGCTTGGCCCACGTG
CTGGTCGAGGACATGGGCCTGGTGCCGGGCAACCGGGTGCTGCTGCGCGGAGCCAACACGCCCTGGCTGGCCGCCTGCTG
GCTGGCGGTGTGGAAGGCGGGCGGCGTCGCCGTCGGCACCATGCCGCTGCTGCGCGCGAAGGAGTTGAAGGAGATCCTGC
GGCTGGCCGAGATCAGCCACGCGCTGTGCGATGCCAGCCTGGCCGAAGAGCTGGAATACGCCCGTGCCGAGAGCCCGACG
CTGCGCCACGTGATGCTGTTCGGCGAAGGGGGCGAACTCGCGGCCCGCATGGACGGCAAGCCGGATCAGTTCGACACCGT
GGCCACCGCCGCCACCGACCCGGCCCTGATCGGTTTCACCTCCGGCACCACTGGGATTCCCAAGGGCACCATCCACTTCC
ACCGCGACGTGATGGCGATGTGCGAGGTCTTCCCGCGCCACTGCCTGAAGCCCACGCAGGACGACGTCTTCATCGGCACG
CCGCCGCTCGCCTTCACCTTCGGCCTCGGCGGCCTGCTGTGCTTTCCGCTGTGGGCGCGCGCCAGCACCGTGCTGCTCGA
AAAGCTCGCGCCCGAACCGCTGATGCAGGCGATCCAGGACCACCAGGCCACGGTCTGCTTCACCTCGCCCACCGCCTACC
GTCAGATGGCGGGCCTGGTGGGCAAGTACGACATCGCCAGCCTGAAGAAGTGTGTTTCCGCCGGCGAGGCGCTGCCCACC
GACACCCGCGACAAGTGGCGCGAGGCGAGCGGCATCCAGATCCACGACGGTATCGGCGGCACCGAGATGATCCACATCTA
CATTGCCTCCGGCCCGGACGACTACCGCCCCGGCGCGCTCGGCAAGCTGCTGCCGGGCTACACCGGCATGATCGTCGATG
ACGACATGAACCCGCTGCCCCCGGGCGAAGTGGGCAAGCTCGCGATCAAAGGGCCGACCGGCTGCCGCTACCTCGCCGAC
GAGCGCCAGCAGAACTACGTGAAGAACGGCTGGAACCTGCCGGGCGACGCCTTTCACATGGATGCGGACGGCTACTTCTA
CTACCACGCGCGGGTGGACGACATCATCGTCACCTCCGGCTACAACGTCTCCAGCCCCGAGGTGGAATGGGCGTTGCTGG
CCCACCCCGCGGTGGCCGAATGCGGCGTGATCGGCGTGCCGGACCCCGACCGCGGCCAGATCATCAAGGCCTTCGTCGTG
CTCAAGCCCGGCCAGGTCGGCGACGAGGCGATGACTAAAACCCTGCAGGACTTCGTCAAGCAGACCGTGGCGCCCTACAA
GTACCCGCGCGCCATCGCCTACGTCGACACCCTGCCCCGCACCGAGACCGGCAAGCTGCAGCGCTTCCGGCTGAAGGCGC
TTGGGTGA

Upstream 100 bases:

>100_bases
CAAAGACTTGATTCACAACGCGCGGCGGCGAACTGCCAGCCGCGCACTGGCCAACGCAGCCAACCGTGAACCGGGGCCCT
ACCCAGGCAGAGGAGACACC

Downstream 100 bases:

>100_bases
GGTTTTGCCGGGCCTGGGCTCGCAACGGGCGCAAAATACCTGCCGATCAAATCAATTTAAGCGTGAATGATTTAACCGAT
TCACGCGTTAGAATGACCGG

Product: putative acetyl-coenzyme a synthetase

Products: NA

Alternate protein names: Benzoyl-CoA synthetase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MNSSAHLDRFVIDNLPPAEQWPELIFERPELQFPEQLNATAELLDRALAEGHAERPAIIGKNIHWTYRQLHQQVNRLAHV
LVEDMGLVPGNRVLLRGANTPWLAACWLAVWKAGGVAVGTMPLLRAKELKEILRLAEISHALCDASLAEELEYARAESPT
LRHVMLFGEGGELAARMDGKPDQFDTVATAATDPALIGFTSGTTGIPKGTIHFHRDVMAMCEVFPRHCLKPTQDDVFIGT
PPLAFTFGLGGLLCFPLWARASTVLLEKLAPEPLMQAIQDHQATVCFTSPTAYRQMAGLVGKYDIASLKKCVSAGEALPT
DTRDKWREASGIQIHDGIGGTEMIHIYIASGPDDYRPGALGKLLPGYTGMIVDDDMNPLPPGEVGKLAIKGPTGCRYLAD
ERQQNYVKNGWNLPGDAFHMDADGYFYYHARVDDIIVTSGYNVSSPEVEWALLAHPAVAECGVIGVPDPDRGQIIKAFVV
LKPGQVGDEAMTKTLQDFVKQTVAPYKYPRAIAYVDTLPRTETGKLQRFRLKALG

Sequences:

>Translated_535_residues
MNSSAHLDRFVIDNLPPAEQWPELIFERPELQFPEQLNATAELLDRALAEGHAERPAIIGKNIHWTYRQLHQQVNRLAHV
LVEDMGLVPGNRVLLRGANTPWLAACWLAVWKAGGVAVGTMPLLRAKELKEILRLAEISHALCDASLAEELEYARAESPT
LRHVMLFGEGGELAARMDGKPDQFDTVATAATDPALIGFTSGTTGIPKGTIHFHRDVMAMCEVFPRHCLKPTQDDVFIGT
PPLAFTFGLGGLLCFPLWARASTVLLEKLAPEPLMQAIQDHQATVCFTSPTAYRQMAGLVGKYDIASLKKCVSAGEALPT
DTRDKWREASGIQIHDGIGGTEMIHIYIASGPDDYRPGALGKLLPGYTGMIVDDDMNPLPPGEVGKLAIKGPTGCRYLAD
ERQQNYVKNGWNLPGDAFHMDADGYFYYHARVDDIIVTSGYNVSSPEVEWALLAHPAVAECGVIGVPDPDRGQIIKAFVV
LKPGQVGDEAMTKTLQDFVKQTVAPYKYPRAIAYVDTLPRTETGKLQRFRLKALG
>Mature_535_residues
MNSSAHLDRFVIDNLPPAEQWPELIFERPELQFPEQLNATAELLDRALAEGHAERPAIIGKNIHWTYRQLHQQVNRLAHV
LVEDMGLVPGNRVLLRGANTPWLAACWLAVWKAGGVAVGTMPLLRAKELKEILRLAEISHALCDASLAEELEYARAESPT
LRHVMLFGEGGELAARMDGKPDQFDTVATAATDPALIGFTSGTTGIPKGTIHFHRDVMAMCEVFPRHCLKPTQDDVFIGT
PPLAFTFGLGGLLCFPLWARASTVLLEKLAPEPLMQAIQDHQATVCFTSPTAYRQMAGLVGKYDIASLKKCVSAGEALPT
DTRDKWREASGIQIHDGIGGTEMIHIYIASGPDDYRPGALGKLLPGYTGMIVDDDMNPLPPGEVGKLAIKGPTGCRYLAD
ERQQNYVKNGWNLPGDAFHMDADGYFYYHARVDDIIVTSGYNVSSPEVEWALLAHPAVAECGVIGVPDPDRGQIIKAFVV
LKPGQVGDEAMTKTLQDFVKQTVAPYKYPRAIAYVDTLPRTETGKLQRFRLKALG

Specific function: Catalyzes the ligation of benzoate and CoA to form benzoyl-CoA at the expense of ATP. The enzyme also ligates 2- aminobenzoate and CoA. The enzyme shows activity toward a number of benzoate derivates [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=529, Percent_Identity=32.5141776937618, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=31.7669172932331, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=29.8676748582231, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI58082049, Length=538, Percent_Identity=30.1115241635688, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI157311624, Length=528, Percent_Identity=29.3560606060606, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI157311622, Length=528, Percent_Identity=29.3560606060606, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI115511026, Length=539, Percent_Identity=29.1280148423006, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI187761345, Length=545, Percent_Identity=28.256880733945, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI187761343, Length=545, Percent_Identity=28.256880733945, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI13375727, Length=554, Percent_Identity=27.0758122743682, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI195947378, Length=400, Percent_Identity=26.5, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI8923896, Length=541, Percent_Identity=25.3234750462107, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI28416953, Length=552, Percent_Identity=24.8188405797101, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI253970489, Length=364, Percent_Identity=28.8461538461538, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI42544134, Length=358, Percent_Identity=27.0949720670391, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI156151445, Length=531, Percent_Identity=24.6704331450094, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI13325057, Length=373, Percent_Identity=28.4182305630027, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788107, Length=547, Percent_Identity=25.2285191956124, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1790505, Length=546, Percent_Identity=26.7399267399267, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=27.9296875, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI145693145, Length=353, Percent_Identity=30.028328611898, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786810, Length=543, Percent_Identity=25.0460405156538, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786529, Length=527, Percent_Identity=25.9962049335863, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1789201, Length=363, Percent_Identity=28.099173553719, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1786801, Length=555, Percent_Identity=25.5855855855856, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=501, Percent_Identity=26.1477045908184, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=533, Percent_Identity=25.703564727955, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=508, Percent_Identity=24.2125984251968, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=498, Percent_Identity=24.6987951807229, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=504, Percent_Identity=23.4126984126984, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559526, Length=545, Percent_Identity=24.4036697247706, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=493, Percent_Identity=24.9492900608519, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983001, Length=564, Percent_Identity=24.468085106383, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982997, Length=564, Percent_Identity=24.468085106383, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560308, Length=533, Percent_Identity=26.4540337711069, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=523, Percent_Identity=23.7093690248566, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71994694, Length=523, Percent_Identity=23.7093690248566, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=523, Percent_Identity=23.7093690248566, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=381, Percent_Identity=27.0341207349081, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560140, Length=349, Percent_Identity=26.3610315186246, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319264, Length=557, Percent_Identity=24.9551166965889, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6323182, Length=564, Percent_Identity=25.531914893617, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319699, Length=363, Percent_Identity=28.099173553719, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24581924, Length=507, Percent_Identity=25.8382642998028, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21355181, Length=495, Percent_Identity=25.0505050505051, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24667955, Length=559, Percent_Identity=24.6869409660107, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI62472339, Length=524, Percent_Identity=24.8091603053435, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24667959, Length=364, Percent_Identity=26.6483516483516, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859661, Length=359, Percent_Identity=26.1838440111421, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21355225, Length=563, Percent_Identity=23.6234458259325, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922652, Length=494, Percent_Identity=24.0890688259109, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656500, Length=501, Percent_Identity=21.5568862275449, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356441, Length=348, Percent_Identity=26.4367816091954, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24648253, Length=476, Percent_Identity=23.9495798319328, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648255, Length=473, Percent_Identity=24.1014799154334, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24648260, Length=356, Percent_Identity=25.8426966292135, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=489, Percent_Identity=22.4948875255624, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011957 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.25 [H]

Molecular weight: Translated: 58665; Mature: 58665

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSAHLDRFVIDNLPPAEQWPELIFERPELQFPEQLNATAELLDRALAEGHAERPAIIG
CCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCEEEC
KNIHWTYRQLHQQVNRLAHVLVEDMGLVPGNRVLLRGANTPWLAACWLAVWKAGGVAVGT
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEECC
MPLLRAKELKEILRLAEISHALCDASLAEELEYARAESPTLRHVMLFGEGGELAARMDGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCC
PDQFDTVATAATDPALIGFTSGTTGIPKGTIHFHRDVMAMCEVFPRHCLKPTQDDVFIGT
CCCHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
PPLAFTFGLGGLLCFPLWARASTVLLEKLAPEPLMQAIQDHQATVCFTSPTAYRQMAGLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCHHHHHHHHHH
GKYDIASLKKCVSAGEALPTDTRDKWREASGIQIHDGIGGTEMIHIYIASGPDDYRPGAL
CCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEECCCCCCEEEEEEEECCCCCCCCCCH
GKLLPGYTGMIVDDDMNPLPPGEVGKLAIKGPTGCRYLADERQQNYVKNGWNLPGDAFHM
HHHCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEE
DADGYFYYHARVDDIIVTSGYNVSSPEVEWALLAHPAVAECGVIGVPDPDRGQIIKAFVV
CCCCEEEEEEEECEEEEECCCCCCCCCCEEEEECCCCHHHCCEECCCCCCCCCEEEEEEE
LKPGQVGDEAMTKTLQDFVKQTVAPYKYPRAIAYVDTLPRTETGKLQRFRLKALG
ECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHEEECCC
>Mature Secondary Structure
MNSSAHLDRFVIDNLPPAEQWPELIFERPELQFPEQLNATAELLDRALAEGHAERPAIIG
CCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCEEEC
KNIHWTYRQLHQQVNRLAHVLVEDMGLVPGNRVLLRGANTPWLAACWLAVWKAGGVAVGT
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEECC
MPLLRAKELKEILRLAEISHALCDASLAEELEYARAESPTLRHVMLFGEGGELAARMDGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCC
PDQFDTVATAATDPALIGFTSGTTGIPKGTIHFHRDVMAMCEVFPRHCLKPTQDDVFIGT
CCCHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
PPLAFTFGLGGLLCFPLWARASTVLLEKLAPEPLMQAIQDHQATVCFTSPTAYRQMAGLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCHHHHHHHHHH
GKYDIASLKKCVSAGEALPTDTRDKWREASGIQIHDGIGGTEMIHIYIASGPDDYRPGAL
CCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEECCCCCCEEEEEEEECCCCCCCCCCH
GKLLPGYTGMIVDDDMNPLPPGEVGKLAIKGPTGCRYLADERQQNYVKNGWNLPGDAFHM
HHHCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEE
DADGYFYYHARVDDIIVTSGYNVSSPEVEWALLAHPAVAECGVIGVPDPDRGQIIKAFVV
CCCCEEEEEEEECEEEEECCCCCCCCCCEEEEECCCCHHHCCEECCCCCCCCCEEEEEEE
LKPGQVGDEAMTKTLQDFVKQTVAPYKYPRAIAYVDTLPRTETGKLQRFRLKALG
ECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12897012 [H]