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The map label for this gene is creC [H]

Identifier: 119896994

GI number: 119896994

Start: 750394

End: 751824

Strand: Reverse

Name: creC [H]

Synonym: azo0703

Alternate gene names: 119896994

Gene position: 751824-750394 (Counterclockwise)

Preceding gene: 119896995

Following gene: 119896993

Centisome position: 17.18

GC content: 73.17

Gene sequence:

>1431_bases
ATGAACATCGCGATCCGCTTCTTCATCGGCTATTTCCTGATCGTCGGGCTCGCGGCCTGGTTCGTGCTCAACATCTTCGC
GCGCGAGGTCGAACCCGGCCTGCGCCAGGCCACTGAAGACACCCTGGTCGACGCCGCCAACCTGCTCGCGGAATTCGCCG
CCGAGCACCTGGGCCCGGGCGACGGCGGCTTCGAACGCGATCGCTTCGCCACCGCGGTGCGCCGCGCCCAGGCCCGCGTG
CCGCGCGCCGACATCTACGGCGTACCGAAAACCGCGGTGGACTTCCGCGTCTATCTGACCGACGCCCGCGGCATCGTGCT
GTTCGACTCCGAAGGCAGCGCGGAGGGGGCCGACTACAGTCAGTGGCGCGACGTCGCCCGCGTGCTGCGCGGCGAATACG
GCGCGCGCAGCACGCGCGACGACCCCGCCGACCCCAACAGCTCGGTGATGTATGTTGCCGCCCCGGTGCTGCTCGATGGG
CGGCTGGCGGGGGTGGTCAGCGTCGCCAAGCCGGCCGCGGCGCTGCTGCCCTACGCCGACCAGGCGCGCGACCGGGTGCG
CCGCGCCGGCTGGCTGCTGCTCGGCAGCTCGGCGCTGATCGGCCTCGCATTCACGTTGTGGCTCACCTGGTCGCTCAACC
GCCTGCGCGACTACGCGCGCGCGGTCGCCCGCGGCGACAAGGCGGTGGCGCCGACCGGCGGCGGCGGCCAGCTCTCGGAA
CTGGCCCGCGCGCTGGCCGAGATGCGCGCGCGGCTGGACGGCAAGCAGTACGTCGAACACTACGTGCAGAGCCTCGCCCA
CGAACTCAAGAGCCCGCTCACCGCGGTGCGCGGCGCCGCCGAACTGCTCGCCGAGGCGCCCTCAGCCGACGACCGCGCGC
GCTTCGTCGGCCACATCGGCGAACAGGCCGAGCGCATGCAGCTGATCATCGACCGCCTGCTCGCGCTGGCCCGCGTGGAG
CAGTTGCAGGCGCCGGAGGCACTCGCCGAAATCGCGCTGGGCGAACTCGCGGCCGAGGTCGTCGCCAGCCGCCAGCCACA
ACTCGCCGCGCGTGGGCTGCAGGTGGACATCGGCGGCGAGGGCGAGCGGCGCGTGCGCGGCGACCGCTTCCTGTTGCAGC
AGGCGCTCGCCAACCTGGTGGACAACGCGATCGACTTTTCCCCGCCCGGCGCCCGCATCGGGCTGACGCTGGGCGGCGAT
GCCAGCCACCACGTCATCACCGTGCGCGACCACGGCCCCGGCGCGCCGGAGTTCGCGCTGCCGCAGCTCTTCGAGCGCTT
CTACTCGCTGCCGCGGCCCGCCACCGGGCGCAAGAGCACCGGCCTCGGGCTGGCCTTCGTGCGCGAAGTGGCGCGGGTGC
ACGGCGGCGATGCCGACTTCGCCAACGCGCCCGAGGGCGGCGCCCAGGCGCGCATCGTGCTGCCGCGCTAA

Upstream 100 bases:

>100_bases
GCGCGGTGCGCGAGGACGAAGACCCGATCGAGACCCACCGCGGCCTGGGCTACAGCCTGCGCCCGGCGCAACGCTGAATT
CCGCACCGCAGGCGCCGCCG

Downstream 100 bases:

>100_bases
GCCGCCCCGCGGCACGGTTTCACACACGCCCCGCGCCACTTCACCCTCGCTTCACCGCGCCTTCACGGCCGCCGCCGAGA
CTTCCCCGCGTCATGTTCAC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MNIAIRFFIGYFLIVGLAAWFVLNIFAREVEPGLRQATEDTLVDAANLLAEFAAEHLGPGDGGFERDRFATAVRRAQARV
PRADIYGVPKTAVDFRVYLTDARGIVLFDSEGSAEGADYSQWRDVARVLRGEYGARSTRDDPADPNSSVMYVAAPVLLDG
RLAGVVSVAKPAAALLPYADQARDRVRRAGWLLLGSSALIGLAFTLWLTWSLNRLRDYARAVARGDKAVAPTGGGGQLSE
LARALAEMRARLDGKQYVEHYVQSLAHELKSPLTAVRGAAELLAEAPSADDRARFVGHIGEQAERMQLIIDRLLALARVE
QLQAPEALAEIALGELAAEVVASRQPQLAARGLQVDIGGEGERRVRGDRFLLQQALANLVDNAIDFSPPGARIGLTLGGD
ASHHVITVRDHGPGAPEFALPQLFERFYSLPRPATGRKSTGLGLAFVREVARVHGGDADFANAPEGGAQARIVLPR

Sequences:

>Translated_476_residues
MNIAIRFFIGYFLIVGLAAWFVLNIFAREVEPGLRQATEDTLVDAANLLAEFAAEHLGPGDGGFERDRFATAVRRAQARV
PRADIYGVPKTAVDFRVYLTDARGIVLFDSEGSAEGADYSQWRDVARVLRGEYGARSTRDDPADPNSSVMYVAAPVLLDG
RLAGVVSVAKPAAALLPYADQARDRVRRAGWLLLGSSALIGLAFTLWLTWSLNRLRDYARAVARGDKAVAPTGGGGQLSE
LARALAEMRARLDGKQYVEHYVQSLAHELKSPLTAVRGAAELLAEAPSADDRARFVGHIGEQAERMQLIIDRLLALARVE
QLQAPEALAEIALGELAAEVVASRQPQLAARGLQVDIGGEGERRVRGDRFLLQQALANLVDNAIDFSPPGARIGLTLGGD
ASHHVITVRDHGPGAPEFALPQLFERFYSLPRPATGRKSTGLGLAFVREVARVHGGDADFANAPEGGAQARIVLPR
>Mature_476_residues
MNIAIRFFIGYFLIVGLAAWFVLNIFAREVEPGLRQATEDTLVDAANLLAEFAAEHLGPGDGGFERDRFATAVRRAQARV
PRADIYGVPKTAVDFRVYLTDARGIVLFDSEGSAEGADYSQWRDVARVLRGEYGARSTRDDPADPNSSVMYVAAPVLLDG
RLAGVVSVAKPAAALLPYADQARDRVRRAGWLLLGSSALIGLAFTLWLTWSLNRLRDYARAVARGDKAVAPTGGGGQLSE
LARALAEMRARLDGKQYVEHYVQSLAHELKSPLTAVRGAAELLAEAPSADDRARFVGHIGEQAERMQLIIDRLLALARVE
QLQAPEALAEIALGELAAEVVASRQPQLAARGLQVDIGGEGERRVRGDRFLLQQALANLVDNAIDFSPPGARIGLTLGGD
ASHHVITVRDHGPGAPEFALPQLFERFYSLPRPATGRKSTGLGLAFVREVARVHGGDADFANAPEGGAQARIVLPR

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=476, Percent_Identity=47.0588235294118, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789403, Length=255, Percent_Identity=32.9411764705882, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=29.0983606557377, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=338, Percent_Identity=27.2189349112426, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=28.1632653061224, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788279, Length=244, Percent_Identity=27.0491803278689, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=27.710843373494, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=215, Percent_Identity=26.9767441860465, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786783, Length=316, Percent_Identity=23.4177215189873, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=27.6363636363636, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=249, Percent_Identity=29.718875502008, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=227, Percent_Identity=30.8370044052863, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=26.6949152542373, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=26.1467889908257, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=248, Percent_Identity=25, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1787894, Length=217, Percent_Identity=27.1889400921659, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=207, Percent_Identity=25.1207729468599, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51273; Mature: 51273

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAIRFFIGYFLIVGLAAWFVLNIFAREVEPGLRQATEDTLVDAANLLAEFAAEHLGPG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGGFERDRFATAVRRAQARVPRADIYGVPKTAVDFRVYLTDARGIVLFDSEGSAEGADYS
CCCCCHHHHHHHHHHHHHCCCCHHCCCCCCHHEEEEEEEECCCEEEEECCCCCCCCCCHH
QWRDVARVLRGEYGARSTRDDPADPNSSVMYVAAPVLLDGRLAGVVSVAKPAAALLPYAD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCHH
QARDRVRRAGWLLLGSSALIGLAFTLWLTWSLNRLRDYARAVARGDKAVAPTGGGGQLSE
HHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LARALAEMRARLDGKQYVEHYVQSLAHELKSPLTAVRGAAELLAEAPSADDRARFVGHIG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
EQAERMQLIIDRLLALARVEQLQAPEALAEIALGELAAEVVASRQPQLAARGLQVDIGGE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCC
GERRVRGDRFLLQQALANLVDNAIDFSPPGARIGLTLGGDASHHVITVRDHGPGAPEFAL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHH
PQLFERFYSLPRPATGRKSTGLGLAFVREVARVHGGDADFANAPEGGAQARIVLPR
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MNIAIRFFIGYFLIVGLAAWFVLNIFAREVEPGLRQATEDTLVDAANLLAEFAAEHLGPG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGGFERDRFATAVRRAQARVPRADIYGVPKTAVDFRVYLTDARGIVLFDSEGSAEGADYS
CCCCCHHHHHHHHHHHHHCCCCHHCCCCCCHHEEEEEEEECCCEEEEECCCCCCCCCCHH
QWRDVARVLRGEYGARSTRDDPADPNSSVMYVAAPVLLDGRLAGVVSVAKPAAALLPYAD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCHH
QARDRVRRAGWLLLGSSALIGLAFTLWLTWSLNRLRDYARAVARGDKAVAPTGGGGQLSE
HHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LARALAEMRARLDGKQYVEHYVQSLAHELKSPLTAVRGAAELLAEAPSADDRARFVGHIG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
EQAERMQLIIDRLLALARVEQLQAPEALAEIALGELAAEVVASRQPQLAARGLQVDIGGE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCC
GERRVRGDRFLLQQALANLVDNAIDFSPPGARIGLTLGGDASHHVITVRDHGPGAPEFAL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHH
PQLFERFYSLPRPATGRKSTGLGLAFVREVARVHGGDADFANAPEGGAQARIVLPR
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]