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The map label for this gene is ndk [H]

Identifier: 119897214

GI number: 119897214

Start: 989496

End: 989921

Strand: Direct

Name: ndk [H]

Synonym: azo0923

Alternate gene names: 119897214

Gene position: 989496-989921 (Clockwise)

Preceding gene: 119897213

Following gene: 119897215

Centisome position: 22.61

GC content: 61.5

Gene sequence:

>426_bases
ATGGCCATCGAACGCACTCTTTCCATCATCAAGCCCGACGCCGTTGCCAAGAACGTGATCGGCAAGATCTACCAGCGCTT
CGAAGACGCCGGCCTGAAGATCATCGCCGCCAAGATGGTGCACCTGTCCGAGCAGGAAGCCGGCCAGTTCTACGCCGTGC
ACAAGGAGCGCCCCTTCTACAAGGATCTGGTCTCGTTCATGACCTCCGGCCCGGTGATGATCCAGTGCCTGGAAGGTGAG
AACGCCATCGCCAAGAACCGCGAACTGATGGGCGCCACCGACCCGAAGAAGGCTGACGCCGGCACCATCCGCGCCGACTT
CGCCGACTCCATCGACGCCAACGCCGTGCATGGTTCCGACGCCCCCGAAACCGCTGCCGTGGAAGTGGCCTTCTTCTTCC
CGGGCATGAACGTTTATTCCCGCTAA

Upstream 100 bases:

>100_bases
GCGCCAGCGCCTGACCCGGCCGGCGCGACAGGCTGTCGCCGAGGTGTAGCGGAAACCTGCTAAAATTCCGCGTTTTGTCA
AACACCCTCGGAGTTTTTCC

Downstream 100 bases:

>100_bases
GCGGTCCATCCTGACGGCCCGTCGCGCCCGCTTCGCGGTAATTTCACCGCGAAAGGCGCGGGCGGGCCGTTTGCGTTGGA
GGCAAACATGAATACCCCCG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGKIYQRFEDAGLKIIAAKMVHLSEQEAGQFYAVHKERPFYKDLVSFMTSGPVMIQCLEGE
NAIAKNRELMGATDPKKADAGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGKIYQRFEDAGLKIIAAKMVHLSEQEAGQFYAVHKERPFYKDLVSFMTSGPVMIQCLEGE
NAIAKNRELMGATDPKKADAGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGKIYQRFEDAGLKIIAAKMVHLSEQEAGQFYAVHKERPFYKDLVSFMTSGPVMIQCLEGEN
AIAKNRELMGATDPKKADAGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=43.9393939393939, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=39.6946564885496, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=39.6946564885496, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=39.6946564885496, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=39.6946564885496, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=39.6946564885496, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI38045913, Length=130, Percent_Identity=39.2307692307692, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI4557797, Length=130, Percent_Identity=39.2307692307692, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=38.4615384615385, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=37.410071942446, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=37.410071942446, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.7664233576642, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=33.8129496402878, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI148839372, Length=129, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=60.1503759398496, Blast_Score=175, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=39.2307692307692, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=38.4615384615385, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=42.3076923076923, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15398; Mature: 15267

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGKIYQRFEDAGLKIIAAKMVHLSEQEAGQFYAVHKERPFY
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCEEEECCCCCHH
KDLVSFMTSGPVMIQCLEGENAIAKNRELMGATDPKKADAGTIRADFADSIDANAVHGSD
HHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
APETAAVEVAFFFPGMNVYSR
CCCCCEEEEEEEECCCHHCCC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGKIYQRFEDAGLKIIAAKMVHLSEQEAGQFYAVHKERPFY
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCEEEECCCCCHH
KDLVSFMTSGPVMIQCLEGENAIAKNRELMGATDPKKADAGTIRADFADSIDANAVHGSD
HHHHHHHCCCCEEEEEECCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
APETAAVEVAFFFPGMNVYSR
CCCCCEEEEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA