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The map label for this gene is fabI1 [H]

Identifier: 119897860

GI number: 119897860

Start: 1726037

End: 1726828

Strand: Reverse

Name: fabI1 [H]

Synonym: azo1569

Alternate gene names: 119897860

Gene position: 1726828-1726037 (Counterclockwise)

Preceding gene: 119897866

Following gene: 119897858

Centisome position: 39.46

GC content: 64.02

Gene sequence:

>792_bases
ATGGGCTTTCTCGCCGGCAAACGCATCCTCATCACCGGTCTGCTCAGCAATCGCTCGATTGCCTACGGCATTGCCAAAGC
CATGCATCGCGAAGGCGCGCAACTCGCGTTCACCTACCAGAACGAGCGGTTCCAGGAGCGCGTGGCGAAGATGGCCGCGG
ACTTCGACAGCGACATGCTGTACGCCTGTGACGTTCAGAACGACGCCGAGATCAACGCCCTTTTCGAGCAGCTCGCCCAG
AAATGGGATGGCCTCGACGGTCTGGTGCACTCCATCGCTTTCGCGCCGAGCGACGCGCTCGAAGGCGACTTCCTCGACGG
TTTCTCGCGTGAAGCGTTCCGCATCTCGCAGGAAGTCAGCGCCTACAGTTTCCCGGCGCTGGCCAAGGCCGCCCGCCCGC
TGATGAAGGGCCGCAATGGCGCGCTGCTGACGCTGTCGTATCTCGGCGCGGTGCGCACCATGCCCAACTACAACATCATG
GGCCTGGCCAAGGCCAGCCTCGAAGCCTCGGTGCGCTACATGGCCGTTTGCGTGGGCCCCGAAGGCACCCGCGTCAACGC
GATCTCGGCGGGTCCGATCAAGACCCTGGCGGCCTCGGGCATCGGCAGCTTCGGCAAGCTACTGGCGTTCAACGAGCGCA
ATGCGCCGCTGCGCCGTAACGTCACCATCGACGAAGTCGGCAACGCCGCCGCGTTCATGTGCTCCGATCTGGCCAGCGGC
ATCACCGGCGAAGTCATGTACGTCGATGCCGGATTCAACACCACCGCGCTCGGCAACTCCGAACAGGTCTGA

Upstream 100 bases:

>100_bases
CGCACAGACCACCGGGCGCGCGCAGGGCGGCCGCCAACAACCCTAAGCAGAGGGCAGTTTTGGCTATAATCCTTGGCTCT
GTCATTCGGAGCTGTACTAC

Downstream 100 bases:

>100_bases
ACCCGACGCGCGCGGCACACCGCCGCCGCATGAAAAAACGCCCGGCTTGGACCGGGCGTTTTTCTTTTTGCCACTGTCCG
CTATTCGCGCGGCGGGGCGG

Product: enoyl-acyl carrier protein reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MGFLAGKRILITGLLSNRSIAYGIAKAMHREGAQLAFTYQNERFQERVAKMAADFDSDMLYACDVQNDAEINALFEQLAQ
KWDGLDGLVHSIAFAPSDALEGDFLDGFSREAFRISQEVSAYSFPALAKAARPLMKGRNGALLTLSYLGAVRTMPNYNIM
GLAKASLEASVRYMAVCVGPEGTRVNAISAGPIKTLAASGIGSFGKLLAFNERNAPLRRNVTIDEVGNAAAFMCSDLASG
ITGEVMYVDAGFNTTALGNSEQV

Sequences:

>Translated_263_residues
MGFLAGKRILITGLLSNRSIAYGIAKAMHREGAQLAFTYQNERFQERVAKMAADFDSDMLYACDVQNDAEINALFEQLAQ
KWDGLDGLVHSIAFAPSDALEGDFLDGFSREAFRISQEVSAYSFPALAKAARPLMKGRNGALLTLSYLGAVRTMPNYNIM
GLAKASLEASVRYMAVCVGPEGTRVNAISAGPIKTLAASGIGSFGKLLAFNERNAPLRRNVTIDEVGNAAAFMCSDLASG
ITGEVMYVDAGFNTTALGNSEQV
>Mature_262_residues
GFLAGKRILITGLLSNRSIAYGIAKAMHREGAQLAFTYQNERFQERVAKMAADFDSDMLYACDVQNDAEINALFEQLAQK
WDGLDGLVHSIAFAPSDALEGDFLDGFSREAFRISQEVSAYSFPALAKAARPLMKGRNGALLTLSYLGAVRTMPNYNIMG
LAKASLEASVRYMAVCVGPEGTRVNAISAGPIKTLAASGIGSFGKLLAFNERNAPLRRNVTIDEVGNAAAFMCSDLASGI
TGEVMYVDAGFNTTALGNSEQV

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=24.5136186770428, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=26.4367816091954, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787545, Length=261, Percent_Identity=60.1532567049808, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=27.7992277992278, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787905, Length=193, Percent_Identity=28.4974093264249, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=26.5384615384615, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644337, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28160; Mature: 28029

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLAGKRILITGLLSNRSIAYGIAKAMHREGAQLAFTYQNERFQERVAKMAADFDSDML
CCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEE
YACDVQNDAEINALFEQLAQKWDGLDGLVHSIAFAPSDALEGDFLDGFSREAFRISQEVS
EEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHH
AYSFPALAKAARPLMKGRNGALLTLSYLGAVRTMPNYNIMGLAKASLEASVRYMAVCVGP
HHCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEEHHHHHCCEEEEEEEECC
EGTRVNAISAGPIKTLAASGIGSFGKLLAFNERNAPLRRNVTIDEVGNAAAFMCSDLASG
CCCEEEEEECCCHHHHHHHCCCCHHHEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHCC
ITGEVMYVDAGFNTTALGNSEQV
CCCEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure 
GFLAGKRILITGLLSNRSIAYGIAKAMHREGAQLAFTYQNERFQERVAKMAADFDSDML
CCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEE
YACDVQNDAEINALFEQLAQKWDGLDGLVHSIAFAPSDALEGDFLDGFSREAFRISQEVS
EEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHH
AYSFPALAKAARPLMKGRNGALLTLSYLGAVRTMPNYNIMGLAKASLEASVRYMAVCVGP
HHCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEEHHHHHCCEEEEEEEECC
EGTRVNAISAGPIKTLAASGIGSFGKLLAFNERNAPLRRNVTIDEVGNAAAFMCSDLASG
CCCEEEEEECCCHHHHHHHCCCCHHHEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHCC
ITGEVMYVDAGFNTTALGNSEQV
CCCEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]