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The map label for this gene is folP [H]

Identifier: 119897679

GI number: 119897679

Start: 1517394

End: 1518215

Strand: Direct

Name: folP [H]

Synonym: azo1388

Alternate gene names: 119897679

Gene position: 1517394-1518215 (Clockwise)

Preceding gene: 119897678

Following gene: 119897680

Centisome position: 34.68

GC content: 64.48

Gene sequence:

>822_bases
ATGCCGAATTTCGTATGCGGTCGGTTTGAACTCGATCTGACGCAGCCACGCATCATGGCCATCATCAACGTGACCGATGA
TTCATTCTCGGGTGATGGCTTGAGAGGAAATCTGGACGGGGCCTTGAATAAGGCGGAGCGTGCCCTGGCCGAAGGGGCGG
ATATCCTCGATCTCGGCGCGGAGTCCACCCGTCCGGGCAGTGATCCGGTACCCGAGCAGCAGGAGATCGACCGGCTGGTA
CCGCTTATCGAGGCCTTGCAGGGCTGCGGTGTGCCGCTATCGGTGGATACGCTGAAGCCTTCGGTGATGCGCGCCGCGCT
TGCGGCAGGTGCGGACCTGATCAACGACGTCAACGGATTCCGGGCGGAAGGCGCGGTCGAGGCTGTCGCGGCCGGCACAG
CGGGGCTCTGCGTGATGCACATGCAGGGCGAACCGCGGACGATGCAGCAGGCGCCCCAGTACGCCAATGTCGTCGATGAG
GTCGGCGCCTTTCTGGTTCGGCGAACGGAAGTGCTCCTGCGGGCAGGAGTCCGCCGCGAGCGGGTGTTGCTGGATCCCGG
ATTCGGTTTCGGCAAGAGCACCGAGCACAACCTGGCCCTGGTTCGCGGACTCGGGGCGCTGCGTGATCTCGGCTACCCGT
TGTTGGTGGGTTTGTCGCGCAAGAGTCTGTTGGGCGCGATTACCGGCAAGCCGGTGGAGGCGCGTGGTCCGGCCAGTGTG
GCTGCGGCGCTGATGGCGGTTCAGTACGGTGCCGCGATCGTTCGTGTGCACGATGTGGCGCCGACCCGCGATGCACTCGC
GGTGTGGCAAGCAATGTCATAA

Upstream 100 bases:

>100_bases
CCCGGGGCCGCGCCGACGGCGGCTGCTCCTGCAGCCTGACAGCGGGATCACAGTCTTCTTCCGGGCCGGTGAAAACCGGC
CTTTTCTTTTGCAGGGAAAA

Downstream 100 bases:

>100_bases
TCCGCGCTTCTAAAAACGCGGATTGGGGGCGGCATGGCGCGGAAGTACTTCGGGACCGACGGGGTCCGTGGACGGGTTGG
CGAGTTGCCCATCACGCCCG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MPNFVCGRFELDLTQPRIMAIINVTDDSFSGDGLRGNLDGALNKAERALAEGADILDLGAESTRPGSDPVPEQQEIDRLV
PLIEALQGCGVPLSVDTLKPSVMRAALAAGADLINDVNGFRAEGAVEAVAAGTAGLCVMHMQGEPRTMQQAPQYANVVDE
VGAFLVRRTEVLLRAGVRRERVLLDPGFGFGKSTEHNLALVRGLGALRDLGYPLLVGLSRKSLLGAITGKPVEARGPASV
AAALMAVQYGAAIVRVHDVAPTRDALAVWQAMS

Sequences:

>Translated_273_residues
MPNFVCGRFELDLTQPRIMAIINVTDDSFSGDGLRGNLDGALNKAERALAEGADILDLGAESTRPGSDPVPEQQEIDRLV
PLIEALQGCGVPLSVDTLKPSVMRAALAAGADLINDVNGFRAEGAVEAVAAGTAGLCVMHMQGEPRTMQQAPQYANVVDE
VGAFLVRRTEVLLRAGVRRERVLLDPGFGFGKSTEHNLALVRGLGALRDLGYPLLVGLSRKSLLGAITGKPVEARGPASV
AAALMAVQYGAAIVRVHDVAPTRDALAVWQAMS
>Mature_272_residues
PNFVCGRFELDLTQPRIMAIINVTDDSFSGDGLRGNLDGALNKAERALAEGADILDLGAESTRPGSDPVPEQQEIDRLVP
LIEALQGCGVPLSVDTLKPSVMRAALAAGADLINDVNGFRAEGAVEAVAAGTAGLCVMHMQGEPRTMQQAPQYANVVDEV
GAFLVRRTEVLLRAGVRRERVLLDPGFGFGKSTEHNLALVRGLGALRDLGYPLLVGLSRKSLLGAITGKPVEARGPASVA
AALMAVQYGAAIVRVHDVAPTRDALAVWQAMS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=43.5114503816794, Blast_Score=223, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6324073, Length=302, Percent_Identity=31.1258278145695, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28713; Mature: 28582

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNFVCGRFELDLTQPRIMAIINVTDDSFSGDGLRGNLDGALNKAERALAEGADILDLGA
CCCCEECEEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
ESTRPGSDPVPEQQEIDRLVPLIEALQGCGVPLSVDTLKPSVMRAALAAGADLINDVNGF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHCCHHHHHHHHHHHHHHHHHCCCC
RAEGAVEAVAAGTAGLCVMHMQGEPRTMQQAPQYANVVDEVGAFLVRRTEVLLRAGVRRE
CCCCHHHHHHCCCCCEEEEEECCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RVLLDPGFGFGKSTEHNLALVRGLGALRDLGYPLLVGLSRKSLLGAITGKPVEARGPASV
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCCCCCHHHH
AAALMAVQYGAAIVRVHDVAPTRDALAVWQAMS
HHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PNFVCGRFELDLTQPRIMAIINVTDDSFSGDGLRGNLDGALNKAERALAEGADILDLGA
CCCEECEEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
ESTRPGSDPVPEQQEIDRLVPLIEALQGCGVPLSVDTLKPSVMRAALAAGADLINDVNGF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHCCHHHHHHHHHHHHHHHHHCCCC
RAEGAVEAVAAGTAGLCVMHMQGEPRTMQQAPQYANVVDEVGAFLVRRTEVLLRAGVRRE
CCCCHHHHHHCCCCCEEEEEECCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RVLLDPGFGFGKSTEHNLALVRGLGALRDLGYPLLVGLSRKSLLGAITGKPVEARGPASV
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCCCCCHHHH
AAALMAVQYGAAIVRVHDVAPTRDALAVWQAMS
HHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]