Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 119897525

GI number: 119897525

Start: 1327954

End: 1329348

Strand: Direct

Name: atoC [H]

Synonym: azo1234

Alternate gene names: 119897525

Gene position: 1327954-1329348 (Clockwise)

Preceding gene: 119897520

Following gene: 119897526

Centisome position: 30.35

GC content: 72.47

Gene sequence:

>1395_bases
ATGGCGTCGATTCCGCCATGGATGGCAGTCATGTGCCCTGATGCCCGCTCGCTCCCCGAACTGGTCTCCTTCCTCGAAAC
GCTGCCCGAGCCGCACATCCTGTGCGACCGCGACTACCGCATCGTCGCCGCCAATGCGGCCTACCGCGCGTCGTGCGCGG
GCGGCGGCGAGGTGATCGGGCGCACCTGCTACGAGGTCTCGCACCGTTACAGCGTGCCCTGCGACCGCGCCGGCGAGTCC
TGCCCGCTCGCGCGCAGCCTCGCGTCCGGCCAGCGCGAGCGCGTGCTGCATCTGCACCACACGCCGCGCGGCGAGGACTA
CGTGAACATCGAGCTGTCGCCACTGCGCGACGCCAGCGGCGAGATCGCGTGGTTCATCGAGAAGATGGAGCCGCTGGCGG
TGGCGCGCGGCGAGGCCGGCGGCCACGGCCTGATCGGCCGCGCGCCGGCCTTCCAGCGCATGCTGGAACTGGTGATGCGG
GTCGCGCCGGCCGAGGCCAGCGTGCTGCTGCAGGGCGAATCCGGCACCGGCAAGGAACTGGTGGCGGCCGCGGTGCACCG
CGCCAGCCGCCGCGCCGAACGCCCCTTCGTGGTGGTGGATTGCTCCGGCCTGCCCGAAACCCTGTTCGAAAGCGAACTCT
TCGGCCACGAGCGCGGCGCCTTCACCGGCGCGGTGTCGCGCAAGCCGGGGCTGGTGGAGGCCGCCGCCGGCGGCACGCTG
TTCCTCGACGAGGTCGGCGACATTCCGCTCGGCATGCAGGTGAAGCTGCTGCGGCTGCTGGAAACCGGCACCTACCGGCG
GGTGGGCGCCACCGAGCTGCGGCGCGCCGACGTGCGCCTGGTATCGGCCACCCACCGCCCGCTGCAACGCATGGTGCGCG
AGGGCGCCTTCCGCCAGGACCTCTACTTCCGCATCAACACCTTCCCGATCACCGTGCCGGCGCTGCGCGAACGGGTCGAA
GACCTGCCGCTGCTGGTCGATTCACTGCTGGAGCGGGTTGCGCCGCGCCGCGGGCTGACGGTGTCGGCGGCGGCGATGCG
GGTACTGGCGGCCTATCCCTTTCCCGGCAACGTGCGCGAGCTGCGCAACGTGCTCGAGCGCGCTAGCCTGATGTGCGACG
GCGAGGTGATCGGGCCTGCGCATCTCGCCGAGGAAGTGCGCGCGCCGGGCGGCCCGGCGGTGGACGATGACGCCCTGCTG
GCGCCCGCCGCCGAACCGCCGCTGGATCTGGCCGAAGTGCAGCGCCAGACCCTGCTGCGTGCCGCCCGCAGCCACCGCGG
CAGCCGCCGCGAACTCGCGCGCAAGCTCGGGTTGAGCGAGCGCACGCTGTACCGGCGCCTGCGCGCCTTGTCGGCAGACG
AGGATTCGGCGCTGCCGGAGCAGGACAGCGACTGA

Upstream 100 bases:

>100_bases
GCCACGCCGGGCCGCGCGGGGAAAGTCCCGCTTATTCCGTTGGTTATACCCCGCAGCGGCTGCGGCGATTGACGCCGGTG
CTGCCAAAGCGGCAGAGTAT

Downstream 100 bases:

>100_bases
CATCGCTGGCAGACATGGCAGCACCTGTCACCCGGCGGCGCGCCGCAATCCCGGGCGGGGGCTGACGAGGCCCGATGGCA
CGCGGCTTGCCATCCTGTTC

Product: transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MASIPPWMAVMCPDARSLPELVSFLETLPEPHILCDRDYRIVAANAAYRASCAGGGEVIGRTCYEVSHRYSVPCDRAGES
CPLARSLASGQRERVLHLHHTPRGEDYVNIELSPLRDASGEIAWFIEKMEPLAVARGEAGGHGLIGRAPAFQRMLELVMR
VAPAEASVLLQGESGTGKELVAAAVHRASRRAERPFVVVDCSGLPETLFESELFGHERGAFTGAVSRKPGLVEAAAGGTL
FLDEVGDIPLGMQVKLLRLLETGTYRRVGATELRRADVRLVSATHRPLQRMVREGAFRQDLYFRINTFPITVPALRERVE
DLPLLVDSLLERVAPRRGLTVSAAAMRVLAAYPFPGNVRELRNVLERASLMCDGEVIGPAHLAEEVRAPGGPAVDDDALL
APAAEPPLDLAEVQRQTLLRAARSHRGSRRELARKLGLSERTLYRRLRALSADEDSALPEQDSD

Sequences:

>Translated_464_residues
MASIPPWMAVMCPDARSLPELVSFLETLPEPHILCDRDYRIVAANAAYRASCAGGGEVIGRTCYEVSHRYSVPCDRAGES
CPLARSLASGQRERVLHLHHTPRGEDYVNIELSPLRDASGEIAWFIEKMEPLAVARGEAGGHGLIGRAPAFQRMLELVMR
VAPAEASVLLQGESGTGKELVAAAVHRASRRAERPFVVVDCSGLPETLFESELFGHERGAFTGAVSRKPGLVEAAAGGTL
FLDEVGDIPLGMQVKLLRLLETGTYRRVGATELRRADVRLVSATHRPLQRMVREGAFRQDLYFRINTFPITVPALRERVE
DLPLLVDSLLERVAPRRGLTVSAAAMRVLAAYPFPGNVRELRNVLERASLMCDGEVIGPAHLAEEVRAPGGPAVDDDALL
APAAEPPLDLAEVQRQTLLRAARSHRGSRRELARKLGLSERTLYRRLRALSADEDSALPEQDSD
>Mature_463_residues
ASIPPWMAVMCPDARSLPELVSFLETLPEPHILCDRDYRIVAANAAYRASCAGGGEVIGRTCYEVSHRYSVPCDRAGESC
PLARSLASGQRERVLHLHHTPRGEDYVNIELSPLRDASGEIAWFIEKMEPLAVARGEAGGHGLIGRAPAFQRMLELVMRV
APAEASVLLQGESGTGKELVAAAVHRASRRAERPFVVVDCSGLPETLFESELFGHERGAFTGAVSRKPGLVEAAAGGTLF
LDEVGDIPLGMQVKLLRLLETGTYRRVGATELRRADVRLVSATHRPLQRMVREGAFRQDLYFRINTFPITVPALRERVED
LPLLVDSLLERVAPRRGLTVSAAAMRVLAAYPFPGNVRELRNVLERASLMCDGEVIGPAHLAEEVRAPGGPAVDDDALLA
PAAEPPLDLAEVQRQTLLRAARSHRGSRRELARKLGLSERTLYRRLRALSADEDSALPEQDSD

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=315, Percent_Identity=45.3968253968254, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1788550, Length=326, Percent_Identity=40.7975460122699, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1789233, Length=368, Percent_Identity=36.9565217391304, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=41.1214953271028, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1788905, Length=257, Percent_Identity=47.0817120622568, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1790299, Length=329, Percent_Identity=41.3373860182371, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=39.2523364485981, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87082152, Length=231, Percent_Identity=47.6190476190476, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786524, Length=325, Percent_Identity=37.5384615384615, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081872, Length=323, Percent_Identity=38.6996904024768, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787583, Length=310, Percent_Identity=35.8064516129032, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789828, Length=247, Percent_Identity=36.8421052631579, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081858, Length=308, Percent_Identity=30.5194805194805, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50712; Mature: 50581

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIPPWMAVMCPDARSLPELVSFLETLPEPHILCDRDYRIVAANAAYRASCAGGGEVIG
CCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCHHHHH
RTCYEVSHRYSVPCDRAGESCPLARSLASGQRERVLHLHHTPRGEDYVNIELSPLRDASG
HHHHHHHHCCCCCHHCCCCCCCHHHHHHCCCHHCEEEEECCCCCCCEEEEEECCCCCCCC
EIAWFIEKMEPLAVARGEAGGHGLIGRAPAFQRMLELVMRVAPAEASVLLQGESGTGKEL
CEEEHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
VAAAVHRASRRAERPFVVVDCSGLPETLFESELFGHERGAFTGAVSRKPGLVEAAAGGTL
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEE
FLDEVGDIPLGMQVKLLRLLETGTYRRVGATELRRADVRLVSATHRPLQRMVREGAFRQD
EEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LYFRINTFPITVPALRERVEDLPLLVDSLLERVAPRRGLTVSAAAMRVLAAYPFPGNVRE
EEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHH
LRNVLERASLMCDGEVIGPAHLAEEVRAPGGPAVDDDALLAPAAEPPLDLAEVQRQTLLR
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHH
AARSHRGSRRELARKLGLSERTLYRRLRALSADEDSALPEQDSD
HHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASIPPWMAVMCPDARSLPELVSFLETLPEPHILCDRDYRIVAANAAYRASCAGGGEVIG
CCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCHHHHH
RTCYEVSHRYSVPCDRAGESCPLARSLASGQRERVLHLHHTPRGEDYVNIELSPLRDASG
HHHHHHHHCCCCCHHCCCCCCCHHHHHHCCCHHCEEEEECCCCCCCEEEEEECCCCCCCC
EIAWFIEKMEPLAVARGEAGGHGLIGRAPAFQRMLELVMRVAPAEASVLLQGESGTGKEL
CEEEHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
VAAAVHRASRRAERPFVVVDCSGLPETLFESELFGHERGAFTGAVSRKPGLVEAAAGGTL
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEE
FLDEVGDIPLGMQVKLLRLLETGTYRRVGATELRRADVRLVSATHRPLQRMVREGAFRQD
EEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LYFRINTFPITVPALRERVEDLPLLVDSLLERVAPRRGLTVSAAAMRVLAAYPFPGNVRE
EEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHH
LRNVLERASLMCDGEVIGPAHLAEEVRAPGGPAVDDDALLAPAAEPPLDLAEVQRQTLLR
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHH
AARSHRGSRRELARKLGLSERTLYRRLRALSADEDSALPEQDSD
HHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]