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The map label for this gene is mutM [H]

Identifier: 119897050

GI number: 119897050

Start: 810989

End: 811807

Strand: Direct

Name: mutM [H]

Synonym: azo0759

Alternate gene names: 119897050

Gene position: 810989-811807 (Clockwise)

Preceding gene: 119897042

Following gene: 119897051

Centisome position: 18.53

GC content: 71.31

Gene sequence:

>819_bases
ATGCCCGAACTGCCCGAAGTGGAAACCACCTGCCGCGGCGTGCGCCCTCATGTCGAAGGTCGGCGCCTGAGCGCGGTCGT
GGTGCGAAACCCGCGGCTGCGCGTGCCGGTGCCGGACAACCTTGCCCAGCTCGCCGCGGGCCAGGTGCTCGCCAGCGTGT
CGCGGCGGGCGAAGTACCTGTTGCTCGATTTCGATCGCGGCGGGCTTGTCGTGCATCTCGGCATGTCGGGCAGTCTGCGG
GTGGTCGCGGCGGGGGAGCCGGCCGGCAAGCACGACCATCTCGACCTGGTGTTCGGCGAGACTTCGCTGCGGCTGCGCGA
CCCGCGGCGTTTCGGCATGGTGCTCTGGCAGGAGGGCGGCGCCGTCGCCCACCCGCTGCTGGCCGGGCTGGGGCCGGAGC
CGCTGGACGACGCGTTCGATGCGCGCTACTGGGTGGCCGCGACCCGCGGCCTGCGGGCCCCCATCAAGCATGTGCTGATG
GATGGCCGGCGGGTGGTCGGCGTGGGCAACATCTACGCCTCCGAAAGTCTGTTCCGGTCGCGTATCCATCCGCTGGAGCC
GGCGGGTGCGATCGGGCCGCAGCGCGCGGCGCGGCTGGTGCTGGCGGTGAAGGAAACGCTAACCGAAGCGATCGCCGCGG
GCGGCAGCACCCTGCGCGATTTCGTCGGTGGCGACGGCCGGCCCGGATACTTCCAGCAGCAGTATTTCGCTTACGACCGT
GAAGGCGAAGCCTGCCGCGTGTGCGGCAGCGTCATCCGCCGCTTCGTCAGCGGCCAGCGCGCGACCTTCTTCTGTCCGCG
CTGCCAGCGCCGCGCCTGA

Upstream 100 bases:

>100_bases
CGGCCATTGGAGGGGTGTTCTAGAATTCCGTTCGCCTCATGGTAGGTACTTTGCAAGGCGCCCCGCAAGTCGGTGCGCGC
CGAGTCGATCCGGAGTCCCG

Downstream 100 bases:

>100_bases
ATAGCGACGGCGATGCCGGCCGCTGCCCGCGGTCCGACCGACGGCGTGGAAGCCGGTCGCGAAGGGCGCTATGCTGACGG
TGTTTTTTGCCGCAGAAAAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPELPEVETTCRGVRPHVEGRRLSAVVVRNPRLRVPVPDNLAQLAAGQVLASVSRRAKYLLLDFDRGGLVVHLGMSGSLR
VVAAGEPAGKHDHLDLVFGETSLRLRDPRRFGMVLWQEGGAVAHPLLAGLGPEPLDDAFDARYWVAATRGLRAPIKHVLM
DGRRVVGVGNIYASESLFRSRIHPLEPAGAIGPQRAARLVLAVKETLTEAIAAGGSTLRDFVGGDGRPGYFQQQYFAYDR
EGEACRVCGSVIRRFVSGQRATFFCPRCQRRA

Sequences:

>Translated_272_residues
MPELPEVETTCRGVRPHVEGRRLSAVVVRNPRLRVPVPDNLAQLAAGQVLASVSRRAKYLLLDFDRGGLVVHLGMSGSLR
VVAAGEPAGKHDHLDLVFGETSLRLRDPRRFGMVLWQEGGAVAHPLLAGLGPEPLDDAFDARYWVAATRGLRAPIKHVLM
DGRRVVGVGNIYASESLFRSRIHPLEPAGAIGPQRAARLVLAVKETLTEAIAAGGSTLRDFVGGDGRPGYFQQQYFAYDR
EGEACRVCGSVIRRFVSGQRATFFCPRCQRRA
>Mature_271_residues
PELPEVETTCRGVRPHVEGRRLSAVVVRNPRLRVPVPDNLAQLAAGQVLASVSRRAKYLLLDFDRGGLVVHLGMSGSLRV
VAAGEPAGKHDHLDLVFGETSLRLRDPRRFGMVLWQEGGAVAHPLLAGLGPEPLDDAFDARYWVAATRGLRAPIKHVLMD
GRRVVGVGNIYASESLFRSRIHPLEPAGAIGPQRAARLVLAVKETLTEAIAAGGSTLRDFVGGDGRPGYFQQQYFAYDRE
GEACRVCGSVIRRFVSGQRATFFCPRCQRRA

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=271, Percent_Identity=49.0774907749078, Blast_Score=248, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 29697; Mature: 29565

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTCRGVRPHVEGRRLSAVVVRNPRLRVPVPDNLAQLAAGQVLASVSRRAKYL
CCCCCCHHHHHCCCCCCCCCCEEEEEEEECCEEECCCCCCHHHHHHHHHHHHHHHCCEEE
LLDFDRGGLVVHLGMSGSLRVVAAGEPAGKHDHLDLVFGETSLRLRDPRRFGMVLWQEGG
EEEECCCCEEEEECCCCCEEEEECCCCCCCCCCEEEEECCCEEEEECCHHHCEEEEECCC
AVAHPLLAGLGPEPLDDAFDARYWVAATRGLRAPIKHVLMDGRRVVGVGNIYASESLFRS
CHHHHHHHCCCCCCCCHHHCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHH
RIHPLEPAGAIGPQRAARLVLAVKETLTEAIAAGGSTLRDFVGGDGRPGYFQQQYFAYDR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHEECC
EGEACRVCGSVIRRFVSGQRATFFCPRCQRRA
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCCC
>Mature Secondary Structure 
PELPEVETTCRGVRPHVEGRRLSAVVVRNPRLRVPVPDNLAQLAAGQVLASVSRRAKYL
CCCCCHHHHHCCCCCCCCCCEEEEEEEECCEEECCCCCCHHHHHHHHHHHHHHHCCEEE
LLDFDRGGLVVHLGMSGSLRVVAAGEPAGKHDHLDLVFGETSLRLRDPRRFGMVLWQEGG
EEEECCCCEEEEECCCCCEEEEECCCCCCCCCCEEEEECCCEEEEECCHHHCEEEEECCC
AVAHPLLAGLGPEPLDDAFDARYWVAATRGLRAPIKHVLMDGRRVVGVGNIYASESLFRS
CHHHHHHHCCCCCCCCHHHCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHH
RIHPLEPAGAIGPQRAARLVLAVKETLTEAIAAGGSTLRDFVGGDGRPGYFQQQYFAYDR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHEECC
EGEACRVCGSVIRRFVSGQRATFFCPRCQRRA
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA