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The map label for this gene is accC1 [H]

Identifier: 119897153

GI number: 119897153

Start: 925814

End: 927175

Strand: Reverse

Name: accC1 [H]

Synonym: azo0862

Alternate gene names: 119897153

Gene position: 927175-925814 (Counterclockwise)

Preceding gene: 119897154

Following gene: 119897152

Centisome position: 21.19

GC content: 64.83

Gene sequence:

>1362_bases
ATGTTTGAAAAGATCCTGATCGCCAACCGCGGCGAAATCGCCCTGCGGGTCCTGCGCGCCTGCCGCGAACTCGGCATCAA
GACCGTCGCGGTGCATTCCGAGGCGGACACCGAAGCCAAGTACGTCACGCTGGCCGACGAATCGGTCTGCATCGGCCCGG
CGCCGTCCGGTCTGAGCTACCTCAACGTGCCGGCGATCATCTCGGCCGCCGAGGTCACCGACGCCGAAGCCATCCACCCT
GGCTACGGCTTCCTGTCGGAAAACGCCGACTTCGCCGAACGTGTCGAGCAATCCGGCTTCGTCTTCATCGGCCCTCGCCC
CGACACCATCCGCCTGATGGGCGACAAGGTTTCCGCCAAGGATGCGATGAAGGCCGCCGGCGTGCCCTGCGTGCCCGGTT
CCGACGGCGCGCTGCCGGAAGAGCCCAAGGAAATCGTCAAGATCGCGCGCGCCATTGGCTACCCGGTGATCATCAAGGCT
GCCGGCGGCGGTGGCGGGCGCGGCATGCGCGTGGTGCACACCGAAGCGGCACTGCTCAACGCGGTCACCACCACCCGTGC
GGAAGCCGGCGCTGCCTTCGGCAACCCGACCGTCTACATGGAGAAGTTCCTGGAGAACCCGCGCCACGTGGAAATCCAGG
TGCTGGCGGACCAGCACGGCAACGCGGTCTACCTCGGCGAACGCGACTGCTCCATGCAGCGCCGCCACCAGAAGGTGATC
GAAGAAGCGCCGGCCCCGGGCATCGACCGCAAGCTGATCGCCAAGATCGGTGAACGCTGCGCCGAAGCCTGCCGCAAGAT
CGGCTACCGCGGCGCGGGCACCTTCGAGTTCCTGTACGAAAACGGCGAGTTCTACTTCATCGAGATGAACACCCGGGTGC
AGGTTGAACACCCGGTCACCGAGATGATCACCGGCATCGACATCGTGCAGACGCAGATCCGTGTCGCCGCGGGTGAAAAG
TTGCCGTTCCAGCAGCGCGACATCCCCTTCCGCGGTCACGCGATCGAATGCCGGATCAACGCCGAAGACCCGTTCAAGTT
CACGCCGTCGCCGGGCCGCATCGACAACTGGCACACCCCGGGCGGTCCCGGCATCCGCGTCGATTCGCATGTGTACAACG
GCTATATGGTGCCGCCGCACTACGATTCGATGATCGGCAAGCTGATCGCCTATGGCGACACTCGCGAGCAGGCGATCCGC
CGCATGCGCATCGCGCTGTCGGAAATGGCGGTTGCCGGCATCAAGACCAACATCCCGCTGCACCAGGAACTGATGATGGA
CGCCCGCTTCGTCGAAGGCGGCACCAGCATTCACTACCTGGAACACAAGCTCGCCGAGCGCAGCGAAGTGAAGAAGGGCT
GA

Upstream 100 bases:

>100_bases
GCCAGCCGCGGCGCCCCGCTGCCGGCCGGCGATGCAGCGGCGCATCCCCACCGCCCCGCGACCGCGCGCGGCACCGGCAA
CTTCGCCGCGGAGACCACTC

Downstream 100 bases:

>100_bases
GCGGCACGCCATGTGGATTTCGGTCATCCTGCAGGCTGAGGCGGCAAAAGCGGAGGCGCTGTCGGACGCGCTGATGGACG
CGGGCGCGCTGTCGGTCTCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFEKILIANRGEIALRVLRACRELGIKTVAVHSEADTEAKYVTLADESVCIGPAPSGLSYLNVPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFVFIGPRPDTIRLMGDKVSAKDAMKAAGVPCVPGSDGALPEEPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALLNAVTTTRAEAGAAFGNPTVYMEKFLENPRHVEIQVLADQHGNAVYLGERDCSMQRRHQKVI
EEAPAPGIDRKLIAKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGIDIVQTQIRVAAGEK
LPFQQRDIPFRGHAIECRINAEDPFKFTPSPGRIDNWHTPGGPGIRVDSHVYNGYMVPPHYDSMIGKLIAYGDTREQAIR
RMRIALSEMAVAGIKTNIPLHQELMMDARFVEGGTSIHYLEHKLAERSEVKKG

Sequences:

>Translated_453_residues
MFEKILIANRGEIALRVLRACRELGIKTVAVHSEADTEAKYVTLADESVCIGPAPSGLSYLNVPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFVFIGPRPDTIRLMGDKVSAKDAMKAAGVPCVPGSDGALPEEPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALLNAVTTTRAEAGAAFGNPTVYMEKFLENPRHVEIQVLADQHGNAVYLGERDCSMQRRHQKVI
EEAPAPGIDRKLIAKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGIDIVQTQIRVAAGEK
LPFQQRDIPFRGHAIECRINAEDPFKFTPSPGRIDNWHTPGGPGIRVDSHVYNGYMVPPHYDSMIGKLIAYGDTREQAIR
RMRIALSEMAVAGIKTNIPLHQELMMDARFVEGGTSIHYLEHKLAERSEVKKG
>Mature_453_residues
MFEKILIANRGEIALRVLRACRELGIKTVAVHSEADTEAKYVTLADESVCIGPAPSGLSYLNVPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFVFIGPRPDTIRLMGDKVSAKDAMKAAGVPCVPGSDGALPEEPKEIVKIARAIGYPVIIKA
AGGGGGRGMRVVHTEAALLNAVTTTRAEAGAAFGNPTVYMEKFLENPRHVEIQVLADQHGNAVYLGERDCSMQRRHQKVI
EEAPAPGIDRKLIAKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEMITGIDIVQTQIRVAAGEK
LPFQQRDIPFRGHAIECRINAEDPFKFTPSPGRIDNWHTPGGPGIRVDSHVYNGYMVPPHYDSMIGKLIAYGDTREQAIR
RMRIALSEMAVAGIKTNIPLHQELMMDARFVEGGTSIHYLEHKLAERSEVKKG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=49.6613995485327, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=49.6613995485327, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=49.6613995485327, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=49.3181818181818, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.6367713004484, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.6367713004484, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.6367713004484, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI38679960, Length=520, Percent_Identity=31.3461538461538, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI38679974, Length=520, Percent_Identity=31.3461538461538, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI38679977, Length=520, Percent_Identity=31.3461538461538, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI38679967, Length=520, Percent_Identity=31.3461538461538, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI38679971, Length=520, Percent_Identity=31.3461538461538, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=30.9021113243762, Blast_Score=235, Evalue=6e-62,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=70.2702702702703, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=48.5327313769752, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=47.8458049886621, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.9664429530201, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=500, Percent_Identity=29, Blast_Score=211, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=516, Percent_Identity=27.5193798449612, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=516, Percent_Identity=27.5193798449612, Blast_Score=204, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.2121896162528, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.9821428571429, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=47.2160356347439, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=30.6513409961686, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6323863, Length=463, Percent_Identity=32.3974082073434, Blast_Score=233, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.5168539325843, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.7477477477478, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.7477477477478, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.7477477477478, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.7477477477478, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.7477477477478, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.7477477477478, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.7477477477478, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.7477477477478, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.7477477477478, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.7477477477478, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=46.9543147208122, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=30.5447470817121, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=30.5447470817121, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=30.5447470817121, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24586458, Length=514, Percent_Identity=30.5447470817121, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49620; Mature: 49620

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRVLRACRELGIKTVAVHSEADTEAKYVTLADESVCIGPAPSGLSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCCCCCCE
LNVPAIISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRLMGDKVSAK
ECCCHHEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCCCHH
DAMKAAGVPCVPGSDGALPEEPKEIVKIARAIGYPVIIKAAGGGGGRGMRVVHTEAALLN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVTTTRAEAGAAFGNPTVYMEKFLENPRHVEIQVLADQHGNAVYLGERDCSMQRRHQKVI
HHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPGIDRKLIAKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGIDIVQTQIRVAAGEKLPFQQRDIPFRGHAIECRINAEDPFKFTPSPGRIDNWHTP
HHHHCHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCC
GGPGIRVDSHVYNGYMVPPHYDSMIGKLIAYGDTREQAIRRMRIALSEMAVAGIKTNIPL
CCCCEEECCEEECCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
HQELMMDARFVEGGTSIHYLEHKLAERSEVKKG
HHHHHHHHHEECCCCEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRVLRACRELGIKTVAVHSEADTEAKYVTLADESVCIGPAPSGLSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCCCCCCE
LNVPAIISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFVFIGPRPDTIRLMGDKVSAK
ECCCHHEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCCCHH
DAMKAAGVPCVPGSDGALPEEPKEIVKIARAIGYPVIIKAAGGGGGRGMRVVHTEAALLN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVTTTRAEAGAAFGNPTVYMEKFLENPRHVEIQVLADQHGNAVYLGERDCSMQRRHQKVI
HHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPGIDRKLIAKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGIDIVQTQIRVAAGEKLPFQQRDIPFRGHAIECRINAEDPFKFTPSPGRIDNWHTP
HHHHCHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCC
GGPGIRVDSHVYNGYMVPPHYDSMIGKLIAYGDTREQAIRRMRIALSEMAVAGIKTNIPL
CCCCEEECCEEECCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
HQELMMDARFVEGGTSIHYLEHKLAERSEVKKG
HHHHHHHHHEECCCCEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]