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The map label for this gene is lepB [H]

Identifier: 119897931

GI number: 119897931

Start: 1801366

End: 1802154

Strand: Direct

Name: lepB [H]

Synonym: azo1640

Alternate gene names: 119897931

Gene position: 1801366-1802154 (Clockwise)

Preceding gene: 119897930

Following gene: 119897932

Centisome position: 41.16

GC content: 61.09

Gene sequence:

>789_bases
GTGAATTTCGCCCTGATCCTGTTCGTCCTGCTCGTCGTCACCGGTGTGCTGTGGTTGGCCGACCGCCTGGTCGCGCGCAA
GCGGCGTGCAGCGGATGCGCCGTCGCCCTGGTGGGTGGAGTACGGTGCCAGCTTCTTCCCGGTGATCCTCGTCGTGTTCG
GCCTGCGCTCCTTCGTCGTCGAACCGTTCAAGATCCCCTCCGGCTCGATGATTCCGACCCTGCTGGTGGGCGATTTCATC
CTGGTCAACAAATGGACCTACGGAATCCGCCTGCCGGTGATCAACAAGAAGATCATCGACGTGAAGGATCCGCAGCGCGG
TGAGGTCATGGTGTTCCGCTATCCGGCGGATCCGTCGCTGGATTACATCAAGCGCGTGGTCGGACTGCCGGGAGACAAGG
TCGAGTACCACCACAAGCAGTTGAAGATCAACGGCCAGCCGGTGCCGCTGAAGGAAGACGGCAACTATCTCCATCCCGAC
CGGCTGTACTACTCGCCGCAGTTTGCCGAAAAGCTCGGTGAGGTCGAGCACCCCATCCTGATCGAGAAGGATGCGCCGGC
CTTCGTGCCGCAGGTGCTCAATTTCCCCGGGCGCGAAAACTGTACCTATACTGGCAGCGGCGTCACCTGCACTGTTCCCC
CCGGACATTATTTCGTGATGGGCGACAACCGCGACGCCAGCAGCGACAGCCGGGTGTGGGGCTTCGTGCCCGACGCCAAC
ATCGTCGGTCGCGCGTTCTTCATCTGGTTCAATTTCAACGATCTGAAGCGCATCGGCAGCTTCCACTAA

Upstream 100 bases:

>100_bases
GCGGATGAAGCAGGTGGGCAACGTCGAGATTCCGCAGGAGGCCTTCCTTGCCGTGCTGCGCGTCGATGAAGGCAAATAAC
CCCGTCCTGCTGGAGTGCCC

Downstream 100 bases:

>100_bases
TTCCGGAGTCAATGGATGAACAGGACTTCCCAGCGCGGCATCAGCCTTGTCGGCCTGCTGATCATCGGTGCCTTTGCTGT
CTTCGTGCTGCTGCTCGGTT

Product: LepB protein

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNFALILFVLLVVTGVLWLADRLVARKRRAADAPSPWWVEYGASFFPVILVVFGLRSFVVEPFKIPSGSMIPTLLVGDFI
LVNKWTYGIRLPVINKKIIDVKDPQRGEVMVFRYPADPSLDYIKRVVGLPGDKVEYHHKQLKINGQPVPLKEDGNYLHPD
RLYYSPQFAEKLGEVEHPILIEKDAPAFVPQVLNFPGRENCTYTGSGVTCTVPPGHYFVMGDNRDASSDSRVWGFVPDAN
IVGRAFFIWFNFNDLKRIGSFH

Sequences:

>Translated_262_residues
MNFALILFVLLVVTGVLWLADRLVARKRRAADAPSPWWVEYGASFFPVILVVFGLRSFVVEPFKIPSGSMIPTLLVGDFI
LVNKWTYGIRLPVINKKIIDVKDPQRGEVMVFRYPADPSLDYIKRVVGLPGDKVEYHHKQLKINGQPVPLKEDGNYLHPD
RLYYSPQFAEKLGEVEHPILIEKDAPAFVPQVLNFPGRENCTYTGSGVTCTVPPGHYFVMGDNRDASSDSRVWGFVPDAN
IVGRAFFIWFNFNDLKRIGSFH
>Mature_262_residues
MNFALILFVLLVVTGVLWLADRLVARKRRAADAPSPWWVEYGASFFPVILVVFGLRSFVVEPFKIPSGSMIPTLLVGDFI
LVNKWTYGIRLPVINKKIIDVKDPQRGEVMVFRYPADPSLDYIKRVVGLPGDKVEYHHKQLKINGQPVPLKEDGNYLHPD
RLYYSPQFAEKLGEVEHPILIEKDAPAFVPQVLNFPGRENCTYTGSGVTCTVPPGHYFVMGDNRDASSDSRVWGFVPDAN
IVGRAFFIWFNFNDLKRIGSFH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=328, Percent_Identity=41.4634146341463, Blast_Score=214, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 29696; Mature: 29696

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVLLVVTGVLWLADRLVARKRRAADAPSPWWVEYGASFFPVILVVFGLRSFVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHC
EPFKIPSGSMIPTLLVGDFILVNKWTYGIRLPVINKKIIDVKDPQRGEVMVFRYPADPSL
CCEECCCCCCCHHHHHCCEEEEECEECEEEEEEECCEEEECCCCCCCCEEEEEECCCCCH
DYIKRVVGLPGDKVEYHHKQLKINGQPVPLKEDGNYLHPDRLYYSPQFAEKLGEVEHPIL
HHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCEECCCCEEECHHHHHHHCCCCCCEE
IEKDAPAFVPQVLNFPGRENCTYTGSGVTCTVPPGHYFVMGDNRDASSDSRVWGFVPDAN
EECCCCHHHHHHHCCCCCCCCEEECCCEEEEECCCEEEEEECCCCCCCCCEEEEECCCCC
IVGRAFFIWFNFNDLKRIGSFH
CEEEEEEEEEECHHHHHHCCCC
>Mature Secondary Structure
MNFALILFVLLVVTGVLWLADRLVARKRRAADAPSPWWVEYGASFFPVILVVFGLRSFVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHC
EPFKIPSGSMIPTLLVGDFILVNKWTYGIRLPVINKKIIDVKDPQRGEVMVFRYPADPSL
CCEECCCCCCCHHHHHCCEEEEECEECEEEEEEECCEEEECCCCCCCCEEEEEECCCCCH
DYIKRVVGLPGDKVEYHHKQLKINGQPVPLKEDGNYLHPDRLYYSPQFAEKLGEVEHPIL
HHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCEECCCCEEECHHHHHHHCCCCCCEE
IEKDAPAFVPQVLNFPGRENCTYTGSGVTCTVPPGHYFVMGDNRDASSDSRVWGFVPDAN
EECCCCHHHHHHHCCCCCCCCEEECCCEEEEECCCEEEEEECCCCCCCCCEEEEECCCCC
IVGRAFFIWFNFNDLKRIGSFH
CEEEEEEEEEECHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]