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The map label for this gene is pccB [H]

Identifier: 119896978

GI number: 119896978

Start: 725698

End: 727233

Strand: Direct

Name: pccB [H]

Synonym: azo0687

Alternate gene names: 119896978

Gene position: 725698-727233 (Clockwise)

Preceding gene: 119896977

Following gene: 119896979

Centisome position: 16.58

GC content: 64.97

Gene sequence:

>1536_bases
ATGCACGACATCATCCGTCAGCTGGACGAGAAGCGCGCTGCGGCCCGCCTGGGCGGCGGCCAGAAGCGGATCGACTCCCA
GCATGCCAAGGGCAAGCTCACCGCGCGCGAGCGCATCGAGCTGCTGCTCGATCCCGATTCCTTCGAGGAATGGGACATGT
TCAAGGAGCACCGCTGCGTCGACTTCGGCATGGACAAGGCGGAGAAGACCCCGGGCGACGGCGTGGTGACCGGCTACGGC
ACCATCAACGGCCGGCTGGTGTTCGTGTTCTCGCAGGACTTCACGGTGTTCGGCGGCTCGCTGTCCGAAACCCACGCCGA
GAAGATCTGCAAGGTGATGGACCACGCGATGAAGGTCGGCGCGCCGGTGATCGGCCTCAACGACTCGGGCGGCGCCCGCA
TCCAGGAAGGCGTGGCCTCGCTCGGCGGCTATGCCGACGTGTTCCAGCGCAACGTGATGGCCTCGGGCGTGATCCCGCAG
ATCTCGATGATCATGGGCCCCTGCGCCGGCGGCGCGGTGTATTCGCCGTCGATGACCGACTTCATCTTCATGGTGAAGGA
TTCGTCGTACATGTTCGTGACCGGTCCGGAAGTGGTGAAGACCGTGACCCACGAAGACGTCACCGCCGAGGAACTCGGCG
GCGCGGTGACCCACACCAGCAAGTCCGGCGTGGCCGATCTCGCGTTCGAGAACGACGTCGAGGCGCTCACCATGCTGCGC
CGCTTCATGAACTACCTGCCGTCGTCCAACCGCGAAAAGCCGCCGGTGCAGCCGACCAACGATCCGGCCGACCGTCAGGA
CTTCTCGCTCGACACCCTGGTGCCGGACAACCCCAACAAGCCGTACGACATGAAGGAGCTGATCATCAAGGTGGTCGATG
ACTGCGACTTCTTCGAACTGCAGCCCGACTACGCCAAGAACATCATCATCGGCATGGCGCGCATGGACGGCCAGCCGGTC
GGCATCGTCGCCAACCAGCCGCTGGTGCTGGCCGGTTGCCTGGACATCAAGAGCGCGATCAAGGCCGCGCGCTTCGTGCG
CTTCTGCGACGCCTTCAACATCCCGGTGGTCACCTTCGTCGACGTCCCGGGCTTCATGCCGGGCACCGCCCAGGAATACG
GCGGCATCATCAAGCACGGCGCCAAGCTGCTGTACGCCTACGCCGAATGCACCGTGCCCAAGGTCACCGTGATCACCCGC
AAGGCCTACGGCGGCGCCTACGACGTGATGGCCTCCAAGCACCTGCGCGGCGACGTCAACCTCGCCTGGCCCAGCGCCGA
GATCGCGGTGATGGGGCCGAAGGGCGCGGTGGAGATCATCTTCCGCGAAGAAAAGAACAACCCGGAAAAGCTCGCCGAGC
GCGAAGCCGAGTACAAGGCCAAGTTCGCCAACCCCTTCGTGGCCGCCAGCCGCGGCTTCATCGACGACGTCGTGATGCCG
CACAACACCCGCAAGCGCATCTGCCGCAGCCTGGCGATGCTGGCAGACAAGCAGCTCGACAACCCGTGGCGCAAGCACGG
CAACATTCCGCTCTGA

Upstream 100 bases:

>100_bases
AGCGCCTGCTCGGCTGCCTGAACCGAACGAATTGAAACGAAAACACGTTCCGCCCGCGATTGCGCGGACGGGCGGCAAGG
AACCTTAAAGGAGGTCATCA

Downstream 100 bases:

>100_bases
TCGCCGGGGAGACTTAACGCAATGTTTACCAAGATCCTGATTGCCAACCGCGGCGACCAGCCGCAAAGCGGCGCAGAGAC
GAAGTCAAATCGCCGTGCGT

Product: propionyl-coa carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MHDIIRQLDEKRAAARLGGGQKRIDSQHAKGKLTARERIELLLDPDSFEEWDMFKEHRCVDFGMDKAEKTPGDGVVTGYG
TINGRLVFVFSQDFTVFGGSLSETHAEKICKVMDHAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQ
ISMIMGPCAGGAVYSPSMTDFIFMVKDSSYMFVTGPEVVKTVTHEDVTAEELGGAVTHTSKSGVADLAFENDVEALTMLR
RFMNYLPSSNREKPPVQPTNDPADRQDFSLDTLVPDNPNKPYDMKELIIKVVDDCDFFELQPDYAKNIIIGMARMDGQPV
GIVANQPLVLAGCLDIKSAIKAARFVRFCDAFNIPVVTFVDVPGFMPGTAQEYGGIIKHGAKLLYAYAECTVPKVTVITR
KAYGGAYDVMASKHLRGDVNLAWPSAEIAVMGPKGAVEIIFREEKNNPEKLAEREAEYKAKFANPFVAASRGFIDDVVMP
HNTRKRICRSLAMLADKQLDNPWRKHGNIPL

Sequences:

>Translated_511_residues
MHDIIRQLDEKRAAARLGGGQKRIDSQHAKGKLTARERIELLLDPDSFEEWDMFKEHRCVDFGMDKAEKTPGDGVVTGYG
TINGRLVFVFSQDFTVFGGSLSETHAEKICKVMDHAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQ
ISMIMGPCAGGAVYSPSMTDFIFMVKDSSYMFVTGPEVVKTVTHEDVTAEELGGAVTHTSKSGVADLAFENDVEALTMLR
RFMNYLPSSNREKPPVQPTNDPADRQDFSLDTLVPDNPNKPYDMKELIIKVVDDCDFFELQPDYAKNIIIGMARMDGQPV
GIVANQPLVLAGCLDIKSAIKAARFVRFCDAFNIPVVTFVDVPGFMPGTAQEYGGIIKHGAKLLYAYAECTVPKVTVITR
KAYGGAYDVMASKHLRGDVNLAWPSAEIAVMGPKGAVEIIFREEKNNPEKLAEREAEYKAKFANPFVAASRGFIDDVVMP
HNTRKRICRSLAMLADKQLDNPWRKHGNIPL
>Mature_511_residues
MHDIIRQLDEKRAAARLGGGQKRIDSQHAKGKLTARERIELLLDPDSFEEWDMFKEHRCVDFGMDKAEKTPGDGVVTGYG
TINGRLVFVFSQDFTVFGGSLSETHAEKICKVMDHAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQ
ISMIMGPCAGGAVYSPSMTDFIFMVKDSSYMFVTGPEVVKTVTHEDVTAEELGGAVTHTSKSGVADLAFENDVEALTMLR
RFMNYLPSSNREKPPVQPTNDPADRQDFSLDTLVPDNPNKPYDMKELIIKVVDDCDFFELQPDYAKNIIIGMARMDGQPV
GIVANQPLVLAGCLDIKSAIKAARFVRFCDAFNIPVVTFVDVPGFMPGTAQEYGGIIKHGAKLLYAYAECTVPKVTVITR
KAYGGAYDVMASKHLRGDVNLAWPSAEIAVMGPKGAVEIIFREEKNNPEKLAEREAEYKAKFANPFVAASRGFIDDVVMP
HNTRKRICRSLAMLADKQLDNPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=70.2169625246548, Blast_Score=736, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=67.5521821631879, Blast_Score=723, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=508, Percent_Identity=33.0708661417323, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679971, Length=391, Percent_Identity=23.0179028132992, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679974, Length=391, Percent_Identity=23.0179028132992, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679977, Length=391, Percent_Identity=23.0179028132992, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679967, Length=391, Percent_Identity=23.0179028132992, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679960, Length=391, Percent_Identity=23.0179028132992, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI134142062, Length=402, Percent_Identity=22.636815920398, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788655, Length=241, Percent_Identity=25.7261410788382, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=67.7165354330709, Blast_Score=733, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=67.7165354330709, Blast_Score=732, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=524, Percent_Identity=32.2519083969466, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71997163, Length=346, Percent_Identity=24.8554913294798, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323863, Length=383, Percent_Identity=22.4543080939948, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=394, Percent_Identity=21.3197969543147, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24586065, Length=515, Percent_Identity=32.8155339805825, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56109; Mature: 56109

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIIRQLDEKRAAARLGGGQKRIDSQHAKGKLTARERIELLLDPDSFEEWDMFKEHRCV
CCHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCHHHCEEEEECCCCCHHHHHHHHCCCH
DFGMDKAEKTPGDGVVTGYGTINGRLVFVFSQDFTVFGGSLSETHAEKICKVMDHAMKVG
HCCCCHHCCCCCCCEEEEEEEECCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHC
APVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQISMIMGPCAGGAVYSPSMTD
CCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCE
FIFMVKDSSYMFVTGPEVVKTVTHEDVTAEELGGAVTHTSKSGVADLAFENDVEALTMLR
EEEEEECCCEEEEECHHHHHHHHCCCCCHHHHCCEEEECCCCCCEEHHHCCCHHHHHHHH
RFMNYLPSSNREKPPVQPTNDPADRQDFSLDTLVPDNPNKPYDMKELIIKVVDDCDFFEL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEE
QPDYAKNIIIGMARMDGQPVGIVANQPLVLAGCLDIKSAIKAARFVRFCDAFNIPVVTFV
CCHHHHHEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEE
DVPGFMPGTAQEYGGIIKHGAKLLYAYAECTVPKVTVITRKAYGGAYDVMASKHLRGDVN
ECCCCCCCCHHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCE
LAWPSAEIAVMGPKGAVEIIFREEKNNPEKLAEREAEYKAKFANPFVAASRGFIDDVVMP
EECCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHCCCCC
HNTRKRICRSLAMLADKQLDNPWRKHGNIPL
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
>Mature Secondary Structure
MHDIIRQLDEKRAAARLGGGQKRIDSQHAKGKLTARERIELLLDPDSFEEWDMFKEHRCV
CCHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCHHHCEEEEECCCCCHHHHHHHHCCCH
DFGMDKAEKTPGDGVVTGYGTINGRLVFVFSQDFTVFGGSLSETHAEKICKVMDHAMKVG
HCCCCHHCCCCCCCEEEEEEEECCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHC
APVIGLNDSGGARIQEGVASLGGYADVFQRNVMASGVIPQISMIMGPCAGGAVYSPSMTD
CCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEECCCCCE
FIFMVKDSSYMFVTGPEVVKTVTHEDVTAEELGGAVTHTSKSGVADLAFENDVEALTMLR
EEEEEECCCEEEEECHHHHHHHHCCCCCHHHHCCEEEECCCCCCEEHHHCCCHHHHHHHH
RFMNYLPSSNREKPPVQPTNDPADRQDFSLDTLVPDNPNKPYDMKELIIKVVDDCDFFEL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEE
QPDYAKNIIIGMARMDGQPVGIVANQPLVLAGCLDIKSAIKAARFVRFCDAFNIPVVTFV
CCHHHHHEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEE
DVPGFMPGTAQEYGGIIKHGAKLLYAYAECTVPKVTVITRKAYGGAYDVMASKHLRGDVN
ECCCCCCCCHHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCE
LAWPSAEIAVMGPKGAVEIIFREEKNNPEKLAEREAEYKAKFANPFVAASRGFIDDVVMP
EECCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHCCCCC
HNTRKRICRSLAMLADKQLDNPWRKHGNIPL
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]