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The map label for this gene is nuoH

Identifier: 119897694

GI number: 119897694

Start: 1531887

End: 1532936

Strand: Direct

Name: nuoH

Synonym: azo1403

Alternate gene names: 119897694

Gene position: 1531887-1532936 (Clockwise)

Preceding gene: 119897693

Following gene: 119897695

Centisome position: 35.01

GC content: 61.71

Gene sequence:

>1050_bases
ATGGAAGGTTTCCTCCAACCCGTCGCCGATTTGTTCGGTCCGTCGTGGCCGGTGGTCTGGACGCTGCTGAAGATCGTCGC
GATCGTTGCGCCGCTGATGGGCTGCGTTGCCTACCTGACGCTCGCCGAGCGCAAAGTCATCGGCTACATGCAGGTCCGTA
TCGGCCCCAATCGCGTCGGCCCCTTCGGGCTGTTGCAACCGATCGCAGACGGCGTGAAGTTGCTGCTCAAGGAAATCATC
TTCCCGAGCAGCGCAAGCAAGGGGCTCTTCATCGTCGGTCCTATTCTCGCGCTGGCGCCGTCGCTCGTGGCGTGGGCGGT
GGTGCCCTTCGATGACGGTCTGGTGCTCGCCAACGTCAACGCCGGCCTGCTGTTCCTGCTGGCCGTGACCTCGATGGAGG
TCTATGGCGTGATCGTCGCCGGCTGGGCGTCCAACTCCAAGTACCCGTTCATCGGTGCGATGCGCGCTGCCGCGCAGATG
GTGTCGTATGAGGTGTCGATGGGTTTCGCGCTGATATGCGTGCTGCTGATTTCGTCGAGCCTGAACCTGTCCGAGATCGT
GAACTCGCAAGGCAGCGGTCGCTTCCACGACATGGGTCTGTCCTTCCTGTCGTGGAACTGGTTGCCGCTGCTGCCGATGT
TTGTGGTGTATCTGATTTCCGGCATCGCCGAGACCAATCGCGCACCGTTCGACGTGGTGGAAGGCGAGGCCGAGATCGTC
GCGGGCCACATGGTCGAATACTCGGGGATGGCGTTCGCGCTGTTCTTCCTCGCCGAGTACGCGAACATGATCCTGGTTTC
GATCCTGACCTCGGTGCTGTTCCTCGGCGGTTGGCTGTCTCCGGTCGGGTTCCTGCCGGATGGATTTCACTGGCTGGCGC
TGAAGACCGCGAGCATTCTTTTCATCTTCCTGTGGGCGCGTGCGACGTTCCCGCGTTTCCGCTACGACCACATCATGCGG
TTGGGCTGGAAGGTGTTCATTCCGGTCACCCTGGTCTGGGTGGTCGTGGTCGCGGTGTGGTTGATGTCGCCGCTGTCGAT
CTGGAAGTAA

Upstream 100 bases:

>100_bases
ATAACGCCGTTGCCGCGGGCTGCGTCCGCGTTGCAGCGGCCCATGTGACGACGGCGGCCCTGGGGCCGCTGAGTGGCACG
ATCACCCTGGAGCGCGTCTG

Downstream 100 bases:

>100_bases
GAGGCTGAACATGGGTGCCAAGGATTACATCGGTAGTCTGTTCCTGAAGGAACTCGTGAAGGGCATGGCCCTGACGGGTC
GCCATTTCTTCGCGCGCAAG

Product: putative NADH-ubiquinone oxidoreductase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MEGFLQPVADLFGPSWPVVWTLLKIVAIVAPLMGCVAYLTLAERKVIGYMQVRIGPNRVGPFGLLQPIADGVKLLLKEII
FPSSASKGLFIVGPILALAPSLVAWAVVPFDDGLVLANVNAGLLFLLAVTSMEVYGVIVAGWASNSKYPFIGAMRAAAQM
VSYEVSMGFALICVLLISSSLNLSEIVNSQGSGRFHDMGLSFLSWNWLPLLPMFVVYLISGIAETNRAPFDVVEGEAEIV
AGHMVEYSGMAFALFFLAEYANMILVSILTSVLFLGGWLSPVGFLPDGFHWLALKTASILFIFLWARATFPRFRYDHIMR
LGWKVFIPVTLVWVVVVAVWLMSPLSIWK

Sequences:

>Translated_349_residues
MEGFLQPVADLFGPSWPVVWTLLKIVAIVAPLMGCVAYLTLAERKVIGYMQVRIGPNRVGPFGLLQPIADGVKLLLKEII
FPSSASKGLFIVGPILALAPSLVAWAVVPFDDGLVLANVNAGLLFLLAVTSMEVYGVIVAGWASNSKYPFIGAMRAAAQM
VSYEVSMGFALICVLLISSSLNLSEIVNSQGSGRFHDMGLSFLSWNWLPLLPMFVVYLISGIAETNRAPFDVVEGEAEIV
AGHMVEYSGMAFALFFLAEYANMILVSILTSVLFLGGWLSPVGFLPDGFHWLALKTASILFIFLWARATFPRFRYDHIMR
LGWKVFIPVTLVWVVVVAVWLMSPLSIWK
>Mature_349_residues
MEGFLQPVADLFGPSWPVVWTLLKIVAIVAPLMGCVAYLTLAERKVIGYMQVRIGPNRVGPFGLLQPIADGVKLLLKEII
FPSSASKGLFIVGPILALAPSLVAWAVVPFDDGLVLANVNAGLLFLLAVTSMEVYGVIVAGWASNSKYPFIGAMRAAAQM
VSYEVSMGFALICVLLISSSLNLSEIVNSQGSGRFHDMGLSFLSWNWLPLLPMFVVYLISGIAETNRAPFDVVEGEAEIV
AGHMVEYSGMAFALFFLAEYANMILVSILTSVLFLGGWLSPVGFLPDGFHWLALKTASILFIFLWARATFPRFRYDHIMR
LGWKVFIPVTLVWVVVVAVWLMSPLSIWK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=298, Percent_Identity=44.2953020134228, Blast_Score=251, Evalue=9e-67,
Organism=Escherichia coli, GI1788618, Length=318, Percent_Identity=42.1383647798742, Blast_Score=254, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_AZOSB (A1K5B5)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932907.1
- STRING:   A1K5B5
- GeneID:   4609425
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1403
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   A1K5B5
- ProtClustDB:   CLSK766888
- BioCyc:   ASP62928:AZO1403-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38239; Mature: 38239

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ac78980)-; HASH(0x1ad2c1ec)-; HASH(0x1ba8ee24)-; HASH(0x1b65650c)-; HASH(0x19316d44)-; HASH(0x1a9889c4)-; HASH(0x1b959320)-; HASH(0x1ba91280)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGFLQPVADLFGPSWPVVWTLLKIVAIVAPLMGCVAYLTLAERKVIGYMQVRIGPNRVG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCC
PFGLLQPIADGVKLLLKEIIFPSSASKGLFIVGPILALAPSLVAWAVVPFDDGLVLANVN
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHEEEEECCCCEEEEECC
AGLLFLLAVTSMEVYGVIVAGWASNSKYPFIGAMRAAAQMVSYEVSMGFALICVLLISSS
HHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LNLSEIVNSQGSGRFHDMGLSFLSWNWLPLLPMFVVYLISGIAETNRAPFDVVEGEAEIV
CCHHHHHCCCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHH
AGHMVEYSGMAFALFFLAEYANMILVSILTSVLFLGGWLSPVGFLPDGFHWLALKTASIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FIFLWARATFPRFRYDHIMRLGWKVFIPVTLVWVVVVAVWLMSPLSIWK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCH
>Mature Secondary Structure
MEGFLQPVADLFGPSWPVVWTLLKIVAIVAPLMGCVAYLTLAERKVIGYMQVRIGPNRVG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCC
PFGLLQPIADGVKLLLKEIIFPSSASKGLFIVGPILALAPSLVAWAVVPFDDGLVLANVN
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHEEEEECCCCEEEEECC
AGLLFLLAVTSMEVYGVIVAGWASNSKYPFIGAMRAAAQMVSYEVSMGFALICVLLISSS
HHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LNLSEIVNSQGSGRFHDMGLSFLSWNWLPLLPMFVVYLISGIAETNRAPFDVVEGEAEIV
CCHHHHHCCCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHH
AGHMVEYSGMAFALFFLAEYANMILVSILTSVLFLGGWLSPVGFLPDGFHWLALKTASIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FIFLWARATFPRFRYDHIMRLGWKVFIPVTLVWVVVVAVWLMSPLSIWK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA