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The map label for this gene is gor [H]

Identifier: 119896950

GI number: 119896950

Start: 694005

End: 695342

Strand: Reverse

Name: gor [H]

Synonym: azo0659

Alternate gene names: 119896950

Gene position: 695342-694005 (Counterclockwise)

Preceding gene: 119896953

Following gene: 119896944

Centisome position: 15.89

GC content: 72.05

Gene sequence:

>1338_bases
ATGACGCACTTTGACTACCTGGTGATCGGCGGCGGCAGCGGCGGCGTCGCCACCGCACGGCGGGCGGCGGAATACGGCGC
GCGCGTGCTGCTGATCGAAAGCGCCCGCCTCGGCGGCACCTGCGTCAATGCCGGCTGCGTGCCCAAGAAGCTGATGTGGC
ATGCGGCGGGCATCGGCCACGCGCTGCACGACGCGGCGGCGTTCGGCTTCCGCGTCGATGGCCTGCGCTTCGACTGGGCT
GCGCTGAAGCGCGGCCGCGACGACTTCGTCGCCTACCTCAACGGCGTCTATGCCAGCCTGCTCGACAAGGCCGGCGTCAG
CGTGGTGCGTGGCCACGCGCGCTTCGTCGATGCGCACACCGTGGAGGTTGGCGGACAGCGCTACAGCGCACCCCACATCG
TCATCGCCACCGGCGGCGAACCGCGCGTGCCGGACTCGCCCGGGGCCGCGCTCGGCATCACGTCGGACGGCTTCTTCGCG
CTCGACCACCTGCCGGCGCGCACCATCGTCGTCGGCGGCGGCTACATCGCGGTCGAGCTGGCGGGCGTGCTCGCGGCGCT
TGGCAGCGAGGTCACGATGCTGGTGCGCGGCGAACATCTGCTGCGCCCCTTCGACGCCATGGTGCGCGACGAACTCGCAT
TGCAGATGCGCGACGCCGGCATCCGCATCGTCACCGGCAGCGAAGCCGGCGCGGTGCGCCGCGCGGACGACGGTGCGCTG
CGGGCGGCCTGCGGCAGCGCCGAGTTCGAGGGCGACACGCTGATCTGGGCGATCGGCCGCCAGGCGCGCACCGCCGGCCT
CAACCTCGCCGCCGCCGGCCTGGGCACAGAGAAGGACGGCAGCATCGCCACCGACGCCTGGCAGGACACCGCGGTGCCCG
GCATCCATGCCATCGGCGACGTCACCGGGCGCGTGGAGCTGACCCCGGTCGCGATCGCTGCCGGCCGCCGTCTTGCCGCG
CGCCTGTTCGGCGGCCAGCCGGAAGCGCGGCTCGACTACGAGAACGTCCCGTCGGTGGTGTTCAGTCATCCGCCGATCGG
CACCGTGGGCCTGACCGAAGAGGCCGCCCGCGCCCGCCATGCGGACGTGCGCGTCTACCACACCCGCTTCACCGCGATGT
ACCACGCGCTCAAGACGCAGCGGCCCAAGACCGCGATGAAGCTGGTGTGCGCCGGCCCGCAGGAGCAGGTGGTCGGCTGC
CACATCATCGGCGAAGGCGCGGACGAAATGCTGCAGGGCTTCGCGGTGGCGATACGGATGGGCGCCACCAAGGCGGACTT
CGACGACACCGTGGCGATCCACCCCACCAGCGCCGAGGAGCTGGTGACGATGCGCTAG

Upstream 100 bases:

>100_bases
ATACCAGAAGATGCCGCCGCACCCGTTTGGTGCCCGGCACGTTCCATTCCCGCCGCATTTCTTCTTCCCGCGCCCCGCGG
CGCCCCTTGCGGAGACGACG

Downstream 100 bases:

>100_bases
GCCGGCGTTCTACAGCGGCGCCAGGTCCTCGCCGCGCAAGCCCACCAGCAGCGCCTTGCCGTCGGCATCCACGCGGAACT
CGCCGAAGCGCGCGGCGGCC

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTHFDYLVIGGGSGGVATARRAAEYGARVLLIESARLGGTCVNAGCVPKKLMWHAAGIGHALHDAAAFGFRVDGLRFDWA
ALKRGRDDFVAYLNGVYASLLDKAGVSVVRGHARFVDAHTVEVGGQRYSAPHIVIATGGEPRVPDSPGAALGITSDGFFA
LDHLPARTIVVGGGYIAVELAGVLAALGSEVTMLVRGEHLLRPFDAMVRDELALQMRDAGIRIVTGSEAGAVRRADDGAL
RAACGSAEFEGDTLIWAIGRQARTAGLNLAAAGLGTEKDGSIATDAWQDTAVPGIHAIGDVTGRVELTPVAIAAGRRLAA
RLFGGQPEARLDYENVPSVVFSHPPIGTVGLTEEAARARHADVRVYHTRFTAMYHALKTQRPKTAMKLVCAGPQEQVVGC
HIIGEGADEMLQGFAVAIRMGATKADFDDTVAIHPTSAEELVTMR

Sequences:

>Translated_445_residues
MTHFDYLVIGGGSGGVATARRAAEYGARVLLIESARLGGTCVNAGCVPKKLMWHAAGIGHALHDAAAFGFRVDGLRFDWA
ALKRGRDDFVAYLNGVYASLLDKAGVSVVRGHARFVDAHTVEVGGQRYSAPHIVIATGGEPRVPDSPGAALGITSDGFFA
LDHLPARTIVVGGGYIAVELAGVLAALGSEVTMLVRGEHLLRPFDAMVRDELALQMRDAGIRIVTGSEAGAVRRADDGAL
RAACGSAEFEGDTLIWAIGRQARTAGLNLAAAGLGTEKDGSIATDAWQDTAVPGIHAIGDVTGRVELTPVAIAAGRRLAA
RLFGGQPEARLDYENVPSVVFSHPPIGTVGLTEEAARARHADVRVYHTRFTAMYHALKTQRPKTAMKLVCAGPQEQVVGC
HIIGEGADEMLQGFAVAIRMGATKADFDDTVAIHPTSAEELVTMR
>Mature_444_residues
THFDYLVIGGGSGGVATARRAAEYGARVLLIESARLGGTCVNAGCVPKKLMWHAAGIGHALHDAAAFGFRVDGLRFDWAA
LKRGRDDFVAYLNGVYASLLDKAGVSVVRGHARFVDAHTVEVGGQRYSAPHIVIATGGEPRVPDSPGAALGITSDGFFAL
DHLPARTIVVGGGYIAVELAGVLAALGSEVTMLVRGEHLLRPFDAMVRDELALQMRDAGIRIVTGSEAGAVRRADDGALR
AACGSAEFEGDTLIWAIGRQARTAGLNLAAAGLGTEKDGSIATDAWQDTAVPGIHAIGDVTGRVELTPVAIAAGRRLAAR
LFGGQPEARLDYENVPSVVFSHPPIGTVGLTEEAARARHADVRVYHTRFTAMYHALKTQRPKTAMKLVCAGPQEQVVGCH
IIGEGADEMLQGFAVAIRMGATKADFDDTVAIHPTSAEELVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=51.3100436681223, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=40.6113537117904, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=36.4035087719298, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=36.4035087719298, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=36.4035087719298, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=36.4035087719298, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=36.4035087719298, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=35.1528384279476, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=32.5274725274725, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI91199540, Length=454, Percent_Identity=30.1762114537445, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1789915, Length=447, Percent_Identity=53.9149888143177, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=29.7117516629712, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87082354, Length=447, Percent_Identity=26.8456375838926, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=26.9058295964126, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=52.6666666666667, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=52.6666666666667, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=36.1702127659575, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=33.7474120082816, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=29.4759825327511, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=48.2758620689655, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321091, Length=460, Percent_Identity=28.2608695652174, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=27.906976744186, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24640553, Length=468, Percent_Identity=39.3162393162393, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI17737741, Length=470, Percent_Identity=40, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24640549, Length=468, Percent_Identity=39.3162393162393, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24640551, Length=468, Percent_Identity=39.3162393162393, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=30.1098901098901, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 46740; Mature: 46609

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHFDYLVIGGGSGGVATARRAAEYGARVLLIESARLGGTCVNAGCVPKKLMWHAAGIGH
CCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCEEECCCCCCHHHHHHHHCCCH
ALHDAAAFGFRVDGLRFDWAALKRGRDDFVAYLNGVYASLLDKAGVSVVRGHARFVDAHT
HHHHHHHCCEEECCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHCCHHEEECCEEEEEEEE
VEVGGQRYSAPHIVIATGGEPRVPDSPGAALGITSDGFFALDHLPARTIVVGGGYIAVEL
EEECCCEECCCEEEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCEEEEEECCEEEHHH
AGVLAALGSEVTMLVRGEHLLRPFDAMVRDELALQMRDAGIRIVTGSEAGAVRRADDGAL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCEEECCCCCH
RAACGSAEFEGDTLIWAIGRQARTAGLNLAAAGLGTEKDGSIATDAWQDTAVPGIHAIGD
HHHCCCCCCCCCEEEEEECCCCHHCCCEEEEECCCCCCCCCEECCCCCCCCCCCCHHHCC
VTGRVELTPVAIAAGRRLAARLFGGQPEARLDYENVPSVVFSHPPIGTVGLTEEAARARH
CCCEEEEEEEEECCCHHHHHHHHCCCCCCEECCCCCCCEEECCCCCCCCCCCHHHHHHHC
ADVRVYHTRFTAMYHALKTQRPKTAMKLVCAGPQEQVVGCHIIGEGADEMLQGFAVAIRM
CCEEEEEHHHHHHHHHHHCCCCCHHEEEEECCCHHCEEEEEEECCCHHHHHHHHEEEEEE
GATKADFDDTVAIHPTSAEELVTMR
CCCCCCCCCEEEECCCCHHHHEECC
>Mature Secondary Structure 
THFDYLVIGGGSGGVATARRAAEYGARVLLIESARLGGTCVNAGCVPKKLMWHAAGIGH
CCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCEEECCCCCCHHHHHHHHCCCH
ALHDAAAFGFRVDGLRFDWAALKRGRDDFVAYLNGVYASLLDKAGVSVVRGHARFVDAHT
HHHHHHHCCEEECCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHCCHHEEECCEEEEEEEE
VEVGGQRYSAPHIVIATGGEPRVPDSPGAALGITSDGFFALDHLPARTIVVGGGYIAVEL
EEECCCEECCCEEEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCEEEEEECCEEEHHH
AGVLAALGSEVTMLVRGEHLLRPFDAMVRDELALQMRDAGIRIVTGSEAGAVRRADDGAL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCEEECCCCCH
RAACGSAEFEGDTLIWAIGRQARTAGLNLAAAGLGTEKDGSIATDAWQDTAVPGIHAIGD
HHHCCCCCCCCCEEEEEECCCCHHCCCEEEEECCCCCCCCCEECCCCCCCCCCCCHHHCC
VTGRVELTPVAIAAGRRLAARLFGGQPEARLDYENVPSVVFSHPPIGTVGLTEEAARARH
CCCEEEEEEEEECCCHHHHHHHHCCCCCCEECCCCCCCEEECCCCCCCCCCCHHHHHHHC
ADVRVYHTRFTAMYHALKTQRPKTAMKLVCAGPQEQVVGCHIIGEGADEMLQGFAVAIRM
CCEEEEEHHHHHHHHHHHCCCCCHHEEEEECCCHHCEEEEEEECCCHHHHHHHHEEEEEE
GATKADFDDTVAIHPTSAEELVTMR
CCCCCCCCCEEEECCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]