Click here to switch to the map view.

The map label for this gene is lapF

Identifier: 119898147

GI number: 119898147

Start: 2038548

End: 2039462

Strand: Direct

Name: lapF

Synonym: azo1856

Alternate gene names: 119898147

Gene position: 2038548-2039462 (Clockwise)

Preceding gene: 119898146

Following gene: 119898148

Centisome position: 46.58

GC content: 65.25

Gene sequence:

>915_bases
ATGAAGAAGATCAAATGCGCCCTGATCGGCTCGGGCAACATCGGCACCGACCTGATCTACAAGATCAAGCGCAGCCCGGT
ACTGGAGCCGGTGTGGATGGTGGGCATCGACCCGGCGTCCGAGGGGCTGGCGCGCGCCCGCGAACTCGGCCTGAAAACCA
CCGCCGACGGCGTGGATGGCCTGCTGCCGCATGTGCTGGAAGACGGCATCCAGATCGCCTTCGACGCCACCAGCGCCTAT
GTGCACGCGGAGAACTCGCGCAAGCTCAACGAGCTGGGCGTGATGATGATCGACCTGACGCCCGCCGCCATCGGCCCGCT
GTGCGTGCCGCCGGTGAACCTGCGCCAGCATGCCGACCGCGTGGAGATGAACGTGAACATGATCTCCTGCGCCGGCCAGG
CGACGATTCCCATCGTCAATGCGGTGTCGCGCGTGCAGGGCGTGGAATACGCCGAGATCGTCGCCAGCCTGGCGTCGAAG
TCGGTGGGGCCGGGCACCCGCGCCAATCTGGACGAATTCACCTACACCACCTCGTCGGCCATCGAAAAAGTCGGCGGCGC
GAAGAAGGGCAAGGCGCTGGCCATCATCAACCCGGCCGAGCCGCCGCTGATCATGCGCAACACCATCTACTGCCTCACCG
AGTCGGCGCCCGACCAGGCGCGCATCACCGAATCCATCCTGCAGATGATCGGTGAAGTGCAGAAATACGTGCCCGGCTAC
CGGCTGGTGAACGGGCCGAGCTACGACGGCAACAAGGTCTCGGTGTTCATGGAGGTCGCCGGCCTGGGCGACTACCTGCC
GAAGTACGCCGGCAATCTGGACATCATGACCGCGGCCGCGACCCGCACCGCCGAGATGTTCGCCGAGGAGATCCTGGCCG
GAAAGATCAAGCTGAAGACCGCGGAGGTGGCGTGA

Upstream 100 bases:

>100_bases
GGATCCTGATTACCGAACACGGCGACGAGGAGTTCTTCGTCGGCGGCATGAACATGGCCCAGCGCGCAGCGGCACAGCGC
GCCGCCGCGGAGGAACAGCA

Downstream 100 bases:

>100_bases
TGAGCGAATCGAACCTGAAGGGGCGCAAGGTCGTCCTGCACGACATGTGTCTGCGCGACGGCATGCACGCCAAGCGCGAG
CAGATCAGCGTGGAGCAGAT

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating] 1

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKKIKCALIGSGNIGTDLIYKIKRSPVLEPVWMVGIDPASEGLARARELGLKTTADGVDGLLPHVLEDGIQIAFDATSAY
VHAENSRKLNELGVMMIDLTPAAIGPLCVPPVNLRQHADRVEMNVNMISCAGQATIPIVNAVSRVQGVEYAEIVASLASK
SVGPGTRANLDEFTYTTSSAIEKVGGAKKGKALAIINPAEPPLIMRNTIYCLTESAPDQARITESILQMIGEVQKYVPGY
RLVNGPSYDGNKVSVFMEVAGLGDYLPKYAGNLDIMTAAATRTAEMFAEEILAGKIKLKTAEVA

Sequences:

>Translated_304_residues
MKKIKCALIGSGNIGTDLIYKIKRSPVLEPVWMVGIDPASEGLARARELGLKTTADGVDGLLPHVLEDGIQIAFDATSAY
VHAENSRKLNELGVMMIDLTPAAIGPLCVPPVNLRQHADRVEMNVNMISCAGQATIPIVNAVSRVQGVEYAEIVASLASK
SVGPGTRANLDEFTYTTSSAIEKVGGAKKGKALAIINPAEPPLIMRNTIYCLTESAPDQARITESILQMIGEVQKYVPGY
RLVNGPSYDGNKVSVFMEVAGLGDYLPKYAGNLDIMTAAATRTAEMFAEEILAGKIKLKTAEVA
>Mature_304_residues
MKKIKCALIGSGNIGTDLIYKIKRSPVLEPVWMVGIDPASEGLARARELGLKTTADGVDGLLPHVLEDGIQIAFDATSAY
VHAENSRKLNELGVMMIDLTPAAIGPLCVPPVNLRQHADRVEMNVNMISCAGQATIPIVNAVSRVQGVEYAEIVASLASK
SVGPGTRANLDEFTYTTSSAIEKVGGAKKGKALAIINPAEPPLIMRNTIYCLTESAPDQARITESILQMIGEVQKYVPGY
RLVNGPSYDGNKVSVFMEVAGLGDYLPKYAGNLDIMTAAATRTAEMFAEEILAGKIKLKTAEVA

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=311, Percent_Identity=55.9485530546624, Blast_Score=306, Evalue=7e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH1_AZOSB (A1K6L8)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933360.1
- STRING:   A1K6L8
- GeneID:   4609116
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1856
- eggNOG:   COG4569
- HOGENOM:   HBG300125
- OMA:   MISCAGQ
- ProtClustDB:   PRK08300
- BioCyc:   ASP62928:AZO1856-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32387; Mature: 32387

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIKCALIGSGNIGTDLIYKIKRSPVLEPVWMVGIDPASEGLARARELGLKTTADGVDG
CCCEEEEEEECCCCCHHHHHEECCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
LLPHVLEDGIQIAFDATSAYVHAENSRKLNELGVMMIDLTPAAIGPLCVPPVNLRQHADR
HHHHHHHCCCEEEEECCEEEEECCCCCCHHHCCEEEEEECHHHCCCCCCCCCCHHHHCCH
VEMNVNMISCAGQATIPIVNAVSRVQGVEYAEIVASLASKSVGPGTRANLDEFTYTTSSA
HEEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHEECHHHH
IEKVGGAKKGKALAIINPAEPPLIMRNTIYCLTESAPDQARITESILQMIGEVQKYVPGY
HHHHCCCCCCCEEEEECCCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCE
RLVNGPSYDGNKVSVFMEVAGLGDYLPKYAGNLDIMTAAATRTAEMFAEEILAGKIKLKT
EEECCCCCCCCEEEEEEEECCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCEEEEEE
AEVA
ECCC
>Mature Secondary Structure
MKKIKCALIGSGNIGTDLIYKIKRSPVLEPVWMVGIDPASEGLARARELGLKTTADGVDG
CCCEEEEEEECCCCCHHHHHEECCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
LLPHVLEDGIQIAFDATSAYVHAENSRKLNELGVMMIDLTPAAIGPLCVPPVNLRQHADR
HHHHHHHCCCEEEEECCEEEEECCCCCCHHHCCEEEEEECHHHCCCCCCCCCCHHHHCCH
VEMNVNMISCAGQATIPIVNAVSRVQGVEYAEIVASLASKSVGPGTRANLDEFTYTTSSA
HEEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHEECHHHH
IEKVGGAKKGKALAIINPAEPPLIMRNTIYCLTESAPDQARITESILQMIGEVQKYVPGY
HHHHCCCCCCCEEEEECCCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCE
RLVNGPSYDGNKVSVFMEVAGLGDYLPKYAGNLDIMTAAATRTAEMFAEEILAGKIKLKT
EEECCCCCCCCEEEEEEEECCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCEEEEEE
AEVA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA