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The map label for this gene is pntB [H]

Identifier: 119897296

GI number: 119897296

Start: 1079340

End: 1080719

Strand: Direct

Name: pntB [H]

Synonym: azo1005

Alternate gene names: 119897296

Gene position: 1079340-1080719 (Clockwise)

Preceding gene: 119897295

Following gene: 119897297

Centisome position: 24.66

GC content: 66.38

Gene sequence:

>1380_bases
ATGACGGCCAAATGGTTCATCGACGCGTCCTACTTCGCGGTCGCTGTTGTCTTCATCCTCGCGCTGAAGGCGATGAGTTC
GCCGGTGACGGCGCGGCGCGGCATCGTCTGGGGCGGCATCGCCATGGTGTTCGCCACCCTGGTCACCTTCGCCACCCCCG
GGCTGCACAACTTCGGCTGGATGATCGTCGCCATCGTCAGTGGCGCCGCGGTGGCCTGGTGGAGCGGCAAGACGGTCAAG
ATGACCGACATGCCGCAGATGGTCGCCATCTACAACGGCATGGGCGGCGGCGCCGCGGCGGCGATCGCGGCGCTGGAATT
CGCCCGCGGCGAAGTGCATGGTCCGGTGGTGACCACGCTCGCAGTGCTCGGCGCGCTGATCGGCTCGGTTGCCTTCTCGG
GTTCGTGCATCGCCTTTGCCAAGCTGCAGGGCATCATGAAGAAGGCCTGGCGGCTGCCGGCGCAGAACGCGGTCAATGTG
GTGCTCGCGCTCGTCACCGTGGGCCTGGGCATCGCGATCATCGCCGCGCCGAGCATCGATCCGGTGCTGGTGATCGTGTT
CTTCGTGCTCGCGCTCATCCTCGGCGCGATCCTCACCAGCCCGATCGGCGGCGCCGACATGCCGGTGGTGATTTCGCTCC
TGAACGCCTTCACCGGTCTGGCGGTCGGCTTTGAAGGCTATGTGCTCGGCAACCCGGCGCTGATCGTGGCCGGCATCGTG
GTCGGCGCCTCGGGCACGCTGCTCACCCAGTTGATGGCGAAAGCCATGAACCGGCCGATCTCCAATGTGCTGTTCACGCC
GATCAGCGGCGCGGCCAGCGGCGGCGGCGAGGGCATCGAAGGCACGATGAAGGAGTTCTCCAGCCTCGATGCGGCCTCGG
TGATGCGCTACGCCAGCAAGGTCATCATCGTGCCGGGCTACGGCATGGCGGTGGCCGGTGCCCAGCACAAGGTGTGGGAG
ATGGCGCAGCTGCTGGAGGAAGGCGGTGTCGAGGTGGTGTTCGCGATCCACCCGGTCGCGGGCCGCATGCCGGGCCACAT
GAACGTGCTGCTGGCCGAAGCGGGCGTGCCCTACGACAAGATCTTCGACCTGGAGGAGATCAACGCCGACTTCGCGCAGG
CCGAGGTGGCGCTGGTCATCGGCGCCAACGACGTGGTGAATCCCGTGGCGCGCACCGACAAGTCGAGCCCGATCTACGGC
ATGCCGATCCTGAATGCGGACATGGCGCAGAACGTGATCGTGGTGAAGCGCGGCAAGGGCGCGGGCTACTCGGGCATCGA
GAACGCGCTGTTCTACAAGGACAACTGCCGCATGCTGTACGGCAGTGCGCAGCAGGCTATCGCCGAGGTCATCACCCACG
TGAAGGCGCTCGAAGCCTGA

Upstream 100 bases:

>100_bases
TGTTCCTCGGCGCGGCCAACGCCGCCGGCGGCTACGTGGTGACCGAGCGCATGCTCGCGATGTTCAACAAGAGTGGCAGC
AGCAAGAAGGAGGGCGCGCA

Downstream 100 bases:

>100_bases
GCGTGGCGGGCGCGGCACCCGGCGGTGCCGCGCGCTCTAAAGTCGGAGGCGACGCGCGCCGTAGACCGTGGCATCCTGAC
CACCGTGTCTTCCCGCGTGT

Product: NAD(P) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTAKWFIDASYFAVAVVFILALKAMSSPVTARRGIVWGGIAMVFATLVTFATPGLHNFGWMIVAIVSGAAVAWWSGKTVK
MTDMPQMVAIYNGMGGGAAAAIAALEFARGEVHGPVVTTLAVLGALIGSVAFSGSCIAFAKLQGIMKKAWRLPAQNAVNV
VLALVTVGLGIAIIAAPSIDPVLVIVFFVLALILGAILTSPIGGADMPVVISLLNAFTGLAVGFEGYVLGNPALIVAGIV
VGASGTLLTQLMAKAMNRPISNVLFTPISGAASGGGEGIEGTMKEFSSLDAASVMRYASKVIIVPGYGMAVAGAQHKVWE
MAQLLEEGGVEVVFAIHPVAGRMPGHMNVLLAEAGVPYDKIFDLEEINADFAQAEVALVIGANDVVNPVARTDKSSPIYG
MPILNADMAQNVIVVKRGKGAGYSGIENALFYKDNCRMLYGSAQQAIAEVITHVKALEA

Sequences:

>Translated_459_residues
MTAKWFIDASYFAVAVVFILALKAMSSPVTARRGIVWGGIAMVFATLVTFATPGLHNFGWMIVAIVSGAAVAWWSGKTVK
MTDMPQMVAIYNGMGGGAAAAIAALEFARGEVHGPVVTTLAVLGALIGSVAFSGSCIAFAKLQGIMKKAWRLPAQNAVNV
VLALVTVGLGIAIIAAPSIDPVLVIVFFVLALILGAILTSPIGGADMPVVISLLNAFTGLAVGFEGYVLGNPALIVAGIV
VGASGTLLTQLMAKAMNRPISNVLFTPISGAASGGGEGIEGTMKEFSSLDAASVMRYASKVIIVPGYGMAVAGAQHKVWE
MAQLLEEGGVEVVFAIHPVAGRMPGHMNVLLAEAGVPYDKIFDLEEINADFAQAEVALVIGANDVVNPVARTDKSSPIYG
MPILNADMAQNVIVVKRGKGAGYSGIENALFYKDNCRMLYGSAQQAIAEVITHVKALEA
>Mature_458_residues
TAKWFIDASYFAVAVVFILALKAMSSPVTARRGIVWGGIAMVFATLVTFATPGLHNFGWMIVAIVSGAAVAWWSGKTVKM
TDMPQMVAIYNGMGGGAAAAIAALEFARGEVHGPVVTTLAVLGALIGSVAFSGSCIAFAKLQGIMKKAWRLPAQNAVNVV
LALVTVGLGIAIIAAPSIDPVLVIVFFVLALILGAILTSPIGGADMPVVISLLNAFTGLAVGFEGYVLGNPALIVAGIVV
GASGTLLTQLMAKAMNRPISNVLFTPISGAASGGGEGIEGTMKEFSSLDAASVMRYASKVIIVPGYGMAVAGAQHKVWEM
AQLLEEGGVEVVFAIHPVAGRMPGHMNVLLAEAGVPYDKIFDLEEINADFAQAEVALVIGANDVVNPVARTDKSSPIYGM
PILNADMAQNVIVVKRGKGAGYSGIENALFYKDNCRMLYGSAQQAIAEVITHVKALEA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=458, Percent_Identity=38.646288209607, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI122939153, Length=458, Percent_Identity=38.646288209607, Blast_Score=296, Evalue=4e-80,
Organism=Escherichia coli, GI1787886, Length=455, Percent_Identity=40.8791208791209, Blast_Score=332, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17550456, Length=461, Percent_Identity=38.3947939262473, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 47536; Mature: 47404

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKWFIDASYFAVAVVFILALKAMSSPVTARRGIVWGGIAMVFATLVTFATPGLHNFGW
CCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHCCEEHHHHHHHHHHHHHHCCCCCCHHHH
MIVAIVSGAAVAWWSGKTVKMTDMPQMVAIYNGMGGGAAAAIAALEFARGEVHGPVVTTL
HHHHHHCCCEEEEECCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
AVLGALIGSVAFSGSCIAFAKLQGIMKKAWRLPAQNAVNVVLALVTVGLGIAIIAAPSID
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEECCCCC
PVLVIVFFVLALILGAILTSPIGGADMPVVISLLNAFTGLAVGFEGYVLGNPALIVAGIV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHH
VGASGTLLTQLMAKAMNRPISNVLFTPISGAASGGGEGIEGTMKEFSSLDAASVMRYASK
HCCCHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCC
VIIVPGYGMAVAGAQHKVWEMAQLLEEGGVEVVFAIHPVAGRMPGHMNVLLAEAGVPYDK
EEEECCCCCEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHH
IFDLEEINADFAQAEVALVIGANDVVNPVARTDKSSPIYGMPILNADMAQNVIVVKRGKG
HCCHHHHCCCHHCCEEEEEECCCHHHHHHHHCCCCCCEECCCCCCHHHHCCEEEEECCCC
AGYSGIENALFYKDNCRMLYGSAQQAIAEVITHVKALEA
CCCCCCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAKWFIDASYFAVAVVFILALKAMSSPVTARRGIVWGGIAMVFATLVTFATPGLHNFGW
CCEEEECHHHHHHHHHHHHHHHHHCCCCHHHCCEEHHHHHHHHHHHHHHCCCCCCHHHH
MIVAIVSGAAVAWWSGKTVKMTDMPQMVAIYNGMGGGAAAAIAALEFARGEVHGPVVTTL
HHHHHHCCCEEEEECCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
AVLGALIGSVAFSGSCIAFAKLQGIMKKAWRLPAQNAVNVVLALVTVGLGIAIIAAPSID
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEECCCCC
PVLVIVFFVLALILGAILTSPIGGADMPVVISLLNAFTGLAVGFEGYVLGNPALIVAGIV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHH
VGASGTLLTQLMAKAMNRPISNVLFTPISGAASGGGEGIEGTMKEFSSLDAASVMRYASK
HCCCHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCC
VIIVPGYGMAVAGAQHKVWEMAQLLEEGGVEVVFAIHPVAGRMPGHMNVLLAEAGVPYDK
EEEECCCCCEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHH
IFDLEEINADFAQAEVALVIGANDVVNPVARTDKSSPIYGMPILNADMAQNVIVVKRGKG
HCCHHHHCCCHHCCEEEEEECCCHHHHHHHHCCCCCCEECCCCCCHHHHCCEEEEECCCC
AGYSGIENALFYKDNCRMLYGSAQQAIAEVITHVKALEA
CCCCCCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]