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The map label for this gene is envZ1 [H]

Identifier: 119897999

GI number: 119897999

Start: 1874441

End: 1875826

Strand: Reverse

Name: envZ1 [H]

Synonym: azo1708

Alternate gene names: 119897999

Gene position: 1875826-1874441 (Counterclockwise)

Preceding gene: 119898000

Following gene: 119897998

Centisome position: 42.87

GC content: 69.41

Gene sequence:

>1386_bases
TTGCGGCGGATCAGGGCAGTCGGTCGTTTTCTCTACGGATGGCTGCCGCGCACCCTGCTCTGGCAGACCTTCCTGCTGGT
AGGACTGCTGCTGACGCTTGCGCTGGCGGCGTGGTCCCACATCTTCCGCTATTTCGAAGAACCACCACGCGCGCGAGATC
TGGCGCAGATGGTGGTGAGCGTCGTCAACCTCACCCGCACCGCGCTGATCAACGCAGAGCCCGGCCGTCGCACAGAACTA
TTGATCGAACTCGCCGCGCTGGAAGGCATCCGCATCTATCCCGCCGAACCGAGCGACGAGGTGGAACCCCTCCCCGACAC
CCGTCCGATGCGCCTGCTGACCGCCGAGGTCCGGCGCCAGCTGGGTGGCGACACGCGCTTCGCCGCCCGCTGGAAAACCC
TGGACGGCTTCTGGGTGAGCTTCCAGCTGGACCCCGAGGACCGGGATGAATACTGGGTCATGCTGCCGCCGGACCGCCTC
GAGAAAACCTATGCGCAGGAATGGGTGGCCTGGGGCAGCGGCGCGCTGCTCGCATCCCTGCTCGGCGCCTACCTGATCGT
GCTGCGGGTCGGCTCGCCGCTGCGGCAGCTGGCCAAGGCGGCGCGGCTCGTCGGCGGCCGCCAGACGCCGCCCCGCCTGG
AGGAGAACGGCCCGCAGGAAATCGCCGTCGTCGCCCGGGCCTTCAACCAGATGACGGGCGACCTCGCGCGCACCGACGCC
GATCGGGCCCTGATCCTCGCCGGGGTGTCGCACGACCTGCGCACACCGCTTGCGCGCCTGCGGCTGGGCATCGAGATGTC
GGGTGCGCCCGAGGACGAAGTGGGCGCGATGGTGGCGGACATCGAAGAGATGGACCGCATCATCGGCCAGTTTCTGGACT
TCGGCCGTGGCTCCGCGCAGGAGCCCCCGCAGGCGCTGGATCTCGTCGAACTCGTCGGCAGCGTGTGCGAACCCTACCGC
CTGCGCGGTTGCCGCATCGAGCTGGAAATGCCCGCCTCGCTGGTCACCGCTGGCCGCGCCCTGCAATTGCGCCGGGCCCT
CGCCAACCTCATCGACAACGCCCTGCGCTACGCCGGCGAGGACAAACCGCTGCTGGTGCGCGTGGAGCGGGGCATGGGTG
AGGCCCTGGTGGAAGTGGCCGACCGCGGCCCCGGCATTCCCGAAAATGAAATCGAGCGCCTGCGCCATCCCTTCACCCGG
CTGGAGACCGCGCGCACCAACACCAAGGGGGCAGGACTCGGGCTGGCCATCATCGAGCGCGTCATGCGCGCCCACAGCGG
CCGGCTCGACCTCCTGCCACGCGACGGCGGCGGGCTCCGTGCCATACTATGCCTGCCGCTCGGCGAGCAGACAGCCGGCA
CGGACCGGACAAGCCGCCGCCAATAA

Upstream 100 bases:

>100_bases
CGCTACATCCAGACTGTGTGGGGATTCGGCTATGTTTTCGTACCGGACGACAACAAACCCGCCGAGGCTGAGTGAGCCGC
GGGTGGCTCGTCCCATTACT

Downstream 100 bases:

>100_bases
GCCCGCGCCGCCGGCGCCCGATCCAGCACCGCCGTCCGGGCGGAGGCAACCCACAACCTGGCGCTGCCCAGACCCGACCG
CACTTCCTACAGGTTTCAAT

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRRIRAVGRFLYGWLPRTLLWQTFLLVGLLLTLALAAWSHIFRYFEEPPRARDLAQMVVSVVNLTRTALINAEPGRRTEL
LIELAALEGIRIYPAEPSDEVEPLPDTRPMRLLTAEVRRQLGGDTRFAARWKTLDGFWVSFQLDPEDRDEYWVMLPPDRL
EKTYAQEWVAWGSGALLASLLGAYLIVLRVGSPLRQLAKAARLVGGRQTPPRLEENGPQEIAVVARAFNQMTGDLARTDA
DRALILAGVSHDLRTPLARLRLGIEMSGAPEDEVGAMVADIEEMDRIIGQFLDFGRGSAQEPPQALDLVELVGSVCEPYR
LRGCRIELEMPASLVTAGRALQLRRALANLIDNALRYAGEDKPLLVRVERGMGEALVEVADRGPGIPENEIERLRHPFTR
LETARTNTKGAGLGLAIIERVMRAHSGRLDLLPRDGGGLRAILCLPLGEQTAGTDRTSRRQ

Sequences:

>Translated_461_residues
MRRIRAVGRFLYGWLPRTLLWQTFLLVGLLLTLALAAWSHIFRYFEEPPRARDLAQMVVSVVNLTRTALINAEPGRRTEL
LIELAALEGIRIYPAEPSDEVEPLPDTRPMRLLTAEVRRQLGGDTRFAARWKTLDGFWVSFQLDPEDRDEYWVMLPPDRL
EKTYAQEWVAWGSGALLASLLGAYLIVLRVGSPLRQLAKAARLVGGRQTPPRLEENGPQEIAVVARAFNQMTGDLARTDA
DRALILAGVSHDLRTPLARLRLGIEMSGAPEDEVGAMVADIEEMDRIIGQFLDFGRGSAQEPPQALDLVELVGSVCEPYR
LRGCRIELEMPASLVTAGRALQLRRALANLIDNALRYAGEDKPLLVRVERGMGEALVEVADRGPGIPENEIERLRHPFTR
LETARTNTKGAGLGLAIIERVMRAHSGRLDLLPRDGGGLRAILCLPLGEQTAGTDRTSRRQ
>Mature_461_residues
MRRIRAVGRFLYGWLPRTLLWQTFLLVGLLLTLALAAWSHIFRYFEEPPRARDLAQMVVSVVNLTRTALINAEPGRRTEL
LIELAALEGIRIYPAEPSDEVEPLPDTRPMRLLTAEVRRQLGGDTRFAARWKTLDGFWVSFQLDPEDRDEYWVMLPPDRL
EKTYAQEWVAWGSGALLASLLGAYLIVLRVGSPLRQLAKAARLVGGRQTPPRLEENGPQEIAVVARAFNQMTGDLARTDA
DRALILAGVSHDLRTPLARLRLGIEMSGAPEDEVGAMVADIEEMDRIIGQFLDFGRGSAQEPPQALDLVELVGSVCEPYR
LRGCRIELEMPASLVTAGRALQLRRALANLIDNALRYAGEDKPLLVRVERGMGEALVEVADRGPGIPENEIERLRHPFTR
LETARTNTKGAGLGLAIIERVMRAHSGRLDLLPRDGGGLRAILCLPLGEQTAGTDRTSRRQ

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=460, Percent_Identity=31.5217391304348, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=29.1970802919708, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=26.3736263736264, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=29.368029739777, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=28.957528957529, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787894, Length=264, Percent_Identity=30.6818181818182, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=293, Percent_Identity=25.5972696245734, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=25.7425742574257, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=27.5, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=29.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=25.5411255411255, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=290, Percent_Identity=27.2413793103448, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=24.6575342465753, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51286; Mature: 51286

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIRAVGRFLYGWLPRTLLWQTFLLVGLLLTLALAAWSHIFRYFEEPPRARDLAQMVVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VVNLTRTALINAEPGRRTELLIELAALEGIRIYPAEPSDEVEPLPDTRPMRLLTAEVRRQ
HHHHHHHHEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
LGGDTRFAARWKTLDGFWVSFQLDPEDRDEYWVMLPPDRLEKTYAQEWVAWGSGALLASL
HCCCCEEHHHEECCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHH
LGAYLIVLRVGSPLRQLAKAARLVGGRQTPPRLEENGPQEIAVVARAFNQMTGDLARTDA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DRALILAGVSHDLRTPLARLRLGIEMSGAPEDEVGAMVADIEEMDRIIGQFLDFGRGSAQ
CCEEEEECCCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPPQALDLVELVGSVCEPYRLRGCRIELEMPASLVTAGRALQLRRALANLIDNALRYAGE
CCHHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DKPLLVRVERGMGEALVEVADRGPGIPENEIERLRHPFTRLETARTNTKGAGLGLAIIER
CCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VMRAHSGRLDLLPRDGGGLRAILCLPLGEQTAGTDRTSRRQ
HHHHCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRIRAVGRFLYGWLPRTLLWQTFLLVGLLLTLALAAWSHIFRYFEEPPRARDLAQMVVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VVNLTRTALINAEPGRRTELLIELAALEGIRIYPAEPSDEVEPLPDTRPMRLLTAEVRRQ
HHHHHHHHEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
LGGDTRFAARWKTLDGFWVSFQLDPEDRDEYWVMLPPDRLEKTYAQEWVAWGSGALLASL
HCCCCEEHHHEECCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHH
LGAYLIVLRVGSPLRQLAKAARLVGGRQTPPRLEENGPQEIAVVARAFNQMTGDLARTDA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DRALILAGVSHDLRTPLARLRLGIEMSGAPEDEVGAMVADIEEMDRIIGQFLDFGRGSAQ
CCEEEEECCCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPPQALDLVELVGSVCEPYRLRGCRIELEMPASLVTAGRALQLRRALANLIDNALRYAGE
CCHHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DKPLLVRVERGMGEALVEVADRGPGIPENEIERLRHPFTRLETARTNTKGAGLGLAIIER
CCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VMRAHSGRLDLLPRDGGGLRAILCLPLGEQTAGTDRTSRRQ
HHHHCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]