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The map label for this gene is guaB [H]

Identifier: 119897871

GI number: 119897871

Start: 1736897

End: 1738357

Strand: Direct

Name: guaB [H]

Synonym: azo1580

Alternate gene names: 119897871

Gene position: 1736897-1738357 (Clockwise)

Preceding gene: 119897869

Following gene: 119897872

Centisome position: 39.69

GC content: 65.5

Gene sequence:

>1461_bases
ATGCGAGTGATCCAGAAGGCGCTGACGTTCGATGACGTCCTTCTCGTTCCCGCCCACTCGACGGTCCTACCGCGCGATGT
GAGCCTGCAGACCCAGCTCACGCGCCGCATCCGCATCAACATCCCGCTGGTTTCCGCCGCGATGGATACCGTCACCGAGG
CCCGCCTCGCGATCGCACTCGCTCAGGAAGGCGGACTGGGCATCGTCCACAAGAACCTCACTCCGAAGCAGCAGGCGGCC
GAAGTCAGCAAGGTCAAGCGCTTCGAATCCGGCGTGCTGAAGGACCCGATCACGATTCCGCCGACGATGAGCGTGCGTGA
AGTCGTGGCGCTCACGCGCCAGCACCGCTTCTCCGGCCTGCCCGTGCTCGAAGGCAAGAAGGTCGTCGGCATCGTCACCA
ATCGCGACCTTCGTTTCGAAACCAATCTCGATCAGCCCGTGTCGGCCATCATGACGCCGCAGTCGCGCCTGGTGACCGTT
AAAGAAGGTGGCAGCCTCGAAGATGCGCGGGCGCTGATGCACAAGCATCGCCTCGAGCGCGTGCTGGTGCTCAACGACGA
GGGTGAACTGCGCGGCCTCATCACCGTGAAGGACATGATGAAGTCCACCGAGCACCCGCTTGCCGCGAAGGACGAGCTCG
GCCGTCTGCGCGTCGGCGCGGCGATCGGTGTCGGGGCCGGCACCGAAGAGCGCGCGGAACTGCTCGCCGACGCCGGCGTG
GATGTGCTGGTGGTGGATACCGCGCACGGCCATTCGCAGGGCGTGCTCGACCGCGTTAACTGGGTCAAGAAGAACTTCCC
CAACGTCGAGGTGATCGGCGGCAACATCGCCACCGGCGACGCGGCGCGTGCGCTGGCCGATTCGGGCGCTGATGCGGTGA
AGGTGGGTATCGGCCCCGGCTCGATCTGCACCACGCGCATCATCGCCGGCGTGGGCGTTCCGCAGATCACCGCGGTCGAC
AACGTTGCAACGGCGCTGGCCGGCACCGGCGTTCCGCTGATCGCGGACGGGGGCATCCGCTTCTCCGGCGATATCGCCAA
GGCGCTTGCCGCGGGTGCCAACGCGGTGATGCTGGGCGGCCTGTTCGCGGGTACCGAGGAATCGCCGGGCGAAACCGTGT
TGTATCAGGGCCGTTCCTACAAGTCCTACCGCGGCATGGGCTCGCTCGGTGCCATGCAGCAGGGCGCAGCCGACCGCTAT
TTCCAGGACAGTTCGGCCAATGTGGACAAACTGGTACCCGAAGGCATCGAAGGGCGCGTGCCCTACAAGGGCGCCGTCAC
CGCCGTGATCCACCAACTGATCGGTGGCGTCCGCGCCTCCATGGGCTATCTTGGCTGCGAGAGCATCGGCGCCATGCACG
AACGCGCCCAGTTCGTCGAGATCACCTCGGCGGGTGTGCGCGAATCCCACGTGCATGACGTTCAGATCACCAAGGAAGCG
CCCAACTACCACGTCGATTAA

Upstream 100 bases:

>100_bases
GACGGTTCGCGCCACGGCTTGGCGCAGGATATATCAGGGGTGACTTACCACCGAGGGAGGCGGTCTGTATAATACGGATT
TGGTTGAAAGGATAGAAGCC

Downstream 100 bases:

>100_bases
CGCTGCATCGTCGTAGCGTCACCTACAGGCGGTCGTCGGGTTGTACCGACGCCGCCTTTCCTGTTTGTTGAGACGGACAT
GTCCCACCAGAAAATCCTCA

Product: IMP dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRVIQKALTFDDVLLVPAHSTVLPRDVSLQTQLTRRIRINIPLVSAAMDTVTEARLAIALAQEGGLGIVHKNLTPKQQAA
EVSKVKRFESGVLKDPITIPPTMSVREVVALTRQHRFSGLPVLEGKKVVGIVTNRDLRFETNLDQPVSAIMTPQSRLVTV
KEGGSLEDARALMHKHRLERVLVLNDEGELRGLITVKDMMKSTEHPLAAKDELGRLRVGAAIGVGAGTEERAELLADAGV
DVLVVDTAHGHSQGVLDRVNWVKKNFPNVEVIGGNIATGDAARALADSGADAVKVGIGPGSICTTRIIAGVGVPQITAVD
NVATALAGTGVPLIADGGIRFSGDIAKALAAGANAVMLGGLFAGTEESPGETVLYQGRSYKSYRGMGSLGAMQQGAADRY
FQDSSANVDKLVPEGIEGRVPYKGAVTAVIHQLIGGVRASMGYLGCESIGAMHERAQFVEITSAGVRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRVIQKALTFDDVLLVPAHSTVLPRDVSLQTQLTRRIRINIPLVSAAMDTVTEARLAIALAQEGGLGIVHKNLTPKQQAA
EVSKVKRFESGVLKDPITIPPTMSVREVVALTRQHRFSGLPVLEGKKVVGIVTNRDLRFETNLDQPVSAIMTPQSRLVTV
KEGGSLEDARALMHKHRLERVLVLNDEGELRGLITVKDMMKSTEHPLAAKDELGRLRVGAAIGVGAGTEERAELLADAGV
DVLVVDTAHGHSQGVLDRVNWVKKNFPNVEVIGGNIATGDAARALADSGADAVKVGIGPGSICTTRIIAGVGVPQITAVD
NVATALAGTGVPLIADGGIRFSGDIAKALAAGANAVMLGGLFAGTEESPGETVLYQGRSYKSYRGMGSLGAMQQGAADRY
FQDSSANVDKLVPEGIEGRVPYKGAVTAVIHQLIGGVRASMGYLGCESIGAMHERAQFVEITSAGVRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRVIQKALTFDDVLLVPAHSTVLPRDVSLQTQLTRRIRINIPLVSAAMDTVTEARLAIALAQEGGLGIVHKNLTPKQQAA
EVSKVKRFESGVLKDPITIPPTMSVREVVALTRQHRFSGLPVLEGKKVVGIVTNRDLRFETNLDQPVSAIMTPQSRLVTV
KEGGSLEDARALMHKHRLERVLVLNDEGELRGLITVKDMMKSTEHPLAAKDELGRLRVGAAIGVGAGTEERAELLADAGV
DVLVVDTAHGHSQGVLDRVNWVKKNFPNVEVIGGNIATGDAARALADSGADAVKVGIGPGSICTTRIIAGVGVPQITAVD
NVATALAGTGVPLIADGGIRFSGDIAKALAAGANAVMLGGLFAGTEESPGETVLYQGRSYKSYRGMGSLGAMQQGAADRY
FQDSSANVDKLVPEGIEGRVPYKGAVTAVIHQLIGGVRASMGYLGCESIGAMHERAQFVEITSAGVRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=41.0596026490066, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=41.0596026490066, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=41.0596026490066, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=41.0596026490066, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=41.0596026490066, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=40.9799554565702, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=40.1766004415011, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=37.9690949227373, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=38.4615384615385, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=38.4615384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=38.4615384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=38.4615384615385, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI156104880, Length=361, Percent_Identity=30.7479224376731, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=62.962962962963, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=36.1607142857143, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=481, Percent_Identity=37.8378378378378, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=39.5784543325527, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17560440, Length=276, Percent_Identity=33.3333333333333, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=41.1157024793388, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.344262295082, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.4628099173554, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.1812865497076, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=41.1764705882353, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=39.5876288659794, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=39.5876288659794, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=40.4063205417607, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51412; Mature: 51412

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVIQKALTFDDVLLVPAHSTVLPRDVSLQTQLTRRIRINIPLVSAAMDTVTEARLAIAL
CCHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEEEEECEEHHHHHHHHHHHHEEEEE
AQEGGLGIVHKNLTPKQQAAEVSKVKRFESGVLKDPITIPPTMSVREVVALTRQHRFSGL
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVLEGKKVVGIVTNRDLRFETNLDQPVSAIMTPQSRLVTVKEGGSLEDARALMHKHRLER
CEECCCEEEEEEECCCEEEECCCCCCHHHHCCCCHHEEEEECCCCHHHHHHHHHHHHCCE
VLVLNDEGELRGLITVKDMMKSTEHPLAAKDELGRLRVGAAIGVGAGTEERAELLADAGV
EEEECCCCCEEEEEEHHHHHHHCCCCCCCHHCCCCEEECEEEECCCCCHHHHHHHHHCCC
DVLVVDTAHGHSQGVLDRVNWVKKNFPNVEVIGGNIATGDAARALADSGADAVKVGIGPG
CEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHCCCCCEEEEECCCC
SICTTRIIAGVGVPQITAVDNVATALAGTGVPLIADGGIRFSGDIAKALAAGANAVMLGG
HHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCCEEEEEE
LFAGTEESPGETVLYQGRSYKSYRGMGSLGAMQQGAADRYFQDSSANVDKLVPEGIEGRV
EEECCCCCCCCEEEECCCCCCHHCCCCCCCHHHCCCCHHCCCCCCCCHHHHCCCCCCCCC
PYKGAVTAVIHQLIGGVRASMGYLGCESIGAMHERAQFVEITSAGVRESHVHDVQITKEA
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRVIQKALTFDDVLLVPAHSTVLPRDVSLQTQLTRRIRINIPLVSAAMDTVTEARLAIAL
CCHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEEEEECEEHHHHHHHHHHHHEEEEE
AQEGGLGIVHKNLTPKQQAAEVSKVKRFESGVLKDPITIPPTMSVREVVALTRQHRFSGL
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVLEGKKVVGIVTNRDLRFETNLDQPVSAIMTPQSRLVTVKEGGSLEDARALMHKHRLER
CEECCCEEEEEEECCCEEEECCCCCCHHHHCCCCHHEEEEECCCCHHHHHHHHHHHHCCE
VLVLNDEGELRGLITVKDMMKSTEHPLAAKDELGRLRVGAAIGVGAGTEERAELLADAGV
EEEECCCCCEEEEEEHHHHHHHCCCCCCCHHCCCCEEECEEEECCCCCHHHHHHHHHCCC
DVLVVDTAHGHSQGVLDRVNWVKKNFPNVEVIGGNIATGDAARALADSGADAVKVGIGPG
CEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHCCCCCEEEEECCCC
SICTTRIIAGVGVPQITAVDNVATALAGTGVPLIADGGIRFSGDIAKALAAGANAVMLGG
HHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCCEEEEEE
LFAGTEESPGETVLYQGRSYKSYRGMGSLGAMQQGAADRYFQDSSANVDKLVPEGIEGRV
EEECCCCCCCCEEEECCCCCCHHCCCCCCCHHHCCCCHHCCCCCCCCHHHHCCCCCCCCC
PYKGAVTAVIHQLIGGVRASMGYLGCESIGAMHERAQFVEITSAGVRESHVHDVQITKEA
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA