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The map label for this gene is lldR [H]

Identifier: 119897461

GI number: 119897461

Start: 1262710

End: 1263492

Strand: Direct

Name: lldR [H]

Synonym: azo1170

Alternate gene names: 119897461

Gene position: 1262710-1263492 (Clockwise)

Preceding gene: 119897455

Following gene: 119897462

Centisome position: 28.86

GC content: 66.92

Gene sequence:

>783_bases
ATGGCCACCGGCAAACTCGTCGTGCAGCGACTTTCCGACACCATCGCCCACGAACTCGAACGCCGCATCCTCGACGGCGT
GCTCAAGCCCGGCGACCGCCTGCAGCCGGAACGCGAACTGGCAGCGGAACTCGGCGTCTCCCGCCCGTCGCTGCGCGAAG
CCATCCAGAAACTCGTCTCCAAGGGCCTGCTGCACAGCCGGCAAGGCGGCGGCACCTACGTCACCGACCAGCTCGAAGCC
GGCTTCACCGACCCCTGGCACGAGATGCTGCGCCAGCACCCCAACATCCAGGACGACCTGCTGGAATTCCGCGGCATGCT
CGAAAAGGAAGCCGCCATCCTTGCCGCCCAACGCGCCACCGCCGCCGACCTGCAGCGCATCGGCGAGGCCTATGCCCGCG
TGGATGCACTATTCGACCAGGGCACCTCGCCCGCGGTGCTGGAACAGCAGGTCAAGGCCGACCTCGCCTTCCACCAGACC
ATCGCCGAAGCCGCCCACAACGTGATGATCGGCCACCTCACCGCCAGCCTGCTGAAAGTCATCAACGACCACATCGACCG
TAACCTGCGCCACCTGCGCCGCAGCGAAGACGACTGGGCCCACCTGCGCGAACAGCACCGCGCCGTGTGGGAAGCCATTC
GCGATGCCGATCCTGTAGCGGCTGCAAGGGCCGTGCAGGGGCATATCGAATTCGTGCACGAAAGCATGAAGGCGCGGGCG
CGCCAGGAAGAAAGGGAAAACCGCGCGAGGGCGCGGCAGTCGGGGGCGGAAGCGGAAGGGTGA

Upstream 100 bases:

>100_bases
CAAACCCCGGGAAAACCTCTAGCCCGCCCGGTGTTTTGCCTTGAGACGCATCAAAGCCGAAAGTAAAATTTTGGTCAGAC
CAATTCAGGGGTGCCCCGTC

Downstream 100 bases:

>100_bases
GGTTTCCGCTGCCCGCTTCATTCACCCGGCAATCGAAAGCGCGGCCCAGTCCGCCAGGACAATTACCCCGCTCCGTTCGC
TCTCAGCCTGCTGAAGGCCA

Product: L-lactate dehydrogenase operon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MATGKLVVQRLSDTIAHELERRILDGVLKPGDRLQPERELAAELGVSRPSLREAIQKLVSKGLLHSRQGGGTYVTDQLEA
GFTDPWHEMLRQHPNIQDDLLEFRGMLEKEAAILAAQRATAADLQRIGEAYARVDALFDQGTSPAVLEQQVKADLAFHQT
IAEAAHNVMIGHLTASLLKVINDHIDRNLRHLRRSEDDWAHLREQHRAVWEAIRDADPVAAARAVQGHIEFVHESMKARA
RQEERENRARARQSGAEAEG

Sequences:

>Translated_260_residues
MATGKLVVQRLSDTIAHELERRILDGVLKPGDRLQPERELAAELGVSRPSLREAIQKLVSKGLLHSRQGGGTYVTDQLEA
GFTDPWHEMLRQHPNIQDDLLEFRGMLEKEAAILAAQRATAADLQRIGEAYARVDALFDQGTSPAVLEQQVKADLAFHQT
IAEAAHNVMIGHLTASLLKVINDHIDRNLRHLRRSEDDWAHLREQHRAVWEAIRDADPVAAARAVQGHIEFVHESMKARA
RQEERENRARARQSGAEAEG
>Mature_259_residues
ATGKLVVQRLSDTIAHELERRILDGVLKPGDRLQPERELAAELGVSRPSLREAIQKLVSKGLLHSRQGGGTYVTDQLEAG
FTDPWHEMLRQHPNIQDDLLEFRGMLEKEAAILAAQRATAADLQRIGEAYARVDALFDQGTSPAVLEQQVKADLAFHQTI
AEAAHNVMIGHLTASLLKVINDHIDRNLRHLRRSEDDWAHLREQHRAVWEAIRDADPVAAARAVQGHIEFVHESMKARAR
QEERENRARARQSGAEAEG

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=237, Percent_Identity=41.3502109704641, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1790032, Length=236, Percent_Identity=34.7457627118644, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789353, Length=226, Percent_Identity=29.646017699115, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994961, Length=223, Percent_Identity=29.5964125560538, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790780, Length=156, Percent_Identity=35.2564102564103, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI48994955, Length=222, Percent_Identity=26.1261261261261, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI87082208, Length=243, Percent_Identity=26.7489711934156, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29141; Mature: 29010

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGKLVVQRLSDTIAHELERRILDGVLKPGDRLQPERELAAELGVSRPSLREAIQKLVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KGLLHSRQGGGTYVTDQLEAGFTDPWHEMLRQHPNIQDDLLEFRGMLEKEAAILAAQRAT
HHHHHCCCCCCCEEHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AADLQRIGEAYARVDALFDQGTSPAVLEQQVKADLAFHQTIAEAAHNVMIGHLTASLLKV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDHIDRNLRHLRRSEDDWAHLREQHRAVWEAIRDADPVAAARAVQGHIEFVHESMKARA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RQEERENRARARQSGAEAEG
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ATGKLVVQRLSDTIAHELERRILDGVLKPGDRLQPERELAAELGVSRPSLREAIQKLVS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KGLLHSRQGGGTYVTDQLEAGFTDPWHEMLRQHPNIQDDLLEFRGMLEKEAAILAAQRAT
HHHHHCCCCCCCEEHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AADLQRIGEAYARVDALFDQGTSPAVLEQQVKADLAFHQTIAEAAHNVMIGHLTASLLKV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDHIDRNLRHLRRSEDDWAHLREQHRAVWEAIRDADPVAAARAVQGHIEFVHESMKARA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RQEERENRARARQSGAEAEG
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]