Click here to switch to the map view.

The map label for this gene is ilvD

Identifier: 119896923

GI number: 119896923

Start: 661937

End: 663787

Strand: Direct

Name: ilvD

Synonym: azo0632

Alternate gene names: 119896923

Gene position: 661937-663787 (Clockwise)

Preceding gene: 119896922

Following gene: 119896924

Centisome position: 15.13

GC content: 67.04

Gene sequence:

>1851_bases
ATGCCCCAATACCGTTCCCGCACCTCCACCGCCGGCCGCAACATGGCAGGTGCCCGCGCCCTGTGGCGCGCCACCGGCAT
GAAGGACGGCGACTTCGAAAAGCCGATCATCGCGATCGCCAACAGCTTCACCCAGTTCGTGCCGGGTCATGTGCACCTGA
AGGACCTCGGCCAGCTTGTCGCGCGCGAGATCGAAGCCGCCGGCGGCGTCGCGAAGGAATTCAACACCATCGCGGTCGAT
GACGGCATCGCCATGGGCCACGGCGGCATGCTGTATTCGCTGCCCTCGCGCGACCTCATCGCCGACAGCGTCGAATACAT
GGTGAACGCGCACACCGCGGACGCGCTGGTGTGCATCTCCAACTGCGACAAGATCACCCCGGGCATGCTGATGGCCGCGC
TGCGCCTCAACATTCCCACCATCTTCGTCTCCGGCGGGCCGATGGAGGCCGGCAAGGTGAAATGGGAAGCCAAGATCATC
CCGCTCGACCTCGTCGATGCGATGGTCAAGGCCGCGGACAAGAACTGTTCGGACGAGGAAGTCGACGCGATCGAACGCTC
CGCCTGTCCCACCTGTGGTTCCTGCTCCGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAAGCGCTGGGCCTGT
CGCTGCCCGGCAATGGCACCACGCTGGCCACCCATGCCGACCGCGAAAAGCTGTTCCGCGAGGCCGGCCGCCGCATCGTC
GATCTCGCCAAGCGCTACTACGAGAAGGACGACGCCACGGTGCTGCCGCGCGCCATCGCCAGCTTCGCCGCGTTCGAGAA
CGCGATCAGCCTGGACGTGGCGATGGGCGGGTCCACCAACACCGTGCTGCACCTGCTCGCCGCCGCCAAGGAGGCAGGGG
TGGACTTCACGATGAAGGACATCGATCGCATCTCGCGCCACGTGCCCTGCCTGTGCAAGGTGGCGCCGGCGGTGCCGGAC
GTGCATATCGAGGACGTGCACCGCGCCGGCGGGATCATGAGCATCCTCGGCGAACTCGACCGCGCTGGCCTGCTCAACCG
TGATGTGCCCACGGTGCACAGCAAGACGCTGGGCGAAGCGCTGGGCCGCTGGGACATCATGCAGGCGCACGACAAGGCGG
TGTTCGATTTCTTCCTCGCCGCTCCGGGCGGCGTGCCGACCCAGGTGGCCTTCAGCCAGAACCGGCGCTGGAACGAACTC
GACATGGACCGCGCCAAGGGCGTGATCCGCAACAAGGCCAACGCCTTCAGCCAGGACGGCGGCCTCGCGGTGCTGTACGG
CAACATCGCCGAAAAGGGCTGCATCGTGAAGACCGCCGGCGTGGATGAGTCGATCTGGCAGTTCACCGGCAAGGCGCGGG
TGTACGAAAGCCAGGAAGACGCCGTCGAAGGCATCCTGGGCGAGCAGGTGCAGGCGGGTGACGTGGTCGTGATCCGCTAC
GAAGGCCCCAAGGGCGGCCCCGGCATGCAGGAGATGCTGTACCCCACCTCGTACCTGAAGAGCCGCGGCCTGGGCAAGGA
GTGTGCGCTGCTGACCGATGGCCGCTTCTCCGGCGGCACTTCGGGCCTGTCGATCGGCCACGCTTCTCCGGAAGCCGCGA
TGGGCGGCGCGATCGCGCTGGTGGAAGACGGCGACACGATCGAGATCGACATCCCCAACCGCCGCATCGCGCTGGCGGTG
TCCGATGAAGAACTTGCCCGCCGCCGCGCCGCGATGGAGGCCAAAGGCGCAGCGGCCTGGAAACCGGCAAACCGCGAGCG
CGTCGTTTCGGCCGCGCTGCAGGCCTATGCTGCGCTCACCACCTCGGCCGACACCGGGGCGGTGCGCGACATCACCCAGG
TCCAGCGCTGA

Upstream 100 bases:

>100_bases
ATCACTATCTGGCGGAGGTCTGCACCGCCTGAGGGCCTGACGCATCGCCGCCGCGGCGGGTAGAATCGACGGTCTACCGC
AGTTCGCCCGGAGTCCCGCA

Downstream 100 bases:

>100_bases
ACGAAGCGGGGGCGGCGATCAAGGCCGCCGCCCCGTCTCCCCCATCAATTGACCGCCTCGCGCGGCCCCCTCTACCATCG
AGACCATGGACGCCGACCTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHTADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKVKWEAKII
PLDLVDAMVKAADKNCSDEEVDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREKLFREAGRRIV
DLAKRYYEKDDATVLPRAIASFAAFENAISLDVAMGGSTNTVLHLLAAAKEAGVDFTMKDIDRISRHVPCLCKVAPAVPD
VHIEDVHRAGGIMSILGELDRAGLLNRDVPTVHSKTLGEALGRWDIMQAHDKAVFDFFLAAPGGVPTQVAFSQNRRWNEL
DMDRAKGVIRNKANAFSQDGGLAVLYGNIAEKGCIVKTAGVDESIWQFTGKARVYESQEDAVEGILGEQVQAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSRGLGKECALLTDGRFSGGTSGLSIGHASPEAAMGGAIALVEDGDTIEIDIPNRRIALAV
SDEELARRRAAMEAKGAAAWKPANRERVVSAALQAYAALTTSADTGAVRDITQVQR

Sequences:

>Translated_616_residues
MPQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHTADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKVKWEAKII
PLDLVDAMVKAADKNCSDEEVDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREKLFREAGRRIV
DLAKRYYEKDDATVLPRAIASFAAFENAISLDVAMGGSTNTVLHLLAAAKEAGVDFTMKDIDRISRHVPCLCKVAPAVPD
VHIEDVHRAGGIMSILGELDRAGLLNRDVPTVHSKTLGEALGRWDIMQAHDKAVFDFFLAAPGGVPTQVAFSQNRRWNEL
DMDRAKGVIRNKANAFSQDGGLAVLYGNIAEKGCIVKTAGVDESIWQFTGKARVYESQEDAVEGILGEQVQAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSRGLGKECALLTDGRFSGGTSGLSIGHASPEAAMGGAIALVEDGDTIEIDIPNRRIALAV
SDEELARRRAAMEAKGAAAWKPANRERVVSAALQAYAALTTSADTGAVRDITQVQR
>Mature_615_residues
PQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRDLIADSVEYMVNAHTADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKVKWEAKIIP
LDLVDAMVKAADKNCSDEEVDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREKLFREAGRRIVD
LAKRYYEKDDATVLPRAIASFAAFENAISLDVAMGGSTNTVLHLLAAAKEAGVDFTMKDIDRISRHVPCLCKVAPAVPDV
HIEDVHRAGGIMSILGELDRAGLLNRDVPTVHSKTLGEALGRWDIMQAHDKAVFDFFLAAPGGVPTQVAFSQNRRWNELD
MDRAKGVIRNKANAFSQDGGLAVLYGNIAEKGCIVKTAGVDESIWQFTGKARVYESQEDAVEGILGEQVQAGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSRGLGKECALLTDGRFSGGTSGLSIGHASPEAAMGGAIALVEDGDTIEIDIPNRRIALAVS
DEELARRRAAMEAKGAAAWKPANRERVVSAALQAYAALTTSADTGAVRDITQVQR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=614, Percent_Identity=74.4299674267101, Blast_Score=944, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=522, Percent_Identity=32.183908045977, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI2367371, Length=573, Percent_Identity=30.5410122164049, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1788157, Length=544, Percent_Identity=29.4117647058824, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=37.4384236453202, Blast_Score=345, Evalue=8e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_AZOSB (A1K344)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932136.1
- STRING:   A1K344
- GeneID:   4606484
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0632
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   A1K344
- ProtClustDB:   PRK12448
- BioCyc:   ASP62928:AZO0632-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65695; Mature: 65563

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHTADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEC
NCDKITPGMLMAALRLNIPTIFVSGGPMEAGKVKWEAKIIPLDLVDAMVKAADKNCSDEE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECHHHHHHHHHHHCCCCCHHH
VDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREKLFREAGRRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
DLAKRYYEKDDATVLPRAIASFAAFENAISLDVAMGGSTNTVLHLLAAAKEAGVDFTMKD
HHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDRISRHVPCLCKVAPAVPDVHIEDVHRAGGIMSILGELDRAGLLNRDVPTVHSKTLGEA
HHHHHHCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LGRWDIMQAHDKAVFDFFLAAPGGVPTQVAFSQNRRWNELDMDRAKGVIRNKANAFSQDG
HCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCC
GLAVLYGNIAEKGCIVKTAGVDESIWQFTGKARVYESQEDAVEGILGEQVQAGDVVVIRY
CEEEEECCCCCCCCEEEECCCCHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSRGLGKECALLTDGRFSGGTSGLSIGHASPEAAMGGAIAL
CCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCEEEE
VEDGDTIEIDIPNRRIALAVSDEELARRRAAMEAKGAAAWKPANRERVVSAALQAYAALT
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADTGAVRDITQVQR
CCCCCCHHHHHHHHCC
>Mature Secondary Structure 
PQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHTADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEC
NCDKITPGMLMAALRLNIPTIFVSGGPMEAGKVKWEAKIIPLDLVDAMVKAADKNCSDEE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECHHHHHHHHHHHCCCCCHHH
VDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREKLFREAGRRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
DLAKRYYEKDDATVLPRAIASFAAFENAISLDVAMGGSTNTVLHLLAAAKEAGVDFTMKD
HHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDRISRHVPCLCKVAPAVPDVHIEDVHRAGGIMSILGELDRAGLLNRDVPTVHSKTLGEA
HHHHHHCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LGRWDIMQAHDKAVFDFFLAAPGGVPTQVAFSQNRRWNELDMDRAKGVIRNKANAFSQDG
HCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCC
GLAVLYGNIAEKGCIVKTAGVDESIWQFTGKARVYESQEDAVEGILGEQVQAGDVVVIRY
CEEEEECCCCCCCCEEEECCCCHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSRGLGKECALLTDGRFSGGTSGLSIGHASPEAAMGGAIAL
CCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCEEEE
VEDGDTIEIDIPNRRIALAVSDEELARRRAAMEAKGAAAWKPANRERVVSAALQAYAALT
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADTGAVRDITQVQR
CCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA