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The map label for this gene is lldA [H]

Identifier: 119897307

GI number: 119897307

Start: 1092645

End: 1093793

Strand: Direct

Name: lldA [H]

Synonym: azo1016

Alternate gene names: 119897307

Gene position: 1092645-1093793 (Clockwise)

Preceding gene: 119897306

Following gene: 119897309

Centisome position: 24.97

GC content: 66.75

Gene sequence:

>1149_bases
ATGCCCGCTGCACCCATCACCTGCATCGACGATCTGCGCCGTCTGGCGCTCAAGCGCGTGCCGCGCATGTTCTACGACTA
CGCGGATTCCGGCTCGTGGACCGAGAGCACCTACCGCGCCAACGAGGCGGACTTCCAGTCGATCAAGCTGCGTCAACGGG
TGGCGGTGAACATGGATGGGCGCACGCTGCGTACCACGATGGCCGGCCAGGAGGTCGCGATGCCGGTCGCGATCGCGCCG
ACCGGACTGACCGGGATGCAGCATGCCGACGGCGAGATCCTCGCGGCGCGCGCGGCGGAGAAGTTCGGTGTGCCCTTCAC
CTTGTCGACGATGAGCATCTGCTCGATCGAGGACGTCGCGGCCCATACCACGGCCCCGTTCTGGTTCCAGGTCTATGTGA
TGCGCGACCGCGACTTCGTCGAACGCCTGATCGATCGCGCCAAAGCGGCGAGGTGTTCGGCGCTGATGCTGACCCTGGAC
CTGCAGATCCTCGGTCAGCGCCACAAGGATCTGAAGAACGGCCTTTCGGCGCCGCCGAAGCCCACCCTGGCCAATCTGAT
CAATCTGGCGACGAAGCCGCGCTGGTGCCTCGGCATGCTGAGGACGCCGCGACGCAGCTTCGGCAACATTGTCGGCCACG
CCCGCGGCGTGGGCGACATGTCCTCACTGGCGAGCTGGACGGCGGAGCAGTTCGATCCGGGGCTGAGCTGGGCGGACGTC
GAGTGGATCAAGAAGCGCTGGGGCGGCAAGCTGATCCTGAAGGGAATCATGGATGCCGAGGACGCGCGCTTGGCCGCCGA
CAGCGGCGCAGATGCACTGGTGGTGTCCAACCACGGCGGGCGCCAGCTCGACGGCGCACCATCATCGATCCACGCCCTGC
CCGGCATCGTCGACGCCGTGGGAAAGTCCATCGAAGTGTGGATGGACGGCGGAATCCGCAGTGGACAGGATGTGTTCAAG
GCCGTGGCGATGGGCGCGCGTGGCACCCTGATCGGCCGTGCCTTCCTCTACGGCCTCGGGGCCATGGGCGAGGCGGGCGT
GGCCAAGAGCCTGGAGCTGATCCGCAAGGAGCTGGACCTGACAATGGCCTTCTGCGGCCACACCGATATCCGCAAGGTCG
ATCGGCGCGTGCTGCTGGAGCGCGCCTGA

Upstream 100 bases:

>100_bases
ACTTGTTTCTGGCGCGCCCTGAACAATATTCCGACATCGGCGCGGCGCCGGTGGCGATGATGGCGGCCATTGCCAACGCC
AACTCCGAGGACGTCCATCC

Downstream 100 bases:

>100_bases
AAAAAGAAAGCGCCGCGAATGCGGCGCTTCTTCTGCGGTGCGGGGCTTACCAGAGCTGCCACCACGGCCGGCGGTCCGGC
GGGCCGCCCGAGTAATAGAC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MPAAPITCIDDLRRLALKRVPRMFYDYADSGSWTESTYRANEADFQSIKLRQRVAVNMDGRTLRTTMAGQEVAMPVAIAP
TGLTGMQHADGEILAARAAEKFGVPFTLSTMSICSIEDVAAHTTAPFWFQVYVMRDRDFVERLIDRAKAARCSALMLTLD
LQILGQRHKDLKNGLSAPPKPTLANLINLATKPRWCLGMLRTPRRSFGNIVGHARGVGDMSSLASWTAEQFDPGLSWADV
EWIKKRWGGKLILKGIMDAEDARLAADSGADALVVSNHGGRQLDGAPSSIHALPGIVDAVGKSIEVWMDGGIRSGQDVFK
AVAMGARGTLIGRAFLYGLGAMGEAGVAKSLELIRKELDLTMAFCGHTDIRKVDRRVLLERA

Sequences:

>Translated_382_residues
MPAAPITCIDDLRRLALKRVPRMFYDYADSGSWTESTYRANEADFQSIKLRQRVAVNMDGRTLRTTMAGQEVAMPVAIAP
TGLTGMQHADGEILAARAAEKFGVPFTLSTMSICSIEDVAAHTTAPFWFQVYVMRDRDFVERLIDRAKAARCSALMLTLD
LQILGQRHKDLKNGLSAPPKPTLANLINLATKPRWCLGMLRTPRRSFGNIVGHARGVGDMSSLASWTAEQFDPGLSWADV
EWIKKRWGGKLILKGIMDAEDARLAADSGADALVVSNHGGRQLDGAPSSIHALPGIVDAVGKSIEVWMDGGIRSGQDVFK
AVAMGARGTLIGRAFLYGLGAMGEAGVAKSLELIRKELDLTMAFCGHTDIRKVDRRVLLERA
>Mature_381_residues
PAAPITCIDDLRRLALKRVPRMFYDYADSGSWTESTYRANEADFQSIKLRQRVAVNMDGRTLRTTMAGQEVAMPVAIAPT
GLTGMQHADGEILAARAAEKFGVPFTLSTMSICSIEDVAAHTTAPFWFQVYVMRDRDFVERLIDRAKAARCSALMLTLDL
QILGQRHKDLKNGLSAPPKPTLANLINLATKPRWCLGMLRTPRRSFGNIVGHARGVGDMSSLASWTAEQFDPGLSWADVE
WIKKRWGGKLILKGIMDAEDARLAADSGADALVVSNHGGRQLDGAPSSIHALPGIVDAVGKSIEVWMDGGIRSGQDVFKA
VAMGARGTLIGRAFLYGLGAMGEAGVAKSLELIRKELDLTMAFCGHTDIRKVDRRVLLERA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=374, Percent_Identity=35.5614973262032, Blast_Score=252, Evalue=3e-67,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=33.6898395721925, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=33.6898395721925, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=43.236074270557, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI193208036, Length=378, Percent_Identity=35.978835978836, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI32566217, Length=295, Percent_Identity=33.5593220338983, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=381, Percent_Identity=30.9711286089239, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI281363140, Length=387, Percent_Identity=35.4005167958656, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI78707190, Length=387, Percent_Identity=35.4005167958656, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI78707188, Length=382, Percent_Identity=35.6020942408377, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41639; Mature: 41507

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAPITCIDDLRRLALKRVPRMFYDYADSGSWTESTYRANEADFQSIKLRQRVAVNMDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHEECCCC
RTLRTTMAGQEVAMPVAIAPTGLTGMQHADGEILAARAAEKFGVPFTLSTMSICSIEDVA
CEEEHHHCCCHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCHHHHCHHHHH
AHTTAPFWFQVYVMRDRDFVERLIDRAKAARCSALMLTLDLQILGQRHKDLKNGLSAPPK
HHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PTLANLINLATKPRWCLGMLRTPRRSFGNIVGHARGVGDMSSLASWTAEQFDPGLSWADV
HHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHH
EWIKKRWGGKLILKGIMDAEDARLAADSGADALVVSNHGGRQLDGAPSSIHALPGIVDAV
HHHHHHCCCCEEEHHHCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
GKSIEVWMDGGIRSGQDVFKAVAMGARGTLIGRAFLYGLGAMGEAGVAKSLELIRKELDL
CCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TMAFCGHTDIRKVDRRVLLERA
HHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAAPITCIDDLRRLALKRVPRMFYDYADSGSWTESTYRANEADFQSIKLRQRVAVNMDG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHEECCCC
RTLRTTMAGQEVAMPVAIAPTGLTGMQHADGEILAARAAEKFGVPFTLSTMSICSIEDVA
CEEEHHHCCCHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCHHHHCHHHHH
AHTTAPFWFQVYVMRDRDFVERLIDRAKAARCSALMLTLDLQILGQRHKDLKNGLSAPPK
HHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PTLANLINLATKPRWCLGMLRTPRRSFGNIVGHARGVGDMSSLASWTAEQFDPGLSWADV
HHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHH
EWIKKRWGGKLILKGIMDAEDARLAADSGADALVVSNHGGRQLDGAPSSIHALPGIVDAV
HHHHHHCCCCEEEHHHCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
GKSIEVWMDGGIRSGQDVFKAVAMGARGTLIGRAFLYGLGAMGEAGVAKSLELIRKELDL
CCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TMAFCGHTDIRKVDRRVLLERA
HHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA