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The map label for this gene is pyrC

Identifier: 119897164

GI number: 119897164

Start: 933728

End: 934762

Strand: Direct

Name: pyrC

Synonym: azo0873

Alternate gene names: 119897164

Gene position: 933728-934762 (Clockwise)

Preceding gene: 119897163

Following gene: 119897165

Centisome position: 21.34

GC content: 68.99

Gene sequence:

>1035_bases
ATGCAATCGATAACCTTCACCCGCCCCGACGACTGGCATCTCCACGTGCGTGACGGCGCCGCCCTGGCCGCCGTCGTGCC
GCACACCGCGGAGCGCTTCGGCCGCGCCCTGATCATGCCGAACCTGCGGCCGCCGGTCACCACGACCGCGCAGGCCCTGG
CCTATCGCGACCGCATCCGCGCAGCGGTGCCGGCCGGGCTCGCGTTCGAGCCGCTGATGAGCCTGTACCTGACCGATAAC
ACCGCACCGGACGAAATCGAGCGCGCGCGGGCATCGGGCGCGGTCATCGCCGCCAAGCTCTATCCGGCCGGCGCCACCAC
CAACTCCGACGCCGGCGTGACTGCGATCGACAAGATCTATCCGGTGCTCGAACGCATGGAGGCCTGCGGCCTGGTGCTGT
GCGTGCATGGCGAAGTAACCGGGGGCGAGGTCGATGTGTTCGACCGCGAGCGCGTATTCATGGAGAAGATCCTGTCGCCG
CTGGTGCGCCGCTTCCCGGCGCTCAAGGTCGTGTTCGAGCACATCACCACCGCGGAGGCGGCGCAGTTCGTCCGGGCGGC
CGGTGCCAATGTGGCCGCCACGGTCACCGCCCATCATCTGCTGCTGAACCGCAACGCCATCTTTGCCGGCGGCATTCGGC
CCCACCACTACTGCCTGCCGGTGCTCAAGCGCGAAACCCACCGTGTCGCGCTGGTCGAGGCCGTCACCTCGGGCAACCCG
CGTTTCTTCCTGGGTACCGACTCCGCGCCCCATGCGCGCAGCACAAAGGAAGCGGCGTGTGGTTGCGCCGGCTGCTACAC
CGCCCATGCCGGCATCGAGCTGTACGCGGAAGTGTTCGACGCGGCCGGTGCGCTGGAGCGGCTGGAAGCCTTCGCGAGCC
TCAACGGCCCGGCCTTCTACGGTCTCGCGCCGAATGCCGACAAGATCACGCTGGTGCGCGAGTCGTGGTCGGTGCCGGCC
GGGTTTCCCTATCTGGATGACGATCCGCTGGTGCCGCTGCGCGCGGGCGAATCGGTGGGCTGGAGGCTGGCGTGA

Upstream 100 bases:

>100_bases
CGCCCGTGCGCTCGAGTTGAAAGGCGAGGCGGAGGGCGAGGGCTGAGCGCGGCTGCCGCCCCGATCCGCCTATAATTCCG
CATCCCCCAGCGAGTCTCAC

Downstream 100 bases:

>100_bases
TCACCCGGCTGCGGCGGGTCCTGTTGCTGGCCGCGCTGCCGCTGCTGGCGGCATGCGAGAACTCGGCGACCGCGTACTCG
ATCGAGGGTAGTCAGCATGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MQSITFTRPDDWHLHVRDGAALAAVVPHTAERFGRALIMPNLRPPVTTTAQALAYRDRIRAAVPAGLAFEPLMSLYLTDN
TAPDEIERARASGAVIAAKLYPAGATTNSDAGVTAIDKIYPVLERMEACGLVLCVHGEVTGGEVDVFDRERVFMEKILSP
LVRRFPALKVVFEHITTAEAAQFVRAAGANVAATVTAHHLLLNRNAIFAGGIRPHHYCLPVLKRETHRVALVEAVTSGNP
RFFLGTDSAPHARSTKEAACGCAGCYTAHAGIELYAEVFDAAGALERLEAFASLNGPAFYGLAPNADKITLVRESWSVPA
GFPYLDDDPLVPLRAGESVGWRLA

Sequences:

>Translated_344_residues
MQSITFTRPDDWHLHVRDGAALAAVVPHTAERFGRALIMPNLRPPVTTTAQALAYRDRIRAAVPAGLAFEPLMSLYLTDN
TAPDEIERARASGAVIAAKLYPAGATTNSDAGVTAIDKIYPVLERMEACGLVLCVHGEVTGGEVDVFDRERVFMEKILSP
LVRRFPALKVVFEHITTAEAAQFVRAAGANVAATVTAHHLLLNRNAIFAGGIRPHHYCLPVLKRETHRVALVEAVTSGNP
RFFLGTDSAPHARSTKEAACGCAGCYTAHAGIELYAEVFDAAGALERLEAFASLNGPAFYGLAPNADKITLVRESWSVPA
GFPYLDDDPLVPLRAGESVGWRLA
>Mature_344_residues
MQSITFTRPDDWHLHVRDGAALAAVVPHTAERFGRALIMPNLRPPVTTTAQALAYRDRIRAAVPAGLAFEPLMSLYLTDN
TAPDEIERARASGAVIAAKLYPAGATTNSDAGVTAIDKIYPVLERMEACGLVLCVHGEVTGGEVDVFDRERVFMEKILSP
LVRRFPALKVVFEHITTAEAAQFVRAAGANVAATVTAHHLLLNRNAIFAGGIRPHHYCLPVLKRETHRVALVEAVTSGNP
RFFLGTDSAPHARSTKEAACGCAGCYTAHAGIELYAEVFDAAGALERLEAFASLNGPAFYGLAPNADKITLVRESWSVPA
GFPYLDDDPLVPLRAGESVGWRLA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=340, Percent_Identity=57.6470588235294, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6323452, Length=365, Percent_Identity=35.8904109589041, Blast_Score=198, Evalue=9e-52,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_AZOSB (A1K3T5)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932377.1
- ProteinModelPortal:   A1K3T5
- SMR:   A1K3T5
- STRING:   A1K3T5
- GeneID:   4606619
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0873
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- PhylomeDB:   A1K3T5
- ProtClustDB:   PRK05451
- BioCyc:   ASP62928:AZO0873-MONOMER
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 37003; Mature: 37003

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSITFTRPDDWHLHVRDGAALAAVVPHTAERFGRALIMPNLRPPVTTTAQALAYRDRIR
CCCCCCCCCCCCEEEEECCCEEEECCCHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHH
AAVPAGLAFEPLMSLYLTDNTAPDEIERARASGAVIAAKLYPAGATTNSDAGVTAIDKIY
HHCCCCCHHHHHHHEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHH
PVLERMEACGLVLCVHGEVTGGEVDVFDRERVFMEKILSPLVRRFPALKVVFEHITTAEA
HHHHHHHHCCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQFVRAAGANVAATVTAHHLLLNRNAIFAGGIRPHHYCLPVLKRETHRVALVEAVTSGNP
HHHHHHCCCCEEEHHHHHHHHEECCEEEECCCCCCHHHHHHHHCCCHHEEEEEEECCCCC
RFFLGTDSAPHARSTKEAACGCAGCYTAHAGIELYAEVFDAAGALERLEAFASLNGPAFY
EEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
GLAPNADKITLVRESWSVPAGFPYLDDDPLVPLRAGESVGWRLA
EECCCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MQSITFTRPDDWHLHVRDGAALAAVVPHTAERFGRALIMPNLRPPVTTTAQALAYRDRIR
CCCCCCCCCCCCEEEEECCCEEEECCCHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHH
AAVPAGLAFEPLMSLYLTDNTAPDEIERARASGAVIAAKLYPAGATTNSDAGVTAIDKIY
HHCCCCCHHHHHHHEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHH
PVLERMEACGLVLCVHGEVTGGEVDVFDRERVFMEKILSPLVRRFPALKVVFEHITTAEA
HHHHHHHHCCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQFVRAAGANVAATVTAHHLLLNRNAIFAGGIRPHHYCLPVLKRETHRVALVEAVTSGNP
HHHHHHCCCCEEEHHHHHHHHEECCEEEECCCCCCHHHHHHHHCCCHHEEEEEEECCCCC
RFFLGTDSAPHARSTKEAACGCAGCYTAHAGIELYAEVFDAAGALERLEAFASLNGPAFY
EEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
GLAPNADKITLVRESWSVPAGFPYLDDDPLVPLRAGESVGWRLA
EECCCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA