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The map label for this gene is fumC [H]

Identifier: 119896989

GI number: 119896989

Start: 743845

End: 745224

Strand: Reverse

Name: fumC [H]

Synonym: azo0698

Alternate gene names: 119896989

Gene position: 745224-743845 (Counterclockwise)

Preceding gene: 119896990

Following gene: 119896988

Centisome position: 17.03

GC content: 68.99

Gene sequence:

>1380_bases
ATGGATCCGAGCACCCGAATCGAACGCGACAGCATGGGCGAGATGGCGGTGCCGCTCGCCGCGCTGTACGGCGCGCAGAC
GCAACGCGCCGTGCTCAACTTCCCCATCAGTGGCCAGCGCCTGCCCCCGGCCTTCATCCGCGCGCTGCTGCTGGTCAAGC
TTGCCGCCGCGCGCGCCAACGTGGAACTCGGGCAGTTGCCCGCGCCCACCGGCGAGGCCATCGCGCAGGCCTGCGAACAA
CTGCTGGCAGGCGAGTTCATGCAGCACTTTCCGGTCGACGTGTTCCAGACCGGTTCCGGCACCAGCTCCAACATGAACGC
CAACGAGGTCGTAGCGACGGTCGCCAGCCGCATCCTCGGCGCGCCGGTCAGCCCCAACGACGACGTCAACCACGGCCAGA
GCAGCAACGACACGGTGCCGAGCGCGATCCACATCGCCGCGGCGATTGCGCTCGCCGGCGAACTGCTGCCCGCCCTGCGC
TACCTCGCCCACACCATCCGCGACAAGGCGCGCACGGTGCATCACCACGTCAAGACCGGCCGCACCCACCTGATGGACGC
GATGCCGGTGCGGATGAGCCAGGTGCTCAACGGCTGGGCGCAGCAGCTCGACACCGACATCGAGCACCTGCGCGCGCTGC
AGCCTTCGGTGCAGAGCCTGGCCCAGGGCGGCACCGCGGTGGGAACCGGCATCAACGCCCATCCGCAGTTCGCTGCCTGC
TTCTGCGCCGAACTCGGCCGCCTGACCGGGCTGGGCTTCACCCCGGCGCACGACTACTTCGCGCTGATGGGAGCGCAGGA
CGTGGCGGTGGCGCTGTCGGGCCAGCTCAAGACCACCGCGGTAAGCCTGATGAAGATCGCCAACGACCTGCGCTGGATGA
ACTCCGGCCCGCTTGCCGGGCTGGGCGAGATCGAGCTGGAGGCACTGCAGCCGGGCTCCTCGATCATGCCGGGCAAGGTG
AACCCGGTGATCCCGGAAGCGACCTGCATGGTCGCGGCGCAGGTCATCGGCAACGACGCCGCGATCACCGTGGCGGGCCA
ATCCGGCAATTTCGAACTCAACGTGATGCTGCCGCTGATCGCCCACAACCTGCTCGGCAGCCTGCACCTGCTGACCACCA
CCAGCCGCCTGCTGGCCGACCGCGCGATCGCGGGCTTCCGGGTAAACGACGCCCGCCTGAAGGAGGCGCTGGCGCGCAAC
CCCATTCTGGTGACTGCGCTGAATCCGGTCATCGGCTACGCCAAGGCGGCGGAAATCGCCAAGCAGGCCTATCGCGAGGG
ACGCCCGATCATCGACGTCGCCGCCGAGCAGACCGGCATCGACCGCGCCGAACTCGAACGCCTGCTCGACCCCGAGAAGC
TCACCGCCGGCGGGCTGTGA

Upstream 100 bases:

>100_bases
CTGCGCCGCCGGCGCGGCTGATACTGCCCACCCCGCGGCGGCCGAACGTTCGGCCGCCGCCGGTGCTCCAACCGCCATCC
CGACGCGACAGGAGAGGCTG

Downstream 100 bases:

>100_bases
GTTTCTTCGGGTTTATCCCCGTCCGCCGTGGGCGAAGCTGTGGACAAGCTGTGGGGCCGGTGCGCAGCGCCTTGAGCGCA
ATGGCTTTTTTCGCCTTGCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MDPSTRIERDSMGEMAVPLAALYGAQTQRAVLNFPISGQRLPPAFIRALLLVKLAAARANVELGQLPAPTGEAIAQACEQ
LLAGEFMQHFPVDVFQTGSGTSSNMNANEVVATVASRILGAPVSPNDDVNHGQSSNDTVPSAIHIAAAIALAGELLPALR
YLAHTIRDKARTVHHHVKTGRTHLMDAMPVRMSQVLNGWAQQLDTDIEHLRALQPSVQSLAQGGTAVGTGINAHPQFAAC
FCAELGRLTGLGFTPAHDYFALMGAQDVAVALSGQLKTTAVSLMKIANDLRWMNSGPLAGLGEIELEALQPGSSIMPGKV
NPVIPEATCMVAAQVIGNDAAITVAGQSGNFELNVMLPLIAHNLLGSLHLLTTTSRLLADRAIAGFRVNDARLKEALARN
PILVTALNPVIGYAKAAEIAKQAYREGRPIIDVAAEQTGIDRAELERLLDPEKLTAGGL

Sequences:

>Translated_459_residues
MDPSTRIERDSMGEMAVPLAALYGAQTQRAVLNFPISGQRLPPAFIRALLLVKLAAARANVELGQLPAPTGEAIAQACEQ
LLAGEFMQHFPVDVFQTGSGTSSNMNANEVVATVASRILGAPVSPNDDVNHGQSSNDTVPSAIHIAAAIALAGELLPALR
YLAHTIRDKARTVHHHVKTGRTHLMDAMPVRMSQVLNGWAQQLDTDIEHLRALQPSVQSLAQGGTAVGTGINAHPQFAAC
FCAELGRLTGLGFTPAHDYFALMGAQDVAVALSGQLKTTAVSLMKIANDLRWMNSGPLAGLGEIELEALQPGSSIMPGKV
NPVIPEATCMVAAQVIGNDAAITVAGQSGNFELNVMLPLIAHNLLGSLHLLTTTSRLLADRAIAGFRVNDARLKEALARN
PILVTALNPVIGYAKAAEIAKQAYREGRPIIDVAAEQTGIDRAELERLLDPEKLTAGGL
>Mature_459_residues
MDPSTRIERDSMGEMAVPLAALYGAQTQRAVLNFPISGQRLPPAFIRALLLVKLAAARANVELGQLPAPTGEAIAQACEQ
LLAGEFMQHFPVDVFQTGSGTSSNMNANEVVATVASRILGAPVSPNDDVNHGQSSNDTVPSAIHIAAAIALAGELLPALR
YLAHTIRDKARTVHHHVKTGRTHLMDAMPVRMSQVLNGWAQQLDTDIEHLRALQPSVQSLAQGGTAVGTGINAHPQFAAC
FCAELGRLTGLGFTPAHDYFALMGAQDVAVALSGQLKTTAVSLMKIANDLRWMNSGPLAGLGEIELEALQPGSSIMPGKV
NPVIPEATCMVAAQVIGNDAAITVAGQSGNFELNVMLPLIAHNLLGSLHLLTTTSRLLADRAIAGFRVNDARLKEALARN
PILVTALNPVIGYAKAAEIAKQAYREGRPIIDVAAEQTGIDRAELERLLDPEKLTAGGL

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=44.4444444444444, Blast_Score=368, Evalue=1e-102,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=45.9518599562363, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=37.5, Blast_Score=281, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17553882, Length=457, Percent_Identity=43.9824945295405, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI32565146, Length=322, Percent_Identity=43.167701863354, Blast_Score=260, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=42.9501084598698, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=45.021645021645, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=45.021645021645, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78710009, Length=459, Percent_Identity=43.1372549019608, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=44.1304347826087, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=39.3939393939394, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48426; Mature: 48426

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPSTRIERDSMGEMAVPLAALYGAQTQRAVLNFPISGQRLPPAFIRALLLVKLAAARAN
CCCCCCCCHHCCCHHHHHHHHHHCCCCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCC
VELGQLPAPTGEAIAQACEQLLAGEFMQHFPVDVFQTGSGTSSNMNANEVVATVASRILG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHC
APVSPNDDVNHGQSSNDTVPSAIHIAAAIALAGELLPALRYLAHTIRDKARTVHHHVKTG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAMPVRMSQVLNGWAQQLDTDIEHLRALQPSVQSLAQGGTAVGTGINAHPQFAAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEECCCCCCCCHHHHH
FCAELGRLTGLGFTPAHDYFALMGAQDVAVALSGQLKTTAVSLMKIANDLRWMNSGPLAG
HHHHHHHHCCCCCCCCHHHHHHHCCCCEEHEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
LGEIELEALQPGSSIMPGKVNPVIPEATCMVAAQVIGNDAAITVAGQSGNFELNVMLPLI
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHH
AHNLLGSLHLLTTTSRLLADRAIAGFRVNDARLKEALARNPILVTALNPVIGYAKAAEIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
KQAYREGRPIIDVAAEQTGIDRAELERLLDPEKLTAGGL
HHHHHCCCCEEEECCHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MDPSTRIERDSMGEMAVPLAALYGAQTQRAVLNFPISGQRLPPAFIRALLLVKLAAARAN
CCCCCCCCHHCCCHHHHHHHHHHCCCCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCC
VELGQLPAPTGEAIAQACEQLLAGEFMQHFPVDVFQTGSGTSSNMNANEVVATVASRILG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHC
APVSPNDDVNHGQSSNDTVPSAIHIAAAIALAGELLPALRYLAHTIRDKARTVHHHVKTG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAMPVRMSQVLNGWAQQLDTDIEHLRALQPSVQSLAQGGTAVGTGINAHPQFAAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEECCCCCCCCHHHHH
FCAELGRLTGLGFTPAHDYFALMGAQDVAVALSGQLKTTAVSLMKIANDLRWMNSGPLAG
HHHHHHHHCCCCCCCCHHHHHHHCCCCEEHEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
LGEIELEALQPGSSIMPGKVNPVIPEATCMVAAQVIGNDAAITVAGQSGNFELNVMLPLI
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHH
AHNLLGSLHLLTTTSRLLADRAIAGFRVNDARLKEALARNPILVTALNPVIGYAKAAEIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
KQAYREGRPIIDVAAEQTGIDRAELERLLDPEKLTAGGL
HHHHHCCCCEEEECCHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8806672; 10984043 [H]