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The map label for this gene is FtsI [H]

Identifier: 119897169

GI number: 119897169

Start: 937628

End: 939388

Strand: Direct

Name: FtsI [H]

Synonym: azo0878

Alternate gene names: 119897169

Gene position: 937628-939388 (Clockwise)

Preceding gene: 119897168

Following gene: 119897170

Centisome position: 21.43

GC content: 67.8

Gene sequence:

>1761_bases
GTGAAGAAGCAGCGCACCGTCACCTTCAACCACAATCCGCTGCTCAAGCGCGAGCTGCCGGCGTGGCGCGCGCGCTTCGT
GCTCGTCATGCTGATGGGGTGCTCGCTGGCGCTGATCGGGCGCGCGCTCTACCTGCAAGGTGTAAACAACAGCTTCCTGC
AGGCCAAGGGCGAAATGCGCTATGCCCGCGTGCTGGAAGTCCCCGCCACGCGCGGACGCATTTCCGATCGCAACGGCGAC
ATGCTGGCGGTGAGCACGCCCGTGCGCTCGATCTGGGCGATCCCGGCCGACGCCCGCCTCGAACCCGCCGCCGCACGCCA
GCTCGCCACGCTGCTCGAAATGGATGTGCGCGAGCTGAACGACAAGCTCGCCCCGGGCCGTGACTTCGTCTATCTCAAGC
GCCAGCTGCCGCCCGAGGTCGCAGACCGCATCGCCGCGCTCAAGCTGCCGGGCGTACATCAGCAGCAGGAATATCGCCGC
TACTACCCCGGTGGCGACGTGACCGCGCACATGCTCGGCTTCACCGGGGTCGAGGACCGCGGCCAGGAAGGCATCGAACT
GGCCTACGAGAAGATGCTGGCCGGCATGCCCGGTTCGCGGCGCGTGATCAAGGACCGCCGCGGCCGCATCGTGGAGGACG
TGGAGTCGATCCGGCCGCCGCGCGACGGCGACGATATCTCGCTCGCGATGGACGGCAAGATCCAGTACATCGCCTACAGC
GCGTTGCGCGAGGCCATGCAGCTCAACAAGGCGAAGGCGGGGGCCGCCGTGGTGCTCGACGCGCGCACCGGGGAAGTCCT
TGCGTTGGCGAACGCGCCCACCTACAACCCGAACAACCGCAGCAACCTCACGGGCGCGCAGCTGCGCAACCGCGTGTTTA
CCGACAGCTTCGAGCCCGGCTCGGTCATGAAGCCGTTCATTGCCGGTCTGGCGCTCGAAACCGGCAAGGTGAAACCGACC
ACGGTGATCGACACCTCCGCCGGACGCATGACCATCGGCACCGCGACCATCTCGGATTCGCACCGCAGCGGCCCCTTGAC
CGTCGCCGAGGTGATCCAGAAGTCGTCCAACATCGGCACCGTCAAGATGGCGCTGCAGTTCACGCCGGCCGAGATGTGGC
AGCTCTATCACCAGCTCGGCTTCGGTTCGCCGCTCAATCTCGGCTTTCCGGGCGAAACCGGCGGCCGTCTGCGCCCGGCC
AAGACCTGGCGCCCGATCGAGCAGGCGACCATGTCCTATGGCCACGGCATCTCGGTCACCCTGATCCAGATGGCGCGCGC
CTATCTGGTGTTCGCACGCGACGGCGAACTCGTACCGCTGTCGCTCACCAAGCTGGACGGGCCGCCCAGCGGCGGAACCC
GCATCTTCTCGCCGCAGACAGTGCAGACGCTGCGCAACATGCTTGAAACCGTCACCCTGCCCGGCGGCACTGCCACCAAG
GCGCAGGTGCCCGGCTACCGCGTCGGGGGCAAGACCGGCACCGCGCTGAAGCTGGAGGGCGGGCACTACACCAAGCGCTA
CATCGCGTCCTTCGTCGGCATCGCGCCGATCTCCAATCCGCGTCTCGTCGTGGCAGTGATGATCGACGAGCCGAGCGCCG
GCAACTACTACGCGGGTACGGTGGCCGCGCCGGTTTTCGCGCGCATCATGGAAGGCTCGCTGCGCACCCTCGGCGTGGCA
CCGGATGCGCCGCTGACGCCGCTGCAGCTGGCCCGCAAGCCCAACGAACCCGCGCCCGCGGCGGTCCGGGAGAGCATGTG
A

Upstream 100 bases:

>100_bases
AAAGCACCTGGGCAGCGCACGCGCGGGTCGAAAAACTCGCCCGCGAACGGCTCGGCATGCGCCCGCCGGTGCCGGGGCAG
ATCGTGGTGCTGGAGGCACA

Downstream 100 bases:

>100_bases
GCAACCCTGCCTTCGTGCTGCTCGATCAGCTCCGCGCCAGCGGCGTCCGGCCCGCCGGCATCACGGCCGATTCGCGTCGT
GTCGGGCCGGGGGCCGTGTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MKKQRTVTFNHNPLLKRELPAWRARFVLVMLMGCSLALIGRALYLQGVNNSFLQAKGEMRYARVLEVPATRGRISDRNGD
MLAVSTPVRSIWAIPADARLEPAAARQLATLLEMDVRELNDKLAPGRDFVYLKRQLPPEVADRIAALKLPGVHQQQEYRR
YYPGGDVTAHMLGFTGVEDRGQEGIELAYEKMLAGMPGSRRVIKDRRGRIVEDVESIRPPRDGDDISLAMDGKIQYIAYS
ALREAMQLNKAKAGAAVVLDARTGEVLALANAPTYNPNNRSNLTGAQLRNRVFTDSFEPGSVMKPFIAGLALETGKVKPT
TVIDTSAGRMTIGTATISDSHRSGPLTVAEVIQKSSNIGTVKMALQFTPAEMWQLYHQLGFGSPLNLGFPGETGGRLRPA
KTWRPIEQATMSYGHGISVTLIQMARAYLVFARDGELVPLSLTKLDGPPSGGTRIFSPQTVQTLRNMLETVTLPGGTATK
AQVPGYRVGGKTGTALKLEGGHYTKRYIASFVGIAPISNPRLVVAVMIDEPSAGNYYAGTVAAPVFARIMEGSLRTLGVA
PDAPLTPLQLARKPNEPAPAAVRESM

Sequences:

>Translated_586_residues
MKKQRTVTFNHNPLLKRELPAWRARFVLVMLMGCSLALIGRALYLQGVNNSFLQAKGEMRYARVLEVPATRGRISDRNGD
MLAVSTPVRSIWAIPADARLEPAAARQLATLLEMDVRELNDKLAPGRDFVYLKRQLPPEVADRIAALKLPGVHQQQEYRR
YYPGGDVTAHMLGFTGVEDRGQEGIELAYEKMLAGMPGSRRVIKDRRGRIVEDVESIRPPRDGDDISLAMDGKIQYIAYS
ALREAMQLNKAKAGAAVVLDARTGEVLALANAPTYNPNNRSNLTGAQLRNRVFTDSFEPGSVMKPFIAGLALETGKVKPT
TVIDTSAGRMTIGTATISDSHRSGPLTVAEVIQKSSNIGTVKMALQFTPAEMWQLYHQLGFGSPLNLGFPGETGGRLRPA
KTWRPIEQATMSYGHGISVTLIQMARAYLVFARDGELVPLSLTKLDGPPSGGTRIFSPQTVQTLRNMLETVTLPGGTATK
AQVPGYRVGGKTGTALKLEGGHYTKRYIASFVGIAPISNPRLVVAVMIDEPSAGNYYAGTVAAPVFARIMEGSLRTLGVA
PDAPLTPLQLARKPNEPAPAAVRESM
>Mature_586_residues
MKKQRTVTFNHNPLLKRELPAWRARFVLVMLMGCSLALIGRALYLQGVNNSFLQAKGEMRYARVLEVPATRGRISDRNGD
MLAVSTPVRSIWAIPADARLEPAAARQLATLLEMDVRELNDKLAPGRDFVYLKRQLPPEVADRIAALKLPGVHQQQEYRR
YYPGGDVTAHMLGFTGVEDRGQEGIELAYEKMLAGMPGSRRVIKDRRGRIVEDVESIRPPRDGDDISLAMDGKIQYIAYS
ALREAMQLNKAKAGAAVVLDARTGEVLALANAPTYNPNNRSNLTGAQLRNRVFTDSFEPGSVMKPFIAGLALETGKVKPT
TVIDTSAGRMTIGTATISDSHRSGPLTVAEVIQKSSNIGTVKMALQFTPAEMWQLYHQLGFGSPLNLGFPGETGGRLRPA
KTWRPIEQATMSYGHGISVTLIQMARAYLVFARDGELVPLSLTKLDGPPSGGTRIFSPQTVQTLRNMLETVTLPGGTATK
AQVPGYRVGGKTGTALKLEGGHYTKRYIASFVGIAPISNPRLVVAVMIDEPSAGNYYAGTVAAPVFARIMEGSLRTLGVA
PDAPLTPLQLARKPNEPAPAAVRESM

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=558, Percent_Identity=43.010752688172, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1786854, Length=624, Percent_Identity=26.9230769230769, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63653; Mature: 63653

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQRTVTFNHNPLLKRELPAWRARFVLVMLMGCSLALIGRALYLQGVNNSFLQAKGEMR
CCCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHCCCCE
YARVLEVPATRGRISDRNGDMLAVSTPVRSIWAIPADARLEPAAARQLATLLEMDVRELN
EEEEEECCCCCCCCCCCCCCEEEEECCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DKLAPGRDFVYLKRQLPPEVADRIAALKLPGVHQQQEYRRYYPGGDVTAHMLGFTGVEDR
HHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCC
GQEGIELAYEKMLAGMPGSRRVIKDRRGRIVEDVESIRPPRDGDDISLAMDGKIQYIAYS
CCCHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCEEEEECCCEEEHHHH
ALREAMQLNKAKAGAAVVLDARTGEVLALANAPTYNPNNRSNLTGAQLRNRVFTDSFEPG
HHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
SVMKPFIAGLALETGKVKPTTVIDTSAGRMTIGTATISDSHRSGPLTVAEVIQKSSNIGT
CHHHHHHHHHEEECCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCE
VKMALQFTPAEMWQLYHQLGFGSPLNLGFPGETGGRLRPAKTWRPIEQATMSYGHGISVT
EEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHH
LIQMARAYLVFARDGELVPLSLTKLDGPPSGGTRIFSPQTVQTLRNMLETVTLPGGTATK
HHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHEECCCCCCCC
AQVPGYRVGGKTGTALKLEGGHYTKRYIASFVGIAPISNPRLVVAVMIDEPSAGNYYAGT
CCCCCEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEECHH
VAAPVFARIMEGSLRTLGVAPDAPLTPLQLARKPNEPAPAAVRESM
HHHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKKQRTVTFNHNPLLKRELPAWRARFVLVMLMGCSLALIGRALYLQGVNNSFLQAKGEMR
CCCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHCCCCE
YARVLEVPATRGRISDRNGDMLAVSTPVRSIWAIPADARLEPAAARQLATLLEMDVRELN
EEEEEECCCCCCCCCCCCCCEEEEECCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHH
DKLAPGRDFVYLKRQLPPEVADRIAALKLPGVHQQQEYRRYYPGGDVTAHMLGFTGVEDR
HHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCC
GQEGIELAYEKMLAGMPGSRRVIKDRRGRIVEDVESIRPPRDGDDISLAMDGKIQYIAYS
CCCHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCEEEEECCCEEEHHHH
ALREAMQLNKAKAGAAVVLDARTGEVLALANAPTYNPNNRSNLTGAQLRNRVFTDSFEPG
HHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
SVMKPFIAGLALETGKVKPTTVIDTSAGRMTIGTATISDSHRSGPLTVAEVIQKSSNIGT
CHHHHHHHHHEEECCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCE
VKMALQFTPAEMWQLYHQLGFGSPLNLGFPGETGGRLRPAKTWRPIEQATMSYGHGISVT
EEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHH
LIQMARAYLVFARDGELVPLSLTKLDGPPSGGTRIFSPQTVQTLRNMLETVTLPGGTATK
HHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHEECCCCCCCC
AQVPGYRVGGKTGTALKLEGGHYTKRYIASFVGIAPISNPRLVVAVMIDEPSAGNYYAGT
CCCCCEEECCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEECHH
VAAPVFARIMEGSLRTLGVAPDAPLTPLQLARKPNEPAPAAVRESM
HHHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]